CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: rabeprazole
Accession: CHEBI:8768
browse the term
Definition: A sulfoxide that has formula C18H21N3O3S.
Synonyms: exact_synonym: 2-({[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfinyl)-1H-benzimidazole
related_synonym: Clofezone; Formula=C18H21N3O3S; InChI=1S/C18H21N3O3S/c1-13-16(19-9-8-17(13)24-11-5-10-23-2)12-25(22)18-20-14-6-3-4-7-15(14)21-18/h3-4,6-9H,5,10-12H2,1-2H3,(H,20,21); InChIKey=YREYEVIYCVEVJK-UHFFFAOYSA-N; SMILES=COCCCOc1ccnc(CS(=O)c2nc3ccccc3[nH]2)c1C
xref: Beilstein:8159014; CAS:117976-89-3; DrugBank:DB01129; Drug_Central:2350; KEGG:C07864; KEGG:D08463; LINCS:LSM-5045
xref_mesh: MESH:D064750
xref: Wikipedia:Rabeprazole
cyclic_relationship: is_conjugate_acid_of CHEBI:49199
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C1qa
complement C1q A chain
decreases expression
EXP
Rabeprazole results in decreased expression of C1QA mRNA
CTD
PMID:25626140
NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
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C1qc
complement C1q C chain
decreases expression
EXP
Rabeprazole results in decreased expression of C1QC mRNA
CTD
PMID:25626140
NCBI chr 5:149,127,412...149,130,757
Ensembl chr 5:149,127,415...149,131,017
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C4bpa
complement component 4 binding protein, alpha
decreases expression
EXP
Rabeprazole results in decreased expression of C4BPA mRNA
CTD
PMID:25626140
NCBI chr13:42,075,715...42,111,205
Ensembl chr13:42,075,717...42,111,205
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C4bpb
complement component 4 binding protein, beta
decreases expression
EXP
Rabeprazole results in decreased expression of C4BPB mRNA
CTD
PMID:25626140
NCBI chr13:42,120,798...42,131,515
Ensembl chr13:42,120,798...42,131,817
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Cfi
complement factor I
decreases expression
EXP
Rabeprazole results in decreased expression of CFI mRNA
CTD
PMID:25626140
NCBI chr 2:218,389,079...218,430,565
Ensembl chr 2:218,387,990...218,430,561
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression decreases activity
ISO EXP
Rabeprazole results in increased expression of CYP1A1 mRNA; Rabeprazole results in increased expression of CYP1A1 protein Rabeprazole results in decreased activity of CYP1A1 protein
CTD
PMID:9041675 PMID:12623754 PMID:25626140 PMID:33814510
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases expression
ISO EXP
Rabeprazole results in increased expression of CYP1A2 mRNA
CTD
PMID:12623754 PMID:25626140
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases activity
ISO
Rabeprazole results in decreased activity of CYP1B1 protein
CTD
PMID:33814510
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
multiple interactions affects response to substance
ISO
CYP2C19 affects the susceptibility to [Tacrolimus co-treated with Rabeprazole] CYP2C19 gene affects the susceptibility to Rabeprazole
CTD
PMID:15903128 PMID:17377957
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
multiple interactions
ISO
CYP3A5 affects the susceptibility to [Tacrolimus co-treated with Rabeprazole]
CTD
PMID:17377957
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Hamp
hepcidin antimicrobial peptide
increases expression
ISO
Rabeprazole results in increased expression of HAMP mRNA
CTD
PMID:31669099
NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
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Pomc
proopiomelanocortin
increases expression
ISO
Rabeprazole results in increased expression of POMC protein
CTD
PMID:16524691
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
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Retsat
retinol saturase
increases expression
EXP
Rabeprazole results in increased expression of RETSAT mRNA
CTD
PMID:25626140
NCBI chr 4:104,653,306...104,662,069
Ensembl chr 4:104,653,155...104,668,310
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Serping1
serpin family G member 1
decreases expression
EXP
Rabeprazole results in decreased expression of SERPING1 mRNA
CTD
PMID:25626140
NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034
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Slc18a2
solute carrier family 18 member A2
multiple interactions
EXP
Rabeprazole promotes the reaction [SLC18A2 protein results in increased secretion of Histamine]
CTD
PMID:14642791
NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Rabeprazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Ugt1a1
UDP glucuronosyltransferase family 1 member A1
increases expression
EXP
Rabeprazole results in increased expression of UGT1A1 mRNA
CTD
PMID:25626140
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt2b1
UDP glucuronosyltransferase 2 family, polypeptide B1
increases expression
EXP
Rabeprazole results in increased expression of UGT2B1 mRNA
CTD
PMID:25626140
NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
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