|
G |
Abca1 |
ATP binding cassette subfamily A member 1 |
increases expression |
ISO |
pantoprazole results in increased expression of ABCA1 mRNA |
CTD |
PMID:20060385 |
|
NCBI chr 5:72,473,676...72,596,563
|
|
G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions |
ISO |
pantoprazole promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide] |
CTD |
PMID:12702717 |
|
NCBI chr 1:252,613,875...252,672,459
|
|
G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
multiple interactions |
ISO |
pantoprazole inhibits the reaction [ABCG2 protein affects the transport of 7-hydroxymethotrexate] |
CTD |
PMID:17032904 |
|
NCBI chr 4:89,006,056...89,132,915
|
|
G |
C1qa |
complement C1q A chain |
decreases expression |
EXP |
pantoprazole results in decreased expression of C1QA mRNA |
CTD |
PMID:25626140 |
|
NCBI chr 5:154,417,086...154,419,933
|
|
G |
C1qc |
complement C1q C chain |
decreases expression |
EXP |
pantoprazole results in decreased expression of C1QC mRNA |
CTD |
PMID:25626140 |
|
NCBI chr 5:154,410,845...154,414,208
|
|
G |
C4bpa |
complement component 4 binding protein, alpha |
decreases expression |
EXP |
pantoprazole results in decreased expression of C4BPA mRNA |
CTD |
PMID:25626140 |
|
NCBI chr13:42,075,715...42,111,205
|
|
G |
C4bpb |
complement component 4 binding protein, beta |
decreases expression |
EXP |
pantoprazole results in decreased expression of C4BPB mRNA |
CTD |
PMID:25626140 |
|
NCBI chr13:42,120,798...42,131,515
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
EXP |
pantoprazole inhibits the reaction [Indomethacin results in increased activity of CASP3 protein] |
CTD |
PMID:18853145 |
|
NCBI chr16:52,395,539...52,413,794
|
|
G |
Cfi |
complement factor I |
decreases expression |
EXP |
pantoprazole results in decreased expression of CFI mRNA |
CTD |
PMID:25626140 |
|
NCBI chr 2:218,389,079...218,430,565
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression decreases expression |
EXP |
pantoprazole results in increased expression of CYP1A1 protein pantoprazole results in decreased expression of CYP1A1 mRNA |
CTD |
PMID:9152597 PMID:25626140 |
|
NCBI chr 8:66,991,940...66,998,014
|
|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression |
EXP |
pantoprazole results in increased expression of CYP1A2 mRNA; pantoprazole results in increased expression of CYP1A2 protein |
CTD |
PMID:9152597 PMID:25626140 |
|
NCBI chr 8:66,971,261...66,978,149
|
|
G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
increases expression |
EXP |
pantoprazole results in increased expression of CYP2B1 protein |
CTD |
PMID:9152597 |
|
NCBI chr 1:90,646,098...90,669,762
|
|
G |
Cyp2b2 |
cytochrome P450, family 2, subfamily b, polypeptide 2 |
increases expression |
EXP |
pantoprazole results in increased expression of CYP2B2 protein |
CTD |
PMID:9152597 |
|
NCBI chr 1:90,722,243...90,736,272
|
|
G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
affects response to substance increases metabolic processing decreases activity multiple interactions |
ISO |
CYP2C19 gene polymorphism affects the susceptibility to pantoprazole CYP2C19 protein results in increased metabolism of pantoprazole pantoprazole results in decreased activity of CYP2C19 protein pantoprazole inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin] |
CTD |
PMID:8930576 PMID:15258107 PMID:20223877 PMID:21795468 |
|
NCBI chr 1:247,879,058...247,916,804
|
|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
ISO |
Pantoprazole results in increased expression of and results in increased activity of CYP2E1 protein |
CTD |
PMID:36243147 |
|
NCBI chr 1:205,269,967...205,280,365
|
|
G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases expression increases metabolic processing multiple interactions |
ISO |
Pantoprazole results in increased expression of CYP3A4 protein CYP3A4 protein results in increased metabolism of Pantoprazole Pantoprazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] |
CTD |
PMID:8930576 PMID:9744552 PMID:15258107 |
|
NCBI chr12:14,321,771...14,343,886
|
|
G |
Hamp |
hepcidin antimicrobial peptide |
increases expression |
ISO |
Pantoprazole results in increased expression of HAMP mRNA |
CTD |
PMID:31669099 |
|
NCBI chr 1:95,298,332...95,300,271
|
|
G |
Jak2 |
Janus kinase 2 |
multiple interactions |
ISO |
pantoprazole decreases expression of JAK2 mRNA and decreases phosphorylation of JAK2 protein in gastrocnemius |
RGD |
PMID:28489606 |
RGD:127285673 |
NCBI chr 1:236,408,905...236,468,769
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
pantoprazole inhibits the reaction [Indomethacin results in increased expression of MPO protein]; pantoprazole inhibits the reaction [Ketoprofen results in increased expression of MPO protein]; pantoprazole inhibits the reaction [Piroxicam results in increased expression of MPO protein] |
CTD |
PMID:16080005 |
|
NCBI chr10:73,092,124...73,102,057
|
|
G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
EXP |
[pantoprazole co-treated with Indomethacin] promotes the reaction [Acetic Acid results in increased expression of PCNA protein]; pantoprazole promotes the reaction [Acetic Acid results in increased expression of PCNA protein] |
CTD |
PMID:18853145 |
|
NCBI chr 3:139,951,948...139,955,820
|
|
G |
Retsat |
retinol saturase |
increases expression |
EXP |
pantoprazole results in increased expression of RETSAT mRNA |
CTD |
PMID:25626140 |
|
NCBI chr 4:104,653,306...104,662,069
|
|
G |
Serping1 |
serpin family G member 1 |
decreases expression |
EXP |
pantoprazole results in decreased expression of SERPING1 mRNA |
CTD |
PMID:25626140 |
|
NCBI chr 3:90,249,410...90,259,299
|
|
G |
Slc22a8 |
solute carrier family 22 member 8 |
multiple interactions |
ISO |
[Pantoprazole results in decreased activity of SLC22A8 protein] which results in decreased uptake of Indican |
CTD |
PMID:36243147 |
|
NCBI chr 1:205,496,331...205,516,378
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
increases expression |
ISO |
Pantoprazole results in increased expression of TGFB1 protein |
CTD |
PMID:36243147 |
|
NCBI chr 1:90,324,312...90,340,627
|
|
G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases expression |
EXP |
pantoprazole results in increased expression of UGT1A1 mRNA |
CTD |
PMID:25626140 |
|
NCBI chr 9:96,249,143...96,256,264
|
|
G |
Ugt2b1 |
UDP glucuronosyltransferase 2 family, polypeptide B1 |
increases expression |
EXP |
pantoprazole results in increased expression of UGT2B1 mRNA |
CTD |
PMID:25626140 |
|
NCBI chr14:21,378,882...21,390,631
|
|