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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:allicin
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Accession:CHEBI:28411 term browser browse the term
Definition:A botanical anti-fungal agent that has formula C6H10OS2.
Synonyms:exact_synonym: S-allyl prop-2-ene-1-sulfinothioate
 related_synonym: 2-Propene-1-sulfinothioic acid S-2-propenyl ester;   Formula=C6H10OS2;   InChI=1S/C6H10OS2/c1-3-5-8-9(7)6-4-2/h3-4H,1-2,5-6H2;   InChIKey=JDLKFOPOAOFWQN-UHFFFAOYSA-N;   SMILES=C=CCSS(=O)CC=C;   thio-2-propene-1-sulfinic acid S-allyl ester
 alt_id: CHEBI:22356;   CHEBI:2595
 xref: Beilstein:1752823;   CAS:539-86-6;   KEGG:C07600;   KNApSAcK:C00001242
 xref_mesh: MESH:C006452

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allicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions ISO allicin inhibits the reaction [Acetaminophen results in decreased expression of ALB protein] CTD PMID:32040233 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO allicin inhibits the reaction [arsenic trioxide results in increased expression of BAX protein] CTD PMID:27561292 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO allicin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein] CTD PMID:32040233 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO allicin inhibits the reaction [arsenic trioxide results in decreased expression of BCL2L1 protein] CTD PMID:27561292 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO allicin inhibits the reaction [Acetaminophen results in increased expression of CASP1 protein] CTD PMID:32040233 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO allicin inhibits the reaction [Acetaminophen results in increased expression of GPT protein] CTD PMID:32040233 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO allicin inhibits the reaction [arsenic trioxide results in decreased expression of HMOX1 protein] CTD PMID:27561292 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO allicin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:12723939 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 ISO
EXP		 allicin inhibits the reaction [IL1B protein affects the localization of RELA protein]; IL1B protein promotes the reaction [allicin results in increased phosphorylation of MAPK1 protein]; IL1B protein promotes the reaction [allicin results in increased phosphorylation of MAPK3 protein]
allicin inhibits the reaction [Acetaminophen results in increased expression of IL1B protein]
allicin results in increased expression of IL1B mRNA
[allicin co-treated with Mesalamine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; [allicin co-treated with Mesalamine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]; [allicin co-treated with Sulfasalazine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; [allicin co-treated with Sulfasalazine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]; allicin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; allicin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]		 CTD PMID:25729217, PMID:32040233 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il4 interleukin 4 multiple interactions EXP [allicin co-treated with Mesalamine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased secretion of IL4 protein] CTD PMID:25729217 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531 		JBrowse link
G Klf9 Kruppel-like factor 9 multiple interactions ISO allicin inhibits the reaction [arsenic trioxide results in decreased expression of KLF9 protein] CTD PMID:27561292 NCBI chr 1:240,908,483...240,933,198
Ensembl chr 1:240,908,483...240,933,198 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO allicin results in increased phosphorylation of MAPK1 protein
IL1B protein promotes the reaction [allicin results in increased phosphorylation of MAPK1 protein]		 CTD PMID:25729217 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO IL1B protein promotes the reaction [allicin results in increased phosphorylation of MAPK3 protein] CTD PMID:25729217 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO allicin inhibits the reaction [arsenic trioxide results in decreased expression of NFE2L2 protein] CTD PMID:27561292 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO allicin inhibits the reaction [Acetaminophen results in increased expression of NLRP3 protein] CTD PMID:32040233 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO allicin inhibits the reaction [arsenic trioxide results in decreased expression of NQO1 protein] CTD PMID:27561292 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO allicin inhibits the reaction [arsenic trioxide results in increased expression of RELA protein]; allicin inhibits the reaction [IL1B protein affects the localization of RELA protein] CTD PMID:25729217, PMID:27561292 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 allicin inhibits the reaction [TNF protein results in increased abundance of Hydrogen Peroxide]; allicin inhibits the reaction [TNF protein results in increased abundance of Nitric Oxide]; allicin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
[allicin co-treated with Mesalamine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; [allicin co-treated with Sulfasalazine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; allicin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]		 CTD PMID:12723939, PMID:25729217 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity
multiple interactions		 EXP
ISO		 allicin results in increased activity of TRPA1 protein
allicin binds to and results in increased activity of TRPA1 protein
[allicin binds to and results in increased activity of TRPA1 protein] which results in increased transport of Calcium; allicin binds to and results in increased activity of TRPA1 protein		 CTD PMID:17684094, PMID:17825279, PMID:20086034 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 affects response to substance
increases response to substance		 ISO TRPV1 protein affects the susceptibility to allicin
TRPV1 protein mutant form results in increased susceptibility to allicin		 CTD PMID:17110039 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        antimicrobial agent 17334
          antibacterial agent 13030
            allicin 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            heteroorganic entity 19184
                              organochalcogen compound 18894
                                organosulfur compound 15223
                                  sulfoxide 3721
                                    allicin 20
paths to the root

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