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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:rabeprazole
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Accession:CHEBI:8768 term browser browse the term
Definition:A sulfoxide that has formula C18H21N3O3S.
Synonyms:exact_synonym: 2-({[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfinyl)-1H-benzimidazole
 related_synonym: Clofezone;   Formula=C18H21N3O3S;   InChI=1S/C18H21N3O3S/c1-13-16(19-9-8-17(13)24-11-5-10-23-2)12-25(22)18-20-14-6-3-4-7-15(14)21-18/h3-4,6-9H,5,10-12H2,1-2H3,(H,20,21);   InChIKey=YREYEVIYCVEVJK-UHFFFAOYSA-N;   SMILES=COCCCOc1ccnc(CS(=O)c2nc3ccccc3[nH]2)c1C
 xref: Beilstein:8159014;   CAS:117976-89-3;   DrugBank:DB01129;   Drug_Central:2350;   KEGG:C07864;   KEGG:D08463;   LINCS:LSM-5045
 xref_mesh: MESH:D064750
 xref: Wikipedia:Rabeprazole
 cyclic_relationship: is_conjugate_acid_of CHEBI:49199


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rabeprazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qa complement C1q A chain decreases expression EXP Rabeprazole results in decreased expression of C1QA mRNA CTD PMID:25626140 NCBI chr 5:155,261,254...155,264,101
Ensembl chr 5:155,261,250...155,264,143
JBrowse link
G C1qc complement C1q C chain decreases expression EXP Rabeprazole results in decreased expression of C1QC mRNA CTD PMID:25626140 NCBI chr 5:155,255,013...155,258,631
Ensembl chr 5:155,255,005...155,258,392
JBrowse link
G C4bpa complement component 4 binding protein, alpha decreases expression EXP Rabeprazole results in decreased expression of C4BPA mRNA CTD PMID:25626140 NCBI chr13:47,342,090...47,377,580
Ensembl chr13:47,342,079...47,377,703
JBrowse link
G C4bpb complement component 4 binding protein, beta decreases expression EXP Rabeprazole results in decreased expression of C4BPB mRNA CTD PMID:25626140 NCBI chr13:47,387,173...47,398,115
Ensembl chr13:47,387,173...47,397,890
JBrowse link
G Cfi complement factor I decreases expression EXP Rabeprazole results in decreased expression of CFI mRNA CTD PMID:25626140 NCBI chr 2:235,264,149...235,305,779
Ensembl chr 2:235,264,219...235,305,781
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO
EXP
Rabeprazole results in increased expression of CYP1A1 mRNA; Rabeprazole results in increased expression of CYP1A1 protein CTD PMID:9041675 PMID:12623754 PMID:25626140 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO
EXP
Rabeprazole results in increased expression of CYP1A2 mRNA CTD PMID:12623754 PMID:25626140 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
affects response to substance
ISO CYP2C19 affects the susceptibility to [Tacrolimus co-treated with Rabeprazole]
CYP2C19 gene affects the susceptibility to Rabeprazole
CTD PMID:15903128 PMID:17377957 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO CYP3A5 affects the susceptibility to [Tacrolimus co-treated with Rabeprazole] CTD PMID:17377957 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Hamp hepcidin antimicrobial peptide increases expression ISO Rabeprazole results in increased expression of HAMP mRNA CTD PMID:31669099 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Pomc proopiomelanocortin increases expression ISO Rabeprazole results in increased expression of POMC protein CTD PMID:16524691 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Retsat retinol saturase increases expression EXP Rabeprazole results in increased expression of RETSAT mRNA CTD PMID:25626140 NCBI chr 4:100,465,365...100,474,128
Ensembl chr 4:100,465,170...100,474,301
JBrowse link
G Serping1 serpin family G member 1 decreases expression EXP Rabeprazole results in decreased expression of SERPING1 mRNA CTD PMID:25626140 NCBI chr 3:72,161,230...72,171,109
Ensembl chr 3:72,161,189...72,171,078
JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions EXP Rabeprazole promotes the reaction [SLC18A2 protein results in increased secretion of Histamine] CTD PMID:14642791 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Rabeprazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression EXP Rabeprazole results in increased expression of UGT1A1 mRNA CTD PMID:25626140 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases expression EXP Rabeprazole results in increased expression of UGT2B1 mRNA CTD PMID:25626140 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link

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  CHEBI ontology 19773
    role 19719
      application 19403
        pharmaceutical 19303
          drug 19303
            anti-ulcer drug 788
              rabeprazole 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19772
      composite particle 19772
        hadron 19772
          baryon 19772
            nucleon 19772
              atomic nucleus 19772
                atom 19772
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19579
                        carbon atom 19569
                          organic molecular entity 19569
                            organic molecule 19502
                              organic cyclic compound 19329
                                organic heterocyclic compound 18544
                                  organic heteropolycyclic compound 18035
                                    organic heterobicyclic compound 16783
                                      benzimidazoles 864
                                        rabeprazole 17
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