Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer VCMap
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pantoprazole
go back to main search page
Accession:CHEBI:7915 term browser browse the term
Definition:A member of the class of benzimidazoles that is 1H-benzimidazole substituted by a difluoromethoxy group at position 5 and a [(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl group at position 2.
Synonyms:exact_synonym: 5-(difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole
 related_synonym: Formula=C16H15F2N3O4S;   InChI=1S/C16H15F2N3O4S/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16/h3-7,15H,8H2,1-2H3,(H,20,21);   InChIKey=IQPSEEYGBUAQFF-UHFFFAOYSA-N;   SMILES=COc1ccnc(CS(=O)c2nc3cc(OC(F)F)ccc3[nH]2)c1OC;   pantoprazol;   pantoprazolum
 xref: Beilstein:5361474;   CAS:102625-70-7;   DrugBank:DB00213;   Drug_Central:2054;   HMDB:HMDB0005017;   KEGG:C11806;   KEGG:D05353;   LINCS:LSM-1390
 xref_mesh: MESH:C064276
 xref: PMID:11110229;   PMID:11240974;   Patent:EP166287;   Patent:US4758579;   Reaxys:5361474;   VSDB:2958;   Wikipedia:Pantoprazole
 cyclic_relationship: is_conjugate_acid_of CHEBI:50358


show annotations for term's descendants           Sort by:
 
pantoprazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO pantoprazole results in increased expression of ABCA1 mRNA CTD PMID:20060385 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO pantoprazole promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide] CTD PMID:12702717 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO pantoprazole inhibits the reaction [ABCG2 protein affects the transport of 7-hydroxymethotrexate] CTD PMID:17032904 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G C1qa complement C1q A chain decreases expression EXP pantoprazole results in decreased expression of C1QA mRNA CTD PMID:25626140 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534 		JBrowse link
G C1qc complement C1q C chain decreases expression EXP pantoprazole results in decreased expression of C1QC mRNA CTD PMID:25626140 NCBI chr 5:149,127,424...149,130,732
Ensembl chr 5:149,127,415...149,131,017 		JBrowse link
G C4bpa complement component 4 binding protein, alpha decreases expression EXP pantoprazole results in decreased expression of C4BPA mRNA CTD PMID:25626140 NCBI chr13:42,075,715...42,111,205
Ensembl chr13:42,075,717...42,111,205 		JBrowse link
G C4bpb complement component 4 binding protein, beta decreases expression EXP pantoprazole results in decreased expression of C4BPB mRNA CTD PMID:25626140 NCBI chr13:42,120,798...42,131,515
Ensembl chr13:42,120,798...42,131,817 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP pantoprazole inhibits the reaction [Indomethacin results in increased activity of CASP3 protein] CTD PMID:18853145 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cfi complement factor I decreases expression EXP pantoprazole results in decreased expression of CFI mRNA CTD PMID:25626140 NCBI chr 2:218,389,079...218,430,565
Ensembl chr 2:218,387,990...218,430,561 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
decreases expression		 EXP pantoprazole results in increased expression of CYP1A1 protein
pantoprazole results in decreased expression of CYP1A1 mRNA		 CTD PMID:9152597 PMID:25626140 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP pantoprazole results in increased expression of CYP1A2 mRNA; pantoprazole results in increased expression of CYP1A2 protein CTD PMID:9152597 PMID:25626140 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP pantoprazole results in increased expression of CYP2B1 protein CTD PMID:9152597 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP pantoprazole results in increased expression of CYP2B2 protein CTD PMID:9152597 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 affects response to substance
multiple interactions
decreases activity
increases metabolic processing		 ISO CYP2C19 gene polymorphism affects the susceptibility to pantoprazole
pantoprazole inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]
pantoprazole results in decreased activity of CYP2C19 protein
CYP2C19 protein results in increased metabolism of pantoprazole		 CTD PMID:8930576 PMID:15258107 PMID:20223877 PMID:21795468 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions
increases metabolic processing		 ISO Pantoprazole results in increased expression of CYP3A4 protein
Pantoprazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]
CYP3A4 protein results in increased metabolism of Pantoprazole		 CTD PMID:8930576 PMID:9744552 PMID:15258107 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Hamp hepcidin antimicrobial peptide increases expression ISO Pantoprazole results in increased expression of HAMP mRNA CTD PMID:31669099 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO pantoprazole decreases expression of JAK2 mRNA and decreases phosphorylation of JAK2 protein in gastrocnemius RGD PMID:28489606 RGD:127285673 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP pantoprazole inhibits the reaction [Indomethacin results in increased expression of MPO protein]; pantoprazole inhibits the reaction [Ketoprofen results in increased expression of MPO protein]; pantoprazole inhibits the reaction [Piroxicam results in increased expression of MPO protein] CTD PMID:16080005 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [pantoprazole co-treated with Indomethacin] promotes the reaction [Acetic Acid results in increased expression of PCNA protein]; pantoprazole promotes the reaction [Acetic Acid results in increased expression of PCNA protein] CTD PMID:18853145 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Retsat retinol saturase increases expression EXP pantoprazole results in increased expression of RETSAT mRNA CTD PMID:25626140 NCBI chr 4:104,653,306...104,662,069
Ensembl chr 4:104,653,155...104,668,310 		JBrowse link
G Serping1 serpin family G member 1 decreases expression EXP pantoprazole results in decreased expression of SERPING1 mRNA CTD PMID:25626140 NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression EXP pantoprazole results in increased expression of UGT1A1 mRNA CTD PMID:25626140 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases expression EXP pantoprazole results in increased expression of UGT2B1 mRNA CTD PMID:25626140 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      biological role 20007
        xenobiotic 18664
          pantoprazole 23
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic molecule 19822
                              organic cyclic compound 19575
                                organic heterocyclic compound 18798
                                  organic heteropolycyclic compound 18272
                                    organic heterobicyclic compound 17159
                                      benzimidazoles 1146
                                        pantoprazole 23
paths to the root