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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lansoprazole
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Accession:CHEBI:6375 term browser browse the term
Definition:A sulfoxide that has formula C16H14F3N3O2S.
Synonyms:exact_synonym: 2-({[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl}sulfinyl)-1H-benzimidazole
 related_synonym: AG 1749;   Bamalite;   Formula=C16H14F3N3O2S;   InChI=1S/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22);   InChIKey=MJIHNNLFOKEZEW-UHFFFAOYSA-N;   Lanzol;   Lanzopral;   Lanzul;   Limpidex;   Monolitum;   Ogastro;   Opiren;   Prevacid;   SMILES=Cc1c(OCC(F)(F)F)ccnc1CS(=O)c1nc2ccccc2[nH]1;   lansoprazol;   lansoprazolum
 xref: Beilstein:4333393;   CAS:103577-45-3;   DrugBank:DB00448;   Drug_Central:1547;   KEGG:D00355;   LINCS:LSM-5064
 xref_mesh: MESH:D064747
 xref: Patent:EP174726;   Patent:US4628098;   Wikipedia:Lansoprazole


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lansoprazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO Lansoprazole results in increased expression of ABCA1 protein
Lansoprazole results in increased expression of ABCA1 mRNA; Lansoprazole results in increased expression of ABCA1 protein
CTD PMID:20060385 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance ISO ABCB1 affects the susceptibility to Lansoprazole CTD PMID:19238367 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Apoe apolipoprotein E increases expression ISO Lansoprazole results in increased expression of APOE mRNA; Lansoprazole results in increased expression of APOE protein CTD PMID:20060385 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Aqp4 aquaporin 4 increases expression ISO Lansoprazole results in increased expression of AQP4 mRNA; Lansoprazole results in increased expression of AQP4 protein CTD PMID:20437101 NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in decreased expression of BCL2 mRNA] CTD PMID:28412091 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G C1qa complement C1q A chain decreases expression EXP Lansoprazole results in decreased expression of C1QA mRNA CTD PMID:25626140 NCBI chr 5:155,261,254...155,264,101
Ensembl chr 5:155,261,250...155,264,143
JBrowse link
G C1qc complement C1q C chain decreases expression EXP Lansoprazole results in decreased expression of C1QC mRNA CTD PMID:25626140 NCBI chr 5:155,255,013...155,258,631
Ensembl chr 5:155,255,005...155,258,392
JBrowse link
G C4bpa complement component 4 binding protein, alpha decreases expression EXP Lansoprazole results in decreased expression of C4BPA mRNA CTD PMID:25626140 NCBI chr13:47,342,090...47,377,580
Ensembl chr13:47,342,079...47,377,703
JBrowse link
G C4bpb complement component 4 binding protein, beta decreases expression EXP Lansoprazole results in decreased expression of C4BPB mRNA CTD PMID:25626140 NCBI chr13:47,387,173...47,398,115
Ensembl chr13:47,387,173...47,397,890
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
Lansoprazole inhibits the reaction [Demecolcine results in increased activity of CASP3 protein]
Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of CASP3 mRNA]; Lansoprazole inhibits the reaction [Ethanol results in increased expression of CASP3 protein]
CTD PMID:12530016 PMID:28412091 PMID:29339218 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions EXP Lansoprazole inhibits the reaction [Ethanol results in decreased activity of CAT protein]; Lansoprazole inhibits the reaction [Indomethacin results in increased activity of CAT protein] CTD PMID:18726076 PMID:29339218 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cfi complement factor I decreases expression EXP Lansoprazole results in decreased expression of CFI mRNA CTD PMID:25626140 NCBI chr 2:235,264,149...235,305,779
Ensembl chr 2:235,264,219...235,305,781
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression
multiple interactions
EXP Lansoprazole results in decreased expression of CXCL1 mRNA; Lansoprazole results in decreased expression of CXCL1 protein
Lansoprazole inhibits the reaction [Indomethacin results in increased expression of CXCL1 mRNA]; Lansoprazole inhibits the reaction [Indomethacin results in increased expression of CXCL1 protein]
CTD PMID:15334676 PMID:16328016 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
increases expression
ISO
EXP
Lansoprazole results in increased activity of CYP1A1 promoter
Lansoprazole results in increased expression of CYP1A1 mRNA; Lansoprazole results in increased expression of CYP1A1 protein
CTD PMID:8169844 PMID:8647108 PMID:8900397 PMID:9041675 PMID:9152597 PMID:9860486 PMID:10859152 PMID:12623754 PMID:14550749 PMID:18502397 PMID:25626140 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO
EXP
Lansoprazole results in increased expression of CYP1A2 mRNA; Lansoprazole results in increased expression of CYP1A2 protein CTD PMID:8169844 PMID:9152597 PMID:9744552 PMID:12623754 PMID:14550749 PMID:25626140 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO Lansoprazole results in increased expression of CYP1B1 mRNA CTD PMID:12623754 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP Lansoprazole results in increased expression of CYP2B1 protein CTD PMID:9152597 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Lansoprazole results in increased expression of CYP2B2 protein CTD PMID:9152597 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 increases hydroxylation ISO CYP2C18 protein results in increased hydroxylation of Lansoprazole CTD PMID:7870052 NCBI chr 1:258,074,797...258,139,176
Ensembl chr 1:258,074,860...258,139,176
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 affects response to substance
increases expression
decreases activity
increases hydroxylation
affects metabolic processing
increases metabolic processing
decreases metabolic processing
multiple interactions
ISO
EXP
CYP2C19 gene affects the susceptibility to Lansoprazole; CYP2C19 gene polymorphism affects the susceptibility to Lansoprazole
Lansoprazole results in increased expression of CYP2C6V1 mRNA; Lansoprazole results in increased expression of CYP2C6V1 protein
Lansoprazole results in decreased activity of CYP2C19 protein
CYP2C19 protein results in increased hydroxylation of Lansoprazole
CYP2C19 protein affects the metabolism of Lansoprazole
CYP2C19 protein results in increased metabolism of Lansoprazole; Lansoprazole results in increased metabolism of CYP2C19 protein
CYP2C19 gene polymorphism results in decreased metabolism of Lansoprazole
CYP2C19 affects the reaction [Lansoprazole affects the susceptibility to Tacrolimus]; CYP2C19 affects the susceptibility to [Tacrolimus co-treated with Lansoprazole]; CYP2C19 gene mutant form affects the susceptibility to [Lansoprazole co-treated with Tacrolimus]; Famotidine inhibits the reaction [CYP2C19 gene affects the susceptibility to Lansoprazole]; Lansoprazole inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]
CTD PMID:8627562 PMID:8930576 PMID:9152597 PMID:9272410 PMID:11829200 PMID:11929404 PMID:12975331 PMID:14550749 PMID:15010519 PMID:15258107 PMID:15285851 PMID:15963082 PMID:17377957 PMID:19814645 PMID:21212520 PMID:21795468 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects metabolic processing
increases hydroxylation
ISO CYP2C8 protein affects the metabolism of Lansoprazole
CYP2C8 protein results in increased hydroxylation of Lansoprazole
CTD PMID:7870052 PMID:8627562 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO CYP3A5 affects the susceptibility to [Tacrolimus co-treated with Lansoprazole] CTD PMID:17377957 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression EXP Lansoprazole results in increased expression of CYP4A1 protein CTD PMID:9152597 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
JBrowse link
G Egfr epidermal growth factor receptor increases expression ISO Lansoprazole results in increased expression of EGFR protein CTD PMID:9881512 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP Lansoprazole inhibits the reaction [Ethanol results in increased expression of FAS protein] CTD PMID:29339218 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions EXP Lansoprazole inhibits the reaction [Ethanol results in increased expression of FASLG protein] CTD PMID:29339218 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression ISO Lansoprazole results in decreased expression of FGF2 protein CTD PMID:9881512 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgf21 fibroblast growth factor 21 increases expression ISO Lansoprazole results in increased expression of FGF21 protein CTD PMID:8774986 NCBI chr 1:101,595,579...101,596,822
Ensembl chr 1:101,595,579...101,596,822
JBrowse link
G Gast gastrin increases expression ISO
EXP
Lansoprazole results in increased expression of GAST protein CTD PMID:7750667 PMID:8792694 PMID:11680587 PMID:11975934 PMID:12189558 PMID:12438555 PMID:20095383 NCBI chr10:88,245,532...88,248,485
Ensembl chr10:88,245,532...88,248,484
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Lansoprazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hamp hepcidin antimicrobial peptide increases expression ISO Lansoprazole results in increased expression of HAMP mRNA CTD PMID:31669099 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
increases activity
ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lansoprazole results in increased expression of HMOX1 mRNA]; Lansoprazole results in increased activity of and results in increased expression of HMOX1 protein
Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of HMOX1 mRNA]; NFE2L2 mRNA affects the reaction [Lansoprazole results in increased expression of HMOX1 mRNA]; NFE2L2 mRNA affects the reaction [Lansoprazole results in increased expression of HMOX1 protein]; U 0126 inhibits the reaction [Lansoprazole results in increased expression of HMOX1 protein]
Lansoprazole results in increased expression of HMOX1 mRNA; Lansoprazole results in increased expression of HMOX1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lansoprazole results in increased activity of HMOX1 promoter]
CTD PMID:16712795 PMID:19628634 PMID:19764090 PMID:28412091 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression
ISO Lansoprazole inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]
Lansoprazole results in decreased expression of IFNG mRNA
CTD PMID:16932910 PMID:19232345 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions EXP Lansoprazole inhibits the reaction [Ethanol results in decreased expression of IL10 protein] CTD PMID:29339218 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions
ISO
EXP
Lansoprazole results in decreased expression of IL1B mRNA
Lansoprazole inhibits the reaction [Ethanol results in increased expression of IL1B protein]
CTD PMID:16932910 PMID:29339218 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
ISO
EXP
Lansoprazole results in decreased expression of IL6 mRNA
Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of IL6 mRNA]
CTD PMID:16932910 PMID:28412091 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases oxidation EXP Lansoprazole results in increased oxidation of KEAP1 protein CTD PMID:19628634 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions
increases expression
EXP Lansoprazole inhibits the reaction [LHB protein results in increased abundance of Testosterone]
Lansoprazole results in increased expression of LHB protein
CTD PMID:7589908 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation EXP Lansoprazole results in increased phosphorylation of MAPK1 protein CTD PMID:19628634 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation EXP Lansoprazole results in increased phosphorylation of MAPK3 protein CTD PMID:19628634 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapt microtubule-associated protein tau affects binding ISO Lansoprazole binds to MAPT protein alternative form CTD PMID:20110603 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Lansoprazole inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MPO protein]; Lansoprazole inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:17151854 PMID:17895592 PMID:18726076 PMID:24337826 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
increases phosphorylation
EXP Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of NFE2L2 mRNA]; NFE2L2 mRNA affects the reaction [Lansoprazole results in increased expression of HMOX1 mRNA]; NFE2L2 mRNA affects the reaction [Lansoprazole results in increased expression of HMOX1 protein]
Lansoprazole results in increased expression of NFE2L2 mRNA
Lansoprazole results in increased phosphorylation of NFE2L2 protein
CTD PMID:19628634 PMID:28412091 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Lansoprazole inhibits the reaction [Ethanol results in decreased expression of and results in increased phosphorylation of NFKBIA protein] CTD PMID:29339218 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 increases activity ISO Lansoprazole results in increased activity of NR1H2 protein CTD PMID:20060385 NCBI chr 1:100,554,577...100,559,896
Ensembl chr 1:100,554,544...100,559,942
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases activity ISO Lansoprazole results in increased activity of NR1H3 protein CTD PMID:20060385 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Lansoprazole results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Phospho1 phosphoethanolamine/phosphocholine phosphatase 1 decreases activity ISO Lansoprazole results in decreased activity of PHOSPHO1 protein CTD PMID:17227223 NCBI chr10:83,635,557...83,643,862
Ensembl chr10:83,636,518...83,643,859
JBrowse link
G Pomc proopiomelanocortin increases expression ISO Lansoprazole results in increased expression of POMC protein CTD PMID:16524691 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
EXP AG-041R inhibits the reaction [Lansoprazole results in increased expression of PTGS2 protein] CTD PMID:12438555 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Lansoprazole inhibits the reaction [Ethanol results in decreased expression of and results in increased phosphorylation of RELA protein] CTD PMID:29339218 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Retsat retinol saturase decreases expression EXP Lansoprazole results in decreased expression of RETSAT mRNA CTD PMID:25626140 NCBI chr 4:100,465,365...100,474,128
Ensembl chr 4:100,465,170...100,474,301
JBrowse link
G Serping1 serpin family G member 1 decreases expression EXP Lansoprazole results in decreased expression of SERPING1 mRNA CTD PMID:25626140 NCBI chr 3:72,161,230...72,171,109
Ensembl chr 3:72,161,189...72,171,078
JBrowse link
G Shh sonic hedgehog signaling molecule decreases expression ISO Lansoprazole results in decreased expression of SHH mRNA CTD PMID:20437101 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Lansoprazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Tgfa transforming growth factor alpha increases expression ISO Lansoprazole results in increased expression of TGFA protein CTD PMID:9881512 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
Lansoprazole inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]
Lansoprazole inhibits the reaction [Ethanol results in increased expression of TNF protein]
Lansoprazole results in decreased expression of TNF mRNA
CTD PMID:16932910 PMID:19232345 PMID:29339218 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of TP53 mRNA] CTD PMID:28412091 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression EXP Lansoprazole results in increased expression of UGT1A1 mRNA CTD PMID:25626140 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases expression EXP Lansoprazole results in increased expression of UGT2B1 mRNA CTD PMID:25626140 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link

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