5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole	go back to main search page
Accession:	CHEBI:77260	browse the term
Definition:	A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.
Synonyms:	related_synonym:	Formula=C17H19N3O3S; InChI=1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20); InChIKey=SUBDBMMJDZJVOS-UHFFFAOYSA-N; SMILES=COc1ccc2[nH]c(nc2c1)S(=O)Cc1ncc(C)c(OC)c1C
	xref:	CAS:73590-58-6; KEGG:C07324; KEGG:D00455
	xref_mesh:	MESH:D009853

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Genes (412)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

increases expression

ISO

Omeprazole results in increased expression of ABCA1 mRNA

NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473

G

ATP binding cassette subfamily B member 11

decreases activity

ISO

Omeprazole results in decreased activity of ABCB11 protein

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

ATP binding cassette subfamily B member 1A

affects expression
multiple interactions

EXP
ISO

Omeprazole affects the expression of ABCB1A mRNA
Omeprazole promotes the reaction [Cisplatin results in increased expression of ABCB1A protein]
Omeprazole promotes the reaction [Cisplatin results in increased expression of ABCB1 protein]

PMID:19483382 PMID:30452898

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily B member 4

decreases expression

ISO

Omeprazole results in decreased expression of ABCB4 mRNA

NCBI chr 4:26,106,895...26,164,440

G

ATP binding cassette subfamily C member 2

multiple interactions

ISO

[Omeprazole results in increased susceptibility to Cisplatin] which results in decreased expression of ABCC2 protein

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

ATP binding cassette subfamily C member 3

increases expression

EXP

Omeprazole results in increased expression of ABCC3 mRNA

NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494

G

ATP binding cassette subfamily C member 6

affects expression

EXP

Omeprazole affects the expression of ABCC6 mRNA

NCBI chr 1:105,583,681...105,637,895
Ensembl chr 1:105,583,682...105,637,895

G

ATP binding cassette subfamily G member 2

increases expression
multiple interactions

ISO

Omeprazole results in increased expression of ABCG2 mRNA alternative form; Omeprazole results in increased expression of ABCG2 protein
Omeprazole inhibits the reaction [ABCG2 protein results in increased transport of lucifer yellow]

PMID:20804740 PMID:31348918

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493

G

ATP binding cassette subfamily G member 5

affects expression

EXP

Omeprazole affects the expression of ABCG5 mRNA

NCBI chr 6:15,717,936...15,743,376
Ensembl chr 6:15,717,936...15,743,376

G

abhydrolase domain containing 1

affects expression

EXP

Omeprazole affects the expression of ABHD1 mRNA

NCBI chr 6:25,422,526...25,427,514
Ensembl chr 6:31,142,476...31,147,464

G

abhydrolase domain containing 14b

affects expression

EXP

Omeprazole affects the expression of ABHD14B mRNA

NCBI chr 8:115,966,792...115,970,829
Ensembl chr 8:115,965,932...115,970,833

G

abhydrolase domain containing 17A, depalmitoylase

affects expression

EXP

Omeprazole affects the expression of ABHD17A mRNA

NCBI chr 7:9,775,016...9,781,447

G

acetyl-CoA carboxylase alpha

affects expression

EXP

Omeprazole affects the expression of ACACA mRNA

NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888

G

acyl-CoA dehydrogenase, long chain

affects expression

EXP

Omeprazole affects the expression of ACADL mRNA

NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:75,783,689...75,822,164

G

angiotensin converting enzyme 2

decreases expression

ISO
EXP

Omeprazole results in decreased expression of ACE2 mRNA

NCBI chr X:33,925,458...33,972,851
Ensembl chr X:33,925,458...33,971,596

G

aconitase 1

affects expression

EXP

Omeprazole affects the expression of ACO1 mRNA

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:60,055,866...60,112,600

G

aconitase 2

affects expression

EXP

Omeprazole affects the expression of ACO2 mRNA

NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:115,265,791...115,308,892

G

acyl-CoA thioesterase 12

affects expression

EXP

Omeprazole affects the expression of ACOT12 mRNA

NCBI chr 2:24,721,648...24,763,686
Ensembl chr 2:24,721,910...24,765,298

G

acyl-CoA thioesterase 4

affects expression

EXP

Omeprazole affects the expression of ACOT4 mRNA

NCBI chr 6:109,399,032...109,405,138
Ensembl chr 6:109,399,578...109,405,138

G

ADAM metallopeptidase domain 15

affects expression

EXP

Omeprazole affects the expression of ADAM15 mRNA

NCBI chr 2:177,052,363...177,062,879
Ensembl chr 2:177,052,363...177,062,849

G

adducin 1

affects expression

EXP

Omeprazole affects the expression of ADD1 mRNA

NCBI chr14:80,333,242...80,401,641
Ensembl chr14:80,333,244...80,391,732

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

decreases expression

ISO

Omeprazole results in decreased expression of ADH1C mRNA

NCBI chr 2:229,470,703...229,482,291
Ensembl chr 2:229,470,703...229,482,291

G

alcohol dehydrogenase 4 (class II), pi polypeptide

affects expression

EXP

Omeprazole affects the expression of ADH4 mRNA

NCBI chr 2:229,622,092...229,640,120
Ensembl chr 2:229,622,095...229,641,879

G

androgen-dependent TFPI-regulating protein

affects expression

EXP

Omeprazole affects the expression of ADTRP mRNA

NCBI chr17:22,907,758...22,993,834
Ensembl chr17:23,135,809...23,216,622

G

afamin

affects expression

EXP

Omeprazole affects the expression of AFM mRNA

NCBI chr14:17,815,194...17,848,042
Ensembl chr14:17,815,194...17,848,039

G

angiotensinogen

affects expression

EXP

Omeprazole affects the expression of AGT mRNA

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

angiotensin II receptor, type 1a

affects expression

EXP

Omeprazole affects the expression of AGTR1A mRNA

NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660

G

aryl hydrocarbon receptor

multiple interactions
decreases activity
increases activity
increases expression
decreases expression
affects localization
increases response to substance

EXP
ISO

[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of AHR mRNA; AHR protein promotes the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Omeprazole affects the localization of [ARNT protein co-treated with AHR protein]
Omeprazole results in decreased activity of AHR protein
Omeprazole results in increased activity of AHR protein
Omeprazole results in increased expression of AHR protein
Omeprazole results in decreased expression of AHR mRNA
AG-879 inhibits the reaction [Omeprazole results in increased activity of AHR protein]; AHR protein affects the reaction [Omeprazole results in decreased expression of CXCR4 mRNA]; AHR protein affects the reaction [Omeprazole results in increased expression of HAMP mRNA]; AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A2 mRNA]; AHR protein mutant form inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Omeprazole results in decreased expression of AHR mRNA]; AHR protein promotes the reaction [Omeprazole results in decreased expression of CYP1A1 mRNA]; BMX mRNA affects the reaction [Omeprazole results in increased activity of AHR protein]; Omeprazole binds to and results in increased activity of AHR protein; Omeprazole promotes the reaction [AHR protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [AHR protein binds to CYP1B1 promoter]; omeprazole sulfide inhibits the reaction [Omeprazole results in increased activity of AHR protein]; Puromycin inhibits the reaction [Omeprazole results in increased expression of AHR protein]
Omeprazole affects the localization of AHR protein
AHR protein results in increased susceptibility to Omeprazole

PMID:9139728 PMID:9395520 PMID:14742684 PMID:16109480 PMID:20171196 More...

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

aldo-keto reductase family 1 member A1

affects expression

EXP

Omeprazole affects the expression of AKR1A1 mRNA

NCBI chr 5:135,329,605...135,367,037
Ensembl chr 5:135,329,606...135,367,035

G

aldo-keto reductase family 7, member A2

affects expression

EXP

Omeprazole affects the expression of AKR7A2 mRNA

NCBI chr 5:156,835,589...156,844,127
Ensembl chr 5:156,835,551...156,844,109

G

aldo-keto reductase family 7 member A3

affects expression
multiple interactions

EXP

Omeprazole affects the expression of AKR7A3 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of AKR7A3 mRNA

PMID:19483382 PMID:22687989

NCBI chr 5:156,876,721...156,884,599
Ensembl chr 5:156,874,086...156,885,153

G

aldehyde dehydrogenase 1 family, member A1

affects expression
multiple interactions

EXP

Omeprazole affects the expression of ALDH1A1 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of ALDH1A1 mRNA

PMID:19483382 PMID:22687989

NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500

G

aldehyde dehydrogenase 1 family, member A3

increases expression

ISO

Omeprazole results in increased expression of ALDH1A3 mRNA

NCBI chr 1:129,392,516...129,436,552
Ensembl chr 1:129,392,516...129,427,777

G

aldehyde dehydrogenase family 1, subfamily A7

affects expression

EXP

Omeprazole affects the expression of ALDH1A7 mRNA

NCBI chr 1:218,201,443...218,241,410
Ensembl chr 1:227,627,448...227,672,523

G

aldehyde dehydrogenase 2 family member

affects expression

EXP

Omeprazole affects the expression of ALDH2 mRNA

NCBI chr12:40,610,244...40,643,220
Ensembl chr12:40,610,224...40,643,219

G

aldehyde dehydrogenase 3 family, member A1

increases expression

ISO

Omeprazole results in increased expression of ALDH3A1 mRNA

NCBI chr10:46,392,464...46,402,151
Ensembl chr10:46,392,411...46,402,151

G

alkB homolog 7

affects expression

EXP

Omeprazole affects the expression of ALKBH7 mRNA

NCBI chr 9:1,925,896...1,928,048
Ensembl chr 9:1,925,743...1,928,048

G

ankyrin repeat domain 40

increases expression

EXP

Omeprazole results in increased expression of TMPRSS2 mRNA

NCBI chr10:79,778,966...79,792,212
Ensembl chr10:56,415,260...56,416,345
Ensembl chr10:56,415,260...56,416,345

G

adaptor related protein complex 2 subunit mu 1

affects expression

EXP

Omeprazole affects the expression of AP2M1 mRNA

NCBI chr11:93,859,690...93,868,600
Ensembl chr11:93,859,690...93,868,480

G

amyloid P component, serum

affects expression

EXP

Omeprazole affects the expression of APCS mRNA

NCBI chr13:87,905,532...87,906,508
Ensembl chr13:87,905,532...87,928,824

G

apolipoprotein A4

affects expression

EXP

Omeprazole affects the expression of APOA4 mRNA

NCBI chr 8:55,435,779...55,438,160
Ensembl chr 8:55,434,168...55,438,164

G

apolipoprotein H

affects expression

EXP

Omeprazole affects the expression of APOH mRNA

NCBI chr10:93,841,992...93,855,897
Ensembl chr10:93,841,966...93,857,127

G

apolipoprotein O-like

affects expression

EXP

Omeprazole affects the expression of APOOL mRNA

NCBI chr X:81,569,960...81,635,906
Ensembl chr X:81,570,053...81,640,036

G

arginase 1

affects expression

EXP

Omeprazole affects the expression of ARG1 mRNA

NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:22,295,322...22,307,713

G

ARL6 interacting reticulophagy regulator 1

affects expression

EXP

Omeprazole affects the expression of ARL6IP1 mRNA

NCBI chr 1:181,864,717...181,874,232
Ensembl chr 1:181,864,746...181,874,232

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions
affects localization

ISO
EXP

Omeprazole promotes the reaction [ARNT protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [ARNT protein binds to CYP1B1 promoter]
Omeprazole affects the localization of ARNT protein
Omeprazole affects the localization of [ARNT protein co-treated with AHR protein]

PMID:9395520 PMID:21703235 PMID:25826687

NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546

G

asialoglycoprotein receptor 2

affects expression

EXP

Omeprazole affects the expression of ASGR2 mRNA

NCBI chr10:55,320,082...55,333,294
Ensembl chr10:55,320,091...55,333,263

G

activating transcription factor 5

affects expression

EXP

Omeprazole affects the expression of ATF5 mRNA

NCBI chr 1:104,432,094...104,437,611
Ensembl chr 1:104,432,094...104,436,183

G

ATP synthase F1 subunit epsilon

affects expression

EXP

Omeprazole affects the expression of ATP5F1E mRNA

NCBI chr 3:183,677,270...183,680,172
Ensembl chr 3:183,677,273...183,680,214

G

ATPase H+ transporting accessory protein 2

affects expression

EXP

Omeprazole affects the expression of ATP6AP2 mRNA

NCBI chr X:12,856,708...12,883,670
Ensembl chr X:12,855,859...12,905,875

G

ATPase H+ transporting V1 subunit A

affects expression

EXP

Omeprazole affects the expression of ATP6V1A mRNA

NCBI chr11:70,066,800...70,120,603
Ensembl chr11:70,035,134...70,120,603

G

ATPase H+ transporting V1 subunit F

affects expression

EXP

Omeprazole affects the expression of ATP6V1F mRNA

NCBI chr 4:59,033,020...59,035,980

G

ATPase copper transporting alpha

multiple interactions

ISO

Omeprazole inhibits the reaction [ATP7A protein results in increased activity of TYR protein]
Omeprazole inhibits the reaction [Copper affects the localization of ATP7A protein]; Omeprazole inhibits the reaction [cupric chloride affects the localization of ATP7A protein]

NCBI chr X:75,159,635...75,267,094
Ensembl chr X:75,159,782...75,267,093

G

bile acid CoA:amino acid N-acyltransferase

affects expression

EXP

Omeprazole affects the expression of BAAT mRNA

NCBI chr 5:68,647,166...68,656,137
Ensembl chr 5:68,646,203...68,656,181

G

BCL2 associated X, apoptosis regulator

multiple interactions

ISO

Omeprazole inhibits the reaction [Cisplatin results in increased expression of BAX protein]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions

ISO

Omeprazole inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

BCL6B, transcription repressor

affects expression

EXP

Omeprazole affects the expression of BCL6B mRNA

NCBI chr10:55,439,566...55,444,631
Ensembl chr10:55,432,382...55,444,631

G

bridge-like lipid transfer protein family member 3B

affects expression

EXP

Omeprazole affects the expression of BLTP3B mRNA

NCBI chr 7:26,068,948...26,149,033
Ensembl chr 7:26,068,955...26,149,083

G

Bcl2 modifying factor

affects expression

EXP

Omeprazole affects the expression of BMF mRNA

NCBI chr 3:125,953,466...125,974,087
Ensembl chr 3:125,953,466...125,974,258

G

BMX non-receptor tyrosine kinase

multiple interactions

ISO

BMX mRNA affects the reaction [Omeprazole results in increased activity of AHR protein]

NCBI chr X:30,227,251...30,290,015
Ensembl chr X:33,859,129...33,921,874

G

BCL2 interacting protein 3

affects expression

EXP

Omeprazole affects the expression of BNIP3 mRNA

NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962

G

basic transcription factor 3

affects expression

EXP

Omeprazole affects the expression of BTF3 mRNA

NCBI chr 2:31,394,010...31,401,138
Ensembl chr 2:31,394,011...31,401,125
Ensembl chr13:31,394,011...31,401,125

G

complement C1q A chain

decreases expression

EXP

Omeprazole results in decreased expression of C1QA mRNA

NCBI chr 5:154,417,086...154,419,933
Ensembl chr 5:154,417,087...154,427,732

G

complement C1q binding protein

affects expression

EXP

Omeprazole affects the expression of C1QBP mRNA

NCBI chr10:56,198,534...56,203,185
Ensembl chr10:56,198,540...56,203,235

G

complement C1q C chain

decreases expression

EXP

Omeprazole results in decreased expression of C1QC mRNA

NCBI chr 5:154,410,845...154,414,208
Ensembl chr 5:154,410,848...154,414,468

G

complement C1s

affects expression

EXP

Omeprazole affects the expression of C1S mRNA

NCBI chr 4:159,116,549...159,128,736
Ensembl chr 4:159,116,549...159,128,736

G

C2 calcium-dependent domain containing 2

affects expression

EXP

Omeprazole affects the expression of C2CD2 mRNA

NCBI chr11:37,225,321...37,289,741
Ensembl chr11:50,694,563...50,759,016

G

complement component 4 binding protein, alpha

affects expression
decreases expression

EXP

Omeprazole affects the expression of C4BPA mRNA
Omeprazole results in decreased expression of C4BPA mRNA

PMID:19483382 PMID:25626140

NCBI chr13:44,627,959...44,663,552
Ensembl chr13:44,627,982...44,663,471

G

complement component 4 binding protein, beta

decreases expression

EXP

Omeprazole results in decreased expression of C4BPB mRNA

NCBI chr13:44,673,064...44,683,781
Ensembl chr13:44,673,065...44,683,793

G

complement C7

affects expression

EXP

Omeprazole affects the expression of C7 mRNA

NCBI chr 2:55,815,687...55,892,605
Ensembl chr 2:55,816,807...55,892,672

G

complement C8 beta chain

affects expression

EXP

Omeprazole affects the expression of C8B mRNA

NCBI chr 5:124,763,974...124,801,522
Ensembl chr 5:124,761,790...124,801,516

G

carbonic anhydrase 3

affects expression

EXP

Omeprazole affects the expression of CAR3 mRNA

NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:88,491,670...88,500,524

G

calcium dependent secretion activator 2

affects expression

EXP

Omeprazole affects the expression of CADPS2 mRNA

NCBI chr 4:52,746,054...53,275,252
Ensembl chr 4:52,746,065...53,275,004

G

cell cycle associated protein 1

affects expression

EXP

Omeprazole affects the expression of CAPRIN1 mRNA

NCBI chr 3:110,606,489...110,685,408
Ensembl chr 3:110,606,489...110,685,562

G

carbonic anhydrase 2

affects expression

EXP

Omeprazole affects the expression of CA2 mRNA

NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:88,462,872...88,478,064

G

caspase 3

increases activity
multiple interactions
affects expression
increases cleavage

ISO
EXP

Omeprazole analog results in increased activity of CASP3 protein; Omeprazole results in increased activity of CASP3 protein
Omeprazole inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
Omeprazole inhibits the reaction [Ethanol results in increased activity of CASP3 protein]; Omeprazole inhibits the reaction [Ethanol results in increased expression of CASP3 mRNA]; Omeprazole inhibits the reaction [Indomethacin results in increased activity of CASP3 protein]
Omeprazole affects the expression of CASP3 mRNA
Omeprazole results in increased cleavage of CASP3 protein

PMID:15461867 PMID:18336733 PMID:19251492 PMID:19483382 PMID:25637687 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

increases cleavage

ISO

Omeprazole analog results in increased cleavage of CASP8 protein

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

catalase

increases activity
multiple interactions

EXP
ISO

Omeprazole results in increased activity of CAT protein
Omeprazole inhibits the reaction [Ethanol results in decreased activity of CAT protein]
Omeprazole inhibits the reaction [Acetic Acid results in increased activity of CAT protein]

PMID:18547560 PMID:28849987 PMID:33245926

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

carbonyl reductase 1

affects expression

EXP

Omeprazole affects the expression of CBR1 mRNA

NCBI chr11:46,346,405...46,348,815
Ensembl chr11:46,378,411...46,381,104
Ensembl chr11:46,378,411...46,381,104

G

cholecystokinin B receptor

multiple interactions

ISO

[Omeprazole co-treated with CCKBR protein] results in increased expression of IER3

NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:169,183,194...169,193,745

G

cyclin D1

decreases expression

EXP

Omeprazole results in decreased expression of CCND1 mRNA

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin-dependent kinase inhibitor 1A

increases expression

ISO

Omeprazole results in increased expression of CDKN1A protein

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cysteine dioxygenase type 1

affects expression

EXP

Omeprazole affects the expression of CDO1 mRNA

NCBI chr18:41,619,076...41,633,719
Ensembl chr18:41,619,070...41,633,891

G

choline/ethanolamine phosphotransferase 1

affects expression

EXP

Omeprazole affects the expression of CEPT1 mRNA

NCBI chr 2:193,994,220...194,036,141
Ensembl chr 2:196,681,681...196,723,812

G

carboxylesterase 2H

affects expression

EXP

Omeprazole affects the expression of CES2 mRNA

NCBI chr19:49,884,164...49,898,764
Ensembl chr19:49,884,164...49,898,752

G

complement factor I

affects expression
decreases expression

EXP

Omeprazole affects the expression of CFI mRNA
Omeprazole results in decreased expression of CFI mRNA

PMID:19483382 PMID:25626140

NCBI chr 2:221,062,206...221,104,790
Ensembl chr 2:221,062,212...221,104,786

G

CF transmembrane conductance regulator

affects metabolic processing

ISO

CFTR protein affects the metabolism of Omeprazole

NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643

G

calcineurin-like EF-hand protein 1

affects expression

EXP

Omeprazole affects the expression of CHP1 mRNA

NCBI chr 3:126,989,800...127,025,071
Ensembl chr 3:126,989,579...127,042,443

G

CDGSH iron sulfur domain 1

affects expression

EXP

Omeprazole affects the expression of CISD1 mRNA

NCBI chr20:17,254,462...17,267,843
Ensembl chr20:17,254,187...17,271,042

G

chloride voltage-gated channel 4

affects expression

EXP

Omeprazole affects the expression of CLCN4 mRNA

NCBI chr X:23,729,194...23,795,391
Ensembl chr X:27,290,868...27,356,939

G

caseinolytic mitochondrial matrix peptidase proteolytic subunit

affects expression

EXP

Omeprazole affects the expression of CLPP mRNA

NCBI chr 9:1,831,680...1,837,700
Ensembl chr 9:1,918,682...1,924,705

G

CLPTM1-like

affects expression

EXP

Omeprazole affects the expression of CLPTM1L mRNA

NCBI chr 1:31,496,094...31,512,148
Ensembl chr 1:31,496,094...31,512,077

G

carboxymethylenebutenolidase homolog

affects expression

EXP

Omeprazole affects the expression of CMBL mRNA

NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:84,242,512...84,301,880

G

cytidine/uridine monophosphate kinase 1

affects expression

EXP

Omeprazole affects the expression of CMPK1 mRNA

NCBI chr 5:133,717,073...133,744,623
Ensembl chr 5:133,717,086...133,744,596

G

COPI coat complex subunit gamma 1

affects expression

EXP

Omeprazole affects the expression of COPG1 mRNA

NCBI chr 4:121,923,644...121,949,819
Ensembl chr 4:121,923,873...121,949,812

G

COP9 signalosome subunit 4

affects expression

EXP

Omeprazole affects the expression of COPS4 mRNA

NCBI chr14:9,078,579...9,108,788
Ensembl chr14:9,382,900...9,413,107

G

coenzyme Q3 methyltransferase

affects expression

EXP

Omeprazole affects the expression of COQ3 mRNA

NCBI chr 5:35,429,567...35,460,613
Ensembl chr 5:40,226,368...40,257,617

G

cytochrome c oxidase subunit 4i1

affects expression

EXP

Omeprazole affects the expression of COX4I1 mRNA

NCBI chr19:48,721,680...48,727,920
Ensembl chr19:65,630,432...65,636,624

G

carboxypeptidase N subunit 1

affects expression

EXP

Omeprazole affects the expression of CPN1 mRNA

NCBI chr 1:252,793,786...252,822,675
Ensembl chr 1:252,793,423...252,822,664

G

carboxypeptidase Q

affects expression

EXP

Omeprazole affects the expression of CPQ mRNA

NCBI chr 7:66,148,973...66,719,189
Ensembl chr 7:66,149,377...66,716,137

G

cAMP responsive element modulator

affects expression

EXP

Omeprazole affects the expression of CREM mRNA

NCBI chr17:58,932,011...59,001,160
Ensembl chr17:58,934,147...59,001,160

G

casein kinase 2 beta

affects expression

EXP

Omeprazole affects the expression of CSNK2B mRNA

NCBI chr20:3,704,833...3,709,999
Ensembl chr20:3,704,904...3,710,525

G

cysteine and glycine-rich protein 1

affects expression

EXP

Omeprazole affects the expression of CSRP1 mRNA

NCBI chr13:49,709,928...49,731,141
Ensembl chr13:49,709,914...49,731,139

G

catenin alpha 1

affects expression

EXP

Omeprazole affects the expression of CTNNA1 mRNA

NCBI chr18:27,002,330...27,135,009
Ensembl chr18:26,999,820...27,135,007

G

cathepsin B

decreases activity

ISO

Omeprazole results in decreased activity of CTSB protein

NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478

G

cathepsin D

multiple interactions

EXP

Omeprazole inhibits the reaction [Cysteamine results in increased expression of CTSD protein]

NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821

G

cathepsin E

decreases expression

EXP

Omeprazole results in decreased expression of CTSE

NCBI chr13:43,091,954...43,114,509
Ensembl chr13:45,644,147...45,666,722

G

C-X-C motif chemokine receptor 4

decreases expression
multiple interactions

ISO

Omeprazole results in decreased expression of CXCR4 mRNA
AHR protein affects the reaction [Omeprazole results in decreased expression of CXCR4 mRNA]

NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression
increases activity
decreases activity

ISO
EXP

AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein mutant form inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Omeprazole results in decreased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; Omeprazole promotes the reaction [AHR protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [ARNT protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [EP300 protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [NCOA1 protein binds to CYP1A1 promoter]
Omeprazole inhibits the reaction [Oxygen results in increased expression of CYP1A1 protein]; Omeprazole promotes the reaction [Oxygen results in decreased expression of CYP1A1 mRNA]
Omeprazole results in increased expression of CYP1A1 mRNA; Omeprazole results in increased expression of CYP1A1 protein
Omeprazole results in increased activity of CYP1A1 protein
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 mRNA; AHR protein promotes the reaction [Omeprazole results in increased expression of CYP1A1 protein]; daidzein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; daidzein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Genistein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; Genistein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; herbimycin inhibits the reaction [Omeprazole results in increased activity of CYP1A1 protein]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; lavendustin A inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Staurosporine inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Tosyllysine Chloromethyl Ketone inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]
Omeprazole results in decreased activity of CYP1A1 protein
Omeprazole results in increased activity of CYP1A1 promoter

PMID:8647108 PMID:8900397 PMID:9041675 PMID:9139728 PMID:9152597 More...

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity
multiple interactions
increases expression
increases activity

ISO
EXP

Omeprazole results in decreased activity of CYP1A2 protein
[Omeprazole results in increased expression of CYP1A2 protein] which results in decreased alkylation of Phenacetin; AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A2 mRNA]; Omeprazole results in increased expression of and results in increased activity of CYP1A2 protein
Omeprazole results in increased expression of CYP1A2 mRNA; Omeprazole results in increased expression of CYP1A2 protein
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A2 mRNA
Omeprazole results in increased activity of CYP1A2 promoter; Omeprazole results in increased activity of CYP1A2 protein

PMID:9152597 PMID:9744552 PMID:12040753 PMID:12623754 PMID:12841937 More...

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions
affects expression
increases expression
decreases activity

ISO

Omeprazole promotes the reaction [AHR protein binds to CYP1B1 promoter]; Omeprazole promotes the reaction [ARNT protein binds to CYP1B1 promoter]; Omeprazole promotes the reaction [EP300 protein binds to CYP1B1 promoter]; Omeprazole promotes the reaction [NCOA1 protein binds to CYP1B1 promoter]
Omeprazole affects the expression of CYP1B1 mRNA
Omeprazole results in increased expression of CYP1B1 mRNA
Omeprazole results in decreased activity of CYP1B1 protein

PMID:12040753 PMID:12623754 PMID:18420780 PMID:21703235 PMID:25826687

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 2, subfamily a, polypeptide 1

affects expression

EXP

Omeprazole affects the expression of CYP2A1 mRNA

NCBI chr 1:91,359,278...91,372,554
Ensembl chr 1:91,359,272...91,389,730

G

cytochrome P450, family 2, subfamily b, polypeptide 1

increases expression

EXP

Omeprazole results in increased expression of CYP2B1 mRNA; Omeprazole results in increased expression of CYP2B1 protein

PMID:9152597 PMID:19118567

NCBI chr 1:90,646,098...90,669,762

G

cytochrome P450, family 2, subfamily b, polypeptide 2

affects expression
increases expression

EXP

Omeprazole affects the expression of CYP2B2 mRNA
Omeprazole results in increased expression of CYP2B2 protein

PMID:9152597 PMID:19483382

NCBI chr 1:90,722,243...90,736,272

G

cytochrome P450, family 2, subfamily b, polypeptide 3

affects expression
decreases activity
increases expression
increases activity

EXP
ISO

Omeprazole affects the expression of CYP2B3 mRNA
Omeprazole results in decreased activity of CYP2B10 protein
Omeprazole results in increased expression of CYP2B6 mRNA
Omeprazole results in increased activity of CYP2B6 protein

PMID:17954527 PMID:18420780 PMID:19118567 PMID:19483382 PMID:22524704

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, family 2, subfamily C, polypeptide 6

affects metabolic processing
decreases activity
multiple interactions
increases metabolic processing
decreases metabolic processing
increases hydroxylation

ISO

CYP2C19 protein affects the metabolism of Omeprazole
Omeprazole results in decreased activity of CYP2C19 protein
[5-bromotryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-chlorotryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-fluoro-alpha-methyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-fluorotryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-methyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [7-methyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [Chloramphenicol results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [Fluconazole results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [indopan results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [N,N-diisopropyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [Omeprazole results in decreased activity of CYP2C19 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine metabolite; [Omeprazole results in decreased activity of CYP2C19 protein] which results in decreased chemical synthesis of Aconitine metabolite; [Tryptamines analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; Omeprazole affects the reaction [CYP2C19 protein affects the metabolism of Warfarin]; Omeprazole inhibits the reaction [CYP2C19 protein results in decreased methylation of adinazolam]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased chemical synthesis of 4-hydroxymephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of auriculasin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of Fluoxetine]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased oxidation of 2-oxo-clopidogrel]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased oxidation of Clopidogrel]
CYP2C19 protein results in increased metabolism of Omeprazole
CYP2C19 gene alternative form results in decreased metabolism of Omeprazole
CYP2C19 protein results in increased hydroxylation of Omeprazole

PMID:8930576 PMID:9600717 PMID:11752104 PMID:12464242 PMID:12467917 More...

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 2, subfamily d, polypeptide 1

increases expression

EXP

Omeprazole results in increased expression of CYP2D9 mRNA

NCBI chr 7:115,789,026...115,793,430
Ensembl chr 7:115,789,023...115,793,479

G

cytochrome P450, family 2, subfamily d, polypeptide 3

affects expression

EXP

Omeprazole affects the expression of CYP2D3 mRNA

NCBI chr 7:113,917,711...113,922,068
Ensembl chr 7:115,797,789...115,802,158

G

cytochrome P450, family 2, subfamily d, polypeptide 4

affects expression
decreases activity

EXP
ISO

Omeprazole affects the expression of CYP2D4 mRNA
Omeprazole results in decreased activity of CYP2D6 protein

PMID:18420780 PMID:19483382

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

ISO

Omeprazole results in increased expression of and results in increased activity of CYP2E1 protein

PMID:15802389 PMID:36243147

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 2, subfamily f, polypeptide 4

affects expression

EXP

Omeprazole affects the expression of CYP2F4 mRNA

NCBI chr 1:91,543,768...91,557,553
Ensembl chr 1:91,543,768...91,557,553

G

cytochrome P450, family 2, subfamily j, polypeptide 4

affects expression

EXP

Omeprazole affects the expression of CYP2J4 mRNA

NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:116,295,694...116,323,042

G

cytochrome P450, family 2, subfamily t, polypeptide 1

affects expression

EXP

Omeprazole affects the expression of CYP2T1 mRNA

NCBI chr 1:82,446,321...82,451,564
Ensembl chr 1:91,574,572...91,579,215

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
increases expression
increases metabolic processing
affects metabolic processing

ISO

[Omeprazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; NR1I2 protein affects the reaction [Omeprazole results in increased expression of CYP3A4 mRNA]; Omeprazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Omeprazole results in increased expression of and results in increased activity of CYP3A4 protein
Omeprazole results in increased expression of CYP3A4 mRNA; Omeprazole results in increased expression of CYP3A4 protein
CYP3A4 protein results in increased metabolism of Omeprazole
CYP3A4 protein affects the metabolism of Omeprazole

PMID:7870052 PMID:8930576 PMID:9744552 PMID:12235278 PMID:12485723 More...

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

affects expression
increases expression

EXP

Omeprazole affects the expression of CYP3A23-3A1 mRNA
Omeprazole results in increased expression of CYP3A23-3A1 mRNA

PMID:19118567 PMID:19483382

NCBI chr12:14,369,950...14,398,803
Ensembl chr12:14,368,266...14,398,813

G

cytochrome P450, family 3, subfamily a, polypeptide 9

affects expression
increases expression

EXP
ISO

Omeprazole affects the expression of CYP3A9 mRNA
Omeprazole results in increased expression of CYP3A5 mRNA

PMID:19118567 PMID:19483382

NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154

G

cytochrome P450, family 4, subfamily a, polypeptide 8

affects expression

EXP

Omeprazole affects the expression of CYP4A8 mRNA

NCBI chr 5:128,702,130...128,733,476
Ensembl chr 5:133,938,883...133,970,226

G

cytochrome P450, family 4, subfamily f, polypeptide 6

affects expression

EXP

Omeprazole affects the expression of CYP4F6 mRNA

NCBI chr 7:12,680,799...12,708,378
Ensembl chr 7:12,680,806...12,708,402

G

diazepam binding inhibitor

affects expression

EXP

Omeprazole affects the expression of DBI mRNA

NCBI chr13:33,794,231...33,802,632
Ensembl chr13:33,759,845...33,821,450

G

DDB1 and CUL4 associated factor 11

affects expression

EXP

Omeprazole affects the expression of DCAF11 mRNA

NCBI chr15:33,015,370...33,027,407
Ensembl chr15:33,016,762...33,027,672

G

dicarbonyl and L-xylulose reductase

affects expression

EXP

Omeprazole affects the expression of DCXR mRNA

NCBI chr10:106,504,730...106,506,619

G

DNA-damage inducible transcript 3

increases expression

ISO

Omeprazole results in increased expression of DDIT3 protein

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

2,4-dienoyl-CoA reductase 1

affects expression

EXP

Omeprazole affects the expression of DECR1 mRNA

NCBI chr 5:34,208,195...34,236,074
Ensembl chr 5:34,208,195...34,236,033

G

Dexi homolog

affects expression

EXP

Omeprazole affects the expression of DEXI mRNA

NCBI chr10:5,632,400...5,645,653
Ensembl chr10:5,632,961...5,645,648

G

diacylglycerol O-acyltransferase 1

affects expression

EXP

Omeprazole affects the expression of DGAT1 mRNA

NCBI chr 7:110,104,514...110,119,091
Ensembl chr 7:110,098,906...110,115,016

G

24-dehydrocholesterol reductase

affects expression

EXP

Omeprazole affects the expression of DHCR24 mRNA

NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:126,573,338...126,599,936

G

dehydrogenase/reductase 4

affects expression

EXP

Omeprazole affects the expression of DHRS4 mRNA

NCBI chr15:28,966,544...28,978,135
Ensembl chr15:32,936,522...32,948,101

G

dehydrogenase/reductase 7B

affects expression

EXP

Omeprazole affects the expression of DHRS7B mRNA

NCBI chr10:45,504,344...45,537,094
Ensembl chr10:46,003,845...46,036,499

G

DEAH-box helicase 16

affects expression

EXP

Omeprazole affects the expression of DHX16 mRNA

NCBI chr20:2,866,804...2,879,790
Ensembl chr20:2,866,804...2,879,751

G

distal membrane arm assembly component 2 like

affects expression

EXP

Omeprazole affects the expression of DMAC2L mRNA

NCBI chr 6:93,941,605...93,959,932
Ensembl chr 6:93,941,690...93,960,662

G

DnaJ heat shock protein family (Hsp40) member C3

affects expression

EXP

Omeprazole affects the expression of DNAJC3 mRNA

NCBI chr15:102,432,667...102,475,643
Ensembl chr15:102,432,663...102,475,643

G

dipeptidylpeptidase 4

affects expression

EXP

Omeprazole affects the expression of DPP4 mRNA

NCBI chr 3:67,370,794...67,452,422
Ensembl chr 3:67,370,804...67,452,422

G

dihydropyrimidine dehydrogenase

affects expression

EXP

Omeprazole affects the expression of DPYD mRNA

NCBI chr 2:209,293,902...210,159,777
Ensembl chr 2:209,293,929...210,159,778

G

glutamyl-tRNA synthetase 2, mitochondrial

affects expression

EXP

Omeprazole affects the expression of EARS2 mRNA

NCBI chr 1:176,597,986...176,625,848

G

enoyl-CoA hydratase, short chain 1

affects expression

EXP

Omeprazole affects the expression of ECHS1 mRNA

NCBI chr 1:204,324,679...204,333,506
Ensembl chr 1:204,324,682...204,333,506

G

enoyl-CoA delta isomerase 1

affects expression

EXP

Omeprazole affects the expression of ECI1 mRNA

NCBI chr10:13,961,250...13,974,595
Ensembl chr10:13,961,218...13,974,773

G

enoyl-CoA delta isomerase 2

affects expression

EXP

Omeprazole affects the expression of ECI2 mRNA

NCBI chr17:30,056,274...30,092,169
Ensembl chr17:30,076,524...30,092,161

G

eukaryotic translation elongation factor 1 gamma

affects expression

EXP

Omeprazole affects the expression of EEF1G mRNA

NCBI chr 1:215,289,815...215,300,421
Ensembl chr 1:215,277,860...215,301,479

G

epidermal growth factor

multiple interactions

ISO

Omeprazole promotes the reaction [Indomethacin results in increased expression of EGF protein]

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297

G

enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

affects expression

EXP

Omeprazole affects the expression of EHHADH mRNA

NCBI chr11:92,746,409...92,779,647
Ensembl chr11:92,746,420...92,779,662

G

eukaryotic translation initiation factor 4A2

affects expression

EXP

Omeprazole affects the expression of EIF4A2 mRNA

NCBI chr11:91,268,730...91,276,738
Ensembl chr11:91,268,731...91,275,323

G

eukaryotic translation initiation factor 4E binding protein 1

affects expression

EXP

Omeprazole affects the expression of EIF4EBP1 mRNA

NCBI chr16:71,495,457...71,508,845
Ensembl chr16:71,487,930...71,508,874

G

eukaryotic translation initiation factor 4H

affects expression

EXP

Omeprazole affects the expression of EIF4H mRNA

NCBI chr12:22,083,155...22,099,876
Ensembl chr12:27,719,321...27,736,346

G

ectodermal-neural cortex 1

affects expression

EXP

Omeprazole affects the expression of ENC1 mRNA

NCBI chr 2:30,285,274...30,297,194
Ensembl chr 2:30,283,736...30,315,721

G

enolase 1

affects expression

EXP

Omeprazole affects the expression of ENO1 mRNA

NCBI chr 5:166,002,867...166,014,252
Ensembl chr 3:77,946,261...77,986,003
Ensembl chr 5:77,946,261...77,986,003

G

glutamyl aminopeptidase

affects expression

EXP

Omeprazole affects the expression of ENPEP mRNA

NCBI chr 2:220,456,258...220,526,218
Ensembl chr 2:220,456,278...220,526,218

G

ectonucleotide pyrophosphatase/phosphodiesterase 1

affects expression

EXP

Omeprazole affects the expression of ENPP1 mRNA

NCBI chr 1:22,518,051...22,583,044
Ensembl chr 1:22,518,069...22,583,044

G

E1A binding protein p300

multiple interactions

ISO

Omeprazole promotes the reaction [EP300 protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [EP300 protein binds to CYP1B1 promoter]

NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574

G

epithelial cell adhesion molecule

affects expression

EXP

Omeprazole affects the expression of EPCAM mRNA

NCBI chr 6:12,633,715...12,649,678
Ensembl chr 6:12,631,611...12,649,702

G

endoplasmic reticulum protein 29

affects expression

EXP

Omeprazole affects the expression of ERP29 mRNA

NCBI chr12:40,750,177...40,756,607
Ensembl chr12:40,750,314...40,757,010

G

esterase D

affects expression

EXP

Omeprazole affects the expression of ESD mRNA

NCBI chr15:56,453,082...56,472,582
Ensembl chr15:56,453,044...56,473,508

G

electron transfer flavoprotein subunit beta

affects expression

EXP

Omeprazole affects the expression of ETFB mRNA

NCBI chr 1:93,851,908...93,866,072
Ensembl chr 1:102,988,499...103,002,659

G

fatty acid amide hydrolase

affects expression

EXP

Omeprazole affects the expression of FAAH mRNA

NCBI chr 5:134,716,545...134,735,396
Ensembl chr 5:134,716,545...134,735,396

G

fatty acid desaturase 2

affects expression

EXP

Omeprazole affects the expression of FADS2 mRNA

NCBI chr 1:216,132,277...216,172,190
Ensembl chr 1:216,133,676...216,172,066

G

fructose-bisphosphatase 1

affects expression

EXP

Omeprazole affects the expression of FBP1 mRNA

NCBI chr17:2,212,941...2,235,749
Ensembl chr17:2,213,492...2,235,746

G

farnesyl diphosphate farnesyl transferase 1

affects expression

EXP

Omeprazole affects the expression of FDFT1 mRNA

NCBI chr15:41,588,114...41,616,168
Ensembl chr15:41,588,117...41,616,168

G

farnesyl diphosphate synthase

affects expression

EXP

Omeprazole affects the expression of FDPS mRNA

NCBI chr 2:176,795,192...176,804,816
Ensembl chr 2:176,795,192...176,807,136

G

ferredoxin 2

affects expression

EXP

Omeprazole affects the expression of FDX2 mRNA

NCBI chr 8:27,881,091...27,886,230
Ensembl chr 8:27,881,091...27,886,015

G

flavin containing dimethylaniline monoxygenase 1

affects expression

EXP

Omeprazole affects the expression of FMO1 mRNA

NCBI chr13:77,715,405...77,747,666
Ensembl chr13:77,715,402...77,747,874

G

guanidinoacetate N-methyltransferase

affects expression

EXP

Omeprazole affects the expression of GAMT mRNA

NCBI chr 7:9,448,590...9,451,413
Ensembl chr 7:10,098,571...10,102,083

G

glyceraldehyde-3-phosphate dehydrogenase

affects expression

EXP

Omeprazole affects the expression of GAPDH mRNA

NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:159,648,592...159,653,377

G

gastrin

increases expression

ISO
EXP

Omeprazole results in increased expression of GAST protein

PMID:11422300 PMID:12189558 PMID:12763636 PMID:15223672 PMID:16618411 More...

NCBI chr10:85,765,216...85,767,881
Ensembl chr10:85,765,216...85,767,880

G

1,4-alpha-glucan branching enzyme 1

affects expression

EXP

Omeprazole affects the expression of GBE1 mRNA

NCBI chr11:22,181,194...22,446,640
Ensembl chr11:22,181,103...22,446,638

G

GTP cyclohydrolase I feedback regulator

affects expression

EXP

Omeprazole affects the expression of GCHFR mRNA

NCBI chr 3:126,611,892...126,615,926
Ensembl chr 3:126,613,240...126,615,926

G

gamma-glutamyl hydrolase

affects expression

EXP

Omeprazole affects the expression of GGH mRNA

NCBI chr 5:33,529,880...33,552,790
Ensembl chr 5:38,326,594...38,349,647

G

gamma-glutamyltransferase 1

multiple interactions

EXP

[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GGT1 mRNA

NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,141...13,088,050

G

gap junction protein, beta 1

affects expression

EXP

Omeprazole affects the expression of GJB1 mRNA

NCBI chr X:70,541,845...70,549,776
Ensembl chr X:70,541,862...70,549,843

G

glycosylphosphatidylinositol specific phospholipase D1

affects expression

EXP

Omeprazole affects the expression of GPLD1 mRNA

NCBI chr17:40,084,427...40,132,035
Ensembl chr17:40,512,660...40,554,975

G

glutathione peroxidase 1

affects expression

EXP

Omeprazole affects the expression of GPX1 mRNA

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glutathione peroxidase 2

multiple interactions

EXP

[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA

NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:101,226,745...101,230,862

G

glutathione peroxidase 4

affects expression

EXP

Omeprazole affects the expression of GPX4 mRNA

NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629

G

glutamate ionotropic receptor NMDA type subunit associated protein 1

affects expression

EXP

Omeprazole affects the expression of GRINA mRNA

NCBI chr 7:109,842,870...109,846,048
Ensembl chr 7:109,843,196...109,846,042

G

GrpE-like 1, mitochondrial

affects expression

EXP

Omeprazole affects the expression of GRPEL1 mRNA

NCBI chr14:74,292,023...74,298,243
Ensembl chr14:78,517,052...78,522,861

G

glutathione S-transferase alpha 5

multiple interactions
increases expression

EXP

[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA
Omeprazole results in increased expression of GSTA5 mRNA

PMID:17202759 PMID:22687989

NCBI chr 8:87,985,768...87,997,766
Ensembl chr 8:87,985,258...87,997,765

G

glutathione S-transferase pi 1

increases expression

EXP

Omeprazole results in increased expression of GSTP1 mRNA

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

glutathione S-transferase theta 1

affects expression

EXP

Omeprazole affects the expression of GSTT1 mRNA

NCBI chr20:12,856,068...12,873,020
Ensembl chr20:12,856,083...12,873,019

G

general transcription factor IIH subunit 5

affects expression

EXP

Omeprazole affects the expression of GTF2H5 mRNA

NCBI chr 1:49,061,904...49,068,612
Ensembl chr 1:49,061,959...49,070,039

G

gulonolactone (L-) oxidase

affects expression

EXP

Omeprazole affects the expression of GULO mRNA

NCBI chr15:44,381,226...44,403,314
Ensembl chr15:44,381,214...44,403,422

G

granzyme A

affects expression

EXP

Omeprazole affects the expression of GZMA mRNA

NCBI chr 2:46,473,763...46,485,696
Ensembl chr 2:46,473,763...46,485,696

G

H3.3 histone B

affects expression

EXP

Omeprazole affects the expression of H3F3B mRNA

NCBI chr10:101,755,404...101,764,616
Ensembl chr10:101,755,404...101,757,636

G

histidine ammonia lyase

affects expression

EXP

Omeprazole affects the expression of HAL mRNA

NCBI chr 7:29,894,495...29,924,744
Ensembl chr 7:29,893,855...29,924,744

G

hepcidin antimicrobial peptide

increases secretion
multiple interactions
increases expression

ISO

Omeprazole results in increased secretion of HAMP protein
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Omeprazole results in increased expression of HAMP mRNA]; AHR protein affects the reaction [Omeprazole results in increased expression of HAMP mRNA]
Omeprazole results in increased expression of HAMP mRNA; Omeprazole results in increased expression of HAMP protein

NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:95,298,307...95,300,297

G

hydroxyacid oxidase 2

affects expression

EXP

Omeprazole affects the expression of HAO2 mRNA

NCBI chr 2:188,888,848...188,921,567
Ensembl chr 2:188,889,212...188,913,133

G

hemoglobin alpha, adult chain 2

affects expression

EXP

Omeprazole affects the expression of HBA-A2 mRNA

NCBI chr10:15,828,291...15,829,138
Ensembl chr10:15,828,377...15,829,141

G

hemoglobin subunit beta

affects expression

EXP

Omeprazole affects the expression of HBB mRNA

NCBI chr 1:167,662,310...167,663,721
Ensembl chr 1:167,630,245...167,663,873

G

histidine decarboxylase

affects expression
increases expression
increases stability
multiple interactions

EXP

Omeprazole affects the expression of HDC mRNA
Omeprazole results in increased expression of HDC mRNA
Omeprazole results in increased stability of HDC protein
Omeprazole results in increased expression of and results in increased activity of HDC protein

PMID:12763636 PMID:19483382

NCBI chr 3:134,300,628...134,318,704
Ensembl chr 3:134,300,632...134,318,711

G

homogentisate 1, 2-dioxygenase

affects expression

EXP

Omeprazole affects the expression of HGD mRNA

NCBI chr11:76,592,202...76,643,776
Ensembl chr11:76,592,204...76,643,767

G

high mobility group nucleosome binding domain 1

affects expression

EXP

Omeprazole affects the expression of HMGN1 mRNA

NCBI chr11:48,891,813...48,897,732
Ensembl chr11:48,891,814...48,897,771

G

heme oxygenase 1

increases expression
multiple interactions

ISO

Omeprazole results in increased expression of HMOX1 mRNA; Omeprazole results in increased expression of HMOX1 protein
Acetylcysteine promotes the reaction [Omeprazole results in increased expression of HMOX1 mRNA]; Acetylcysteine promotes the reaction [Omeprazole results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 protein]; Omeprazole results in increased expression of and results in increased activity of HMOX1 protein

PMID:16712795 PMID:27725188

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

hypoxanthine phosphoribosyltransferase 1

affects expression

EXP

Omeprazole affects the expression of HPRT1 mRNA

NCBI chr X:137,655,744...137,687,718
Ensembl chr X:137,655,680...137,687,712

G

HPS5, biogenesis of lysosomal organelles complex 2 subunit 2

affects expression

EXP

Omeprazole affects the expression of HPS5 mRNA

NCBI chr 1:97,281,626...97,320,945
Ensembl chr 1:106,417,902...106,452,859

G

hydroxysteroid (17-beta) dehydrogenase 4

affects expression

EXP

Omeprazole affects the expression of HSD17B4 mRNA

NCBI chr18:43,328,903...43,417,950
Ensembl chr18:45,515,373...45,604,467

G

hydroxysteroid dehydrogenase like 2

affects expression

EXP

Omeprazole affects the expression of HSDL2 mRNA

NCBI chr 5:79,238,881...79,274,051
Ensembl chr 5:79,212,525...79,274,798

G

heat shock protein family A (Hsp70) member 1A

multiple interactions
decreases expression

EXP

Zinc Compounds analog inhibits the reaction [Omeprazole results in decreased expression of HSPA1A protein]; Zinc Sulfate inhibits the reaction [Omeprazole results in decreased expression of HSPA1A protein]
Omeprazole results in decreased expression of HSPA1A mRNA; Omeprazole results in decreased expression of HSPA1A protein

PMID:15223672 PMID:16945336

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 1 like

multiple interactions

EXP

Omeprazole inhibits the reaction [Ethanol results in increased expression of HSPA1L mRNA]

NCBI chr20:3,853,496...3,860,223
Ensembl chr20:3,853,331...3,876,877

G

HtrA serine peptidase 1

affects expression

EXP

Omeprazole affects the expression of HTRA1 mRNA

NCBI chr 1:194,928,069...194,977,619
Ensembl chr 1:194,927,687...194,977,620

G

immediate early response 3

multiple interactions

ISO

[Omeprazole co-treated with CCKBR protein] results in increased expression of IER3

NCBI chr20:2,933,173...2,934,377
Ensembl chr20:2,933,174...2,934,377

G

interferon gamma

multiple interactions

ISO

Omeprazole inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

insulin-like growth factor 1

affects expression

EXP

Omeprazole affects the expression of IGF1 mRNA

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764

G

insulin-like growth factor binding protein, acid labile subunit

affects expression

EXP

Omeprazole affects the expression of IGFALS mRNA

NCBI chr10:14,397,076...14,408,439
Ensembl chr10:14,403,399...14,407,138

G

insulin-like growth factor binding protein 2

affects expression

EXP

Omeprazole affects the expression of IGFBP2 mRNA

NCBI chr 9:81,864,811...81,892,179
Ensembl chr 9:81,864,783...81,892,171

G

interleukin 10

multiple interactions

ISO
EXP

Omeprazole inhibits the reaction [Ethanol results in decreased expression of IL10 protein]

PMID:26970604 PMID:38341112

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 16

multiple interactions

EXP

Omeprazole inhibits the reaction [Ethanol results in increased expression of IL16 protein]

NCBI chr 1:147,026,852...147,127,177
Ensembl chr 1:147,027,097...147,127,023

G

interleukin 1 beta

multiple interactions

EXP

Omeprazole inhibits the reaction [Cisplatin results in increased expression of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

EXP
ISO

Omeprazole inhibits the reaction [Cisplatin results in increased expression of IL6 protein]; Omeprazole inhibits the reaction [Ethanol results in decreased expression of IL6 protein]
Omeprazole inhibits the reaction [Ethanol results in increased expression of IL6 protein]

PMID:25637687 PMID:32418911 PMID:38341112

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

inositol monophosphatase 1

affects expression

EXP

Omeprazole affects the expression of IMPA1 mRNA

NCBI chr 2:91,462,781...91,484,057
Ensembl chr 2:93,370,299...93,391,468

G

inhibin subunit beta E

affects expression

EXP

Omeprazole affects the expression of INHBE mRNA

NCBI chr 7:65,061,531...65,064,519
Ensembl chr 7:65,061,531...65,064,519

G

inositol-3-phosphate synthase 1

affects expression

EXP

Omeprazole affects the expression of ISYNA1 mRNA

NCBI chr16:18,839,143...18,841,979
Ensembl chr16:18,873,121...18,875,955

G

inter-alpha-trypsin inhibitor heavy chain 4

affects expression

EXP

Omeprazole affects the expression of ITIH4 mRNA

NCBI chr16:6,086,985...6,102,162
Ensembl chr16:6,086,973...6,102,160

G

Janus kinase 1

affects expression

EXP

Omeprazole affects the expression of JAK1 mRNA

NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:120,896,046...120,996,758

G

KDEL endoplasmic reticulum protein retention receptor 2

affects expression

EXP

Omeprazole affects the expression of KDELR2 mRNA

NCBI chr12:11,138,820...11,157,117
Ensembl chr12:16,252,424...16,270,719

G

kinase insert domain receptor

affects expression
multiple interactions

EXP
ISO

Omeprazole affects the expression of KDR mRNA
Omeprazole promotes the reaction [Oxygen results in decreased expression of KDR protein]

PMID:19483382 PMID:26272953

NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192

G

keratin 8

affects expression

EXP

Omeprazole affects the expression of KRT8 mRNA

NCBI chr 7:135,002,886...135,010,339
Ensembl chr 7:135,002,894...135,010,403

G

lecithin cholesterol acyltransferase

affects expression

EXP

Omeprazole affects the expression of LCAT mRNA

NCBI chr19:50,744,598...50,748,064
Ensembl chr19:50,744,601...50,748,081

G

leucine carboxyl methyltransferase 1

affects expression

EXP

Omeprazole affects the expression of LCMT1 mRNA

NCBI chr 1:187,335,173...187,391,195
Ensembl chr 1:187,327,706...187,391,516

G

lipase C, hepatic type

affects expression

EXP

Omeprazole affects the expression of LIPC mRNA

NCBI chr 8:80,390,470...80,516,463
Ensembl chr 8:80,390,471...80,516,285

G

lysyl oxidase

affects expression

EXP

Omeprazole affects the expression of LOX mRNA

NCBI chr18:48,162,889...48,175,640
Ensembl chr18:48,165,688...48,239,810

G

LDL receptor related protein 3

affects expression

EXP

Omeprazole affects the expression of LRP3 mRNA

NCBI chr 1:87,843,815...87,859,147
Ensembl chr 1:96,981,815...96,996,057

G

mannosidase, alpha, class 2B, member 1

affects expression

EXP

Omeprazole affects the expression of MAN2B1 mRNA

NCBI chr19:39,959,964...39,979,299
Ensembl chr19:39,959,965...39,979,246

G

mitogen activated protein kinase kinase 2

affects expression

EXP

Omeprazole affects the expression of MAP2K2 mRNA

NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:9,241,310...9,260,940

G

mitogen activated protein kinase 14

multiple interactions

ISO

Omeprazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK14 protein]

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

MBL associated serine protease 2

affects expression

EXP

Omeprazole affects the expression of MASP2 mRNA

NCBI chr 5:164,319,017...164,332,686
Ensembl chr 5:164,308,991...164,332,705

G

malic enzyme 1

affects expression
multiple interactions

EXP

Omeprazole affects the expression of ME1 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of ME1 mRNA

PMID:19483382 PMID:22687989

NCBI chr 8:96,429,057...96,540,244
Ensembl chr 8:96,429,057...96,540,275

G

matrix metallopeptidase 14

multiple interactions

EXP

Omeprazole inhibits the reaction [Indomethacin results in decreased expression of MMP14 protein]

NCBI chr15:31,857,824...31,867,049
Ensembl chr15:31,857,546...31,869,893

G

matrix metallopeptidase 2

multiple interactions

EXP

Omeprazole inhibits the reaction [Hydrogen Peroxide results in decreased activity of MMP2 protein]

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

methylmalonyl-CoA mutase

affects expression

EXP

Omeprazole affects the expression of MMUT mRNA

NCBI chr 9:27,425,935...27,454,202
Ensembl chr 9:27,425,935...27,454,342

G

myeloperoxidase

multiple interactions
decreases activity

ISO
EXP

Omeprazole inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; Omeprazole inhibits the reaction [Acids results in increased activity of MPO protein]
Omeprazole results in decreased activity of MPO protein
Omeprazole inhibits the reaction [Acetic Acid results in increased activity of MPO protein]; Omeprazole inhibits the reaction [Cysteamine results in increased expression of MPO protein]; Omeprazole inhibits the reaction [Ethanol results in increased activity of MPO protein]; Omeprazole inhibits the reaction [Indomethacin results in increased activity of MPO protein]

PMID:16091555 PMID:17151854 PMID:20165931 PMID:25637687 PMID:27780710 More...

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

maestro

affects expression

EXP

Omeprazole affects the expression of MRO mRNA

NCBI chr18:67,450,186...67,467,593
Ensembl chr18:69,725,798...69,743,031

G

mitochondrial ribosomal protein L2

affects expression

EXP

Omeprazole affects the expression of MRPL2 mRNA

NCBI chr 9:21,830,834...21,834,607
Ensembl chr 9:21,830,835...21,834,641

G

mitochondrial ribosomal protein L9

affects expression

EXP

Omeprazole affects the expression of MRPL9 mRNA

NCBI chr 2:184,768,837...184,775,787
Ensembl chr 2:184,763,529...184,775,777

G

murinoglobulin 2

affects expression

EXP

Omeprazole affects the expression of PZP mRNA

NCBI chr 4:155,164,061...155,236,894

G

myeloid-associated differentiation marker

affects expression

EXP

Omeprazole affects the expression of MYADM mRNA

NCBI chr 1:65,864,180...65,874,701
Ensembl chr 1:74,775,698...74,789,710

G

MYC binding protein 2

affects expression

EXP

Omeprazole affects the expression of MYCBP2 mRNA

NCBI chr15:86,352,061...86,590,126
Ensembl chr15:86,352,061...86,590,325

G

myosin ID

affects expression

EXP

Omeprazole affects the expression of MYO1D mRNA

NCBI chr10:65,489,153...65,765,812
Ensembl chr10:65,975,122...66,263,958

G

N(alpha)-acetyltransferase 38, NatC auxiliary subunit

affects expression

EXP

Omeprazole affects the expression of NAA38 mRNA

NCBI chr10:54,588,304...54,617,715
Ensembl chr10:54,592,990...54,617,715

G

nucleosome assembly protein 1-like 1

affects expression

EXP

Omeprazole affects the expression of NAP1L1 mRNA

NCBI chr 7:48,819,464...48,844,108
Ensembl chr 7:48,819,477...48,844,104

G

N-acetyltransferase 8

affects expression

EXP

Omeprazole affects the expression of NAT8 mRNA

NCBI chr 4:119,836,986...119,837,764
Ensembl chr 4:119,835,645...119,843,159

G

nuclear receptor coactivator 1

multiple interactions

ISO

Omeprazole promotes the reaction [NCOA1 protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [NCOA1 protein binds to CYP1B1 promoter]

NCBI chr 6:32,952,090...33,229,829
Ensembl chr 6:32,952,090...33,195,924

G

NDRG family member 2

affects expression

EXP

Omeprazole affects the expression of NDRG2 mRNA

NCBI chr15:27,074,481...27,087,376
Ensembl chr15:27,074,481...27,083,125

G

NADH:ubiquinone oxidoreductase subunit S5

affects expression

EXP

Omeprazole affects the expression of NDUFS5 mRNA

NCBI chr 5:141,258,828...141,264,552
Ensembl chr 2:184,849,197...185,028,909
Ensembl chr 5:184,849,197...185,028,909
Ensembl chr14:184,849,197...185,028,909

G

NADH:ubiquinone oxidoreductase subunit V3

affects expression

EXP

Omeprazole affects the expression of NDUFV3 mRNA

NCBI chr20:9,613,786...9,622,941
Ensembl chr13:48,468,224...48,488,847
Ensembl chr20:48,468,224...48,488,847

G

neuraminidase 2

affects expression

EXP

Omeprazole affects the expression of NEU2 mRNA

NCBI chr 9:88,218,494...88,267,356
Ensembl chr 9:95,696,507...95,715,208

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 protein]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NFKB inhibitor alpha

multiple interactions

EXP

Omeprazole inhibits the reaction [Cisplatin results in decreased expression of NFKBIA protein]

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nuclear transcription factor, X-box binding 1

affects expression

EXP

Omeprazole affects the expression of NFX1 mRNA

NCBI chr 5:60,900,140...60,958,889
Ensembl chr 5:60,901,217...60,958,889

G

NIPA-like domain containing 2

affects expression

EXP

Omeprazole affects the expression of NIPAL2 mRNA

NCBI chr 7:65,774,477...65,884,807
Ensembl chr 7:67,659,628...67,769,959

G

nitrilase 1

affects expression

EXP

Omeprazole affects the expression of NIT1 mRNA

NCBI chr13:86,302,334...86,305,770
Ensembl chr13:86,298,387...86,305,770

G

NLR family, pyrin domain containing 3

multiple interactions

EXP

Lipopolysaccharides inhibits the reaction [Omeprazole inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]]; Omeprazole inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394

G

NME/NM23 nucleoside diphosphate kinase 2

affects expression

EXP

Omeprazole affects the expression of NME2 mRNA

NCBI chr10:78,898,097...78,903,514
Ensembl chr20:11,179,066...11,179,497
Ensembl chr10:11,179,066...11,179,497

G

NAD(P)H quinone dehydrogenase 1

increases expression
multiple interactions

EXP
ISO

Omeprazole results in increased expression of NQO1 mRNA
Omeprazole inhibits the reaction [Oxygen results in increased expression of NQO1 mRNA]; Omeprazole inhibits the reaction [Oxygen results in increased expression of NQO1 protein]
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of NQO1 mRNA

PMID:17202759 PMID:22687989 PMID:26272953

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
increases activity

ISO
EXP

[Omeprazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; NR1I2 protein affects the reaction [Omeprazole results in increased expression of CYP3A4 mRNA]

PMID:12695340 PMID:17041008 PMID:25680588 PMID:26187274 PMID:27732639

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

nuclear receptor subfamily 1, group I, member 3

affects expression
decreases metabolic processing
increases expression

EXP
ISO

Omeprazole affects the expression of NR1I3 mRNA
NR1I3 gene mutant form results in decreased metabolism of Omeprazole
Omeprazole results in increased expression of NR1I3 mRNA

PMID:19118567 PMID:19483382 PMID:27434302

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

G

nuclear receptor subfamily 3, group C, member 1

affects expression

EXP

Omeprazole affects the expression of NR3C1 mRNA

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843

G

out at first homolog

affects expression

EXP

Omeprazole affects the expression of OAF mRNA

NCBI chr 8:52,491,314...52,509,285
Ensembl chr 8:52,491,315...52,509,285

G

alpha-2u globulin PGCL4

affects expression

EXP

Omeprazole affects the expression of OBP3 mRNA

NCBI chr 5:79,637,234...79,640,810
Ensembl chr 5:79,637,234...79,640,675

G

oxoglutarate dehydrogenase

affects expression

EXP

Omeprazole affects the expression of OGDH mRNA

NCBI chr14:85,363,949...85,431,405
Ensembl chr14:85,364,014...85,432,271

G

olfactory receptor 59

affects expression

EXP

Omeprazole affects the expression of OLR59 mRNA

NCBI chr 1:157,193,051...157,227,707
Ensembl chr 1:166,604,141...166,623,265

G

oligosaccharyltransferase complex non-catalytic subunit

affects expression

EXP

Omeprazole affects the expression of OSTC mRNA

NCBI chr 2:219,250,549...219,266,076
Ensembl chr 2:221,874,948...221,940,267

G

ornithine transcarbamylase

affects expression

EXP

Omeprazole affects the expression of OTC mRNA

NCBI chr X:15,126,358...15,202,473
Ensembl chr X:15,126,358...15,239,555

G

poly(A) binding protein, cytoplasmic 4

affects expression

EXP

Omeprazole affects the expression of PABPC4 mRNA

NCBI chr 5:140,847,835...140,864,089
Ensembl chr 5:140,848,225...140,864,087

G

phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase

affects expression

EXP

Omeprazole affects the expression of PAICS mRNA

NCBI chr14:31,553,355...31,586,843
Ensembl chr14:31,553,357...31,587,027

G

poly (ADP-ribose) polymerase 1

increases cleavage

ISO

Omeprazole results in increased cleavage of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

pyruvate carboxylase

affects expression

EXP

Omeprazole affects the expression of PCX mRNA

NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:211,228,731...211,329,940

G

propionyl-CoA carboxylase subunit beta

affects expression

EXP

Omeprazole affects the expression of PCCB mRNA

NCBI chr 8:101,591,218...101,641,213
Ensembl chr 8:110,469,934...110,520,187

G

proliferating cell nuclear antigen

multiple interactions

EXP
ISO

[Omeprazole co-treated with Indomethacin] promotes the reaction [Acetic Acid results in increased expression of PCNA protein]; Omeprazole promotes the reaction [Acetic Acid results in increased expression of PCNA protein]
Omeprazole inhibits the reaction [Ethanol results in decreased expression of PCNA protein]

PMID:19251492 PMID:26970604

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

proprotein convertase subtilisin/kexin type 6

affects expression

EXP

Omeprazole affects the expression of PCSK6 mRNA

NCBI chr 1:119,428,978...119,627,626
Ensembl chr 1:128,839,232...129,052,128

G

phosphatidylcholine transfer protein

affects expression

EXP

Omeprazole affects the expression of PCTP mRNA

NCBI chr10:75,305,999...75,351,919
Ensembl chr10:75,305,999...75,326,432

G

phosducin-like 3

affects expression

EXP

Omeprazole affects the expression of PDCL3 mRNA

NCBI chr 9:41,234,322...41,243,769
Ensembl chr 9:48,723,767...48,739,529

G

protein disulfide isomerase family A, member 3

affects expression

EXP

Omeprazole affects the expression of PDIA3 mRNA

NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:128,841,917...128,867,327

G

protein disulfide isomerase family A, member 6

affects expression

EXP

Omeprazole affects the expression of PDIA6 mRNA

NCBI chr 6:45,791,704...45,808,947
Ensembl chr 6:45,791,678...45,810,091

G

peroxisomal biogenesis factor 19

affects expression

EXP

Omeprazole affects the expression of PEX19 mRNA

NCBI chr13:87,124,654...87,141,170
Ensembl chr13:87,124,698...87,141,757

G

phosphoglycerate mutase 1

affects expression

EXP

Omeprazole affects the expression of PGAM1 mRNA

NCBI chr 1:250,673,152...250,680,762
Ensembl chr 1:250,673,049...250,690,203

G

progesterone receptor membrane component 1

affects expression

EXP

Omeprazole affects the expression of PGRMC1 mRNA

NCBI chr X:120,698,610...120,706,805
Ensembl chr X:120,698,610...120,706,805

G

phytanoyl-CoA 2-hydroxylase

affects expression

EXP

Omeprazole affects the expression of PHYH mRNA

NCBI chr17:78,238,747...78,255,645
Ensembl chr17:78,238,747...78,255,645

G

phosphatidylinositol glycan anchor biosynthesis, class P

affects expression

EXP

Omeprazole affects the expression of PIGP mRNA

NCBI chr11:47,152,601...47,158,766
Ensembl chr11:47,148,465...47,160,082

G

pyruvate kinase L/R

affects expression

EXP

Omeprazole affects the expression of PKLR mRNA

NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:176,840,764...176,849,644

G

phospholipase A2 group 4A

increases phosphorylation
multiple interactions

ISO

Omeprazole results in increased phosphorylation of PLA2G4A protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Omeprazole results in increased phosphorylation of PLA2G4A protein]

NCBI chr13:64,427,921...64,572,352
Ensembl chr13:64,427,916...64,589,641

G

phospholipase B domain containing 1

affects expression

EXP

Omeprazole affects the expression of PLBD1 mRNA

NCBI chr 4:169,472,983...169,529,277
Ensembl chr 4:171,204,198...171,260,488

G

plasminogen

affects expression

EXP

Omeprazole affects the expression of PLG mRNA

NCBI chr 1:50,872,927...50,915,406
Ensembl chr 1:50,872,926...50,917,320

G

plastin 3

affects expression

EXP

Omeprazole affects the expression of PLS3 mRNA

NCBI chr X:116,401,247...116,495,898
Ensembl chr X:116,401,293...116,495,893

G

paraoxonase 2

affects expression

EXP

Omeprazole affects the expression of PON2 mRNA

NCBI chr 4:34,356,270...34,391,684
Ensembl chr 4:34,356,274...34,391,996

G

POU class 2 homeobox 2

multiple interactions

ISO
EXP

Omeprazole inhibits the reaction [Cisplatin results in increased expression of POU2F2 protein]

NCBI chr 1:89,810,153...89,897,560
Ensembl chr 1:89,812,093...89,897,564

G

pancreatic progenitor cell differentiation and proliferation factor

affects expression

EXP

Omeprazole affects the expression of PPDPF mRNA

NCBI chr 3:168,299,309...168,301,040
Ensembl chr 3:188,676,965...188,678,599

G

peroxiredoxin 2

affects expression

EXP

Omeprazole affects the expression of PRDX2 mRNA

NCBI chr19:40,085,788...40,091,083
Ensembl chr19:40,084,430...40,091,006

G

peroxiredoxin 6

affects expression

EXP

Omeprazole affects the expression of PRDX6 mRNA

NCBI chr13:76,062,082...76,072,631
Ensembl chr13:76,061,554...76,072,657

G

prolactin

increases expression

ISO

Omeprazole results in increased expression of PRL protein

NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217

G

protein C, inactivator of coagulation factors Va and VIIIa

affects expression

EXP

Omeprazole affects the expression of PROC mRNA

NCBI chr18:24,038,596...24,049,061
Ensembl chr18:24,038,597...24,048,964

G

phosphoribosyl pyrophosphate synthetase-associated protein 1

affects expression

EXP

Omeprazole affects the expression of PRPSAP1 mRNA

NCBI chr10:102,199,949...102,221,642
Ensembl chr10:102,199,950...102,221,642

G

proteasome 20S subunit alpha 6

affects expression

EXP

Omeprazole affects the expression of PSMA6 mRNA

NCBI chr 6:72,765,534...72,796,554
Ensembl chr 6:78,500,736...78,531,717

G

proteasome 20S subunit beta 1

affects expression

EXP

Omeprazole affects the expression of PSMB1 mRNA

NCBI chr 1:65,115,770...65,136,516
Ensembl chr 1:65,114,724...65,136,640

G

proteasome 20S subunit beta 3

affects expression

EXP

Omeprazole affects the expression of PSMB3 mRNA

NCBI chr10:83,193,787...83,200,883
Ensembl chr10:83,193,787...83,200,883

G

proteasome 26S subunit, ATPase 1

affects expression

EXP

Omeprazole affects the expression of PSMC1 mRNA

NCBI chr 6:119,392,833...119,405,233
Ensembl chr 6:125,122,490...125,134,858

G

proteasome 26S subunit, ATPase 3

affects expression

EXP

Omeprazole affects the expression of PSMC3 mRNA

NCBI chr 3:77,031,825...77,037,207
Ensembl chr 3:97,487,632...97,499,176

G

proteasome 26S subunit, ATPase 5

affects expression

EXP

Omeprazole affects the expression of PSMC5 mRNA

NCBI chr10:91,687,553...91,693,487
Ensembl chr10:91,686,295...91,695,921

G

proteasome 26S subunit, non-ATPase 1

affects expression

EXP

Omeprazole affects the expression of PSMD1 mRNA

NCBI chr 9:94,157,971...94,233,218
Ensembl chr 9:94,157,971...94,233,218

G

proteasome 26S subunit ubiquitin receptor, non-ATPase 4

affects expression

EXP

Omeprazole affects the expression of PSMD4 mRNA

NCBI chr 2:185,287,941...185,297,238
Ensembl chr 2:185,286,868...185,297,201

G

prostaglandin-endoperoxide synthase 2

multiple interactions

EXP
ISO

[Omeprazole co-treated with beta-Naphthoflavone] results in increased expression of PTGS2 mRNA; [Omeprazole co-treated with beta-Naphthoflavone] results in increased expression of PTGS2 protein
Omeprazole inhibits the reaction [Ethanol results in increased expression of PTGS2 protein]

PMID:23038005 PMID:26970604

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

parathymosin

affects expression

EXP

Omeprazole affects the expression of PTMS mRNA

NCBI chr 4:159,408,647...159,412,837
Ensembl chr 4:159,408,649...159,415,212

G

protein tyrosine phosphatase, receptor type, F

affects expression

EXP

Omeprazole affects the expression of PTPRF mRNA

NCBI chr 5:137,027,376...137,109,405
Ensembl chr 5:137,028,164...137,095,426

G

PTTG1 interacting protein

affects expression

EXP

Omeprazole affects the expression of PTTG1IP mRNA

NCBI chr20:11,029,608...11,047,395
Ensembl chr20:11,029,608...11,046,909

G

glycogen phosphorylase L

affects expression

EXP

Omeprazole affects the expression of PYGL mRNA

NCBI chr 6:94,433,558...94,476,219
Ensembl chr 6:94,426,346...94,476,269

G

RAB5 interacting factor

affects expression

EXP

Omeprazole affects the expression of RAB5IF mRNA

NCBI chr 3:165,818,060...165,828,071
Ensembl chr 3:165,816,588...165,828,067

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

EXP
ISO

[Omeprazole co-treated with Indomethacin] promotes the reaction [Acetic Acid results in increased expression of RELA protein]; Lipopolysaccharides inhibits the reaction [Omeprazole inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]]; Omeprazole inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]
Omeprazole inhibits the reaction [Cisplatin affects the localization of RELA protein]

PMID:19251492 PMID:30452898 PMID:32418911

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

retinol saturase

increases expression

EXP

Omeprazole results in increased expression of RETSAT mRNA

NCBI chr 4:104,653,306...104,662,069
Ensembl chr 4:106,211,436...106,229,552

G

reactive intermediate imine deaminase A homolog

affects expression

EXP

Omeprazole affects the expression of RIDA mRNA

NCBI chr 7:67,576,586...67,590,493
Ensembl chr 7:67,576,586...67,590,692

G

ribonuclease A family member 4

affects expression

EXP

Omeprazole affects the expression of RNASE4 mRNA

NCBI chr15:26,786,287...26,803,634
Ensembl chr15:26,786,079...26,803,639

G

ring finger protein 103

affects expression

EXP

Omeprazole affects the expression of RNF103 mRNA

NCBI chr 4:103,526,456...103,542,529
Ensembl chr 4:105,084,686...105,106,809

G

RNA binding protein with serine rich domain 1

affects expression

EXP

Omeprazole affects the expression of RNPS1 mRNA

NCBI chr10:13,950,151...13,960,396
Ensembl chr10:13,950,184...13,960,393

G

ribosomal protein L11

affects expression

EXP

Omeprazole affects the expression of RPL11 mRNA

NCBI chr 5:153,557,592...153,561,230
Ensembl chr 5:153,557,597...153,561,127

G

ribosomal protein L13

affects expression

EXP

Omeprazole affects the expression of RPL13 mRNA

NCBI chr19:68,062,442...68,065,065
Ensembl chr19:68,062,493...68,065,059

G

ribosomal protein L15

affects expression

EXP

Omeprazole affects the expression of RPL15 mRNA

NCBI chr15:9,934,663...9,937,946
Ensembl chr15:9,934,679...9,938,308

G

ribosomal protein L17

affects expression

EXP

Omeprazole affects the expression of RPL17 mRNA

NCBI chr18:70,856,275...70,859,388
Ensembl chr 3:111,722,010...111,722,638
Ensembl chr18:111,722,010...111,722,638

G

ribosomal protein L23

affects expression

EXP

Omeprazole affects the expression of RPL23 mRNA

NCBI chr10:83,268,223...83,272,184
Ensembl chr10:83,262,592...83,272,214

G

ribosomal protein L3

affects expression

EXP

Omeprazole affects the expression of RPL3 mRNA

NCBI chr 7:113,491,943...113,508,115
Ensembl chr 7:113,501,960...113,507,990

G

ribosomal protein L32

affects expression

EXP

Omeprazole affects the expression of RPL32 mRNA

NCBI chr 4:148,864,048...148,867,612
Ensembl chr 4:150,536,646...150,540,214

G

ribosomal protein L4

affects expression

EXP

Omeprazole affects the expression of RPL4 mRNA

NCBI chr 8:73,566,477...73,571,600
Ensembl chr 8:73,566,466...73,571,788

G

ribophorin II

affects expression

EXP

Omeprazole affects the expression of RPN2 mRNA

NCBI chr 3:166,361,955...166,409,272
Ensembl chr 3:166,362,049...166,409,922

G

ribosomal protein S14

affects expression

EXP

Omeprazole affects the expression of RPS14 mRNA

NCBI chr18:56,492,010...56,503,092
Ensembl chr18:56,498,245...56,503,091

G

ribosomal protein S18

affects expression

EXP

Omeprazole affects the expression of RPS18 mRNA

NCBI chr20:4,933,741...4,937,423
Ensembl chr20:4,917,095...4,937,423

G

ribosomal protein S19

affects expression

EXP

Omeprazole affects the expression of RPS19 mRNA

NCBI chr 1:89,608,408...89,614,390
Ensembl chr 7:104,324,520...104,325,132
Ensembl chr 1:104,324,520...104,325,132

G

ribosomal protein S20

affects expression

EXP

Omeprazole affects the expression of RPS20 mRNA

NCBI chr 5:21,616,687...21,618,068
Ensembl chr 3:42,839,965...43,095,621
Ensembl chr 9:42,839,965...43,095,621
Ensembl chr 5:42,839,965...43,095,621

G

ribosomal protein S3a

affects expression

EXP

Omeprazole affects the expression of RPS3A mRNA

NCBI chr 2:173,822,673...173,827,042
Ensembl chr 2:173,822,488...173,827,043

G

ribosomal protein S6

affects expression

EXP

Omeprazole affects the expression of RPS6 mRNA

NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:106,417,680...106,420,566

G

ribosomal protein S8

affects expression

EXP

Omeprazole affects the expression of RPS8 mRNA

NCBI chr 5:135,866,941...135,869,511
Ensembl chr 5:135,866,941...135,869,548

G

RAS related 2

affects expression

EXP

Omeprazole affects the expression of RRAS2 mRNA

NCBI chr 1:177,668,143...177,737,551
Ensembl chr 1:177,668,144...177,737,551

G

RT1 class II, locus DMa

affects expression

ISO

Omeprazole affects the expression of HLA-DMA mRNA

NCBI chr20:4,707,028...4,710,432
Ensembl chr20:4,708,933...4,712,335

G

RT1 class Ib, locus M3, gene 1

affects expression

ISO

Omeprazole affects the expression of HLA-G mRNA

NCBI chr20:1,329,227...1,333,394
Ensembl chr20:1,329,225...1,333,366

G

RT1 class Ib, locus S3

affects expression

EXP

Omeprazole affects the expression of RT1-S3 mRNA

NCBI chr20:2,675,463...2,680,229

G

sphingosine-1-phosphate receptor 1

affects expression

EXP

Omeprazole affects the expression of S1PR1 mRNA

NCBI chr 2:206,309,715...206,314,070
Ensembl chr 2:205,900,836...206,328,689

G

somatomedin B and thrombospondin, type 1 domain containing

affects expression

EXP

Omeprazole affects the expression of SBSPON mRNA

NCBI chr 5:3,402,763...3,433,338
Ensembl chr 5:8,185,985...8,218,898

G

syndecan 2

affects expression

EXP

Omeprazole affects the expression of SDC2 mRNA

NCBI chr 7:66,012,405...66,125,101
Ensembl chr 7:66,108,853...66,126,294

G

succinate dehydrogenase complex subunit C

affects expression

EXP

Omeprazole affects the expression of SDHC mRNA

NCBI chr13:86,077,133...86,098,025
Ensembl chr13:86,077,134...86,098,044

G

succinate dehydrogenase complex subunit D

affects expression

EXP

Omeprazole affects the expression of SDHD mRNA

NCBI chr 8:59,841,090...59,850,641
Ensembl chr 8:59,841,090...59,850,641

G

selectin L

decreases expression

EXP

Omeprazole results in decreased expression of SELL protein

NCBI chr13:78,950,100...78,969,604
Ensembl chr13:78,950,015...78,969,600

G

serine incorporator 3

affects expression

EXP

Omeprazole affects the expression of SERINC3 mRNA

NCBI chr 3:172,721,208...172,749,853
Ensembl chr 3:172,721,321...172,740,765

G

serpin family A member 1

affects expression

EXP

Omeprazole affects the expression of SERPINA1 mRNA

NCBI chr 6:128,631,101...128,653,125
Ensembl chr 6:128,619,382...128,660,703

G

serpin family A member 10

affects expression

EXP

Omeprazole affects the expression of SERPINA10 mRNA

NCBI chr 6:128,520,894...128,529,332
Ensembl chr 6:128,520,896...128,529,332

G

serpin family A member 4

affects expression

EXP

Omeprazole affects the expression of SERPINA4 mRNA

NCBI chr 6:128,764,738...128,773,858
Ensembl chr 6:128,764,769...128,776,028

G

serpin family F member 2

affects expression

EXP

Omeprazole affects the expression of SERPINF2 mRNA

NCBI chr10:60,770,698...60,778,782
Ensembl chr10:60,770,698...60,778,996

G

serpin family G member 1

decreases expression

EXP

Omeprazole results in decreased expression of SERPING1 mRNA

NCBI chr 3:90,249,410...90,259,299
Ensembl chr 3:90,249,423...90,258,717

G

sideroflexin 1

affects expression

EXP

Omeprazole affects the expression of SFXN1 mRNA

NCBI chr17:10,491,315...10,527,793
Ensembl chr17:10,491,344...10,527,456

G

serine hydroxymethyltransferase 2

affects expression

EXP

Omeprazole affects the expression of SHMT2 mRNA

NCBI chr 7:65,244,247...65,249,580
Ensembl chr 7:65,244,247...65,249,567

G

solute carrier family 22 member 1

affects expression

EXP

Omeprazole affects the expression of SLC22A1 mRNA

NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436

G

solute carrier family 22 member 2

multiple interactions

ISO

Omeprazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 22 member 5

multiple interactions

EXP

Dithioerythritol inhibits the reaction [Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]]; Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]

NCBI chr10:38,509,072...38,536,240
Ensembl chr10:38,509,072...38,536,077

G

solute carrier family 22 member 8

multiple interactions

ISO

[Omeprazole results in decreased activity of SLC22A8 protein] which results in decreased uptake of Indican

NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588

G

solute carrier family 23 member 1

affects expression

EXP

Omeprazole affects the expression of SLC23A1 mRNA

NCBI chr18:27,490,549...27,504,563
Ensembl chr18:27,490,374...27,504,702

G

solute carrier family 25 member 13

affects expression

EXP

Omeprazole affects the expression of SLC25A13 mRNA

NCBI chr 4:34,179,224...34,361,912
Ensembl chr 4:35,145,721...35,328,360

G

solute carrier family 25 member 3

affects expression

EXP

Omeprazole affects the expression of SLC25A3 mRNA

NCBI chr 7:25,611,937...25,619,401
Ensembl chr 7:27,499,165...27,506,309

G

solute carrier family 27 member 2

affects expression

EXP

Omeprazole affects the expression of SLC27A2 mRNA

NCBI chr 3:134,258,101...134,295,581
Ensembl chr 3:134,258,101...134,295,581

G

solute carrier family 39 member 8

affects expression

EXP

Omeprazole affects the expression of SLC39A8 mRNA

NCBI chr 2:224,171,787...224,319,326
Ensembl chr 2:226,929,644...226,992,667

G

solute carrier family 40 member 1

decreases expression

ISO

Omeprazole results in decreased expression of SLC40A1 protein

NCBI chr 9:55,525,457...55,633,463
Ensembl chr 9:55,525,532...55,543,460

G

solute carrier family 46 member 1

affects expression

EXP

Omeprazole affects the expression of SLC46A1 mRNA

NCBI chr10:63,859,551...63,865,987
Ensembl chr10:63,859,504...63,866,869

G

solute carrier family 66 member 2

affects expression

EXP

Omeprazole affects the expression of SLC66A2 mRNA

NCBI chr18:73,702,472...73,739,678
Ensembl chr18:75,977,458...76,014,651

G

solute carrier family 6 member 6

affects expression

EXP

Omeprazole affects the expression of SLC6A6 mRNA

NCBI chr 4:125,752,340...125,826,033
Ensembl chr 4:125,752,372...125,826,032

G

solute carrier organic anion transporter family, member 1a1

affects expression

EXP

Omeprazole affects the expression of SLCO1A1 mRNA

NCBI chr 4:174,877,045...174,950,900
Ensembl chr 4:176,607,687...176,681,992

G

solute carrier organic anion transporter family, member 1a4

increases expression

ISO

Omeprazole results in increased expression of SLCO1A2 mRNA

NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:176,441,104...176,495,816

G

superoxide dismutase 1

multiple interactions

ISO

Omeprazole inhibits the reaction [Ethanol results in decreased activity of SOD1 protein]

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

signal peptide peptidase-like 2A

affects expression

EXP

Omeprazole affects the expression of SPPL2A mRNA

NCBI chr 3:114,149,337...114,193,408
Ensembl chr 3:134,605,750...134,646,752

G

spermidine synthase

affects expression

EXP

Omeprazole affects the expression of SRM mRNA

NCBI chr 5:164,309,002...164,312,203
Ensembl chr 5:164,308,991...164,332,705

G

SRP receptor subunit beta

affects expression

EXP

Omeprazole affects the expression of SRPRB mRNA

NCBI chr 8:112,647,577...112,661,524

G

SSX family member 2 interacting protein

affects expression

EXP

Omeprazole affects the expression of SSX2IP mRNA

NCBI chr 2:237,958,286...237,991,026
Ensembl chr 2:237,958,465...237,991,017

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

affects expression

EXP

Omeprazole affects the expression of ST3GAL6 mRNA

NCBI chr11:42,061,282...42,121,801
Ensembl chr11:55,530,248...55,598,720

G

ST6 beta-galactoside alpha-2,6-sialyltransferase 1

affects expression

EXP

Omeprazole affects the expression of ST6GAL1 mRNA

NCBI chr11:91,031,481...91,158,111
Ensembl chr11:91,032,450...91,040,415

G

succinate-CoA ligase GDP/ADP-forming subunit alpha

affects expression

EXP

Omeprazole affects the expression of SUCLG1 mRNA

NCBI chr 4:105,308,236...105,337,595
Ensembl chr 4:106,866,114...106,895,689

G

surfeit 4

affects expression

EXP

Omeprazole affects the expression of SURF4 mRNA

NCBI chr 3:30,646,435...30,659,641
Ensembl chr 3:30,638,299...30,661,390

G

synaptojanin 2 binding protein

affects expression

EXP

Omeprazole affects the expression of SYNJ2BP mRNA

NCBI chr 6:101,189,714...101,227,400
Ensembl chr 6:106,920,970...106,966,543

G

tachykinin receptor 1

multiple interactions

ISO

Omeprazole inhibits the reaction [Acids affects the localization of TACR1 protein]

NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:116,478,617...116,647,492

G

transforming growth factor, beta 1

increases expression

ISO

Omeprazole results in increased expression of TGFB1 protein

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

transforming growth factor, beta induced

affects expression

EXP

Omeprazole affects the expression of TGFBI mRNA

NCBI chr17:7,960,885...7,990,234
Ensembl chr17:7,960,516...7,990,471

G

threonine synthase-like 2

affects expression

EXP

Omeprazole affects the expression of THNSL2 mRNA

NCBI chr 4:103,112,974...103,132,122
Ensembl chr 4:104,670,925...104,691,959

G

translocase of inner mitochondrial membrane 21

affects expression

EXP

Omeprazole affects the expression of TIMM21 mRNA

NCBI chr18:78,314,900...78,319,362
Ensembl chr18:80,589,783...80,594,237

G

TIMP metallopeptidase inhibitor 2

multiple interactions

EXP

Omeprazole inhibits the reaction [Indomethacin results in increased expression of TIMP2 protein]

NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214

G

triokinase and FMN cyclase

affects expression

EXP

Omeprazole affects the expression of TKFC mRNA

NCBI chr 1:216,664,446...216,677,815
Ensembl chr 1:216,661,477...216,677,928

G

toll-like receptor 4

multiple interactions

EXP

Lipopolysaccharides inhibits the reaction [Omeprazole inhibits the reaction [Cisplatin results in increased expression of TLR4 protein]]; Omeprazole inhibits the reaction [Cisplatin results in increased expression of TLR4 protein]

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007

G

transmembrane BAX inhibitor motif containing 1

affects expression

EXP

Omeprazole affects the expression of TMBIM1 mRNA

NCBI chr 9:83,320,972...83,338,469
Ensembl chr 9:83,320,979...83,338,657

G

transmembrane BAX inhibitor motif containing 6

affects expression

EXP

Omeprazole affects the expression of TEGT mRNA

NCBI chr 7:132,405,217...132,422,492
Ensembl chr 7:132,386,134...132,422,492

G

transmembrane and coiled-coil domains 1

affects expression

EXP

Omeprazole affects the expression of TMCO1 mRNA

NCBI chr13:81,993,172...82,016,496
Ensembl chr13:81,993,097...82,017,201

G

transmembrane p24 trafficking protein 2

affects expression

EXP

Omeprazole affects the expression of TMED2 mRNA

NCBI chr12:37,713,522...37,722,606
Ensembl chr12:37,713,529...37,722,606

G

transmembrane p24 trafficking protein 7

affects expression

EXP

Omeprazole affects the expression of TMED7 mRNA

NCBI chr18:41,505,167...41,512,243
Ensembl chr18:41,478,539...41,512,243

G

transmembrane protein 123

affects expression

EXP

Omeprazole affects the expression of TMEM123 mRNA

NCBI chr 8:13,206,907...13,237,069
Ensembl chr 8:13,206,403...13,257,427

G

transmembrane protein 97

affects expression

EXP

Omeprazole affects the expression of TMEM97 mRNA

NCBI chr10:63,936,276...63,945,359
Ensembl chr10:63,936,271...63,945,818

G

tumor necrosis factor

multiple interactions

ISO
EXP

Omeprazole inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]; Omeprazole inhibits the reaction [Ethanol results in increased expression of TNF protein]
Omeprazole inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Omeprazole inhibits the reaction [Ethanol results in decreased expression of TNF protein]; Omeprazole inhibits the reaction [Ethanol results in increased expression of TNF protein]

PMID:19232345 PMID:25637687 PMID:26970604 PMID:30452898 PMID:32418911 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

thioredoxin 1

affects expression

EXP

Omeprazole affects the expression of TXN1 mRNA

NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307

G

thioredoxin-like 1

affects expression

EXP

Omeprazole affects the expression of TXNL1 mRNA

NCBI chr18:59,397,275...59,428,072
Ensembl chr18:59,398,535...59,435,518

G

tyrosinase

multiple interactions
decreases expression

ISO

Omeprazole affects the N-linked glycosylation of and results in increased degradation of TYR protein; Omeprazole inhibits the reaction [ATP7A protein results in increased activity of TYR protein]
Omeprazole results in decreased expression of TYR protein

NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:150,527,687...150,622,857

G

ubiquitin A-52 residue ribosomal protein fusion product 1

affects expression

EXP

Omeprazole affects the expression of UBA52 mRNA

NCBI chr16:18,952,583...18,954,780

G

ubiquitin-conjugating enzyme E2N

affects expression

EXP

Omeprazole affects the expression of UBE2N mRNA

NCBI chr 7:32,041,190...32,071,252

G

ubiquitin recognition factor in ER associated degradation 1

affects expression

EXP

Omeprazole affects the expression of UFD1 mRNA

NCBI chr11:95,665,971...95,689,423
Ensembl chr11:95,665,972...95,689,434

G

UDP glucuronosyltransferase family 1 member A1

increases expression
affects expression

ISO
EXP

Omeprazole results in increased expression of UGT1A1 mRNA
Omeprazole affects the expression of UGT1A1 mRNA

PMID:19118567 PMID:19483382 PMID:25626140

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases expression

ISO

Omeprazole results in increased expression of UGT1A2 mRNA; Omeprazole results in increased expression of UGT1A3 mRNA

NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glycosyltransferase 1 family, polypeptide A3

increases expression

ISO

Omeprazole results in increased expression of UGT1A5 mRNA

NCBI chr 9:88,780,328...88,808,465
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A5

increases expression

ISO

Omeprazole results in increased expression of UGT1A4 mRNA

NCBI chr 9:96,210,053...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A6

multiple interactions
increases expression

EXP
ISO

[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of UGT1A6 mRNA
Omeprazole results in increased expression of UGT1A6 mRNA

PMID:19118567 PMID:22687989

NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A9

increases expression

ISO

Omeprazole results in increased expression of UGT1A9 mRNA

NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase 2 family, polypeptide B1

increases expression

EXP

Omeprazole results in increased expression of UGT2B1 mRNA

NCBI chr14:21,378,882...21,390,631
Ensembl chr14:21,378,853...21,392,331

G

ubiquinol-cytochrome c reductase, complex III subunit XI

affects expression

EXP

Omeprazole affects the expression of UQCR11 mRNA

NCBI chr 7:9,955,717...9,960,432
Ensembl chr 7:9,955,764...9,959,047

G

vanin 1

affects expression

EXP

Omeprazole affects the expression of VNN1 mRNA

NCBI chr 1:23,356,324...23,366,629
Ensembl chr 1:23,356,330...23,366,629

G

WD repeat domain 26

affects expression

EXP

Omeprazole affects the expression of WDR26 mRNA

NCBI chr13:92,930,282...92,972,061
Ensembl chr13:95,462,020...95,503,738

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma

affects expression

EXP

Omeprazole affects the expression of YWHAG mRNA

NCBI chr12:26,381,106...26,409,466
Ensembl chr12:26,380,816...26,409,465

G

zinc finger DHHC-type palmitoyltransferase 23

affects expression

EXP

Omeprazole affects the expression of ZDHHC23 mRNA

NCBI chr11:56,718,702...56,735,063
Ensembl chr11:70,225,045...70,240,102

G

ZW10 interacting kinetochore protein

affects expression

EXP

Omeprazole affects the expression of ZWINT mRNA

NCBI chr20:15,502,559...15,953,701
Ensembl chr20:15,937,396...15,953,203

5'-hydroxyomeprazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

EXP

5-hydroxymethylomeprazole results in increased expression of CYP1A1 protein

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression

ISO

Mycophenolic Acid promotes the reaction [Esomeprazole results in increased expression of CYP1A1 mRNA]

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

increases expression

ISO

Omeprazole results in increased expression of ABCA1 mRNA

NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473

G

ATP binding cassette subfamily B member 11

decreases activity

ISO

Omeprazole results in decreased activity of ABCB11 protein

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

ATP binding cassette subfamily B member 1A

affects expression
multiple interactions

EXP
ISO

Omeprazole affects the expression of ABCB1A mRNA
Omeprazole promotes the reaction [Cisplatin results in increased expression of ABCB1A protein]
Omeprazole promotes the reaction [Cisplatin results in increased expression of ABCB1 protein]

PMID:19483382 PMID:30452898

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily B member 4

decreases expression

ISO

Omeprazole results in decreased expression of ABCB4 mRNA

NCBI chr 4:26,106,895...26,164,440

G

ATP binding cassette subfamily C member 2

multiple interactions

ISO

[Omeprazole results in increased susceptibility to Cisplatin] which results in decreased expression of ABCC2 protein

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

ATP binding cassette subfamily C member 3

increases expression

EXP

Omeprazole results in increased expression of ABCC3 mRNA

NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494

G

ATP binding cassette subfamily C member 6

affects expression

EXP

Omeprazole affects the expression of ABCC6 mRNA

NCBI chr 1:105,583,681...105,637,895
Ensembl chr 1:105,583,682...105,637,895

G

ATP binding cassette subfamily G member 2

increases expression
multiple interactions

ISO

Omeprazole results in increased expression of ABCG2 mRNA alternative form; Omeprazole results in increased expression of ABCG2 protein
Omeprazole inhibits the reaction [ABCG2 protein results in increased transport of lucifer yellow]

PMID:20804740 PMID:31348918

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493

G

ATP binding cassette subfamily G member 5

affects expression

EXP

Omeprazole affects the expression of ABCG5 mRNA

NCBI chr 6:15,717,936...15,743,376
Ensembl chr 6:15,717,936...15,743,376

G

abhydrolase domain containing 1

affects expression

EXP

Omeprazole affects the expression of ABHD1 mRNA

NCBI chr 6:25,422,526...25,427,514
Ensembl chr 6:31,142,476...31,147,464

G

abhydrolase domain containing 14b

affects expression

EXP

Omeprazole affects the expression of ABHD14B mRNA

NCBI chr 8:115,966,792...115,970,829
Ensembl chr 8:115,965,932...115,970,833

G

abhydrolase domain containing 17A, depalmitoylase

affects expression

EXP

Omeprazole affects the expression of ABHD17A mRNA

NCBI chr 7:9,775,016...9,781,447

G

acetyl-CoA carboxylase alpha

affects expression

EXP

Omeprazole affects the expression of ACACA mRNA

NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888

G

acyl-CoA dehydrogenase, long chain

affects expression

EXP

Omeprazole affects the expression of ACADL mRNA

NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:75,783,689...75,822,164

G

angiotensin converting enzyme 2

decreases expression

EXP
ISO

Omeprazole results in decreased expression of ACE2 mRNA

NCBI chr X:33,925,458...33,972,851
Ensembl chr X:33,925,458...33,971,596

G

aconitase 1

affects expression

EXP

Omeprazole affects the expression of ACO1 mRNA

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:60,055,866...60,112,600

G

aconitase 2

affects expression

EXP

Omeprazole affects the expression of ACO2 mRNA

NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:115,265,791...115,308,892

G

acyl-CoA thioesterase 12

affects expression

EXP

Omeprazole affects the expression of ACOT12 mRNA

NCBI chr 2:24,721,648...24,763,686
Ensembl chr 2:24,721,910...24,765,298

G

acyl-CoA thioesterase 4

affects expression

EXP

Omeprazole affects the expression of ACOT4 mRNA

NCBI chr 6:109,399,032...109,405,138
Ensembl chr 6:109,399,578...109,405,138

G

ADAM metallopeptidase domain 15

affects expression

EXP

Omeprazole affects the expression of ADAM15 mRNA

NCBI chr 2:177,052,363...177,062,879
Ensembl chr 2:177,052,363...177,062,849

G

adducin 1

affects expression

EXP

Omeprazole affects the expression of ADD1 mRNA

NCBI chr14:80,333,242...80,401,641
Ensembl chr14:80,333,244...80,391,732

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

decreases expression

ISO

Omeprazole results in decreased expression of ADH1C mRNA

NCBI chr 2:229,470,703...229,482,291
Ensembl chr 2:229,470,703...229,482,291

G

alcohol dehydrogenase 4 (class II), pi polypeptide

affects expression

EXP

Omeprazole affects the expression of ADH4 mRNA

NCBI chr 2:229,622,092...229,640,120
Ensembl chr 2:229,622,095...229,641,879

G

androgen-dependent TFPI-regulating protein

affects expression

EXP

Omeprazole affects the expression of ADTRP mRNA

NCBI chr17:22,907,758...22,993,834
Ensembl chr17:23,135,809...23,216,622

G

afamin

affects expression

EXP

Omeprazole affects the expression of AFM mRNA

NCBI chr14:17,815,194...17,848,042
Ensembl chr14:17,815,194...17,848,039

G

angiotensinogen

affects expression

EXP

Omeprazole affects the expression of AGT mRNA

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

angiotensin II receptor, type 1a

affects expression

EXP

Omeprazole affects the expression of AGTR1A mRNA

NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660

G

aryl hydrocarbon receptor

multiple interactions
increases response to substance
affects localization
decreases expression
increases expression
increases activity
decreases activity

ISO
EXP

AG-879 inhibits the reaction [Omeprazole results in increased activity of AHR protein]; AHR protein affects the reaction [Omeprazole results in decreased expression of CXCR4 mRNA]; AHR protein affects the reaction [Omeprazole results in increased expression of HAMP mRNA]; AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A2 mRNA]; AHR protein mutant form inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Omeprazole results in decreased expression of AHR mRNA]; AHR protein promotes the reaction [Omeprazole results in decreased expression of CYP1A1 mRNA]; BMX mRNA affects the reaction [Omeprazole results in increased activity of AHR protein]; Omeprazole binds to and results in increased activity of AHR protein; Omeprazole promotes the reaction [AHR protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [AHR protein binds to CYP1B1 promoter]; omeprazole sulfide inhibits the reaction [Omeprazole results in increased activity of AHR protein]; Puromycin inhibits the reaction [Omeprazole results in increased expression of AHR protein]
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of AHR mRNA; AHR protein promotes the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Omeprazole affects the localization of [ARNT protein co-treated with AHR protein]
AHR protein results in increased susceptibility to Omeprazole
Omeprazole affects the localization of AHR protein
Omeprazole results in decreased activity of AHR protein

PMID:9139728 PMID:9395520 PMID:14742684 PMID:16109480 PMID:20171196 More...

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

aldo-keto reductase family 1 member A1

affects expression

EXP

Omeprazole affects the expression of AKR1A1 mRNA

NCBI chr 5:135,329,605...135,367,037
Ensembl chr 5:135,329,606...135,367,035

G

aldo-keto reductase family 7, member A2

affects expression

EXP

Omeprazole affects the expression of AKR7A2 mRNA

NCBI chr 5:156,835,589...156,844,127
Ensembl chr 5:156,835,551...156,844,109

G

aldo-keto reductase family 7 member A3

affects expression
multiple interactions

EXP

Omeprazole affects the expression of AKR7A3 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of AKR7A3 mRNA

PMID:19483382 PMID:22687989

NCBI chr 5:156,876,721...156,884,599
Ensembl chr 5:156,874,086...156,885,153

G

aldehyde dehydrogenase 1 family, member A1

affects expression
multiple interactions

EXP

Omeprazole affects the expression of ALDH1A1 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of ALDH1A1 mRNA

PMID:19483382 PMID:22687989

NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500

G

aldehyde dehydrogenase 1 family, member A3

increases expression

ISO

Omeprazole results in increased expression of ALDH1A3 mRNA

NCBI chr 1:129,392,516...129,436,552
Ensembl chr 1:129,392,516...129,427,777

G

aldehyde dehydrogenase family 1, subfamily A7

affects expression

EXP

Omeprazole affects the expression of ALDH1A7 mRNA

NCBI chr 1:218,201,443...218,241,410
Ensembl chr 1:227,627,448...227,672,523

G

aldehyde dehydrogenase 2 family member

affects expression

EXP

Omeprazole affects the expression of ALDH2 mRNA

NCBI chr12:40,610,244...40,643,220
Ensembl chr12:40,610,224...40,643,219

G

aldehyde dehydrogenase 3 family, member A1

increases expression

ISO

Omeprazole results in increased expression of ALDH3A1 mRNA

NCBI chr10:46,392,464...46,402,151
Ensembl chr10:46,392,411...46,402,151

G

alkB homolog 7

affects expression

EXP

Omeprazole affects the expression of ALKBH7 mRNA

NCBI chr 9:1,925,896...1,928,048
Ensembl chr 9:1,925,743...1,928,048

G

ankyrin repeat domain 40

increases expression

EXP

Omeprazole results in increased expression of TMPRSS2 mRNA

NCBI chr10:79,778,966...79,792,212
Ensembl chr10:56,415,260...56,416,345
Ensembl chr10:56,415,260...56,416,345

G

adaptor related protein complex 2 subunit mu 1

affects expression

EXP

Omeprazole affects the expression of AP2M1 mRNA

NCBI chr11:93,859,690...93,868,600
Ensembl chr11:93,859,690...93,868,480

G

amyloid P component, serum

affects expression

EXP

Omeprazole affects the expression of APCS mRNA

NCBI chr13:87,905,532...87,906,508
Ensembl chr13:87,905,532...87,928,824

G

apolipoprotein A4

affects expression

EXP

Omeprazole affects the expression of APOA4 mRNA

NCBI chr 8:55,435,779...55,438,160
Ensembl chr 8:55,434,168...55,438,164

G

apolipoprotein H

affects expression

EXP

Omeprazole affects the expression of APOH mRNA

NCBI chr10:93,841,992...93,855,897
Ensembl chr10:93,841,966...93,857,127

G

apolipoprotein O-like

affects expression

EXP

Omeprazole affects the expression of APOOL mRNA

NCBI chr X:81,569,960...81,635,906
Ensembl chr X:81,570,053...81,640,036

G

arginase 1

affects expression

EXP

Omeprazole affects the expression of ARG1 mRNA

NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:22,295,322...22,307,713

G

ARL6 interacting reticulophagy regulator 1

affects expression

EXP

Omeprazole affects the expression of ARL6IP1 mRNA

NCBI chr 1:181,864,717...181,874,232
Ensembl chr 1:181,864,746...181,874,232

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions
affects localization

ISO
EXP

Omeprazole promotes the reaction [ARNT protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [ARNT protein binds to CYP1B1 promoter]
Omeprazole affects the localization of [ARNT protein co-treated with AHR protein]
Omeprazole affects the localization of ARNT protein

PMID:9395520 PMID:21703235 PMID:25826687

NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546

G

asialoglycoprotein receptor 2

affects expression

EXP

Omeprazole affects the expression of ASGR2 mRNA

NCBI chr10:55,320,082...55,333,294
Ensembl chr10:55,320,091...55,333,263

G

activating transcription factor 5

affects expression

EXP

Omeprazole affects the expression of ATF5 mRNA

NCBI chr 1:104,432,094...104,437,611
Ensembl chr 1:104,432,094...104,436,183

G

ATP synthase F1 subunit epsilon

affects expression

EXP

Omeprazole affects the expression of ATP5F1E mRNA

NCBI chr 3:183,677,270...183,680,172
Ensembl chr 3:183,677,273...183,680,214

G

ATPase H+ transporting accessory protein 2

affects expression

EXP

Omeprazole affects the expression of ATP6AP2 mRNA

NCBI chr X:12,856,708...12,883,670
Ensembl chr X:12,855,859...12,905,875

G

ATPase H+ transporting V1 subunit A

affects expression

EXP

Omeprazole affects the expression of ATP6V1A mRNA

NCBI chr11:70,066,800...70,120,603
Ensembl chr11:70,035,134...70,120,603

G

ATPase H+ transporting V1 subunit F

affects expression

EXP

Omeprazole affects the expression of ATP6V1F mRNA

NCBI chr 4:59,033,020...59,035,980

G

ATPase copper transporting alpha

multiple interactions

ISO

Omeprazole inhibits the reaction [ATP7A protein results in increased activity of TYR protein]
Omeprazole inhibits the reaction [Copper affects the localization of ATP7A protein]; Omeprazole inhibits the reaction [cupric chloride affects the localization of ATP7A protein]

NCBI chr X:75,159,635...75,267,094
Ensembl chr X:75,159,782...75,267,093

G

bile acid CoA:amino acid N-acyltransferase

affects expression

EXP

Omeprazole affects the expression of BAAT mRNA

NCBI chr 5:68,647,166...68,656,137
Ensembl chr 5:68,646,203...68,656,181

G

BCL2 associated X, apoptosis regulator

multiple interactions

ISO

Omeprazole inhibits the reaction [Cisplatin results in increased expression of BAX protein]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions

ISO

Omeprazole inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

BCL6B, transcription repressor

affects expression

EXP

Omeprazole affects the expression of BCL6B mRNA

NCBI chr10:55,439,566...55,444,631
Ensembl chr10:55,432,382...55,444,631

G

bridge-like lipid transfer protein family member 3B

affects expression

EXP

Omeprazole affects the expression of BLTP3B mRNA

NCBI chr 7:26,068,948...26,149,033
Ensembl chr 7:26,068,955...26,149,083

G

Bcl2 modifying factor

affects expression

EXP

Omeprazole affects the expression of BMF mRNA

NCBI chr 3:125,953,466...125,974,087
Ensembl chr 3:125,953,466...125,974,258

G

BMX non-receptor tyrosine kinase

multiple interactions

ISO

BMX mRNA affects the reaction [Omeprazole results in increased activity of AHR protein]

NCBI chr X:30,227,251...30,290,015
Ensembl chr X:33,859,129...33,921,874

G

BCL2 interacting protein 3

affects expression

EXP

Omeprazole affects the expression of BNIP3 mRNA

NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962

G

basic transcription factor 3

affects expression

EXP

Omeprazole affects the expression of BTF3 mRNA

NCBI chr 2:31,394,010...31,401,138
Ensembl chr 2:31,394,011...31,401,125
Ensembl chr13:31,394,011...31,401,125

G

complement C1q A chain

decreases expression

EXP

Omeprazole results in decreased expression of C1QA mRNA

NCBI chr 5:154,417,086...154,419,933
Ensembl chr 5:154,417,087...154,427,732

G

complement C1q binding protein

affects expression

EXP

Omeprazole affects the expression of C1QBP mRNA

NCBI chr10:56,198,534...56,203,185
Ensembl chr10:56,198,540...56,203,235

G

complement C1q C chain

decreases expression

EXP

Omeprazole results in decreased expression of C1QC mRNA

NCBI chr 5:154,410,845...154,414,208
Ensembl chr 5:154,410,848...154,414,468

G

complement C1s

affects expression

EXP

Omeprazole affects the expression of C1S mRNA

NCBI chr 4:159,116,549...159,128,736
Ensembl chr 4:159,116,549...159,128,736

G

C2 calcium-dependent domain containing 2

affects expression

EXP

Omeprazole affects the expression of C2CD2 mRNA

NCBI chr11:37,225,321...37,289,741
Ensembl chr11:50,694,563...50,759,016

G

complement component 4 binding protein, alpha

affects expression
decreases expression

EXP

Omeprazole affects the expression of C4BPA mRNA
Omeprazole results in decreased expression of C4BPA mRNA

PMID:19483382 PMID:25626140

NCBI chr13:44,627,959...44,663,552
Ensembl chr13:44,627,982...44,663,471

G

complement component 4 binding protein, beta

decreases expression

EXP

Omeprazole results in decreased expression of C4BPB mRNA

NCBI chr13:44,673,064...44,683,781
Ensembl chr13:44,673,065...44,683,793

G

complement C7

affects expression

EXP

Omeprazole affects the expression of C7 mRNA

NCBI chr 2:55,815,687...55,892,605
Ensembl chr 2:55,816,807...55,892,672

G

complement C8 beta chain

affects expression

EXP

Omeprazole affects the expression of C8B mRNA

NCBI chr 5:124,763,974...124,801,522
Ensembl chr 5:124,761,790...124,801,516

G

carbonic anhydrase 3

affects expression

EXP

Omeprazole affects the expression of CAR3 mRNA

NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:88,491,670...88,500,524

G

calcium dependent secretion activator 2

affects expression

EXP

Omeprazole affects the expression of CADPS2 mRNA

NCBI chr 4:52,746,054...53,275,252
Ensembl chr 4:52,746,065...53,275,004

G

cell cycle associated protein 1

affects expression

EXP

Omeprazole affects the expression of CAPRIN1 mRNA

NCBI chr 3:110,606,489...110,685,408
Ensembl chr 3:110,606,489...110,685,562

G

carbonic anhydrase 2

affects expression

EXP

Omeprazole affects the expression of CA2 mRNA

NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:88,462,872...88,478,064

G

caspase 3

increases activity
increases cleavage
affects expression
multiple interactions

ISO
EXP

Omeprazole analog results in increased activity of CASP3 protein; Omeprazole results in increased activity of CASP3 protein
Omeprazole results in increased cleavage of CASP3 protein
Omeprazole affects the expression of CASP3 mRNA
Omeprazole inhibits the reaction [Ethanol results in increased activity of CASP3 protein]; Omeprazole inhibits the reaction [Ethanol results in increased expression of CASP3 mRNA]; Omeprazole inhibits the reaction [Indomethacin results in increased activity of CASP3 protein]
Omeprazole inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]

PMID:15461867 PMID:18336733 PMID:19251492 PMID:19483382 PMID:25637687 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

increases cleavage

ISO

Omeprazole analog results in increased cleavage of CASP8 protein

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

catalase

increases activity
multiple interactions

EXP
ISO

Omeprazole results in increased activity of CAT protein
Omeprazole inhibits the reaction [Acetic Acid results in increased activity of CAT protein]
Omeprazole inhibits the reaction [Ethanol results in decreased activity of CAT protein]

PMID:18547560 PMID:28849987 PMID:33245926

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

carbonyl reductase 1

affects expression

EXP

Omeprazole affects the expression of CBR1 mRNA

NCBI chr11:46,346,405...46,348,815
Ensembl chr11:46,378,411...46,381,104
Ensembl chr11:46,378,411...46,381,104

G

cholecystokinin B receptor

multiple interactions

ISO

[Omeprazole co-treated with CCKBR protein] results in increased expression of IER3

NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:169,183,194...169,193,745

G

cyclin D1

decreases expression

EXP

Omeprazole results in decreased expression of CCND1 mRNA

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin-dependent kinase inhibitor 1A

increases expression

ISO

Omeprazole results in increased expression of CDKN1A protein

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cysteine dioxygenase type 1

affects expression

EXP

Omeprazole affects the expression of CDO1 mRNA

NCBI chr18:41,619,076...41,633,719
Ensembl chr18:41,619,070...41,633,891

G

choline/ethanolamine phosphotransferase 1

affects expression

EXP

Omeprazole affects the expression of CEPT1 mRNA

NCBI chr 2:193,994,220...194,036,141
Ensembl chr 2:196,681,681...196,723,812

G

carboxylesterase 2H

affects expression

EXP

Omeprazole affects the expression of CES2 mRNA

NCBI chr19:49,884,164...49,898,764
Ensembl chr19:49,884,164...49,898,752

G

complement factor I

affects expression
decreases expression

EXP

Omeprazole affects the expression of CFI mRNA
Omeprazole results in decreased expression of CFI mRNA

PMID:19483382 PMID:25626140

NCBI chr 2:221,062,206...221,104,790
Ensembl chr 2:221,062,212...221,104,786

G

CF transmembrane conductance regulator

affects metabolic processing

ISO

CFTR protein affects the metabolism of Omeprazole

NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643

G

calcineurin-like EF-hand protein 1

affects expression

EXP

Omeprazole affects the expression of CHP1 mRNA

NCBI chr 3:126,989,800...127,025,071
Ensembl chr 3:126,989,579...127,042,443

G

CDGSH iron sulfur domain 1

affects expression

EXP

Omeprazole affects the expression of CISD1 mRNA

NCBI chr20:17,254,462...17,267,843
Ensembl chr20:17,254,187...17,271,042

G

chloride voltage-gated channel 4

affects expression

EXP

Omeprazole affects the expression of CLCN4 mRNA

NCBI chr X:23,729,194...23,795,391
Ensembl chr X:27,290,868...27,356,939

G

caseinolytic mitochondrial matrix peptidase proteolytic subunit

affects expression

EXP

Omeprazole affects the expression of CLPP mRNA

NCBI chr 9:1,831,680...1,837,700
Ensembl chr 9:1,918,682...1,924,705

G

CLPTM1-like

affects expression

EXP

Omeprazole affects the expression of CLPTM1L mRNA

NCBI chr 1:31,496,094...31,512,148
Ensembl chr 1:31,496,094...31,512,077

G

carboxymethylenebutenolidase homolog

affects expression

EXP

Omeprazole affects the expression of CMBL mRNA

NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:84,242,512...84,301,880

G

cytidine/uridine monophosphate kinase 1

affects expression

EXP

Omeprazole affects the expression of CMPK1 mRNA

NCBI chr 5:133,717,073...133,744,623
Ensembl chr 5:133,717,086...133,744,596

G

COPI coat complex subunit gamma 1

affects expression

EXP

Omeprazole affects the expression of COPG1 mRNA

NCBI chr 4:121,923,644...121,949,819
Ensembl chr 4:121,923,873...121,949,812

G

COP9 signalosome subunit 4

affects expression

EXP

Omeprazole affects the expression of COPS4 mRNA

NCBI chr14:9,078,579...9,108,788
Ensembl chr14:9,382,900...9,413,107

G

coenzyme Q3 methyltransferase

affects expression

EXP

Omeprazole affects the expression of COQ3 mRNA

NCBI chr 5:35,429,567...35,460,613
Ensembl chr 5:40,226,368...40,257,617

G

cytochrome c oxidase subunit 4i1

affects expression

EXP

Omeprazole affects the expression of COX4I1 mRNA

NCBI chr19:48,721,680...48,727,920
Ensembl chr19:65,630,432...65,636,624

G

carboxypeptidase N subunit 1

affects expression

EXP

Omeprazole affects the expression of CPN1 mRNA

NCBI chr 1:252,793,786...252,822,675
Ensembl chr 1:252,793,423...252,822,664

G

carboxypeptidase Q

affects expression

EXP

Omeprazole affects the expression of CPQ mRNA

NCBI chr 7:66,148,973...66,719,189
Ensembl chr 7:66,149,377...66,716,137

G

cAMP responsive element modulator

affects expression

EXP

Omeprazole affects the expression of CREM mRNA

NCBI chr17:58,932,011...59,001,160
Ensembl chr17:58,934,147...59,001,160

G

casein kinase 2 beta

affects expression

EXP

Omeprazole affects the expression of CSNK2B mRNA

NCBI chr20:3,704,833...3,709,999
Ensembl chr20:3,704,904...3,710,525

G

cysteine and glycine-rich protein 1

affects expression

EXP

Omeprazole affects the expression of CSRP1 mRNA

NCBI chr13:49,709,928...49,731,141
Ensembl chr13:49,709,914...49,731,139

G

catenin alpha 1

affects expression

EXP

Omeprazole affects the expression of CTNNA1 mRNA

NCBI chr18:27,002,330...27,135,009
Ensembl chr18:26,999,820...27,135,007

G

cathepsin B

decreases activity

ISO

Omeprazole results in decreased activity of CTSB protein

NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478

G

cathepsin D

multiple interactions

EXP

Omeprazole inhibits the reaction [Cysteamine results in increased expression of CTSD protein]

NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821

G

cathepsin E

decreases expression

EXP

Omeprazole results in decreased expression of CTSE

NCBI chr13:43,091,954...43,114,509
Ensembl chr13:45,644,147...45,666,722

G

C-X-C motif chemokine receptor 4

decreases expression
multiple interactions

ISO

Omeprazole results in decreased expression of CXCR4 mRNA
AHR protein affects the reaction [Omeprazole results in decreased expression of CXCR4 mRNA]

NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity
multiple interactions
increases expression
decreases activity

ISO
EXP

Omeprazole results in increased activity of CYP1A1 promoter
Omeprazole results in increased activity of CYP1A1 protein
AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein mutant form inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Omeprazole results in decreased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; Omeprazole promotes the reaction [AHR protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [ARNT protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [EP300 protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [NCOA1 protein binds to CYP1A1 promoter]
Omeprazole results in increased expression of CYP1A1 mRNA; Omeprazole results in increased expression of CYP1A1 protein
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 mRNA; AHR protein promotes the reaction [Omeprazole results in increased expression of CYP1A1 protein]; daidzein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; daidzein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Genistein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; Genistein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; herbimycin inhibits the reaction [Omeprazole results in increased activity of CYP1A1 protein]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; lavendustin A inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Staurosporine inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Tosyllysine Chloromethyl Ketone inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]
Omeprazole results in decreased activity of CYP1A1 protein
Omeprazole inhibits the reaction [Oxygen results in increased expression of CYP1A1 protein]; Omeprazole promotes the reaction [Oxygen results in decreased expression of CYP1A1 mRNA]

PMID:8647108 PMID:8900397 PMID:9041675 PMID:9139728 PMID:9152597 More...

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases activity
decreases activity
multiple interactions
increases expression

ISO
EXP

Omeprazole results in increased activity of CYP1A2 promoter; Omeprazole results in increased activity of CYP1A2 protein
Omeprazole results in decreased activity of CYP1A2 protein
[Omeprazole results in increased expression of CYP1A2 protein] which results in decreased alkylation of Phenacetin; AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A2 mRNA]; Omeprazole results in increased expression of and results in increased activity of CYP1A2 protein
Omeprazole results in increased expression of CYP1A2 mRNA; Omeprazole results in increased expression of CYP1A2 protein
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A2 mRNA

PMID:9152597 PMID:9744552 PMID:12040753 PMID:12623754 PMID:12841937 More...

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions
increases expression
decreases activity
affects expression

ISO

Omeprazole promotes the reaction [AHR protein binds to CYP1B1 promoter]; Omeprazole promotes the reaction [ARNT protein binds to CYP1B1 promoter]; Omeprazole promotes the reaction [EP300 protein binds to CYP1B1 promoter]; Omeprazole promotes the reaction [NCOA1 protein binds to CYP1B1 promoter]
Omeprazole results in increased expression of CYP1B1 mRNA
Omeprazole results in decreased activity of CYP1B1 protein
Omeprazole affects the expression of CYP1B1 mRNA

PMID:12040753 PMID:12623754 PMID:18420780 PMID:21703235 PMID:25826687

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 2, subfamily a, polypeptide 1

affects expression

EXP

Omeprazole affects the expression of CYP2A1 mRNA

NCBI chr 1:91,359,278...91,372,554
Ensembl chr 1:91,359,272...91,389,730

G

cytochrome P450, family 2, subfamily b, polypeptide 1

increases expression

EXP

Omeprazole results in increased expression of CYP2B1 mRNA; Omeprazole results in increased expression of CYP2B1 protein

PMID:9152597 PMID:19118567

NCBI chr 1:90,646,098...90,669,762

G

cytochrome P450, family 2, subfamily b, polypeptide 2

increases expression
affects expression

EXP

Omeprazole results in increased expression of CYP2B2 protein
Omeprazole affects the expression of CYP2B2 mRNA

PMID:9152597 PMID:19483382

NCBI chr 1:90,722,243...90,736,272

G

cytochrome P450, family 2, subfamily b, polypeptide 3

affects expression
increases activity
increases expression
decreases activity

EXP
ISO

Omeprazole affects the expression of CYP2B3 mRNA
Omeprazole results in increased activity of CYP2B6 protein
Omeprazole results in increased expression of CYP2B6 mRNA
Omeprazole results in decreased activity of CYP2B10 protein

PMID:17954527 PMID:18420780 PMID:19118567 PMID:19483382 PMID:22524704

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases metabolic processing
affects metabolic processing
increases metabolic processing
increases hydroxylation
multiple interactions
decreases activity

ISO

CYP2C19 gene alternative form results in decreased metabolism of Omeprazole
CYP2C19 protein affects the metabolism of Omeprazole
CYP2C19 protein results in increased metabolism of Omeprazole
CYP2C19 protein results in increased hydroxylation of Omeprazole
[5-bromotryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-chlorotryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-fluoro-alpha-methyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-fluorotryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-methyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [7-methyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [Chloramphenicol results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [Fluconazole results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [indopan results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [N,N-diisopropyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [Omeprazole results in decreased activity of CYP2C19 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine metabolite; [Omeprazole results in decreased activity of CYP2C19 protein] which results in decreased chemical synthesis of Aconitine metabolite; [Tryptamines analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; Omeprazole affects the reaction [CYP2C19 protein affects the metabolism of Warfarin]; Omeprazole inhibits the reaction [CYP2C19 protein results in decreased methylation of adinazolam]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased chemical synthesis of 4-hydroxymephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of auriculasin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of Fluoxetine]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased oxidation of 2-oxo-clopidogrel]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased oxidation of Clopidogrel]

PMID:8930576 PMID:9600717 PMID:11752104 PMID:12464242 PMID:12467917 More...

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 2, subfamily d, polypeptide 1

increases expression

EXP

Omeprazole results in increased expression of CYP2D9 mRNA

NCBI chr 7:115,789,026...115,793,430
Ensembl chr 7:115,789,023...115,793,479

G

cytochrome P450, family 2, subfamily d, polypeptide 3

affects expression

EXP

Omeprazole affects the expression of CYP2D3 mRNA

NCBI chr 7:113,917,711...113,922,068
Ensembl chr 7:115,797,789...115,802,158

G

cytochrome P450, family 2, subfamily d, polypeptide 4

affects expression
decreases activity

EXP
ISO

Omeprazole affects the expression of CYP2D4 mRNA
Omeprazole results in decreased activity of CYP2D6 protein

PMID:18420780 PMID:19483382

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

ISO

Omeprazole results in increased expression of and results in increased activity of CYP2E1 protein

PMID:15802389 PMID:36243147

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 2, subfamily f, polypeptide 4

affects expression

EXP

Omeprazole affects the expression of CYP2F4 mRNA

NCBI chr 1:91,543,768...91,557,553
Ensembl chr 1:91,543,768...91,557,553

G

cytochrome P450, family 2, subfamily j, polypeptide 4

affects expression

EXP

Omeprazole affects the expression of CYP2J4 mRNA

NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:116,295,694...116,323,042

G

cytochrome P450, family 2, subfamily t, polypeptide 1

affects expression

EXP

Omeprazole affects the expression of CYP2T1 mRNA

NCBI chr 1:82,446,321...82,451,564
Ensembl chr 1:91,574,572...91,579,215

G

cytochrome P450, family 3, subfamily a, polypeptide 2

affects metabolic processing
increases expression
multiple interactions
increases metabolic processing

ISO

CYP3A4 protein affects the metabolism of Omeprazole
Omeprazole results in increased expression of CYP3A4 mRNA; Omeprazole results in increased expression of CYP3A4 protein
[Omeprazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; NR1I2 protein affects the reaction [Omeprazole results in increased expression of CYP3A4 mRNA]; Omeprazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Omeprazole results in increased expression of and results in increased activity of CYP3A4 protein
CYP3A4 protein results in increased metabolism of Omeprazole

PMID:7870052 PMID:8930576 PMID:9744552 PMID:12235278 PMID:12485723 More...

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

affects expression
increases expression

EXP

Omeprazole affects the expression of CYP3A23-3A1 mRNA
Omeprazole results in increased expression of CYP3A23-3A1 mRNA

PMID:19118567 PMID:19483382

NCBI chr12:14,369,950...14,398,803
Ensembl chr12:14,368,266...14,398,813

G

cytochrome P450, family 3, subfamily a, polypeptide 9

affects expression
increases expression

EXP
ISO

Omeprazole affects the expression of CYP3A9 mRNA
Omeprazole results in increased expression of CYP3A5 mRNA

PMID:19118567 PMID:19483382

NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154

G

cytochrome P450, family 4, subfamily a, polypeptide 8

affects expression

EXP

Omeprazole affects the expression of CYP4A8 mRNA

NCBI chr 5:128,702,130...128,733,476
Ensembl chr 5:133,938,883...133,970,226

G

cytochrome P450, family 4, subfamily f, polypeptide 6

affects expression

EXP

Omeprazole affects the expression of CYP4F6 mRNA

NCBI chr 7:12,680,799...12,708,378
Ensembl chr 7:12,680,806...12,708,402

G

diazepam binding inhibitor

affects expression

EXP

Omeprazole affects the expression of DBI mRNA

NCBI chr13:33,794,231...33,802,632
Ensembl chr13:33,759,845...33,821,450

G

DDB1 and CUL4 associated factor 11

affects expression

EXP

Omeprazole affects the expression of DCAF11 mRNA

NCBI chr15:33,015,370...33,027,407
Ensembl chr15:33,016,762...33,027,672

G

dicarbonyl and L-xylulose reductase

affects expression

EXP

Omeprazole affects the expression of DCXR mRNA

NCBI chr10:106,504,730...106,506,619

G

DNA-damage inducible transcript 3

increases expression

ISO

Omeprazole results in increased expression of DDIT3 protein

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

2,4-dienoyl-CoA reductase 1

affects expression

EXP

Omeprazole affects the expression of DECR1 mRNA

NCBI chr 5:34,208,195...34,236,074
Ensembl chr 5:34,208,195...34,236,033

G

Dexi homolog

affects expression

EXP

Omeprazole affects the expression of DEXI mRNA

NCBI chr10:5,632,400...5,645,653
Ensembl chr10:5,632,961...5,645,648

G

diacylglycerol O-acyltransferase 1

affects expression

EXP

Omeprazole affects the expression of DGAT1 mRNA

NCBI chr 7:110,104,514...110,119,091
Ensembl chr 7:110,098,906...110,115,016

G

24-dehydrocholesterol reductase

affects expression

EXP

Omeprazole affects the expression of DHCR24 mRNA

NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:126,573,338...126,599,936

G

dehydrogenase/reductase 4

affects expression

EXP

Omeprazole affects the expression of DHRS4 mRNA

NCBI chr15:28,966,544...28,978,135
Ensembl chr15:32,936,522...32,948,101

G

dehydrogenase/reductase 7B

affects expression

EXP

Omeprazole affects the expression of DHRS7B mRNA

NCBI chr10:45,504,344...45,537,094
Ensembl chr10:46,003,845...46,036,499

G

DEAH-box helicase 16

affects expression

EXP

Omeprazole affects the expression of DHX16 mRNA

NCBI chr20:2,866,804...2,879,790
Ensembl chr20:2,866,804...2,879,751

G

distal membrane arm assembly component 2 like

affects expression

EXP

Omeprazole affects the expression of DMAC2L mRNA

NCBI chr 6:93,941,605...93,959,932
Ensembl chr 6:93,941,690...93,960,662

G

DnaJ heat shock protein family (Hsp40) member C3

affects expression

EXP

Omeprazole affects the expression of DNAJC3 mRNA

NCBI chr15:102,432,667...102,475,643
Ensembl chr15:102,432,663...102,475,643

G

dipeptidylpeptidase 4

affects expression

EXP

Omeprazole affects the expression of DPP4 mRNA

NCBI chr 3:67,370,794...67,452,422
Ensembl chr 3:67,370,804...67,452,422

G

dihydropyrimidine dehydrogenase

affects expression

EXP

Omeprazole affects the expression of DPYD mRNA

NCBI chr 2:209,293,902...210,159,777
Ensembl chr 2:209,293,929...210,159,778

G

glutamyl-tRNA synthetase 2, mitochondrial

affects expression

EXP

Omeprazole affects the expression of EARS2 mRNA

NCBI chr 1:176,597,986...176,625,848

G

enoyl-CoA hydratase, short chain 1

affects expression

EXP

Omeprazole affects the expression of ECHS1 mRNA

NCBI chr 1:204,324,679...204,333,506
Ensembl chr 1:204,324,682...204,333,506

G

enoyl-CoA delta isomerase 1

affects expression

EXP

Omeprazole affects the expression of ECI1 mRNA

NCBI chr10:13,961,250...13,974,595
Ensembl chr10:13,961,218...13,974,773

G

enoyl-CoA delta isomerase 2

affects expression

EXP

Omeprazole affects the expression of ECI2 mRNA

NCBI chr17:30,056,274...30,092,169
Ensembl chr17:30,076,524...30,092,161

G

eukaryotic translation elongation factor 1 gamma

affects expression

EXP

Omeprazole affects the expression of EEF1G mRNA

NCBI chr 1:215,289,815...215,300,421
Ensembl chr 1:215,277,860...215,301,479

G

epidermal growth factor

multiple interactions

ISO

Omeprazole promotes the reaction [Indomethacin results in increased expression of EGF protein]

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297

G

enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

affects expression

EXP

Omeprazole affects the expression of EHHADH mRNA

NCBI chr11:92,746,409...92,779,647
Ensembl chr11:92,746,420...92,779,662

G

eukaryotic translation initiation factor 4A2

affects expression

EXP

Omeprazole affects the expression of EIF4A2 mRNA

NCBI chr11:91,268,730...91,276,738
Ensembl chr11:91,268,731...91,275,323

G

eukaryotic translation initiation factor 4E binding protein 1

affects expression

EXP

Omeprazole affects the expression of EIF4EBP1 mRNA

NCBI chr16:71,495,457...71,508,845
Ensembl chr16:71,487,930...71,508,874

G

eukaryotic translation initiation factor 4H

affects expression

EXP

Omeprazole affects the expression of EIF4H mRNA

NCBI chr12:22,083,155...22,099,876
Ensembl chr12:27,719,321...27,736,346

G

ectodermal-neural cortex 1

affects expression

EXP

Omeprazole affects the expression of ENC1 mRNA

NCBI chr 2:30,285,274...30,297,194
Ensembl chr 2:30,283,736...30,315,721

G

enolase 1

affects expression

EXP

Omeprazole affects the expression of ENO1 mRNA

NCBI chr 5:166,002,867...166,014,252
Ensembl chr 3:77,946,261...77,986,003
Ensembl chr 5:77,946,261...77,986,003

G

glutamyl aminopeptidase

affects expression

EXP

Omeprazole affects the expression of ENPEP mRNA

NCBI chr 2:220,456,258...220,526,218
Ensembl chr 2:220,456,278...220,526,218

G

ectonucleotide pyrophosphatase/phosphodiesterase 1

affects expression

EXP

Omeprazole affects the expression of ENPP1 mRNA

NCBI chr 1:22,518,051...22,583,044
Ensembl chr 1:22,518,069...22,583,044

G

E1A binding protein p300

multiple interactions

ISO

Omeprazole promotes the reaction [EP300 protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [EP300 protein binds to CYP1B1 promoter]

NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574

G

epithelial cell adhesion molecule

affects expression

EXP

Omeprazole affects the expression of EPCAM mRNA

NCBI chr 6:12,633,715...12,649,678
Ensembl chr 6:12,631,611...12,649,702

G

endoplasmic reticulum protein 29

affects expression

EXP

Omeprazole affects the expression of ERP29 mRNA

NCBI chr12:40,750,177...40,756,607
Ensembl chr12:40,750,314...40,757,010

G

esterase D

affects expression

EXP

Omeprazole affects the expression of ESD mRNA

NCBI chr15:56,453,082...56,472,582
Ensembl chr15:56,453,044...56,473,508

G

electron transfer flavoprotein subunit beta

affects expression

EXP

Omeprazole affects the expression of ETFB mRNA

NCBI chr 1:93,851,908...93,866,072
Ensembl chr 1:102,988,499...103,002,659

G

fatty acid amide hydrolase

affects expression

EXP

Omeprazole affects the expression of FAAH mRNA

NCBI chr 5:134,716,545...134,735,396
Ensembl chr 5:134,716,545...134,735,396

G

fatty acid desaturase 2

affects expression

EXP

Omeprazole affects the expression of FADS2 mRNA

NCBI chr 1:216,132,277...216,172,190
Ensembl chr 1:216,133,676...216,172,066

G

fructose-bisphosphatase 1

affects expression

EXP

Omeprazole affects the expression of FBP1 mRNA

NCBI chr17:2,212,941...2,235,749
Ensembl chr17:2,213,492...2,235,746

G

farnesyl diphosphate farnesyl transferase 1

affects expression

EXP

Omeprazole affects the expression of FDFT1 mRNA

NCBI chr15:41,588,114...41,616,168
Ensembl chr15:41,588,117...41,616,168

G

farnesyl diphosphate synthase

affects expression

EXP

Omeprazole affects the expression of FDPS mRNA

NCBI chr 2:176,795,192...176,804,816
Ensembl chr 2:176,795,192...176,807,136

G

ferredoxin 2

affects expression

EXP

Omeprazole affects the expression of FDX2 mRNA

NCBI chr 8:27,881,091...27,886,230
Ensembl chr 8:27,881,091...27,886,015

G

flavin containing dimethylaniline monoxygenase 1

affects expression

EXP

Omeprazole affects the expression of FMO1 mRNA

NCBI chr13:77,715,405...77,747,666
Ensembl chr13:77,715,402...77,747,874

G

guanidinoacetate N-methyltransferase

affects expression

EXP

Omeprazole affects the expression of GAMT mRNA

NCBI chr 7:9,448,590...9,451,413
Ensembl chr 7:10,098,571...10,102,083

G

glyceraldehyde-3-phosphate dehydrogenase

affects expression

EXP

Omeprazole affects the expression of GAPDH mRNA

NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:159,648,592...159,653,377

G

gastrin

increases expression

ISO
EXP

Omeprazole results in increased expression of GAST protein

PMID:11422300 PMID:12189558 PMID:12763636 PMID:15223672 PMID:16618411 More...

NCBI chr10:85,765,216...85,767,881
Ensembl chr10:85,765,216...85,767,880

G

1,4-alpha-glucan branching enzyme 1

affects expression

EXP

Omeprazole affects the expression of GBE1 mRNA

NCBI chr11:22,181,194...22,446,640
Ensembl chr11:22,181,103...22,446,638

G

GTP cyclohydrolase I feedback regulator

affects expression

EXP

Omeprazole affects the expression of GCHFR mRNA

NCBI chr 3:126,611,892...126,615,926
Ensembl chr 3:126,613,240...126,615,926

G

gamma-glutamyl hydrolase

affects expression

EXP

Omeprazole affects the expression of GGH mRNA

NCBI chr 5:33,529,880...33,552,790
Ensembl chr 5:38,326,594...38,349,647

G

gamma-glutamyltransferase 1

multiple interactions

EXP

[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GGT1 mRNA

NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,141...13,088,050

G

gap junction protein, beta 1

affects expression

EXP

Omeprazole affects the expression of GJB1 mRNA

NCBI chr X:70,541,845...70,549,776
Ensembl chr X:70,541,862...70,549,843

G

glycosylphosphatidylinositol specific phospholipase D1

affects expression

EXP

Omeprazole affects the expression of GPLD1 mRNA

NCBI chr17:40,084,427...40,132,035
Ensembl chr17:40,512,660...40,554,975

G

glutathione peroxidase 1

affects expression

EXP

Omeprazole affects the expression of GPX1 mRNA

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glutathione peroxidase 2

multiple interactions

EXP

[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA

NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:101,226,745...101,230,862

G

glutathione peroxidase 4

affects expression

EXP

Omeprazole affects the expression of GPX4 mRNA

NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629

G

glutamate ionotropic receptor NMDA type subunit associated protein 1

affects expression

EXP

Omeprazole affects the expression of GRINA mRNA

NCBI chr 7:109,842,870...109,846,048
Ensembl chr 7:109,843,196...109,846,042

G

GrpE-like 1, mitochondrial

affects expression

EXP

Omeprazole affects the expression of GRPEL1 mRNA

NCBI chr14:74,292,023...74,298,243
Ensembl chr14:78,517,052...78,522,861

G

glutathione S-transferase alpha 5

increases expression
multiple interactions

EXP

Omeprazole results in increased expression of GSTA5 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA

PMID:17202759 PMID:22687989

NCBI chr 8:87,985,768...87,997,766
Ensembl chr 8:87,985,258...87,997,765

G

glutathione S-transferase pi 1

increases expression

EXP

Omeprazole results in increased expression of GSTP1 mRNA

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

glutathione S-transferase theta 1

affects expression

EXP

Omeprazole affects the expression of GSTT1 mRNA

NCBI chr20:12,856,068...12,873,020
Ensembl chr20:12,856,083...12,873,019

G

general transcription factor IIH subunit 5

affects expression

EXP

Omeprazole affects the expression of GTF2H5 mRNA

NCBI chr 1:49,061,904...49,068,612
Ensembl chr 1:49,061,959...49,070,039

G

gulonolactone (L-) oxidase

affects expression

EXP

Omeprazole affects the expression of GULO mRNA

NCBI chr15:44,381,226...44,403,314
Ensembl chr15:44,381,214...44,403,422

G

granzyme A

affects expression

EXP

Omeprazole affects the expression of GZMA mRNA

NCBI chr 2:46,473,763...46,485,696
Ensembl chr 2:46,473,763...46,485,696

G

H3.3 histone B

affects expression

EXP

Omeprazole affects the expression of H3F3B mRNA

NCBI chr10:101,755,404...101,764,616
Ensembl chr10:101,755,404...101,757,636

G

histidine ammonia lyase

affects expression

EXP

Omeprazole affects the expression of HAL mRNA

NCBI chr 7:29,894,495...29,924,744
Ensembl chr 7:29,893,855...29,924,744

G

hepcidin antimicrobial peptide

increases expression
increases secretion
multiple interactions

ISO

Omeprazole results in increased expression of HAMP mRNA
Omeprazole results in increased secretion of HAMP protein
Omeprazole results in increased expression of HAMP mRNA; Omeprazole results in increased expression of HAMP protein
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Omeprazole results in increased expression of HAMP mRNA]; AHR protein affects the reaction [Omeprazole results in increased expression of HAMP mRNA]

NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:95,298,307...95,300,297

G

hydroxyacid oxidase 2

affects expression

EXP

Omeprazole affects the expression of HAO2 mRNA

NCBI chr 2:188,888,848...188,921,567
Ensembl chr 2:188,889,212...188,913,133

G

hemoglobin alpha, adult chain 2

affects expression

EXP

Omeprazole affects the expression of HBA-A2 mRNA

NCBI chr10:15,828,291...15,829,138
Ensembl chr10:15,828,377...15,829,141

G

hemoglobin subunit beta

affects expression

EXP

Omeprazole affects the expression of HBB mRNA

NCBI chr 1:167,662,310...167,663,721
Ensembl chr 1:167,630,245...167,663,873

G

histidine decarboxylase

affects expression
multiple interactions
increases expression
increases stability

EXP

Omeprazole affects the expression of HDC mRNA
Omeprazole results in increased expression of and results in increased activity of HDC protein
Omeprazole results in increased expression of HDC mRNA
Omeprazole results in increased stability of HDC protein

PMID:12763636 PMID:19483382

NCBI chr 3:134,300,628...134,318,704
Ensembl chr 3:134,300,632...134,318,711

G

homogentisate 1, 2-dioxygenase

affects expression

EXP

Omeprazole affects the expression of HGD mRNA

NCBI chr11:76,592,202...76,643,776
Ensembl chr11:76,592,204...76,643,767

G

high mobility group nucleosome binding domain 1

affects expression

EXP

Omeprazole affects the expression of HMGN1 mRNA

NCBI chr11:48,891,813...48,897,732
Ensembl chr11:48,891,814...48,897,771

G

heme oxygenase 1

multiple interactions
increases expression

ISO

Acetylcysteine promotes the reaction [Omeprazole results in increased expression of HMOX1 mRNA]; Acetylcysteine promotes the reaction [Omeprazole results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 protein]; Omeprazole results in increased expression of and results in increased activity of HMOX1 protein
Omeprazole results in increased expression of HMOX1 mRNA; Omeprazole results in increased expression of HMOX1 protein

PMID:16712795 PMID:27725188

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

hypoxanthine phosphoribosyltransferase 1

affects expression

EXP

Omeprazole affects the expression of HPRT1 mRNA

NCBI chr X:137,655,744...137,687,718
Ensembl chr X:137,655,680...137,687,712

G

HPS5, biogenesis of lysosomal organelles complex 2 subunit 2

affects expression

EXP

Omeprazole affects the expression of HPS5 mRNA

NCBI chr 1:97,281,626...97,320,945
Ensembl chr 1:106,417,902...106,452,859

G

hydroxysteroid (17-beta) dehydrogenase 4

affects expression

EXP

Omeprazole affects the expression of HSD17B4 mRNA

NCBI chr18:43,328,903...43,417,950
Ensembl chr18:45,515,373...45,604,467

G

hydroxysteroid dehydrogenase like 2

affects expression

EXP

Omeprazole affects the expression of HSDL2 mRNA

NCBI chr 5:79,238,881...79,274,051
Ensembl chr 5:79,212,525...79,274,798

G

heat shock protein family A (Hsp70) member 1A

decreases expression
multiple interactions

EXP

Omeprazole results in decreased expression of HSPA1A mRNA; Omeprazole results in decreased expression of HSPA1A protein
Zinc Compounds analog inhibits the reaction [Omeprazole results in decreased expression of HSPA1A protein]; Zinc Sulfate inhibits the reaction [Omeprazole results in decreased expression of HSPA1A protein]

PMID:15223672 PMID:16945336

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 1 like

multiple interactions

EXP

Omeprazole inhibits the reaction [Ethanol results in increased expression of HSPA1L mRNA]

NCBI chr20:3,853,496...3,860,223
Ensembl chr20:3,853,331...3,876,877

G

HtrA serine peptidase 1

affects expression

EXP

Omeprazole affects the expression of HTRA1 mRNA

NCBI chr 1:194,928,069...194,977,619
Ensembl chr 1:194,927,687...194,977,620

G

immediate early response 3

multiple interactions

ISO

[Omeprazole co-treated with CCKBR protein] results in increased expression of IER3

NCBI chr20:2,933,173...2,934,377
Ensembl chr20:2,933,174...2,934,377

G

interferon gamma

multiple interactions

ISO

Omeprazole inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

insulin-like growth factor 1

affects expression

EXP

Omeprazole affects the expression of IGF1 mRNA

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764

G

insulin-like growth factor binding protein, acid labile subunit

affects expression

EXP

Omeprazole affects the expression of IGFALS mRNA

NCBI chr10:14,397,076...14,408,439
Ensembl chr10:14,403,399...14,407,138

G

insulin-like growth factor binding protein 2

affects expression

EXP

Omeprazole affects the expression of IGFBP2 mRNA

NCBI chr 9:81,864,811...81,892,179
Ensembl chr 9:81,864,783...81,892,171

G

interleukin 10

multiple interactions

ISO
EXP

Omeprazole inhibits the reaction [Ethanol results in decreased expression of IL10 protein]

PMID:26970604 PMID:38341112

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 16

multiple interactions

EXP

Omeprazole inhibits the reaction [Ethanol results in increased expression of IL16 protein]

NCBI chr 1:147,026,852...147,127,177
Ensembl chr 1:147,027,097...147,127,023

G

interleukin 1 beta

multiple interactions

EXP

Omeprazole inhibits the reaction [Cisplatin results in increased expression of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

EXP
ISO

Omeprazole inhibits the reaction [Cisplatin results in increased expression of IL6 protein]; Omeprazole inhibits the reaction [Ethanol results in decreased expression of IL6 protein]
Omeprazole inhibits the reaction [Ethanol results in increased expression of IL6 protein]

PMID:25637687 PMID:32418911 PMID:38341112

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

inositol monophosphatase 1

affects expression

EXP

Omeprazole affects the expression of IMPA1 mRNA

NCBI chr 2:91,462,781...91,484,057
Ensembl chr 2:93,370,299...93,391,468

G

inhibin subunit beta E

affects expression

EXP

Omeprazole affects the expression of INHBE mRNA

NCBI chr 7:65,061,531...65,064,519
Ensembl chr 7:65,061,531...65,064,519

G

inositol-3-phosphate synthase 1

affects expression

EXP

Omeprazole affects the expression of ISYNA1 mRNA

NCBI chr16:18,839,143...18,841,979
Ensembl chr16:18,873,121...18,875,955

G

inter-alpha-trypsin inhibitor heavy chain 4

affects expression

EXP

Omeprazole affects the expression of ITIH4 mRNA

NCBI chr16:6,086,985...6,102,162
Ensembl chr16:6,086,973...6,102,160

G

Janus kinase 1

affects expression

EXP

Omeprazole affects the expression of JAK1 mRNA

NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:120,896,046...120,996,758

G

KDEL endoplasmic reticulum protein retention receptor 2

affects expression

EXP

Omeprazole affects the expression of KDELR2 mRNA

NCBI chr12:11,138,820...11,157,117
Ensembl chr12:16,252,424...16,270,719

G

kinase insert domain receptor

affects expression
multiple interactions

EXP
ISO

Omeprazole affects the expression of KDR mRNA
Omeprazole promotes the reaction [Oxygen results in decreased expression of KDR protein]

PMID:19483382 PMID:26272953

NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192

G

keratin 8

affects expression

EXP

Omeprazole affects the expression of KRT8 mRNA

NCBI chr 7:135,002,886...135,010,339
Ensembl chr 7:135,002,894...135,010,403

G

lecithin cholesterol acyltransferase

affects expression

EXP

Omeprazole affects the expression of LCAT mRNA

NCBI chr19:50,744,598...50,748,064
Ensembl chr19:50,744,601...50,748,081

G

leucine carboxyl methyltransferase 1

affects expression

EXP

Omeprazole affects the expression of LCMT1 mRNA

NCBI chr 1:187,335,173...187,391,195
Ensembl chr 1:187,327,706...187,391,516

G

lipase C, hepatic type

affects expression

EXP

Omeprazole affects the expression of LIPC mRNA

NCBI chr 8:80,390,470...80,516,463
Ensembl chr 8:80,390,471...80,516,285

G

lysyl oxidase

affects expression

EXP

Omeprazole affects the expression of LOX mRNA

NCBI chr18:48,162,889...48,175,640
Ensembl chr18:48,165,688...48,239,810

G

LDL receptor related protein 3

affects expression

EXP

Omeprazole affects the expression of LRP3 mRNA

NCBI chr 1:87,843,815...87,859,147
Ensembl chr 1:96,981,815...96,996,057

G

mannosidase, alpha, class 2B, member 1

affects expression

EXP

Omeprazole affects the expression of MAN2B1 mRNA

NCBI chr19:39,959,964...39,979,299
Ensembl chr19:39,959,965...39,979,246

G

mitogen activated protein kinase kinase 2

affects expression

EXP

Omeprazole affects the expression of MAP2K2 mRNA

NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:9,241,310...9,260,940

G

mitogen activated protein kinase 14

multiple interactions

ISO

Omeprazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK14 protein]

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

MBL associated serine protease 2

affects expression

EXP

Omeprazole affects the expression of MASP2 mRNA

NCBI chr 5:164,319,017...164,332,686
Ensembl chr 5:164,308,991...164,332,705

G

malic enzyme 1

affects expression
multiple interactions

EXP

Omeprazole affects the expression of ME1 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of ME1 mRNA

PMID:19483382 PMID:22687989

NCBI chr 8:96,429,057...96,540,244
Ensembl chr 8:96,429,057...96,540,275

G

matrix metallopeptidase 14

multiple interactions

EXP

Omeprazole inhibits the reaction [Indomethacin results in decreased expression of MMP14 protein]

NCBI chr15:31,857,824...31,867,049
Ensembl chr15:31,857,546...31,869,893

G

matrix metallopeptidase 2

multiple interactions

EXP

Omeprazole inhibits the reaction [Hydrogen Peroxide results in decreased activity of MMP2 protein]

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

methylmalonyl-CoA mutase

affects expression

EXP

Omeprazole affects the expression of MMUT mRNA

NCBI chr 9:27,425,935...27,454,202
Ensembl chr 9:27,425,935...27,454,342

G

myeloperoxidase

multiple interactions
decreases activity

ISO
EXP

Omeprazole inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; Omeprazole inhibits the reaction [Acids results in increased activity of MPO protein]
Omeprazole inhibits the reaction [Acetic Acid results in increased activity of MPO protein]; Omeprazole inhibits the reaction [Cysteamine results in increased expression of MPO protein]; Omeprazole inhibits the reaction [Ethanol results in increased activity of MPO protein]; Omeprazole inhibits the reaction [Indomethacin results in increased activity of MPO protein]
Omeprazole results in decreased activity of MPO protein

PMID:16091555 PMID:17151854 PMID:20165931 PMID:25637687 PMID:27780710 More...

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

maestro

affects expression

EXP

Omeprazole affects the expression of MRO mRNA

NCBI chr18:67,450,186...67,467,593
Ensembl chr18:69,725,798...69,743,031

G

mitochondrial ribosomal protein L2

affects expression

EXP

Omeprazole affects the expression of MRPL2 mRNA

NCBI chr 9:21,830,834...21,834,607
Ensembl chr 9:21,830,835...21,834,641

G

mitochondrial ribosomal protein L9

affects expression

EXP

Omeprazole affects the expression of MRPL9 mRNA

NCBI chr 2:184,768,837...184,775,787
Ensembl chr 2:184,763,529...184,775,777

G

murinoglobulin 2

affects expression

EXP

Omeprazole affects the expression of PZP mRNA

NCBI chr 4:155,164,061...155,236,894

G

myeloid-associated differentiation marker

affects expression

EXP

Omeprazole affects the expression of MYADM mRNA

NCBI chr 1:65,864,180...65,874,701
Ensembl chr 1:74,775,698...74,789,710

G

MYC binding protein 2

affects expression

EXP

Omeprazole affects the expression of MYCBP2 mRNA

NCBI chr15:86,352,061...86,590,126
Ensembl chr15:86,352,061...86,590,325

G

myosin ID

affects expression

EXP

Omeprazole affects the expression of MYO1D mRNA

NCBI chr10:65,489,153...65,765,812
Ensembl chr10:65,975,122...66,263,958

G

N(alpha)-acetyltransferase 38, NatC auxiliary subunit

affects expression

EXP

Omeprazole affects the expression of NAA38 mRNA

NCBI chr10:54,588,304...54,617,715
Ensembl chr10:54,592,990...54,617,715

G

nucleosome assembly protein 1-like 1

affects expression

EXP

Omeprazole affects the expression of NAP1L1 mRNA

NCBI chr 7:48,819,464...48,844,108
Ensembl chr 7:48,819,477...48,844,104

G

N-acetyltransferase 8

affects expression

EXP

Omeprazole affects the expression of NAT8 mRNA

NCBI chr 4:119,836,986...119,837,764
Ensembl chr 4:119,835,645...119,843,159

G

nuclear receptor coactivator 1

multiple interactions

ISO

Omeprazole promotes the reaction [NCOA1 protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [NCOA1 protein binds to CYP1B1 promoter]

NCBI chr 6:32,952,090...33,229,829
Ensembl chr 6:32,952,090...33,195,924

G

NDRG family member 2

affects expression

EXP

Omeprazole affects the expression of NDRG2 mRNA

NCBI chr15:27,074,481...27,087,376
Ensembl chr15:27,074,481...27,083,125

G

NADH:ubiquinone oxidoreductase subunit S5

affects expression

EXP

Omeprazole affects the expression of NDUFS5 mRNA

NCBI chr 5:141,258,828...141,264,552
Ensembl chr 2:184,849,197...185,028,909
Ensembl chr 5:184,849,197...185,028,909
Ensembl chr14:184,849,197...185,028,909

G

NADH:ubiquinone oxidoreductase subunit V3

affects expression

EXP

Omeprazole affects the expression of NDUFV3 mRNA

NCBI chr20:9,613,786...9,622,941
Ensembl chr13:48,468,224...48,488,847
Ensembl chr20:48,468,224...48,488,847

G

neuraminidase 2

affects expression

EXP

Omeprazole affects the expression of NEU2 mRNA

NCBI chr 9:88,218,494...88,267,356
Ensembl chr 9:95,696,507...95,715,208

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 protein]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NFKB inhibitor alpha

multiple interactions

EXP

Omeprazole inhibits the reaction [Cisplatin results in decreased expression of NFKBIA protein]

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nuclear transcription factor, X-box binding 1

affects expression

EXP

Omeprazole affects the expression of NFX1 mRNA

NCBI chr 5:60,900,140...60,958,889
Ensembl chr 5:60,901,217...60,958,889

G

NIPA-like domain containing 2

affects expression

EXP

Omeprazole affects the expression of NIPAL2 mRNA

NCBI chr 7:65,774,477...65,884,807
Ensembl chr 7:67,659,628...67,769,959

G

nitrilase 1

affects expression

EXP

Omeprazole affects the expression of NIT1 mRNA

NCBI chr13:86,302,334...86,305,770
Ensembl chr13:86,298,387...86,305,770

G

NLR family, pyrin domain containing 3

multiple interactions

EXP

Lipopolysaccharides inhibits the reaction [Omeprazole inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]]; Omeprazole inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394

G

NME/NM23 nucleoside diphosphate kinase 2

affects expression

EXP

Omeprazole affects the expression of NME2 mRNA

NCBI chr10:78,898,097...78,903,514
Ensembl chr20:11,179,066...11,179,497
Ensembl chr10:11,179,066...11,179,497

G

NAD(P)H quinone dehydrogenase 1

increases expression
multiple interactions

EXP
ISO

Omeprazole results in increased expression of NQO1 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of NQO1 mRNA
Omeprazole inhibits the reaction [Oxygen results in increased expression of NQO1 mRNA]; Omeprazole inhibits the reaction [Oxygen results in increased expression of NQO1 protein]

PMID:17202759 PMID:22687989 PMID:26272953

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
increases activity

ISO
EXP

[Omeprazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; NR1I2 protein affects the reaction [Omeprazole results in increased expression of CYP3A4 mRNA]

PMID:12695340 PMID:17041008 PMID:25680588 PMID:26187274 PMID:27732639

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

nuclear receptor subfamily 1, group I, member 3

affects expression
increases expression
decreases metabolic processing

EXP
ISO

Omeprazole affects the expression of NR1I3 mRNA
Omeprazole results in increased expression of NR1I3 mRNA
NR1I3 gene mutant form results in decreased metabolism of Omeprazole

PMID:19118567 PMID:19483382 PMID:27434302

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

G

nuclear receptor subfamily 3, group C, member 1

affects expression

EXP

Omeprazole affects the expression of NR3C1 mRNA

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843

G

out at first homolog

affects expression

EXP

Omeprazole affects the expression of OAF mRNA

NCBI chr 8:52,491,314...52,509,285
Ensembl chr 8:52,491,315...52,509,285

G

alpha-2u globulin PGCL4

affects expression

EXP

Omeprazole affects the expression of OBP3 mRNA

NCBI chr 5:79,637,234...79,640,810
Ensembl chr 5:79,637,234...79,640,675

G

oxoglutarate dehydrogenase

affects expression

EXP

Omeprazole affects the expression of OGDH mRNA

NCBI chr14:85,363,949...85,431,405
Ensembl chr14:85,364,014...85,432,271

G

olfactory receptor 59

affects expression

EXP

Omeprazole affects the expression of OLR59 mRNA

NCBI chr 1:157,193,051...157,227,707
Ensembl chr 1:166,604,141...166,623,265

G

oligosaccharyltransferase complex non-catalytic subunit

affects expression

EXP

Omeprazole affects the expression of OSTC mRNA

NCBI chr 2:219,250,549...219,266,076
Ensembl chr 2:221,874,948...221,940,267

G

ornithine transcarbamylase

affects expression

EXP

Omeprazole affects the expression of OTC mRNA

NCBI chr X:15,126,358...15,202,473
Ensembl chr X:15,126,358...15,239,555

G

poly(A) binding protein, cytoplasmic 4

affects expression

EXP

Omeprazole affects the expression of PABPC4 mRNA

NCBI chr 5:140,847,835...140,864,089
Ensembl chr 5:140,848,225...140,864,087

G

phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase

affects expression

EXP

Omeprazole affects the expression of PAICS mRNA

NCBI chr14:31,553,355...31,586,843
Ensembl chr14:31,553,357...31,587,027

G

poly (ADP-ribose) polymerase 1

increases cleavage

ISO

Omeprazole results in increased cleavage of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

pyruvate carboxylase

affects expression

EXP

Omeprazole affects the expression of PCX mRNA

NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:211,228,731...211,329,940

G

propionyl-CoA carboxylase subunit beta

affects expression

EXP

Omeprazole affects the expression of PCCB mRNA

NCBI chr 8:101,591,218...101,641,213
Ensembl chr 8:110,469,934...110,520,187

G

proliferating cell nuclear antigen

multiple interactions

EXP
ISO

[Omeprazole co-treated with Indomethacin] promotes the reaction [Acetic Acid results in increased expression of PCNA protein]; Omeprazole promotes the reaction [Acetic Acid results in increased expression of PCNA protein]
Omeprazole inhibits the reaction [Ethanol results in decreased expression of PCNA protein]

PMID:19251492 PMID:26970604

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

proprotein convertase subtilisin/kexin type 6

affects expression

EXP

Omeprazole affects the expression of PCSK6 mRNA

NCBI chr 1:119,428,978...119,627,626
Ensembl chr 1:128,839,232...129,052,128

G

phosphatidylcholine transfer protein

affects expression

EXP

Omeprazole affects the expression of PCTP mRNA

NCBI chr10:75,305,999...75,351,919
Ensembl chr10:75,305,999...75,326,432

G

phosducin-like 3

affects expression

EXP

Omeprazole affects the expression of PDCL3 mRNA

NCBI chr 9:41,234,322...41,243,769
Ensembl chr 9:48,723,767...48,739,529

G

protein disulfide isomerase family A, member 3

affects expression

EXP

Omeprazole affects the expression of PDIA3 mRNA

NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:128,841,917...128,867,327

G

protein disulfide isomerase family A, member 6

affects expression

EXP

Omeprazole affects the expression of PDIA6 mRNA

NCBI chr 6:45,791,704...45,808,947
Ensembl chr 6:45,791,678...45,810,091

G

peroxisomal biogenesis factor 19

affects expression

EXP

Omeprazole affects the expression of PEX19 mRNA

NCBI chr13:87,124,654...87,141,170
Ensembl chr13:87,124,698...87,141,757

G

phosphoglycerate mutase 1

affects expression

EXP

Omeprazole affects the expression of PGAM1 mRNA

NCBI chr 1:250,673,152...250,680,762
Ensembl chr 1:250,673,049...250,690,203

G

progesterone receptor membrane component 1

affects expression

EXP

Omeprazole affects the expression of PGRMC1 mRNA

NCBI chr X:120,698,610...120,706,805
Ensembl chr X:120,698,610...120,706,805

G

phytanoyl-CoA 2-hydroxylase

affects expression

EXP

Omeprazole affects the expression of PHYH mRNA

NCBI chr17:78,238,747...78,255,645
Ensembl chr17:78,238,747...78,255,645

G

phosphatidylinositol glycan anchor biosynthesis, class P

affects expression

EXP

Omeprazole affects the expression of PIGP mRNA

NCBI chr11:47,152,601...47,158,766
Ensembl chr11:47,148,465...47,160,082

G

pyruvate kinase L/R

affects expression

EXP

Omeprazole affects the expression of PKLR mRNA

NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:176,840,764...176,849,644

G

phospholipase A2 group 4A

increases phosphorylation
multiple interactions

ISO

Omeprazole results in increased phosphorylation of PLA2G4A protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Omeprazole results in increased phosphorylation of PLA2G4A protein]

NCBI chr13:64,427,921...64,572,352
Ensembl chr13:64,427,916...64,589,641

G

phospholipase B domain containing 1

affects expression

EXP

Omeprazole affects the expression of PLBD1 mRNA

NCBI chr 4:169,472,983...169,529,277
Ensembl chr 4:171,204,198...171,260,488

G

plasminogen

affects expression

EXP

Omeprazole affects the expression of PLG mRNA

NCBI chr 1:50,872,927...50,915,406
Ensembl chr 1:50,872,926...50,917,320

G

plastin 3

affects expression

EXP

Omeprazole affects the expression of PLS3 mRNA

NCBI chr X:116,401,247...116,495,898
Ensembl chr X:116,401,293...116,495,893

G

paraoxonase 2

affects expression

EXP

Omeprazole affects the expression of PON2 mRNA

NCBI chr 4:34,356,270...34,391,684
Ensembl chr 4:34,356,274...34,391,996

G

POU class 2 homeobox 2

multiple interactions

EXP
ISO

Omeprazole inhibits the reaction [Cisplatin results in increased expression of POU2F2 protein]

NCBI chr 1:89,810,153...89,897,560
Ensembl chr 1:89,812,093...89,897,564

G

pancreatic progenitor cell differentiation and proliferation factor

affects expression

EXP

Omeprazole affects the expression of PPDPF mRNA

NCBI chr 3:168,299,309...168,301,040
Ensembl chr 3:188,676,965...188,678,599

G

peroxiredoxin 2

affects expression

EXP

Omeprazole affects the expression of PRDX2 mRNA

NCBI chr19:40,085,788...40,091,083
Ensembl chr19:40,084,430...40,091,006

G

peroxiredoxin 6

affects expression

EXP

Omeprazole affects the expression of PRDX6 mRNA

NCBI chr13:76,062,082...76,072,631
Ensembl chr13:76,061,554...76,072,657

G

prolactin

increases expression

ISO

Omeprazole results in increased expression of PRL protein

NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217

G

protein C, inactivator of coagulation factors Va and VIIIa

affects expression

EXP

Omeprazole affects the expression of PROC mRNA

NCBI chr18:24,038,596...24,049,061
Ensembl chr18:24,038,597...24,048,964

G

phosphoribosyl pyrophosphate synthetase-associated protein 1

affects expression

EXP

Omeprazole affects the expression of PRPSAP1 mRNA

NCBI chr10:102,199,949...102,221,642
Ensembl chr10:102,199,950...102,221,642

G

proteasome 20S subunit alpha 6

affects expression

EXP

Omeprazole affects the expression of PSMA6 mRNA

NCBI chr 6:72,765,534...72,796,554
Ensembl chr 6:78,500,736...78,531,717

G

proteasome 20S subunit beta 1

affects expression

EXP

Omeprazole affects the expression of PSMB1 mRNA

NCBI chr 1:65,115,770...65,136,516
Ensembl chr 1:65,114,724...65,136,640

G

proteasome 20S subunit beta 3

affects expression

EXP

Omeprazole affects the expression of PSMB3 mRNA

NCBI chr10:83,193,787...83,200,883
Ensembl chr10:83,193,787...83,200,883

G

proteasome 26S subunit, ATPase 1

affects expression

EXP

Omeprazole affects the expression of PSMC1 mRNA

NCBI chr 6:119,392,833...119,405,233
Ensembl chr 6:125,122,490...125,134,858

G

proteasome 26S subunit, ATPase 3

affects expression

EXP

Omeprazole affects the expression of PSMC3 mRNA

NCBI chr 3:77,031,825...77,037,207
Ensembl chr 3:97,487,632...97,499,176

G

proteasome 26S subunit, ATPase 5

affects expression

EXP

Omeprazole affects the expression of PSMC5 mRNA

NCBI chr10:91,687,553...91,693,487
Ensembl chr10:91,686,295...91,695,921

G

proteasome 26S subunit, non-ATPase 1

affects expression

EXP

Omeprazole affects the expression of PSMD1 mRNA

NCBI chr 9:94,157,971...94,233,218
Ensembl chr 9:94,157,971...94,233,218

G

proteasome 26S subunit ubiquitin receptor, non-ATPase 4

affects expression

EXP

Omeprazole affects the expression of PSMD4 mRNA

NCBI chr 2:185,287,941...185,297,238
Ensembl chr 2:185,286,868...185,297,201

G

prostaglandin-endoperoxide synthase 2

multiple interactions

EXP
ISO

[Omeprazole co-treated with beta-Naphthoflavone] results in increased expression of PTGS2 mRNA; [Omeprazole co-treated with beta-Naphthoflavone] results in increased expression of PTGS2 protein
Omeprazole inhibits the reaction [Ethanol results in increased expression of PTGS2 protein]

PMID:23038005 PMID:26970604

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

parathymosin

affects expression

EXP

Omeprazole affects the expression of PTMS mRNA

NCBI chr 4:159,408,647...159,412,837
Ensembl chr 4:159,408,649...159,415,212

G

protein tyrosine phosphatase, receptor type, F

affects expression

EXP

Omeprazole affects the expression of PTPRF mRNA

NCBI chr 5:137,027,376...137,109,405
Ensembl chr 5:137,028,164...137,095,426

G

PTTG1 interacting protein

affects expression

EXP

Omeprazole affects the expression of PTTG1IP mRNA

NCBI chr20:11,029,608...11,047,395
Ensembl chr20:11,029,608...11,046,909

G

glycogen phosphorylase L

affects expression

EXP

Omeprazole affects the expression of PYGL mRNA

NCBI chr 6:94,433,558...94,476,219
Ensembl chr 6:94,426,346...94,476,269

G

RAB5 interacting factor

affects expression

EXP

Omeprazole affects the expression of RAB5IF mRNA

NCBI chr 3:165,818,060...165,828,071
Ensembl chr 3:165,816,588...165,828,067

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

EXP
ISO

[Omeprazole co-treated with Indomethacin] promotes the reaction [Acetic Acid results in increased expression of RELA protein]; Lipopolysaccharides inhibits the reaction [Omeprazole inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]]; Omeprazole inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]
Omeprazole inhibits the reaction [Cisplatin affects the localization of RELA protein]

PMID:19251492 PMID:30452898 PMID:32418911

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

retinol saturase

increases expression

EXP

Omeprazole results in increased expression of RETSAT mRNA

NCBI chr 4:104,653,306...104,662,069
Ensembl chr 4:106,211,436...106,229,552

G

reactive intermediate imine deaminase A homolog

affects expression

EXP

Omeprazole affects the expression of RIDA mRNA

NCBI chr 7:67,576,586...67,590,493
Ensembl chr 7:67,576,586...67,590,692

G

ribonuclease A family member 4

affects expression

EXP

Omeprazole affects the expression of RNASE4 mRNA

NCBI chr15:26,786,287...26,803,634
Ensembl chr15:26,786,079...26,803,639

G

ring finger protein 103

affects expression

EXP

Omeprazole affects the expression of RNF103 mRNA

NCBI chr 4:103,526,456...103,542,529
Ensembl chr 4:105,084,686...105,106,809

G

RNA binding protein with serine rich domain 1

affects expression

EXP

Omeprazole affects the expression of RNPS1 mRNA

NCBI chr10:13,950,151...13,960,396
Ensembl chr10:13,950,184...13,960,393

G

ribosomal protein L11

affects expression

EXP

Omeprazole affects the expression of RPL11 mRNA

NCBI chr 5:153,557,592...153,561,230
Ensembl chr 5:153,557,597...153,561,127

G

ribosomal protein L13

affects expression

EXP

Omeprazole affects the expression of RPL13 mRNA

NCBI chr19:68,062,442...68,065,065
Ensembl chr19:68,062,493...68,065,059

G

ribosomal protein L15

affects expression

EXP

Omeprazole affects the expression of RPL15 mRNA

NCBI chr15:9,934,663...9,937,946
Ensembl chr15:9,934,679...9,938,308

G

ribosomal protein L17

affects expression

EXP

Omeprazole affects the expression of RPL17 mRNA

NCBI chr18:70,856,275...70,859,388
Ensembl chr 3:111,722,010...111,722,638
Ensembl chr18:111,722,010...111,722,638

G

ribosomal protein L23

affects expression

EXP

Omeprazole affects the expression of RPL23 mRNA

NCBI chr10:83,268,223...83,272,184
Ensembl chr10:83,262,592...83,272,214

G

ribosomal protein L3

affects expression

EXP

Omeprazole affects the expression of RPL3 mRNA

NCBI chr 7:113,491,943...113,508,115
Ensembl chr 7:113,501,960...113,507,990

G

ribosomal protein L32

affects expression

EXP

Omeprazole affects the expression of RPL32 mRNA

NCBI chr 4:148,864,048...148,867,612
Ensembl chr 4:150,536,646...150,540,214

G

ribosomal protein L4

affects expression

EXP

Omeprazole affects the expression of RPL4 mRNA

NCBI chr 8:73,566,477...73,571,600
Ensembl chr 8:73,566,466...73,571,788

G

ribophorin II

affects expression

EXP

Omeprazole affects the expression of RPN2 mRNA

NCBI chr 3:166,361,955...166,409,272
Ensembl chr 3:166,362,049...166,409,922

G

ribosomal protein S14

affects expression

EXP

Omeprazole affects the expression of RPS14 mRNA

NCBI chr18:56,492,010...56,503,092
Ensembl chr18:56,498,245...56,503,091

G

ribosomal protein S18

affects expression

EXP

Omeprazole affects the expression of RPS18 mRNA

NCBI chr20:4,933,741...4,937,423
Ensembl chr20:4,917,095...4,937,423

G

ribosomal protein S19

affects expression

EXP

Omeprazole affects the expression of RPS19 mRNA

NCBI chr 1:89,608,408...89,614,390
Ensembl chr 7:104,324,520...104,325,132
Ensembl chr 1:104,324,520...104,325,132

G

ribosomal protein S20

affects expression

EXP

Omeprazole affects the expression of RPS20 mRNA

NCBI chr 5:21,616,687...21,618,068
Ensembl chr 3:42,839,965...43,095,621
Ensembl chr 9:42,839,965...43,095,621
Ensembl chr 5:42,839,965...43,095,621

G

ribosomal protein S3a

affects expression

EXP

Omeprazole affects the expression of RPS3A mRNA

NCBI chr 2:173,822,673...173,827,042
Ensembl chr 2:173,822,488...173,827,043

G

ribosomal protein S6

affects expression

EXP

Omeprazole affects the expression of RPS6 mRNA

NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:106,417,680...106,420,566

G

ribosomal protein S8

affects expression

EXP

Omeprazole affects the expression of RPS8 mRNA

NCBI chr 5:135,866,941...135,869,511
Ensembl chr 5:135,866,941...135,869,548

G

RAS related 2

affects expression

EXP

Omeprazole affects the expression of RRAS2 mRNA

NCBI chr 1:177,668,143...177,737,551
Ensembl chr 1:177,668,144...177,737,551

G

RT1 class II, locus DMa

affects expression

ISO

Omeprazole affects the expression of HLA-DMA mRNA

NCBI chr20:4,707,028...4,710,432
Ensembl chr20:4,708,933...4,712,335

G

RT1 class Ib, locus M3, gene 1

affects expression

ISO

Omeprazole affects the expression of HLA-G mRNA

NCBI chr20:1,329,227...1,333,394
Ensembl chr20:1,329,225...1,333,366

G

RT1 class Ib, locus S3

affects expression

EXP

Omeprazole affects the expression of RT1-S3 mRNA

NCBI chr20:2,675,463...2,680,229

G

sphingosine-1-phosphate receptor 1

affects expression

EXP

Omeprazole affects the expression of S1PR1 mRNA

NCBI chr 2:206,309,715...206,314,070
Ensembl chr 2:205,900,836...206,328,689

G

somatomedin B and thrombospondin, type 1 domain containing

affects expression

EXP

Omeprazole affects the expression of SBSPON mRNA

NCBI chr 5:3,402,763...3,433,338
Ensembl chr 5:8,185,985...8,218,898

G

syndecan 2

affects expression

EXP

Omeprazole affects the expression of SDC2 mRNA

NCBI chr 7:66,012,405...66,125,101
Ensembl chr 7:66,108,853...66,126,294

G

succinate dehydrogenase complex subunit C

affects expression

EXP

Omeprazole affects the expression of SDHC mRNA

NCBI chr13:86,077,133...86,098,025
Ensembl chr13:86,077,134...86,098,044

G

succinate dehydrogenase complex subunit D

affects expression

EXP

Omeprazole affects the expression of SDHD mRNA

NCBI chr 8:59,841,090...59,850,641
Ensembl chr 8:59,841,090...59,850,641

G

selectin L

decreases expression

EXP

Omeprazole results in decreased expression of SELL protein

NCBI chr13:78,950,100...78,969,604
Ensembl chr13:78,950,015...78,969,600

G

serine incorporator 3

affects expression

EXP

Omeprazole affects the expression of SERINC3 mRNA

NCBI chr 3:172,721,208...172,749,853
Ensembl chr 3:172,721,321...172,740,765

G

serpin family A member 1

affects expression

EXP

Omeprazole affects the expression of SERPINA1 mRNA

NCBI chr 6:128,631,101...128,653,125
Ensembl chr 6:128,619,382...128,660,703

G

serpin family A member 10

affects expression

EXP

Omeprazole affects the expression of SERPINA10 mRNA

NCBI chr 6:128,520,894...128,529,332
Ensembl chr 6:128,520,896...128,529,332

G

serpin family A member 4

affects expression

EXP

Omeprazole affects the expression of SERPINA4 mRNA

NCBI chr 6:128,764,738...128,773,858
Ensembl chr 6:128,764,769...128,776,028

G

serpin family F member 2

affects expression

EXP

Omeprazole affects the expression of SERPINF2 mRNA

NCBI chr10:60,770,698...60,778,782
Ensembl chr10:60,770,698...60,778,996

G

serpin family G member 1

decreases expression

EXP

Omeprazole results in decreased expression of SERPING1 mRNA

NCBI chr 3:90,249,410...90,259,299
Ensembl chr 3:90,249,423...90,258,717

G

sideroflexin 1

affects expression

EXP

Omeprazole affects the expression of SFXN1 mRNA

NCBI chr17:10,491,315...10,527,793
Ensembl chr17:10,491,344...10,527,456

G

serine hydroxymethyltransferase 2

affects expression

EXP

Omeprazole affects the expression of SHMT2 mRNA

NCBI chr 7:65,244,247...65,249,580
Ensembl chr 7:65,244,247...65,249,567

G

solute carrier family 22 member 1

affects expression

EXP

Omeprazole affects the expression of SLC22A1 mRNA

NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436

G

solute carrier family 22 member 2

multiple interactions

ISO

Omeprazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 22 member 5

multiple interactions

EXP

Dithioerythritol inhibits the reaction [Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]]; Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]

NCBI chr10:38,509,072...38,536,240
Ensembl chr10:38,509,072...38,536,077

G

solute carrier family 22 member 8

multiple interactions

ISO

[Omeprazole results in decreased activity of SLC22A8 protein] which results in decreased uptake of Indican

NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588

G

solute carrier family 23 member 1

affects expression

EXP

Omeprazole affects the expression of SLC23A1 mRNA

NCBI chr18:27,490,549...27,504,563
Ensembl chr18:27,490,374...27,504,702

G

solute carrier family 25 member 13

affects expression

EXP

Omeprazole affects the expression of SLC25A13 mRNA

NCBI chr 4:34,179,224...34,361,912
Ensembl chr 4:35,145,721...35,328,360

G

solute carrier family 25 member 3

affects expression

EXP

Omeprazole affects the expression of SLC25A3 mRNA

NCBI chr 7:25,611,937...25,619,401
Ensembl chr 7:27,499,165...27,506,309

G

solute carrier family 27 member 2

affects expression

EXP

Omeprazole affects the expression of SLC27A2 mRNA

NCBI chr 3:134,258,101...134,295,581
Ensembl chr 3:134,258,101...134,295,581

G

solute carrier family 39 member 8

affects expression

EXP

Omeprazole affects the expression of SLC39A8 mRNA

NCBI chr 2:224,171,787...224,319,326
Ensembl chr 2:226,929,644...226,992,667

G

solute carrier family 40 member 1

decreases expression

ISO

Omeprazole results in decreased expression of SLC40A1 protein

NCBI chr 9:55,525,457...55,633,463
Ensembl chr 9:55,525,532...55,543,460

G

solute carrier family 46 member 1

affects expression

EXP

Omeprazole affects the expression of SLC46A1 mRNA

NCBI chr10:63,859,551...63,865,987
Ensembl chr10:63,859,504...63,866,869

G

solute carrier family 66 member 2

affects expression

EXP

Omeprazole affects the expression of SLC66A2 mRNA

NCBI chr18:73,702,472...73,739,678
Ensembl chr18:75,977,458...76,014,651

G

solute carrier family 6 member 6

affects expression

EXP

Omeprazole affects the expression of SLC6A6 mRNA

NCBI chr 4:125,752,340...125,826,033
Ensembl chr 4:125,752,372...125,826,032

G

solute carrier organic anion transporter family, member 1a1

affects expression

EXP

Omeprazole affects the expression of SLCO1A1 mRNA

NCBI chr 4:174,877,045...174,950,900
Ensembl chr 4:176,607,687...176,681,992

G

solute carrier organic anion transporter family, member 1a4

increases expression

ISO

Omeprazole results in increased expression of SLCO1A2 mRNA

NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:176,441,104...176,495,816

G

superoxide dismutase 1

multiple interactions

ISO

Omeprazole inhibits the reaction [Ethanol results in decreased activity of SOD1 protein]

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

signal peptide peptidase-like 2A

affects expression

EXP

Omeprazole affects the expression of SPPL2A mRNA

NCBI chr 3:114,149,337...114,193,408
Ensembl chr 3:134,605,750...134,646,752

G

spermidine synthase

affects expression

EXP

Omeprazole affects the expression of SRM mRNA

NCBI chr 5:164,309,002...164,312,203
Ensembl chr 5:164,308,991...164,332,705

G

SRP receptor subunit beta

affects expression

EXP

Omeprazole affects the expression of SRPRB mRNA

NCBI chr 8:112,647,577...112,661,524

G

SSX family member 2 interacting protein

affects expression

EXP

Omeprazole affects the expression of SSX2IP mRNA

NCBI chr 2:237,958,286...237,991,026
Ensembl chr 2:237,958,465...237,991,017

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

affects expression

EXP

Omeprazole affects the expression of ST3GAL6 mRNA

NCBI chr11:42,061,282...42,121,801
Ensembl chr11:55,530,248...55,598,720

G

ST6 beta-galactoside alpha-2,6-sialyltransferase 1

affects expression

EXP

Omeprazole affects the expression of ST6GAL1 mRNA

NCBI chr11:91,031,481...91,158,111
Ensembl chr11:91,032,450...91,040,415

G

succinate-CoA ligase GDP/ADP-forming subunit alpha

affects expression

EXP

Omeprazole affects the expression of SUCLG1 mRNA

NCBI chr 4:105,308,236...105,337,595
Ensembl chr 4:106,866,114...106,895,689

G

surfeit 4

affects expression

EXP

Omeprazole affects the expression of SURF4 mRNA

NCBI chr 3:30,646,435...30,659,641
Ensembl chr 3:30,638,299...30,661,390

G

synaptojanin 2 binding protein

affects expression

EXP

Omeprazole affects the expression of SYNJ2BP mRNA

NCBI chr 6:101,189,714...101,227,400
Ensembl chr 6:106,920,970...106,966,543

G

tachykinin receptor 1

multiple interactions

ISO

Omeprazole inhibits the reaction [Acids affects the localization of TACR1 protein]

NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:116,478,617...116,647,492

G

transforming growth factor, beta 1

increases expression

ISO

Omeprazole results in increased expression of TGFB1 protein

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

transforming growth factor, beta induced

affects expression

EXP

Omeprazole affects the expression of TGFBI mRNA

NCBI chr17:7,960,885...7,990,234
Ensembl chr17:7,960,516...7,990,471

G

threonine synthase-like 2

affects expression

EXP

Omeprazole affects the expression of THNSL2 mRNA

NCBI chr 4:103,112,974...103,132,122
Ensembl chr 4:104,670,925...104,691,959

G

translocase of inner mitochondrial membrane 21

affects expression

EXP

Omeprazole affects the expression of TIMM21 mRNA

NCBI chr18:78,314,900...78,319,362
Ensembl chr18:80,589,783...80,594,237

G

TIMP metallopeptidase inhibitor 2

multiple interactions

EXP

Omeprazole inhibits the reaction [Indomethacin results in increased expression of TIMP2 protein]

NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214

G

triokinase and FMN cyclase

affects expression

EXP

Omeprazole affects the expression of TKFC mRNA

NCBI chr 1:216,664,446...216,677,815
Ensembl chr 1:216,661,477...216,677,928

G

toll-like receptor 4

multiple interactions

EXP

Lipopolysaccharides inhibits the reaction [Omeprazole inhibits the reaction [Cisplatin results in increased expression of TLR4 protein]]; Omeprazole inhibits the reaction [Cisplatin results in increased expression of TLR4 protein]

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007

G

transmembrane BAX inhibitor motif containing 1

affects expression

EXP

Omeprazole affects the expression of TMBIM1 mRNA

NCBI chr 9:83,320,972...83,338,469
Ensembl chr 9:83,320,979...83,338,657

G

transmembrane BAX inhibitor motif containing 6

affects expression

EXP

Omeprazole affects the expression of TEGT mRNA

NCBI chr 7:132,405,217...132,422,492
Ensembl chr 7:132,386,134...132,422,492

G

transmembrane and coiled-coil domains 1

affects expression

EXP

Omeprazole affects the expression of TMCO1 mRNA

NCBI chr13:81,993,172...82,016,496
Ensembl chr13:81,993,097...82,017,201

G

transmembrane p24 trafficking protein 2

affects expression

EXP

Omeprazole affects the expression of TMED2 mRNA

NCBI chr12:37,713,522...37,722,606
Ensembl chr12:37,713,529...37,722,606

G

transmembrane p24 trafficking protein 7

affects expression

EXP

Omeprazole affects the expression of TMED7 mRNA

NCBI chr18:41,505,167...41,512,243
Ensembl chr18:41,478,539...41,512,243

G

transmembrane protein 123

affects expression

EXP

Omeprazole affects the expression of TMEM123 mRNA

NCBI chr 8:13,206,907...13,237,069
Ensembl chr 8:13,206,403...13,257,427

G

transmembrane protein 97

affects expression

EXP

Omeprazole affects the expression of TMEM97 mRNA

NCBI chr10:63,936,276...63,945,359
Ensembl chr10:63,936,271...63,945,818

G

tumor necrosis factor

multiple interactions

ISO
EXP

Omeprazole inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]; Omeprazole inhibits the reaction [Ethanol results in increased expression of TNF protein]
Omeprazole inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Omeprazole inhibits the reaction [Ethanol results in decreased expression of TNF protein]; Omeprazole inhibits the reaction [Ethanol results in increased expression of TNF protein]

PMID:19232345 PMID:25637687 PMID:26970604 PMID:30452898 PMID:32418911 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

thioredoxin 1

affects expression

EXP

Omeprazole affects the expression of TXN1 mRNA

NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307

G

thioredoxin-like 1

affects expression

EXP

Omeprazole affects the expression of TXNL1 mRNA

NCBI chr18:59,397,275...59,428,072
Ensembl chr18:59,398,535...59,435,518

G

tyrosinase

multiple interactions
decreases expression

ISO

Omeprazole affects the N-linked glycosylation of and results in increased degradation of TYR protein; Omeprazole inhibits the reaction [ATP7A protein results in increased activity of TYR protein]
Omeprazole results in decreased expression of TYR protein

NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:150,527,687...150,622,857

G

ubiquitin A-52 residue ribosomal protein fusion product 1

affects expression

EXP

Omeprazole affects the expression of UBA52 mRNA

NCBI chr16:18,952,583...18,954,780

G

ubiquitin-conjugating enzyme E2N

affects expression

EXP

Omeprazole affects the expression of UBE2N mRNA

NCBI chr 7:32,041,190...32,071,252

G

ubiquitin recognition factor in ER associated degradation 1

affects expression

EXP

Omeprazole affects the expression of UFD1 mRNA

NCBI chr11:95,665,971...95,689,423
Ensembl chr11:95,665,972...95,689,434

G

UDP glucuronosyltransferase family 1 member A1

increases expression
affects expression

ISO
EXP

Omeprazole results in increased expression of UGT1A1 mRNA
Omeprazole affects the expression of UGT1A1 mRNA

PMID:19118567 PMID:19483382 PMID:25626140

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases expression

ISO

Omeprazole results in increased expression of UGT1A2 mRNA; Omeprazole results in increased expression of UGT1A3 mRNA

NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glycosyltransferase 1 family, polypeptide A3

increases expression

ISO

Omeprazole results in increased expression of UGT1A5 mRNA

NCBI chr 9:88,780,328...88,808,465
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A5

increases expression

ISO

Omeprazole results in increased expression of UGT1A4 mRNA

NCBI chr 9:96,210,053...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A6

increases expression
multiple interactions

EXP
ISO

Omeprazole results in increased expression of UGT1A6 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of UGT1A6 mRNA

PMID:19118567 PMID:22687989

NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A9

increases expression

ISO

Omeprazole results in increased expression of UGT1A9 mRNA

NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase 2 family, polypeptide B1

increases expression

EXP

Omeprazole results in increased expression of UGT2B1 mRNA

NCBI chr14:21,378,882...21,390,631
Ensembl chr14:21,378,853...21,392,331

G

ubiquinol-cytochrome c reductase, complex III subunit XI

affects expression

EXP

Omeprazole affects the expression of UQCR11 mRNA

NCBI chr 7:9,955,717...9,960,432
Ensembl chr 7:9,955,764...9,959,047

G

vanin 1

affects expression

EXP

Omeprazole affects the expression of VNN1 mRNA

NCBI chr 1:23,356,324...23,366,629
Ensembl chr 1:23,356,330...23,366,629

G

WD repeat domain 26

affects expression

EXP

Omeprazole affects the expression of WDR26 mRNA

NCBI chr13:92,930,282...92,972,061
Ensembl chr13:95,462,020...95,503,738

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma

affects expression

EXP

Omeprazole affects the expression of YWHAG mRNA

NCBI chr12:26,381,106...26,409,466
Ensembl chr12:26,380,816...26,409,465

G

zinc finger DHHC-type palmitoyltransferase 23

affects expression

EXP

Omeprazole affects the expression of ZDHHC23 mRNA

NCBI chr11:56,718,702...56,735,063
Ensembl chr11:70,225,045...70,240,102

G

ZW10 interacting kinetochore protein

affects expression

EXP

Omeprazole affects the expression of ZWINT mRNA

NCBI chr20:15,502,559...15,953,701
Ensembl chr20:15,937,396...15,953,203

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20862
chemical entity	20860
atom	20860
nonmetal atom	20766
sulfur atom	18048
sulfur molecular entity	18048
organosulfur compound	17763
sulfoxide	6555
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole	412
(R)-omeprazole +	412
esomeprazole +	412
Path 2
Term	Annotations
CHEBI ontology	20862
subatomic particle	20860
composite particle	20860
hadron	20860
baryon	20860
nucleon	20860
atomic nucleus	20860
atom	20860
main group element atom	20781
p-block element atom	20781
carbon group element atom	20715
carbon atom	20710
organic molecular entity	20710
organic molecule	20654
organic cyclic compound	20404
organic heterocyclic compound	19388
organic heteropolycyclic compound	18651
organic heterobicyclic compound	17545
benzimidazoles	1225
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole	412
(R)-omeprazole +	412
esomeprazole +	412

paths to the root