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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pantoprazole
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Accession:CHEBI:7915 term browser browse the term
Definition:A member of the class of benzimidazoles that is 1H-benzimidazole substituted by a difluoromethoxy group at position 5 and a [(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl group at position 2.
Synonyms:exact_synonym: 5-(difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole
 related_synonym: Formula=C16H15F2N3O4S;   InChI=1S/C16H15F2N3O4S/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16/h3-7,15H,8H2,1-2H3,(H,20,21);   InChIKey=IQPSEEYGBUAQFF-UHFFFAOYSA-N;   SMILES=COc1ccnc(CS(=O)c2nc3cc(OC(F)F)ccc3[nH]2)c1OC;   pantoprazol;   pantoprazolum
 xref: Beilstein:5361474;   CAS:102625-70-7;   DrugBank:DB00213;   Drug_Central:2054;   HMDB:HMDB0005017;   KEGG:C11806;   KEGG:D05353;   LINCS:LSM-1390
 xref_mesh: MESH:C064276
 xref: PMID:11110229;   PMID:11240974;   Patent:EP166287;   Patent:US4758579;   Reaxys:5361474;   VSDB:2958;   Wikipedia:Pantoprazole
 cyclic_relationship: is_conjugate_acid_of CHEBI:50358

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pantoprazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO pantoprazole results in increased expression of ABCA1 mRNA CTD PMID:20060385 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO pantoprazole promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide] CTD PMID:12702717 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO pantoprazole inhibits the reaction [ABCG2 protein affects the transport of 7-hydroxymethotrexate] CTD PMID:17032904 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621 		JBrowse link
G C1qa complement C1q A chain decreases expression EXP pantoprazole results in decreased expression of C1QA mRNA CTD PMID:25626140 NCBI chr 5:155,261,254...155,264,101
Ensembl chr 5:155,261,250...155,264,143 		JBrowse link
G C1qc complement C1q C chain decreases expression EXP pantoprazole results in decreased expression of C1QC mRNA CTD PMID:25626140 NCBI chr 5:155,255,013...155,258,631
Ensembl chr 5:155,255,005...155,258,392 		JBrowse link
G C4bpa complement component 4 binding protein, alpha decreases expression EXP pantoprazole results in decreased expression of C4BPA mRNA CTD PMID:25626140 NCBI chr13:47,342,090...47,377,580
Ensembl chr13:47,342,079...47,377,703 		JBrowse link
G C4bpb complement component 4 binding protein, beta decreases expression EXP pantoprazole results in decreased expression of C4BPB mRNA CTD PMID:25626140 NCBI chr13:47,387,173...47,398,115
Ensembl chr13:47,387,173...47,397,890 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP pantoprazole inhibits the reaction [Indomethacin results in increased activity of CASP3 protein] CTD PMID:18853145 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cfi complement factor I decreases expression EXP pantoprazole results in decreased expression of CFI mRNA CTD PMID:25626140 NCBI chr 2:235,264,149...235,305,779
Ensembl chr 2:235,264,219...235,305,781 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
decreases expression		 EXP pantoprazole results in increased expression of CYP1A1 protein
pantoprazole results in decreased expression of CYP1A1 mRNA		 CTD PMID:9152597 PMID:25626140 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP pantoprazole results in increased expression of CYP1A2 mRNA; pantoprazole results in increased expression of CYP1A2 protein CTD PMID:9152597 PMID:25626140 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP pantoprazole results in increased expression of CYP2B1 protein CTD PMID:9152597 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP pantoprazole results in increased expression of CYP2B2 protein CTD PMID:9152597 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 affects response to substance
multiple interactions
decreases activity
increases metabolic processing		 ISO CYP2C19 gene polymorphism affects the susceptibility to pantoprazole
pantoprazole inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]
pantoprazole results in decreased activity of CYP2C19 protein
CYP2C19 protein results in increased metabolism of pantoprazole		 CTD PMID:8930576 PMID:15258107 PMID:20223877 PMID:21795468 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Hamp hepcidin antimicrobial peptide increases expression ISO Pantoprazole results in increased expression of HAMP mRNA CTD PMID:31669099 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP pantoprazole inhibits the reaction [Indomethacin results in increased expression of MPO protein]; pantoprazole inhibits the reaction [Ketoprofen results in increased expression of MPO protein]; pantoprazole inhibits the reaction [Piroxicam results in increased expression of MPO protein] CTD PMID:16080005 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [pantoprazole co-treated with Indomethacin] promotes the reaction [Acetic Acid results in increased expression of PCNA protein]; pantoprazole promotes the reaction [Acetic Acid results in increased expression of PCNA protein] CTD PMID:18853145 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570 		JBrowse link
G Retsat retinol saturase increases expression EXP pantoprazole results in increased expression of RETSAT mRNA CTD PMID:25626140 NCBI chr 4:100,465,365...100,474,128
Ensembl chr 4:100,465,170...100,474,301 		JBrowse link
G Serping1 serpin family G member 1 decreases expression EXP pantoprazole results in decreased expression of SERPING1 mRNA CTD PMID:25626140 NCBI chr 3:72,161,230...72,171,109
Ensembl chr 3:72,161,189...72,171,078 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression EXP pantoprazole results in increased expression of UGT1A1 mRNA CTD PMID:25626140 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases expression EXP pantoprazole results in increased expression of UGT2B1 mRNA CTD PMID:25626140 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19781
    role 19726
      biological role 19726
        xenobiotic 18398
          pantoprazole 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19781
    subatomic particle 19779
      composite particle 19779
        hadron 19779
          baryon 19779
            nucleon 19779
              atomic nucleus 19779
                atom 19779
                  main group element atom 19669
                    p-block element atom 19669
                      carbon group element atom 19588
                        carbon atom 19578
                          organic molecular entity 19578
                            organic molecule 19510
                              organic cyclic compound 19337
                                organic heterocyclic compound 18550
                                  organic heteropolycyclic compound 18038
                                    organic heterobicyclic compound 16778
                                      benzimidazoles 865
                                        pantoprazole 21
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