CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: pantoprazole
Accession: CHEBI:7915
browse the term
Definition: A member of the class of benzimidazoles that is 1H-benzimidazole substituted by a difluoromethoxy group at position 5 and a [(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl group at position 2.
Synonyms: exact_synonym: 5-(difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole
related_synonym: Formula=C16H15F2N3O4S; InChI=1S/C16H15F2N3O4S/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16/h3-7,15H,8H2,1-2H3,(H,20,21); InChIKey=IQPSEEYGBUAQFF-UHFFFAOYSA-N; SMILES=COc1ccnc(CS(=O)c2nc3cc(OC(F)F)ccc3[nH]2)c1OC; pantoprazol; pantoprazolum
xref: Beilstein:5361474; CAS:102625-70-7; DrugBank:DB00213; Drug_Central:2054; HMDB:HMDB0005017; KEGG:C11806; KEGG:D05353; LINCS:LSM-1390
xref_mesh: MESH:C064276
xref: PMID:11110229; PMID:11240974; Patent:EP166287; Patent:US4758579; Reaxys:5361474; VSDB:2958; Wikipedia:Pantoprazole
cyclic_relationship: is_conjugate_acid_of CHEBI:50358
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Abca1
ATP binding cassette subfamily A member 1
increases expression
ISO
pantoprazole results in increased expression of ABCA1 mRNA
CTD
PMID:20060385
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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Abcc2
ATP binding cassette subfamily C member 2
multiple interactions
ISO
pantoprazole promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]
CTD
PMID:12702717
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Abcg2
ATP binding cassette subfamily G member 2
multiple interactions
ISO
pantoprazole inhibits the reaction [ABCG2 protein affects the transport of 7-hydroxymethotrexate]
CTD
PMID:17032904
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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C1qa
complement C1q A chain
decreases expression
EXP
pantoprazole results in decreased expression of C1QA mRNA
CTD
PMID:25626140
NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
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C1qc
complement C1q C chain
decreases expression
EXP
pantoprazole results in decreased expression of C1QC mRNA
CTD
PMID:25626140
NCBI chr 5:149,127,424...149,130,732
Ensembl chr 5:149,127,415...149,131,017
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C4bpa
complement component 4 binding protein, alpha
decreases expression
EXP
pantoprazole results in decreased expression of C4BPA mRNA
CTD
PMID:25626140
NCBI chr13:42,075,715...42,111,205
Ensembl chr13:42,075,717...42,111,205
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C4bpb
complement component 4 binding protein, beta
decreases expression
EXP
pantoprazole results in decreased expression of C4BPB mRNA
CTD
PMID:25626140
NCBI chr13:42,120,798...42,131,515
Ensembl chr13:42,120,798...42,131,817
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Casp3
caspase 3
multiple interactions
EXP
pantoprazole inhibits the reaction [Indomethacin results in increased activity of CASP3 protein]
CTD
PMID:18853145
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cfi
complement factor I
decreases expression
EXP
pantoprazole results in decreased expression of CFI mRNA
CTD
PMID:25626140
NCBI chr 2:218,389,079...218,430,565
Ensembl chr 2:218,387,990...218,430,561
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression decreases expression
EXP
pantoprazole results in increased expression of CYP1A1 protein pantoprazole results in decreased expression of CYP1A1 mRNA
CTD
PMID:9152597 PMID:25626140
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases expression
EXP
pantoprazole results in increased expression of CYP1A2 mRNA; pantoprazole results in increased expression of CYP1A2 protein
CTD
PMID:9152597 PMID:25626140
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
increases expression
EXP
pantoprazole results in increased expression of CYP2B1 protein
CTD
PMID:9152597
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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Cyp2b2
cytochrome P450, family 2, subfamily b, polypeptide 2
increases expression
EXP
pantoprazole results in increased expression of CYP2B2 protein
CTD
PMID:9152597
NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
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Cyp2c6v1
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1
affects response to substance multiple interactions decreases activity increases metabolic processing
ISO
CYP2C19 gene polymorphism affects the susceptibility to pantoprazole pantoprazole inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin] pantoprazole results in decreased activity of CYP2C19 protein CYP2C19 protein results in increased metabolism of pantoprazole
CTD
PMID:8930576 PMID:15258107 PMID:20223877 PMID:21795468
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases expression multiple interactions increases metabolic processing
ISO
Pantoprazole results in increased expression of CYP3A4 protein Pantoprazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] CYP3A4 protein results in increased metabolism of Pantoprazole
CTD
PMID:8930576 PMID:9744552 PMID:15258107
NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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Hamp
hepcidin antimicrobial peptide
increases expression
ISO
Pantoprazole results in increased expression of HAMP mRNA
CTD
PMID:31669099
NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
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Jak2
Janus kinase 2
multiple interactions
ISO
pantoprazole decreases expression of JAK2 mRNA and decreases phosphorylation of JAK2 protein in gastrocnemius
RGD
PMID:28489606
RGD:127285673
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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Mpo
myeloperoxidase
multiple interactions
EXP
pantoprazole inhibits the reaction [Indomethacin results in increased expression of MPO protein]; pantoprazole inhibits the reaction [Ketoprofen results in increased expression of MPO protein]; pantoprazole inhibits the reaction [Piroxicam results in increased expression of MPO protein]
CTD
PMID:16080005
NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Pcna
proliferating cell nuclear antigen
multiple interactions
EXP
[pantoprazole co-treated with Indomethacin] promotes the reaction [Acetic Acid results in increased expression of PCNA protein]; pantoprazole promotes the reaction [Acetic Acid results in increased expression of PCNA protein]
CTD
PMID:18853145
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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Retsat
retinol saturase
increases expression
EXP
pantoprazole results in increased expression of RETSAT mRNA
CTD
PMID:25626140
NCBI chr 4:104,653,306...104,662,069
Ensembl chr 4:104,653,155...104,668,310
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Serping1
serpin family G member 1
decreases expression
EXP
pantoprazole results in decreased expression of SERPING1 mRNA
CTD
PMID:25626140
NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034
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Ugt1a1
UDP glucuronosyltransferase family 1 member A1
increases expression
EXP
pantoprazole results in increased expression of UGT1A1 mRNA
CTD
PMID:25626140
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt2b17
UDP glucuronosyltransferase family 2 member B17
increases expression
EXP
pantoprazole results in increased expression of UGT2B1 mRNA
CTD
PMID:25626140
NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
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