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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:SB 203580
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Accession:CHEBI:90705 term browser browse the term
Definition:A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.
Synonyms:exact_synonym: 4-{4-(4-fluorophenyl)-2-[4-(methanesulfinyl)phenyl]-1H-imidazol-5-yl}pyridine
 related_synonym: 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole;   Formula=C21H16FN3OS;   InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25);   InChIKey=CDMGBJANTYXAIV-UHFFFAOYSA-N;   SB203580;   SMILES=S(C=1C=CC(C2=NC(C=3C=CN=CC3)=C(N2)C4=CC=C(C=C4)F)=CC1)(C)=O
 xref: CAS:152121-47-6;   LINCS:LSM-1168
 xref_mesh: MESH:C093642
 xref: PMID:11457647;   PMID:24563432;   PMID:25172309;   PMID:25242011;   PMID:25366607;   PMID:25465717;   PMID:25496832;   PMID:25500336;   PMID:25593217;   PMID:25655298;   PMID:25676262;   PMID:25724654;   PMID:25727011;   PMID:25744405;   PMID:25924425;   PMID:26277520;   PMID:26350014;   PMID:26423029;   PMID:26537343;   Reaxys:8078222


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SB 203580 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions ISO SB 203580 inhibits the reaction [Quercetin results in increased expression of ABCA1 mRNA]; SB 203580 inhibits the reaction [Quercetin results in increased expression of ABCA1 protein] CTD PMID:22711909 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO SB 203580 inhibits the reaction [Mercuric Chloride results in increased expression of and affects the localization of ABCC1 protein] CTD PMID:15585369 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO SB 203580 inhibits the reaction [Anisomycin results in increased expression of ABCC3 mRNA]; SB 203580 inhibits the reaction [Clotrimazole results in increased expression of ABCC3 mRNA] CTD PMID:27507784 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Ace2 angiotensin I converting enzyme 2 multiple interactions EXP SB 203580 inhibits the reaction [2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid inhibits the reaction [ACE2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]]; SB 203580 inhibits the reaction [2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid inhibits the reaction [ACE2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]]; SB 203580 inhibits the reaction [7-Ala-angiotensin (1-7) inhibits the reaction [ACE2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]]; SB 203580 inhibits the reaction [7-Ala-angiotensin (1-7) inhibits the reaction [ACE2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]] CTD PMID:27302421 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression
ISO SB 203580 inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
SB 203580 results in decreased expression of ACTA2 mRNA
CTD PMID:11591817 PMID:21712382 PMID:28694203 PMID:29673704 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
increases secretion
increases expression
EXP
ISO
SB 203580 inhibits the reaction [Ethanol results in decreased secretion of ADIPOQ protein]
SB 203580 inhibits the reaction [ADIPOQ protein results in increased expression of CXCL1 protein]; SB 203580 inhibits the reaction [ADIPOQ protein results in increased expression of CXCL8 protein]
SB 203580 results in increased secretion of ADIPOQ protein
SB 203580 results in increased expression of ADIPOQ mRNA
CTD PMID:24412557 PMID:28176455 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Adm adrenomedullin multiple interactions
increases secretion
EXP SB 203580 inhibits the reaction [diphenylarsinic acid results in increased secretion of ADM protein]
SB 203580 results in increased secretion of ADM protein
CTD PMID:28087833 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP SB 203580 inhibits the reaction [Vitamin A results in increased expression of AGER protein] CTD PMID:21807062 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Ago2 argonaute RISC catalytic component 2 multiple interactions ISO SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased localization of AGO2 protein] CTD PMID:18476811 NCBI chr 7:105,018,202...105,105,120
Ensembl chr 7:105,029,120...105,104,974
JBrowse link
G Agt angiotensinogen multiple interactions
decreases response to substance
ISO
EXP
SB 203580 inhibits the reaction [AGT protein modified form results in decreased susceptibility to Acetylcholine]; SB 203580 inhibits the reaction [AGT protein modified form results in increased expression of ARG1 protein]; SB 203580 inhibits the reaction [AGT protein modified form results in increased expression of ARG2 protein]
SB 203580 inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; SB 203580 inhibits the reaction [AGT protein modified form results in increased activity of GATA4 protein]; SB 203580 inhibits the reaction [AGT protein modified form results in increased expression of FGF2 mRNA]; SB 203580 inhibits the reaction [AGT protein modified form results in increased expression of FGF2 protein]; SB 203580 inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]; SB 203580 inhibits the reaction [AGT protein results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [AGT protein results in increased expression of REG3G mRNA]; SB 203580 inhibits the reaction [AGT protein results in increased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [Glucose results in increased expression of AGT mRNA]; SB 203580 inhibits the reaction [Glucose results in increased expression of AGT protein]
SB 203580 results in decreased susceptibility to AGT protein modified form
CTD PMID:12130563 PMID:17485602 PMID:19145780 PMID:21108934 PMID:21289285 More... NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity
ISO
EXP
[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] results in decreased susceptibility to [SB 203580 results in increased expression of CYP1A1]; AHR protein affects the susceptibility to [SB 203580 results in increased expression of CYP1A1]
SB 203580 results in increased activity of AHR protein
[SB 203580 binds to and results in increased activity of AHR protein] which results in increased susceptibility to sunitinib
SB 203580 affects the localization of and affects the activity of AHR protein
CTD PMID:15659807 PMID:21732638 PMID:24247421 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO SB 203580 inhibits the reaction [nitrofen affects the localization of AIFM1 protein]
SB 203580 inhibits the reaction [Cadmium Chloride affects the localization of AIFM1 protein]
CTD PMID:17439724 PMID:18506790 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Akna AT-hook transcription factor multiple interactions EXP SB 203580 inhibits the reaction [T-2 Toxin results in decreased expression of AKNA mRNA] CTD PMID:29079362 NCBI chr 5:76,777,415...76,824,380
Ensembl chr 5:76,777,415...76,816,017
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B multiple interactions EXP SB 203580 inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA] CTD PMID:17640564 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
decreases activity
ISO SB 203580 inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of AKT1 protein]; SB 203580 inhibits the reaction [Indomethacin results in increased phosphorylation of AKT1 protein]; SB 203580 inhibits the reaction [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide affects the phosphorylation of AKT1 protein]; SB 203580 inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein]; SB 203580 promotes the reaction [Emodin results in decreased phosphorylation of AKT1 protein]
SB 203580 results in decreased phosphorylation of AKT1 protein
SB 203580 results in decreased activity of AKT1 protein
CTD PMID:10998351 PMID:11788791 PMID:15980035 PMID:17341418 PMID:17640974 More... NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alb albumin multiple interactions ISO SB 203580 inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein]; SB 203580 inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; SB 203580 inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein] CTD PMID:16908450 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO
EXP
SB 203580 inhibits the reaction [Calcimycin results in increased phosphorylation of and results in increased activity of ALOX5 protein]; SB 203580 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of ALOX5 protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased activity of ALOX5 protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of ALOX5 protein]; SB 203580 inhibits the reaction [Sorbitol results in increased activity of ALOX5 protein]; SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of ALOX5 protein]; SB 203580 inhibits the reaction [Thapsigargin results in increased phosphorylation of and results in increased activity of ALOX5 protein]; SB 203580 inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of ALOX5 protein]; SB 203580 results in decreased phosphorylation of and results in decreased activity of ALOX5 protein
SB 203580 inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein]; SB 203580 inhibits the reaction [Hydrogen Peroxide affects the localization of ALOX5 protein]
SB 203580 inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of ALOX5 mRNA]
CTD PMID:10779545 PMID:18951527 PMID:20382172 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO SB 203580 inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of ALPL mRNA]] CTD PMID:25789987 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO [pirinixic acid co-treated with SB 203580] inhibits the reaction [TNF protein results in decreased expression of APOA1 mRNA] CTD PMID:19883121 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO SB 203580 inhibits the reaction [APP protein results in increased expression of and results in increased cleavage of CASP1 protein]; SB 203580 inhibits the reaction [APP protein results in increased expression of and results in increased cleavage of IL1B protein]; SB 203580 inhibits the reaction [APP protein results in increased expression of NLRP3 protein]; SB 203580 inhibits the reaction [Copper results in increased expression of APP mRNA] CTD PMID:18583042 PMID:28004443 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Aqp1 aquaporin 1 multiple interactions ISO SB 203580 inhibits the reaction [cobaltous chloride results in increased expression of AQP1 protein]; SB 203580 inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of AQP1 protein]; SB 203580 inhibits the reaction [Peptidoglycan results in decreased expression of AQP1 protein] CTD PMID:21647617 PMID:22415096 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
JBrowse link
G Aqp4 aquaporin 4 multiple interactions ISO SB 203580 inhibits the reaction [[ferrous chloride results in increased abundance of Iron] which results in increased expression of AQP4 protein] CTD PMID:30914277 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
JBrowse link
G Areg amphiregulin decreases activity EXP SB 203580 results in decreased activity of AREG protein CTD PMID:12589827 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
JBrowse link
G Arg1 arginase 1 multiple interactions ISO SB 203580 inhibits the reaction [AGT protein modified form results in increased expression of ARG1 protein] CTD PMID:21289285 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Arg2 arginase 2 multiple interactions ISO SB 203580 inhibits the reaction [AGT protein modified form results in increased expression of ARG2 protein] CTD PMID:21289285 NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378
JBrowse link
G Arpc2 actin related protein 2/3 complex, subunit 2 multiple interactions EXP SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of ARPC2 protein] CTD PMID:24152438 NCBI chr 9:75,820,782...75,851,471
Ensembl chr 9:75,820,770...75,851,471
JBrowse link
G Atf1 activating transcription factor 1 multiple interactions ISO
EXP
[SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Anisomycin results in increased phosphorylation of ATF1 protein]; SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of ATF1 protein]
SB 203580 inhibits the reaction [deoxynivalenol results in increased phosphorylation of ATF1 protein]; SB 203580 inhibits the reaction [Oxygen deficiency results in increased phosphorylation of ATF1 protein]
SB 203580 inhibits the reaction [manganese chloride results in increased phosphorylation of ATF1 protein]; SB 203580 inhibits the reaction [Manganese results in increased phosphorylation of ATF1 protein]
CTD PMID:12660819 PMID:16424113 PMID:16787641 PMID:18579531 NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO
EXP
SB 203580 inhibits the reaction [2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased phosphorylation of ATF2 protein]; SB 203580 inhibits the reaction [IL18 protein results in increased phosphorylation of ATF2 protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased expression of ATF2 mRNA]; SB 203580 inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein modified form]; SB 203580 inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein]; SB 203580 inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ATF2 protein]; SB 203580 inhibits the reaction [TGFB1 protein results in increased phosphorylation of ATF2 protein]; SB 203580 inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of ATF2 protein]
SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of ATF2 protein]; SB 203580 inhibits the reaction [perfluorooctane sulfonic acid results in increased phosphorylation of ATF2 protein]
SB 203580 inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased phosphorylation of ATF2 protein]; SB 203580 inhibits the reaction [Oxaliplatin results in increased phosphorylation of ATF2 protein]
CTD PMID:10611455 PMID:18215737 PMID:19428505 PMID:21303922 PMID:23591579 More... NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
JBrowse link
G Atf3 activating transcription factor 3 multiple interactions ISO SB 203580 inhibits the reaction [Clotrimazole results in increased expression of ATF3 mRNA]; SB 203580 inhibits the reaction [deoxynivalenol results in decreased degradation of ATF3 mRNA]; SB 203580 inhibits the reaction [deoxynivalenol results in decreased degradation of ATF3 protein]
SB 203580 inhibits the reaction [Acrylamide results in increased expression of ATF3 protein]
CTD PMID:19101521 PMID:25531190 PMID:27507784 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atg5 autophagy related 5 multiple interactions ISO SB 203580 inhibits the reaction [Calcitriol results in increased activity of ATG5 mRNA] CTD PMID:19748465 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 multiple interactions ISO [SB 203580 co-treated with CSF1R protein co-treated with TNFSF11 protein] results in decreased expression of ATP6V0D2 mRNA; [SB 203580 co-treated with sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in decreased expression of ATP6V0D2 mRNA; SB 203580 affects the reaction [[NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of ATP6V0D2 mRNA]]; SB 203580 inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 mRNA] CTD PMID:30742845 NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354
JBrowse link
G Bace1 beta-secretase 1 multiple interactions ISO SB 203580 inhibits the reaction [Copper results in increased expression of BACE1 mRNA] CTD PMID:18583042 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
JBrowse link
G Bach1 BTB domain and CNC homolog 1 multiple interactions ISO SB 203580 inhibits the reaction [Cadmium results in decreased activity of BACH1 protein] CTD PMID:14504288 NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO SB 203580 inhibits the reaction [Sulindac affects the localization of BAK1 protein] CTD PMID:17136320 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO
EXP
saikosaponin D promotes the reaction [SB 203580 results in increased expression of BAX protein]; SB 203580 affects the reaction [Emodin affects the expression of BAX protein]; SB 203580 inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased expression of BAX protein]; SB 203580 inhibits the reaction [4-vinyl-2,6-dimethoxyphenol results in increased expression of BAX protein]; SB 203580 inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]; SB 203580 inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of BAX protein]; SB 203580 inhibits the reaction [Lapatinib inhibits the reaction [sodium arsenite results in decreased expression of BAX protein]]; SB 203580 inhibits the reaction [Pt(O,O'-acac)(gamma-acac)(DMS) affects the localization of BAX protein]; SB 203580 inhibits the reaction [Stilbenes analog affects the localization of BAX protein]; SB 203580 inhibits the reaction [Sulindac affects the localization of BAX protein]; SB 203580 promotes the reaction [Resveratrol results in increased activity of BAX protein]
SB 203580 inhibits the reaction [Cisplatin results in increased expression of BAX protein]; SB 203580 inhibits the reaction [oxaliplatin results in increased expression of BAX protein]; SB 203580 promotes the reaction [Cisplatin results in increased expression of BAX protein]
SB 203580 inhibits the reaction [[Nitroprusside results in increased abundance of Nitric Oxide] which affects the localization of BAX protein]; SB 203580 inhibits the reaction [chloroacetic acid results in increased expression of BAX mRNA]
CTD PMID:17136320 PMID:17237268 PMID:18449500 PMID:19428505 PMID:19578154 More... NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO
EXP
saikosaponin D promotes the reaction [SB 203580 results in decreased expression of BCL2 protein]; SB 203580 affects the reaction [Emodin affects the expression of BCL2 protein]; SB 203580 inhibits the reaction [1,4-naphthoquinone analog results in decreased expression of BCL2 protein]; SB 203580 inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in decreased expression of BCL2 protein]; SB 203580 inhibits the reaction [4-vinyl-2,6-dimethoxyphenol results in decreased expression of BCL2 protein]; SB 203580 inhibits the reaction [Lapatinib inhibits the reaction [sodium arsenite results in increased expression of BCL2 protein]]; SB 203580 inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]; SB 203580 inhibits the reaction [Pt(O,O'-acac)(gamma-acac)(DMS) results in decreased expression of BCL2 protein]; SB 203580 promotes the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]
SB 203580 inhibits the reaction [chloroacetic acid results in decreased expression of BCL2 mRNA]; SB 203580 inhibits the reaction [Sodium Glutamate results in increased expression of BCL2 mRNA]
SB 203580 inhibits the reaction [Cisplatin results in increased phosphorylation of and results in decreased activity of BCL2 protein]; SB 203580 inhibits the reaction [oxaliplatin results in increased phosphorylation of and results in decreased activity of BCL2 protein]
CTD PMID:16782274 PMID:16818652 PMID:19428505 PMID:21420390 PMID:23103613 More... NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP SB 203580 promotes the reaction [Cisplatin results in decreased expression of BCL2L1 protein] CTD PMID:19578154 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions EXP SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of BCL2L11 protein] CTD PMID:16818494 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Bcl3 BCL3, transcription coactivator multiple interactions ISO SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of BCL3 mRNA] CTD PMID:28329830 NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607
JBrowse link
G Becn1 beclin 1 multiple interactions ISO
EXP
SB 203580 inhibits the reaction [Calcitriol results in increased activity of BECN1 mRNA]
SB 203580 inhibits the reaction [decamethrin results in increased expression of BECN1 protein]
CTD PMID:19748465 PMID:26588882 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions EXP [pyrazolanthrone co-treated with SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Quercetin results in increased expression of BGLAP protein]; SB 203580 inhibits the reaction [cobaltous chloride results in increased expression of BGLAP protein]; SB 203580 inhibits the reaction [Quercetin results in increased expression of BGLAP protein] CTD PMID:26136938 PMID:31472278 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO SB 203580 promotes the reaction [Emodin results in increased degradation of BID protein] CTD PMID:27032576 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
increases expression
ISO SB 203580 affects the reaction [[gambogic acid co-treated with Doxorubicin] affects the expression of BIRC5 protein]; SB 203580 inhibits the reaction [arsenic trioxide results in decreased expression of BIRC5 protein]; SB 203580 inhibits the reaction [baicalein results in decreased expression of BIRC5 protein]; SB 203580 inhibits the reaction [tanshinone results in decreased expression of BIRC5 mRNA]
SB 203580 results in increased expression of BIRC5 mRNA
CTD PMID:16328441 PMID:18025287 PMID:21165580 PMID:21594580 PMID:25824409 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Bmp2 bone morphogenetic protein 2 decreases expression
multiple interactions
ISO
EXP
SB 203580 results in decreased expression of BMP2 mRNA
SB 203580 inhibits the reaction [Quercetin results in increased expression of BMP2 mRNA]
SB 203580 inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of ALPL mRNA]]; SB 203580 inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP2 mRNA]]; SB 203580 inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP6 mRNA]]; SB 203580 inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP7 mRNA]]; SB 203580 inhibits the reaction [5-Methoxypsoralen results in increased expression of BMP2 mRNA]; SB 203580 inhibits the reaction [imperatorin results in increased expression of BMP2 mRNA]
CTD PMID:17980360 PMID:20660070 PMID:25789987 PMID:26136938 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions ISO SB 203580 inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP6 mRNA]] CTD PMID:25789987 NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365
JBrowse link
G Bmp7 bone morphogenetic protein 7 multiple interactions ISO SB 203580 inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP7 mRNA]] CTD PMID:25789987 NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788
JBrowse link
G Bsg basigin (Ok blood group) multiple interactions ISO SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BSG mRNA]; SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BSG protein] CTD PMID:18647594 NCBI chr 7:9,993,170...10,000,387
Ensembl chr 7:9,993,170...10,000,387
JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G multiple interactions EXP SB 203580 inhibits the reaction [telmisartan results in decreased expression of CACNA1G mRNA] CTD PMID:19292980 NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H multiple interactions EXP SB 203580 inhibits the reaction [telmisartan results in decreased expression of CACNA1H mRNA] CTD PMID:19292980 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376
JBrowse link
G Camp cathelicidin antimicrobial peptide multiple interactions ISO SB 203580 promotes the reaction [Calcitriol promotes the reaction [resveratrol results in increased expression of CAMP mRNA]]; SB 203580 promotes the reaction [resveratrol promotes the reaction [Calcitriol results in increased expression of CAMP mRNA]] CTD PMID:24039193 NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543
JBrowse link
G Casp1 caspase 1 multiple interactions ISO
EXP
SB 203580 inhibits the reaction [APP protein results in increased expression of and results in increased cleavage of CASP1 protein]
SB 203580 inhibits the reaction [Acrolein results in increased cleavage of CASP1 protein]
CTD PMID:28004443 PMID:31639409 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
ISO
EXP
saikosaponin D promotes the reaction [SB 203580 results in increased cleavage of and results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [1,4-naphthoquinone analog results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [[ESR1 protein results in increased susceptibility to Quercetin] which results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [[ESR2 protein results in increased susceptibility to Estradiol] which results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [[ESR2 protein results in increased susceptibility to Quercetin] which results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of and results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [Acetaldehyde results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [Biological Products results in increased expression of CASP3 mRNA]; SB 203580 inhibits the reaction [cantharidic acid results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [Chlorpyrifos results in increased expression of CASP3 protein modified form]; SB 203580 inhibits the reaction [DDT results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [Emodin results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [Indomethacin results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [Lapatinib inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]]; SB 203580 inhibits the reaction [licochalcone A results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [malvidin results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [Paraquat results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [Pyrogallol results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [Thimerosal results in increased activity of CASP3 protein]; SB 203580 promotes the reaction [Cadmium results in increased activity of and results in increased cleavage of CASP3 protein]; SB 203580 promotes the reaction [Resveratrol results in increased activity of CASP3 protein]; SB 203580 results in increased cleavage of and results in increased activity of CASP3 protein
SB 203580 inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; SB 203580 inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein]; SB 203580 inhibits the reaction [cobaltous chloride results in increased cleavage of and results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [Cocaine results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [decamethrin results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; SB 203580 inhibits the reaction [satratoxin H results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [tributyltin results in increased expression of CASP3 protein]; SB 203580 promotes the reaction [Cadmium results in increased activity of and results in increased cleavage of CASP3 protein]; SB 203580 promotes the reaction [Cisplatin results in increased activity of CASP3 protein]
SB 203580 inhibits the reaction [[GMFB protein co-treated with Hydrogen Peroxide] results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [[Nitroprusside results in increased abundance of Nitric Oxide] which results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [chloroacetic acid results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [deoxynivalenol results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [Mercuric Chloride results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [Methylmercury Compounds results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [Morphine results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [Uranyl Nitrate results in increased activity of CASP3 protein]
SB 203580 results in increased expression of CASP3 protein modified form
CTD PMID:12791701 PMID:14722101 PMID:15050407 PMID:15365088 PMID:15603917 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp6 caspase 6 multiple interactions ISO SB 203580 inhibits the reaction [Indomethacin results in increased activity of CASP6 protein] CTD PMID:17341418 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
JBrowse link
G Casp7 caspase 7 multiple interactions ISO SB 203580 inhibits the reaction [DDT results in increased activity of CASP7 protein]
SB 203580 inhibits the reaction [chloroacetic acid results in increased activity of CASP7 protein]
CTD PMID:15603917 PMID:23103613 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [Resveratrol co-treated with SB 203580] results in increased activity of CASP8 protein; SB 203580 inhibits the reaction [cantharidic acid results in increased cleavage of CASP8 protein]; SB 203580 inhibits the reaction [licochalcone A results in increased cleavage of CASP8 protein]; SB 203580 promotes the reaction [Emodin results in increased activity of CASP8 protein] CTD PMID:22644961 PMID:27032576 PMID:29159945 PMID:30983163 PMID:31916385 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions ISO
EXP
[Resveratrol co-treated with SB 203580] results in increased activity of CASP9 protein; SB 203580 inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein]; SB 203580 inhibits the reaction [cantharidic acid results in increased cleavage of CASP9 protein]; SB 203580 inhibits the reaction [Indomethacin results in increased activity of CASP9 protein]; SB 203580 inhibits the reaction [licochalcone A results in increased cleavage of CASP9 protein]; SB 203580 inhibits the reaction [Pt(O,O'-acac)(gamma-acac)(DMS) results in increased activity of CASP9 protein]
SB 203580 inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased cleavage of CASP9 protein]; SB 203580 inhibits the reaction [Cocaine results in increased activity of CASP9 protein]
CTD PMID:15365088 PMID:17237268 PMID:17341418 PMID:21420390 PMID:22644961 More... NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions ISO SB 203580 promotes the reaction [Pyrogallol results in decreased expression of CAT protein] CTD PMID:20191265 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cav1 caveolin 1 multiple interactions ISO SB 203580 inhibits the reaction [Hydrogen Peroxide promotes the reaction [SP1 protein results in increased expression of CAV1 protein]]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of CAV1 protein]
[SB 203580 results in decreased activity of MAPK14 protein] inhibits the reaction [[octanoic acid co-treated with Dexamethasone] results in increased expression of CAV1 protein]; SB 203580 inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of CAV1 mRNA]; SB 203580 inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of CAV1 protein]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of CAV1 protein]
CTD PMID:14984747 PMID:17108117 PMID:21457723 PMID:25512378 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO SB 203580 inhibits the reaction [TNF protein results in increased expression of CCL11 protein] CTD PMID:23707484 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP
SB 203580 inhibits the reaction [Allopurinol results in increased expression of CCL2 mRNA]; SB 203580 inhibits the reaction [chlorobenzene results in increased expression of CCL2 protein]; SB 203580 inhibits the reaction [Diclofenac analog results in increased expression of CCL2 mRNA]; SB 203580 inhibits the reaction [Folic Acid deficiency results in increased expression of and results in increased secretion of CCL2 protein]; SB 203580 inhibits the reaction [Folic Acid deficiency results in increased expression of CCL2 mRNA]; SB 203580 inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; SB 203580 inhibits the reaction [Glucose results in increased expression of CCL2 protein]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of CCL2 mRNA]; SB 203580 inhibits the reaction [IL17A protein results in increased expression of CCL2 protein]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]; SB 203580 inhibits the reaction [melamine results in increased expression of CCL2 mRNA]; SB 203580 inhibits the reaction [Particulate Matter analog results in decreased secretion of CCL2 protein]; SB 203580 inhibits the reaction [TNF results in increased expression of CCL2 protein]; SB 203580 inhibits the reaction [Vehicle Emissions analog results in decreased secretion of CCL2 protein]; SB 203580 promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dermatophagoides pteronyssinus antigen p 1 results in increased secretion of CCL2 protein]]; SB 203580 promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter analog results in decreased secretion of CCL2 protein]]; SB 203580 promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Vehicle Emissions analog results in decreased secretion of CCL2 protein]]
SB 203580 inhibits the reaction [[Paraquat results in increased abundance of Reactive Oxygen Species] which results in increased secretion of CCL2 protein]; SB 203580 inhibits the reaction [diphenylarsinic acid results in increased secretion of CCL2 protein]
SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of CCL2 mRNA]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]
CTD PMID:10919993 PMID:12016129 PMID:16143069 PMID:17655880 PMID:18645721 More... NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO SB 203580 inhibits the reaction [Methotrexate results in decreased expression of CCL3 protein] CTD PMID:19100307 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO SB 203580 affects the reaction [Methotrexate results in decreased expression of CCL4 protein] CTD PMID:19100307 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO SB 203580 inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein]; SB 203580 inhibits the reaction [Buthionine Sulfoximine promotes the reaction [TNF protein results in increased expression of CCL5 protein]]; SB 203580 inhibits the reaction [Dermatophagoides pteronyssinus antigen p 1 results in increased secretion of CCL5 protein]; SB 203580 inhibits the reaction [Particulate Matter analog results in increased secretion of CCL5 protein]; SB 203580 inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; SB 203580 inhibits the reaction [Vehicle Emissions analog results in increased secretion of CCL5 protein]; SB 203580 promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter analog results in decreased secretion of CCL5 protein]]; SB 203580 promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Vehicle Emissions analog results in decreased secretion of CCL5 protein]]; SB 203580 promotes the reaction [Methotrexate results in increased expression of CCL5 protein] CTD PMID:10919993 PMID:11167962 PMID:16908450 PMID:19100307 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 multiple interactions ISO SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of CCL7 mRNA] CTD PMID:28329830 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
JBrowse link
G Ccn1 cellular communication network factor 1 increases expression
multiple interactions
ISO SB 203580 results in increased expression of CCN1 protein
[sclareol co-treated with SB 203580] results in increased expression of CCN1 protein
CTD PMID:33423118 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions
decreases expression
ISO SB 203580 analog inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein]; SB 203580 inhibits the reaction [Glucose results in increased expression of CCN2 protein]
SB 203580 results in decreased expression of CCN2 protein
CTD PMID:19369054 PMID:20864298 PMID:26054450 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO SB 203580 inhibits the reaction [ochratoxin A inhibits the reaction [CDK1 protein binds to CCNB1 protein]]; SB 203580 inhibits the reaction [ochratoxin A results in decreased expression of CCNB1 protein] CTD PMID:22230261 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND1 mRNA]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]; SB 203580 inhibits the reaction [Lapatinib inhibits the reaction [sodium arsenite results in increased expression of CCND1 protein]]; SB 203580 inhibits the reaction [TGFB1 protein results in decreased expression of CCND1 protein]
SB 203580 results in decreased expression of CCND1 protein
CTD PMID:21712382 PMID:23112108 PMID:30801954 PMID:32890875 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd3 cyclin D3 multiple interactions ISO SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND3 mRNA]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND3 protein] CTD PMID:23112108 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 multiple interactions ISO SB 203580 inhibits the reaction [Silicon Dioxide results in increased expression of CCR2 protein] CTD PMID:26163174 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 multiple interactions ISO SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of CCR7 mRNA] CTD PMID:28329830 NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309
JBrowse link
G Cd14 CD14 molecule multiple interactions ISO SB 203580 inhibits the reaction [gefitinib promotes the reaction [arsenic trioxide results in increased expression of CD14 protein]]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 protein] CTD PMID:18180316 PMID:20226526 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cd38 CD38 molecule multiple interactions ISO SB 203580 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased cleavage of CD38 protein] CTD PMID:15494208 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986
JBrowse link
G Cd63 Cd63 molecule multiple interactions ISO SB 203580 inhibits the reaction [Mustard Gas promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of CD63 protein]] CTD PMID:22036725 NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178
JBrowse link
G Cd83 CD83 molecule multiple interactions ISO SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of CD83 protein]; SB 203580 inhibits the reaction [Poly I-C results in increased expression of CD83 protein]; SB 203580 inhibits the reaction [Zymosan results in increased expression of CD83 protein] CTD PMID:17698565 NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083
JBrowse link
G Cd86 CD86 molecule multiple interactions ISO SB 203580 inhibits the reaction [1,10-phenanthroline results in increased expression of CD86 mRNA]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]; SB 203580 inhibits the reaction [Poly I-C results in increased expression of CD86 protein]; SB 203580 inhibits the reaction [Zymosan results in increased expression of CD86 protein] CTD PMID:17698565 PMID:19641517 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO SB 203580 inhibits the reaction [ochratoxin A results in decreased expression of CDC25C protein modified form]; SB 203580 inhibits the reaction [ochratoxin A results in decreased expression of CDC25C protein] CTD PMID:22230261 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
JBrowse link
G Cdc6 cell division cycle 6 multiple interactions ISO SB 203580 inhibits the reaction [arsenic trioxide results in increased expression of CDC6 protein] CTD PMID:20862710 NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO SB 203580 inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDH1 mRNA]; SB 203580 inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDH1 protein]; SB 203580 inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein] CTD PMID:28694203 PMID:33396024 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh5 cadherin 5 multiple interactions ISO SB 203580 inhibits the reaction [Varenicline results in decreased expression of CDH5] CTD PMID:28842382 NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO SB 203580 inhibits the reaction [baicalein results in decreased phosphorylation of CDK1 protein]; SB 203580 inhibits the reaction [ochratoxin A inhibits the reaction [CDK1 protein binds to CCNB1 protein]]; SB 203580 inhibits the reaction [ochratoxin A results in decreased expression of CDK1 protein modified form]; SB 203580 inhibits the reaction [ochratoxin A results in decreased expression of CDK1 protein] CTD PMID:18025287 PMID:22230261 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO
EXP
SB 203580 inhibits the reaction [sodium arsenite results in decreased activity of CDK2 protein]
SB 203580 inhibits the reaction [esculetin results in decreased expression of CDK2 protein]
CTD PMID:11807808 PMID:21600278 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions EXP SB 203580 inhibits the reaction [esculetin results in decreased expression of CDK4 protein] CTD PMID:21600278 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 multiple interactions ISO SB 203580 inhibits the reaction [resveratrol results in decreased expression of CDK5R1 mRNA] CTD PMID:21736731 NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456
JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions ISO SB 203580 inhibits the reaction [Furazolidone results in increased expression of CDK6 mRNA]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CDK6 protein] CTD PMID:23112108 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO
EXP
SB 203580 inhibits the reaction [[sodium arsenite co-treated with Vitamin K 3] results in increased expression of CDKN1A protein]; SB 203580 inhibits the reaction [Cadmium results in increased expression of CDKN1A protein]; SB 203580 inhibits the reaction [Hemin results in increased expression of CDKN1A protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased expression of CDKN1A protein]
SB 203580 inhibits the reaction [esculetin results in increased expression of CDKN1A protein]; SB 203580 inhibits the reaction [pyrrolidine dithiocarbamic acid results in increased expression of CDKN1A protein]
SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of CDKN1A mRNA]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of CDKN1A protein]; SB 203580 inhibits the reaction [Methylcholanthrene results in increased expression of CDKN1A mRNA]; SB 203580 inhibits the reaction [sodium arsenite results in increased expression of CDKN1A protein]
CTD PMID:11807808 PMID:14603533 PMID:14647439 PMID:15734884 PMID:15882963 More... NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO SB 203580 inhibits the reaction [[sodium arsenite co-treated with Vitamin K 3] results in increased expression of CDKN1B protein] CTD PMID:19082730 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions ISO SB 203580 inhibits the reaction [Arsenic Trioxide results in increased expression of CDKN2A protein] CTD PMID:31734849 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Cdon cell adhesion associated, oncogene regulated multiple interactions ISO SB 203580 inhibits the reaction [bakuchiol results in increased expression of CDON protein] CTD PMID:26902638 NCBI chr 8:33,775,123...33,861,635
Ensembl chr 8:33,806,183...33,859,033
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO SB 203580 inhibits the reaction [Glucose results in increased localization of and results in increased activity of CEBPA protein] CTD PMID:24376792 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO SB 203580 inhibits the reaction [Glucose results in increased localization of and results in increased activity of CEBPB protein]; SB 203580 inhibits the reaction [IFNG protein results in increased phosphorylation of CEBPB protein] CTD PMID:16355272 PMID:24376792 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta multiple interactions ISO SB 203580 inhibits the reaction [Glucose results in increased localization of and results in increased activity of CEBPD protein] CTD PMID:24376792 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions ISO SB 203580 inhibits the reaction [Lipopolysaccharides results in decreased expression of CES1 mRNA] CTD PMID:21237253 NCBI chr19:13,873,490...13,912,035 JBrowse link
G Ces2h carboxylesterase 2H multiple interactions ISO SB 203580 inhibits the reaction [Lipopolysaccharides results in decreased expression of CES2 mRNA] CTD PMID:21237253 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions EXP SB 203580 inhibits the reaction [Particulate Matter results in increased expression of CHRM3 mRNA]; SB 203580 inhibits the reaction [Particulate Matter results in increased expression of CHRM3 protein] CTD PMID:26916448 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of CHUK protein] CTD PMID:19616567 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Cldn1 claudin 1 multiple interactions ISO [SB 203580 co-treated with Dextran Sulfate] results in decreased expression of CLDN1 protein CTD PMID:27920472 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
JBrowse link
G Cldn11 claudin 11 multiple interactions ISO SB 203580 inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of CLDN11 protein] CTD PMID:23761298 NCBI chr 2:112,207,745...112,221,050
Ensembl chr 2:112,207,745...112,221,050
JBrowse link
G Cldn2 claudin 2 multiple interactions EXP SB 203580 inhibits the reaction [CLDN2 protein results in increased expression of IL1B mRNA]; SB 203580 inhibits the reaction [CLDN2 protein results in increased expression of IL1B protein] CTD PMID:15350541 NCBI chr  X:103,459,870...103,473,794
Ensembl chr  X:103,459,780...103,474,838
JBrowse link
G Cnn1 calponin 1 multiple interactions ISO SB 203580 inhibits the reaction [TGFB1 protein results in increased expression of CNN1 protein] CTD PMID:21712382 NCBI chr 8:20,632,434...20,641,097
Ensembl chr 8:20,632,338...20,641,098
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions ISO SB 203580 inhibits the reaction [Dextran Sulfate results in increased expression of CNR1 protein] CTD PMID:27920472 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions ISO SB 203580 inhibits the reaction [Dextran Sulfate results in increased expression of CNR2 protein] CTD PMID:27920472 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548
JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain multiple interactions
decreases expression
ISO SB 203580 inhibits the reaction [Oxygen deficiency results in increased expression of COL18A1 mRNA]
SB 203580 results in decreased expression of COL18A1 mRNA
CTD PMID:13679210 NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression
ISO
EXP
SB 203580 inhibits the reaction [TGFB2 protein results in increased expression of COL1A1 mRNA]
SB 203580 inhibits the reaction [Acetaldehyde results in increased expression of COL1A1 mRNA]
SB 203580 results in decreased expression of COL1A1 mRNA
CTD PMID:12065697 PMID:18253093 PMID:27235791 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions EXP SB 203580 inhibits the reaction [cobaltous chloride results in increased expression of COL1A2 mRNA]; SB 203580 inhibits the reaction [cobaltous chloride results in increased expression of COL1A2 protein] CTD PMID:31472278 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Cp ceruloplasmin multiple interactions ISO SB 203580 inhibits the reaction [CP protein results in increased abundance of Nitrites] CTD PMID:17727827 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
decreases phosphorylation
ISO
EXP
SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [Cannabidiol results in increased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [Formaldehyde results in increased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of CREB1 protein]
[N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with SB 203580] inhibits the reaction [perfluorooctane sulfonic acid inhibits the reaction [[CRTC2 protein binds to CREB1 protein modified form] which binds to STAR promoter]]; [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with SB 203580] inhibits the reaction [perfluorooctane sulfonic acid results in increased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [deoxynivalenol results in increased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [perfluorooctane sulfonic acid inhibits the reaction [[CRTC2 protein binds to CREB1 protein modified form] which binds to STAR promoter]]; SB 203580 inhibits the reaction [perfluorooctane sulfonic acid results in increased phosphorylation of CREB1 protein]
SB 203580 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [AGT protein results in increased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [diphenylarsinic acid results in increased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [EDN1 protein results in increased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [manganese chloride results in increased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [Manganese results in increased phosphorylation of CREB1 protein]
SB 203580 results in decreased phosphorylation of CREB1 protein
CTD PMID:12660819 PMID:14741741 PMID:16424113 PMID:16787641 PMID:19145780 More... NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Crebbp CREB binding protein multiple interactions ISO SB 203580 inhibits the reaction [o,p'-DDT results in increased activity of CREBBP protein] CTD PMID:22609851 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Crh corticotropin releasing hormone multiple interactions EXP
ISO
SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of CRH mRNA]
SB 203580 inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CRH mRNA]
CTD PMID:21959975 PMID:28189027 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Crp C-reactive protein multiple interactions ISO SB 203580 inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of and results in increased secretion of CRP protein] CTD PMID:17388968 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Crtc2 CREB regulated transcription coactivator 2 multiple interactions ISO [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with SB 203580] inhibits the reaction [perfluorooctane sulfonic acid inhibits the reaction [[CRTC2 protein binds to CREB1 protein modified form] which binds to STAR promoter]]; [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with SB 203580] inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of CRTC2 protein]; SB 203580 inhibits the reaction [perfluorooctane sulfonic acid inhibits the reaction [[CRTC2 protein binds to CREB1 protein modified form] which binds to STAR promoter]]; SB 203580 inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of CRTC2 protein] CTD PMID:33359577 NCBI chr 2:175,709,603...175,719,768
Ensembl chr 2:175,709,644...175,719,763
JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions ISO [SB 203580 co-treated with CSF1R protein co-treated with TNFSF11 protein] results in decreased expression of ATP6V0D2 mRNA; [SB 203580 co-treated with CSF1R protein co-treated with TNFSF11 protein] results in decreased expression of CTSK mRNA; [SB 203580 co-treated with sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in decreased expression of ATP6V0D2 mRNA; [SB 203580 co-treated with sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in decreased expression of CTSK mRNA; SB 203580 affects the reaction [[NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of ATP6V0D2 mRNA]]; SB 203580 affects the reaction [[NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of CTSK mRNA]]; SB 203580 inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 mRNA]; SB 203580 inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA] CTD PMID:30742845 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO SB 203580 inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; SB 203580 inhibits the reaction [Particulate Matter results in increased secretion of CSF2 protein]; SB 203580 inhibits the reaction [Vehicle Emissions results in increased secretion of CSF2 protein] CTD PMID:10645887 PMID:16908450 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO SB 203580 inhibits the reaction [DEFA1 protein results in decreased phosphorylation of and results in increased activity of CTNNB1 protein]; SB 203580 inhibits the reaction [DEFA2 protein results in decreased phosphorylation of and results in increased activity of CTNNB1 protein] CTD PMID:19814765 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctsk cathepsin K multiple interactions ISO [SB 203580 co-treated with CSF1R protein co-treated with TNFSF11 protein] results in decreased expression of CTSK mRNA; [SB 203580 co-treated with sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in decreased expression of CTSK mRNA; SB 203580 affects the reaction [[NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of CTSK mRNA]]; SB 203580 inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA] CTD PMID:30742845 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 multiple interactions ISO SB 203580 inhibits the reaction [Glucose results in increased expression of CX3CL1 mRNA]; SB 203580 inhibits the reaction [Glucose results in increased expression of CX3CL1 protein] CTD PMID:19132243 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions
decreases secretion
EXP
ISO
SB 203580 inhibits the reaction [diphenylarsinic acid results in increased secretion of CXCL1 protein]; SB 203580 inhibits the reaction [resveratrol results in decreased expression of CXCL1 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of CXCL1 protein]
SB 203580 inhibits the reaction [ADIPOQ protein results in increased expression of CXCL1 protein]
SB 203580 results in decreased secretion of CXCL1 protein
CTD PMID:21192278 PMID:23285267 PMID:28087833 PMID:28176455 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO
EXP
SB 203580 inhibits the reaction [endotoxin, Escherichia coli results in increased expression of CXCL2 protein]; SB 203580 inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CXCL2 protein]; SB 203580 inhibits the reaction [Paraquat promotes the reaction [endotoxin, Escherichia coli results in increased expression of CXCL2 protein]]; SB 203580 inhibits the reaction [Paraquat results in increased expression of CXCL2 protein]
SB 203580 inhibits the reaction [[Paraquat results in increased abundance of Reactive Oxygen Species] which results in increased secretion of CXCL2 protein]; SB 203580 inhibits the reaction [resveratrol results in decreased expression of CXCL2 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of CXCL2 protein]
CTD PMID:16919916 PMID:21192278 PMID:21507677 PMID:23285267 PMID:24376630 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO SB 203580 inhibits the reaction [ADIPOQ protein results in increased expression of CXCL1 protein] CTD PMID:28176455 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 multiple interactions ISO SB 203580 inhibits the reaction [Lipopolysaccharides results in decreased expression of CXCR2 protein] CTD PMID:10950785 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions ISO SB 203580 inhibits the reaction [Ethanol results in increased expression of CYBA mRNA] CTD PMID:23978445 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO SB 203580 inhibits the reaction [Ethanol results in increased expression of CYBB mRNA] CTD PMID:23978445 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP
ISO
SB 203580 promotes the reaction [Cisplatin affects the localization of CYCS protein]
SB 203580 inhibits the reaction [4-vinyl-2,6-dimethoxyphenol results in increased expression of CYCS protein]
CTD PMID:19578154 PMID:30653946 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions EXP SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 mRNA]; SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 protein] CTD PMID:29567110 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions EXP SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 mRNA]; SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 protein] CTD PMID:29567110 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
increases expression
multiple interactions
ISO
EXP
SB 203580 results in increased activity of CYP1A1 protein
SB 203580 results in increased expression of CYP1A1 mRNA
SB 203580 promotes the reaction [sunitinib results in increased expression of CYP1A1 mRNA]
SB 203580 results in increased expression of CYP1A1 mRNA; SB 203580 results in increased expression of CYP1A1 protein
[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] results in decreased susceptibility to [SB 203580 results in increased expression of CYP1A1]; AHR protein affects the susceptibility to [SB 203580 results in increased expression of CYP1A1]; Dactinomycin inhibits the reaction [SB 203580 results in increased expression of CYP1A1 mRNA]; SB 203580 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; SB 203580 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; SB 203580 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1]; SB 203580 results in increased expression of and results in increased activity of CYP1A1 protein
CTD PMID:18078826 PMID:21732638 PMID:24247421 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 multiple interactions ISO SB 203580 inhibits the reaction [IFNG protein results in increased expression of CYP27B1 mRNA] CTD PMID:16355272 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO SB 203580 promotes the reaction [Arachidonic Acid promotes the reaction [CYP2E1 protein results in increased expression of KLF6 mRNA]]; SB 203580 promotes the reaction [CYP2E1 protein results in increased expression of KLF6 mRNA] CTD PMID:22486562 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Daxx death-domain associated protein multiple interactions ISO SB 203580 inhibits the reaction [Cadmium Chloride affects the localization of DAXX protein] CTD PMID:12508112 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843
JBrowse link
G Dct dopachrome tautomerase multiple interactions ISO SB 203580 inhibits the reaction [Cannabidiol results in increased expression of DCT mRNA] CTD PMID:28601556 NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO SB 203580 inhibits the reaction [baicalein-7-O-diglucoside results in increased expression of DDIT3 protein]; SB 203580 inhibits the reaction [Indomethacin results in increased expression of DDIT3 protein]
SB 203580 inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]
CTD PMID:17341418 PMID:26253462 PMID:30508555 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 multiple interactions ISO SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of DDIT4 mRNA] CTD PMID:28329830 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
JBrowse link
G Dio2 iodothyronine deiodinase 2 multiple interactions EXP SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of DIO2 mRNA] CTD PMID:18420745 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases expression
multiple interactions
ISO
EXP
SB 203580 results in decreased expression of DIO3
SB 203580 inhibits the reaction [Fluoxetine results in increased expression of DIO3 mRNA]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased activity of DIO3 protein]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of DIO3 mRNA]
CTD PMID:15456934 PMID:18420745 PMID:26825960 NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 multiple interactions ISO SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of DNAJB9 mRNA] CTD PMID:28329830 NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063
JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions ISO
EXP
SB 203580 inhibits the reaction [arsenite results in increased expression of DUSP1 mRNA]
SB 203580 inhibits the reaction [Cadmium results in increased expression of DUSP1 mRNA]; SB 203580 inhibits the reaction [Cadmium results in increased expression of DUSP1 protein]; SB 203580 inhibits the reaction [Oxygen deficiency results in increased expression of DUSP1 mRNA]; SB 203580 promotes the reaction [Lipopolysaccharides results in increased phosphorylation of DUSP1 protein]
CTD PMID:11577072 PMID:11689710 PMID:18573614 PMID:20885979 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Dusp5 dual specificity phosphatase 5 multiple interactions ISO SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of DUSP5 mRNA] CTD PMID:28329830 NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
JBrowse link
G Dusp6 dual specificity phosphatase 6 multiple interactions ISO SB 203580 inhibits the reaction [Asbestos, Crocidolite results in increased expression of DUSP6 mRNA] CTD PMID:18314537 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
JBrowse link
G Ece1 endothelin converting enzyme 1 affects expression EXP SB 203580 affects the expression of ECE1 mRNA CTD PMID:21084678 NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO
EXP
SB 203580 inhibits the reaction [cobaltous chloride results in increased secretion of EDN1 protein]; SB 203580 inhibits the reaction [EDN1 protein results in increased expression of CXCL8 mRNA]; SB 203580 inhibits the reaction [EDN1 protein results in increased expression of EDN1 mRNA]; SB 203580 inhibits the reaction [EDN1 protein results in increased expression of IL6 mRNA]; SB 203580 inhibits the reaction [EDN1 protein results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [EDN1 protein results in increased expression of VCAM1 mRNA]; SB 203580 inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]
SB 203580 inhibits the reaction [EDN1 protein results in increased phosphorylation of CREB1 protein]
CTD PMID:14741741 PMID:18457675 PMID:24376792 PMID:27297870 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP SB 203580 inhibits the reaction [Cyclosporine results in increased expression of EDNRB mRNA]; SB 203580 inhibits the reaction [Cyclosporine results in increased expression of EDNRB protein]; SB 203580 inhibits the reaction [Particulate Matter results in increased expression of EDNRB mRNA]; SB 203580 inhibits the reaction [Particulate Matter results in increased expression of EDNRB protein]; SB 203580 inhibits the reaction [Smoke results in increased expression of EDNRB mRNA]; SB 203580 inhibits the reaction [Smoke results in increased expression of EDNRB protein] CTD PMID:18718921 PMID:20561571 PMID:25772258 PMID:26496744 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
JBrowse link
G Egf epidermal growth factor multiple interactions ISO
EXP
SB 203580 inhibits the reaction [EGF protein results in increased secretion of MUC5AC protein]
SB 203580 results in decreased activity of [arsenite co-treated with EGF protein]
CTD PMID:9733710 PMID:22766066 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO
EXP
SB 203580 inhibits the reaction [Fluorouracil results in increased expression of EGR1 mRNA]; SB 203580 inhibits the reaction [Fluorouracil results in increased expression of EGR1 protein]; SB 203580 promotes the reaction [3,4-dihydroxyphenylethanol results in increased expression of EGR1 mRNA]; SB 203580 promotes the reaction [pyrrolidine dithiocarbamic acid results in increased expression of EGR1 mRNA]; SB 203580 promotes the reaction [Resveratrol results in increased expression of EGR1 mRNA]
SB 203580 inhibits the reaction [Quercetin results in increased expression of EGR1 mRNA]; SB 203580 inhibits the reaction [Quercetin results in increased expression of EGR1 protein]
SB 203580 inhibits the reaction [Anisomycin results in increased expression of EGR1 mRNA]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 mRNA]; SB 203580 inhibits the reaction [Particulate Matter promotes the reaction [Tobacco Smoke Pollution results in increased expression of EGR1 mRNA]]; SB 203580 inhibits the reaction [Tobacco Smoke Pollution promotes the reaction [Particulate Matter results in increased expression of EGR1 mRNA]]; SB 203580 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EGR1 mRNA]; SB 203580 promotes the reaction [sodium arsenite results in increased expression of EGR1 mRNA]
CTD PMID:9671412 PMID:12482581 PMID:18757417 PMID:22046279 PMID:22174042 More... NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO SB 203580 results in increased phosphorylation of EIF2S1 protein CTD PMID:21090173 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with SB 203580] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]; MAPK14 protein mutant form inhibits the reaction [SB 203580 inhibits the reaction [arsenite results in increased phosphorylation of EIF4E protein]]; SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of EIF4E protein]; SB 203580 inhibits the reaction [arsenite results in increased phosphorylation of EIF4E protein]; SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]; SB 203580 inhibits the reaction [TNF protein results in increased phosphorylation of EIF4E protein]; SB 203580 promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]]
[SB 203580 co-treated with U 0126] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of EIF4E protein]; SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of EIF4E protein]
CTD PMID:9545260 PMID:12781867 PMID:16431125 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
JBrowse link
G Eif4g1 eukaryotic translation initiation factor 4 gamma, 1 multiple interactions ISO [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with SB 203580] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4G1 protein] CTD PMID:12781867 NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941
JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions
affects activity
ISO
EXP
[SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [sodium arsenite results in increased phosphorylation of ELK1 protein]; SB 203580 inhibits the reaction [IL1B protein results in increased phosphorylation of ELK1 protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of ELK1 protein]
SB 203580 affects the activity of ELK1 protein
CTD PMID:10903806 PMID:12660819 PMID:21084678 PMID:21642427 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713
JBrowse link
G Enc1 ectodermal-neural cortex 1 multiple interactions ISO SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of ENC1 mRNA] CTD PMID:28329830 NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions EXP SB 203580 inhibits the reaction [Doxorubicin results in decreased expression of EP300 protein]; SB 203580 inhibits the reaction [MAP2K6 protein results in decreased expression of EP300 protein] CTD PMID:15767673 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions ISO SB 203580 inhibits the reaction [ERBB2 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CXCL8 mRNA]]; SB 203580 inhibits the reaction [ERBB2 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased secretion of CXCL8 protein]] CTD PMID:33396024 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit increases expression
multiple interactions
ISO SB 203580 results in increased expression of ERCC1 mRNA
SB 203580 inhibits the reaction [tanshinone results in decreased expression of ERCC1 mRNA]
CTD PMID:21165580 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963
JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 multiple interactions ISO SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of ERRFI1 mRNA] CTD PMID:28329830 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases expression
ISO [SB 203580 co-treated with naringenin] results in increased degradation of ESR1 protein; SB 203580 inhibits the reaction [[ESR1 protein results in increased susceptibility to Quercetin] which results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [[ESR1 protein results in increased susceptibility to Quercetin] which results in increased cleavage of PARP1 protein]; SB 203580 promotes the reaction [Estradiol results in increased degradation of ESR1 protein]
SB 203580 results in decreased expression of ESR1 protein
SB 203580 inhibits the reaction [Estradiol results in increased expression of ESR1 protein]
CTD PMID:19194971 PMID:19340542 PMID:24586459 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO SB 203580 inhibits the reaction [[ESR2 protein results in increased susceptibility to Estradiol] which results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [[ESR2 protein results in increased susceptibility to Estradiol] which results in increased cleavage of PARP1 protein]; SB 203580 inhibits the reaction [[ESR2 protein results in increased susceptibility to Quercetin] which results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [[ESR2 protein results in increased susceptibility to Quercetin] which results in increased cleavage of PARP1 protein] CTD PMID:21732360 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor multiple interactions ISO SB 203580 inhibits the reaction [benz(a)anthracene results in increased expression of ETS1 mRNA]; SB 203580 inhibits the reaction [benzo(k)fluoranthene results in increased expression of ETS1 mRNA]; SB 203580 inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of ETS1 mRNA]; SB 203580 inhibits the reaction [VEGFA protein affects the localization of ETS1 protein] CTD PMID:21635667 PMID:22270366 NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010
JBrowse link
G Ezr ezrin multiple interactions ISO SB 203580 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of EZR protein] CTD PMID:24677693 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
JBrowse link
G F11r F11 receptor multiple interactions ISO SB 203580 inhibits the reaction [Poly I-C results in decreased expression of F11R protein] CTD PMID:20932985 NCBI chr13:83,873,797...83,897,388
Ensembl chr13:83,873,797...83,897,402
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions
decreases expression
ISO SB 203580 inhibits the reaction [Asbestos, Crocidolite results in increased expression of F3 mRNA]; SB 203580 inhibits the reaction [Histamine results in increased expression of F3]; SB 203580 inhibits the reaction [IL1B protein results in increased expression of F3 protein]; SB 203580 inhibits the reaction [indoleacetic acid results in increased expression of F3 mRNA]; SB 203580 inhibits the reaction [indoleacetic acid results in increased expression of F3 protein]; SB 203580 inhibits the reaction [TNF protein results in increased expression of F3 mRNA]
SB 203580 results in decreased expression of F3 mRNA
CTD PMID:15371228 PMID:16009787 PMID:20118172 PMID:27556861 PMID:30324315 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fadd Fas associated via death domain multiple interactions ISO SB 203580 inhibits the reaction [S-allylcysteine promotes the reaction [FAS protein binds to FADD protein]] CTD PMID:31067004 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Fancd2 FA complementation group D2 multiple interactions ISO SB 203580 inhibits the reaction [Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]] CTD PMID:24124520 NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO SB 203580 inhibits the reaction [S-allylcysteine promotes the reaction [FAS protein binds to FADD protein]]; SB 203580 inhibits the reaction [S-allylcysteine promotes the reaction [FAS protein binds to FASLG protein]] CTD PMID:31067004 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand multiple interactions ISO SB 203580 affects the reaction [Temozolomide results in increased expression of FASLG mRNA]; SB 203580 inhibits the reaction [S-allylcysteine promotes the reaction [FAS protein binds to FASLG protein]]; SB 203580 promotes the reaction [Emodin results in increased expression of FASLG protein]; SB 203580 promotes the reaction [Resveratrol results in increased cleavage of FASLG protein]
SB 203580 inhibits the reaction [Sodium Glutamate results in increased expression of FASL mRNA]
CTD PMID:16782274 PMID:22644961 PMID:26418950 PMID:27032576 PMID:31067004 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions EXP SB 203580 inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA] CTD PMID:15121739 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
increases secretion
decreases activity
ISO
EXP
SB 203580 inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK14 protein]; SB 203580 inhibits the reaction [FGF2 protein results in increased phosphorylation of RB1 protein]; SB 203580 inhibits the reaction [Sodium Chloride results in increased expression of FGF2 mRNA]
SB 203580 results in increased secretion of FGF2 protein
SB 203580 inhibits the reaction [AGT protein modified form results in increased expression of FGF2 mRNA]; SB 203580 inhibits the reaction [AGT protein modified form results in increased expression of FGF2 protein]; SB 203580 promotes the reaction [diphenylarsinic acid results in increased secretion of FGF2 protein]
SB 203580 inhibits the reaction [FGF2 protein results in increased secretion of TNFRSF11B protein]
SB 203580 results in decreased activity of FGF2 protein
CTD PMID:15249425 PMID:15631803 PMID:21108934 PMID:25290095 PMID:26800359 More... NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fgf23 fibroblast growth factor 23 multiple interactions ISO SB 203580 inhibits the reaction [FGF23 protein results in increased chemical synthesis of and affects the secretion of Dinoprostone] CTD PMID:16144964 NCBI chr 4:159,914,393...159,922,073
Ensembl chr 4:159,914,272...159,923,821
JBrowse link
G Fgf7 fibroblast growth factor 7 multiple interactions ISO SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of FGF7 mRNA] CTD PMID:28329830 NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP SB 203580 inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; SB 203580 inhibits the reaction [Pyruvaldehyde results in increased expression of FN1 mRNA] CTD PMID:17635749 PMID:22406263 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
increases expression
ISO
EXP
SB 203580 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased expression of FOS protein]; SB 203580 inhibits the reaction [IL1B protein results in increased expression of FOS mRNA]; SB 203580 inhibits the reaction [IL1B protein results in increased phosphorylation of FOS protein]; SB 203580 inhibits the reaction [TNF protein results in increased expression of FOS mRNA]; SB 203580 promotes the reaction [sodium arsenite results in increased expression of FOS mRNA]
SB 203580 promotes the reaction [diphenylarsinic acid results in increased expression of and results in increased phosphorylation of FOS protein]
SB 203580 results in decreased expression of FOS mRNA
SB 203580 results in increased expression of FOS protein
SB 203580 inhibits the reaction [icariin results in increased expression of FOS protein]
CTD PMID:11053056 PMID:12547826 PMID:15322261 PMID:18423597 PMID:18982426 More... NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit multiple interactions ISO SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of FOSL1 mRNA] CTD PMID:28329830 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO
EXP
SB 203580 inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein]; SB 203580 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein]
SB 203580 inhibits the reaction [Manganese results in increased phosphorylation of FOXO3 protein]
CTD PMID:23673518 PMID:24787138 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP SB 203580 inhibits the reaction [FSHB protein results in increased abundance of Estradiol] CTD PMID:22067323 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Gabpa GA binding protein transcription factor subunit alpha multiple interactions ISO SB 203580 inhibits the reaction [Gallic Acid results in increased expression of GABPA protein] CTD PMID:16308312 NCBI chr11:23,888,586...23,917,612
Ensembl chr11:23,888,815...23,917,605
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO troglitazone promotes the reaction [SB 203580 results in increased expression of GADD45A mRNA] CTD PMID:15064713 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Galnt3 polypeptide N-acetylgalactosaminyltransferase 3 multiple interactions ISO SB 203580 inhibits the reaction [Cadmium results in increased expression of GALNT3 mRNA] CTD PMID:24614234 NCBI chr 3:50,742,500...50,779,266
Ensembl chr 3:50,742,512...50,766,268
JBrowse link
G Gata2 GATA binding protein 2 multiple interactions ISO SB 203580 inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of GATA2 protein] CTD PMID:23940812 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
JBrowse link
G Gata4 GATA binding protein 4 affects activity
multiple interactions
EXP SB 203580 affects the activity of GATA4 protein
SB 203580 inhibits the reaction [AGT protein modified form results in increased activity of GATA4 protein]
CTD PMID:21084678 PMID:21108934 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
JBrowse link
G Gcg glucagon multiple interactions ISO SB 203580 inhibits the reaction [Chitosan results in increased expression of GCG mRNA]; SB 203580 inhibits the reaction [Chitosan results in increased secretion of GCG protein] CTD PMID:23611362 NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO SB 203580 inhibits the reaction [Plant Extracts results in increased expression of GCLC protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased expression of GCLC protein]
SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of GCLC mRNA]
CTD PMID:25201354 PMID:30626086 PMID:31029725 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO SB 203580 inhibits the reaction [Quercetin results in increased expression of GCLM mRNA] CTD PMID:22197970 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions ISO [SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [jasplakinolide results in increased expression of GDF15 protein]; [SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [latrunculin B results in increased expression of GDF15 protein]; [SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GDF15 protein]; SB 203580 inhibits the reaction [rottlerin results in increased expression of GDF15 protein]; SB 203580 inhibits the reaction [silybin results in increased expression of GDF15 protein] CTD PMID:22410117 PMID:23996089 PMID:24440808 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Gh1 growth hormone 1 multiple interactions EXP SB 203580 inhibits the reaction [deoxynivalenol results in decreased expression of GH1 mRNA]; SB 203580 inhibits the reaction [deoxynivalenol results in decreased expression of GH1 protein]; SB 203580 inhibits the reaction [T-2 Toxin results in decreased expression of GH1 mRNA] CTD PMID:26141394 PMID:29079362 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO
EXP
SB 203580 inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of and results in decreased phosphorylation of GJA1 protein]; SB 203580 inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of GJA1 protein]; SB 203580 inhibits the reaction [resveratrol results in increased expression of GJA1 protein]
SB 203580 inhibits the reaction [fulvestrant promotes the reaction [NEDD4 protein binds to and results in increased ubiquitination of GJA1 protein]]; SB 203580 inhibits the reaction [fulvestrant results in decreased expression of GJA1 mRNA]; SB 203580 inhibits the reaction [fulvestrant results in decreased expression of GJA1 protein]
SB 203580 inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein]
CTD PMID:18445782 PMID:23761298 PMID:24449132 PMID:27818224 PMID:29180066 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gjb1 gap junction protein, beta 1 multiple interactions ISO SB 203580 inhibits the reaction [1-methylanthracene affects the expression of and affects the activity of GJB1 protein]; SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] affects the expression of and affects the activity of GJB1 protein]; SB 203580 inhibits the reaction [fluoranthene affects the expression of and affects the activity of GJB1 protein] CTD PMID:28329830 NCBI chr  X:66,501,848...66,509,783
Ensembl chr  X:66,501,820...66,509,925
JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions ISO pyrazolanthrone promotes the reaction [SB 203580 inhibits the reaction [Arsenic Trioxide results in increased activity of GLB1 protein]]; SB 203580 inhibits the reaction [Arsenic Trioxide results in increased activity of GLB1 protein]; SB 203580 promotes the reaction [pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased activity of GLB1 protein]] CTD PMID:31734849 NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127
JBrowse link
G Glul glutamate-ammonia ligase multiple interactions EXP SB 203580 inhibits the reaction [[Paraquat results in increased abundance of Reactive Oxygen Species] which results in decreased expression of GLUL protein] CTD PMID:24376630 NCBI chr13:65,969,064...66,035,121
Ensembl chr13:66,025,630...66,035,108
JBrowse link
G Gmfb glia maturation factor, beta multiple interactions ISO SB 203580 inhibits the reaction [[GMFB protein co-treated with Hydrogen Peroxide] results in increased abundance of Hydrogen Peroxide]; SB 203580 inhibits the reaction [[GMFB protein co-treated with Hydrogen Peroxide] results in increased activity of CASP3 protein] CTD PMID:12791701 NCBI chr15:20,069,923...20,081,005
Ensembl chr15:20,067,263...20,080,331
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO SB 203580 inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein] CTD PMID:26218279 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO SB 203580 inhibits the reaction [Quercetin results in increased expression of GPX1 mRNA] CTD PMID:22197970 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 multiple interactions EXP SB 203580 affects the reaction [Sodium Glutamate affects the expression of GRIA2] CTD PMID:15139026 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
decreases activity
ISO SB 203580 inhibits the reaction [DEFA1 protein results in increased phosphorylation of GSK3B protein]; SB 203580 inhibits the reaction [DEFA2 protein results in increased phosphorylation of GSK3B protein]
SB 203580 results in decreased activity of GSK3B protein
CTD PMID:10998351 PMID:19814765 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO SB 203580 inhibits the reaction [Quercetin results in increased expression of GSR mRNA] CTD PMID:22197970 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO SB 203580 inhibits the reaction [Quercetin results in increased expression of GSTP1 mRNA] CTD PMID:22197970 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Has2 hyaluronan synthase 2 multiple interactions ISO SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of HAS2 mRNA] CTD PMID:28329830 NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933
JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions ISO SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of HBEGF mRNA]; SB 203580 inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA]; SB 203580 inhibits the reaction [vanadium pentoxide results in increased expression of HBEGF mRNA] CTD PMID:11159045 PMID:12676768 PMID:26800359 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression
ISO [U 0126 co-treated with SB 203580] inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased expression of HIF1A protein]; SB 203580 inhibits the reaction [[nickel sulfate co-treated with Dinoprostone] results in increased expression of HIF1A protein]; SB 203580 inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein]; SB 203580 inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]; SB 203580 inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; SB 203580 inhibits the reaction [Lapatinib inhibits the reaction [sodium arsenite results in increased expression of HIF1A protein]]; SB 203580 inhibits the reaction [manganese chloride results in increased expression of and results in increased activity of and results in increased stability of HIF1A protein]; SB 203580 inhibits the reaction [manganese chloride results in increased expression of and results in increased activity of HIF1A protein]; SB 203580 inhibits the reaction [nickel sulfate results in increased expression of HIF1A protein]; SB 203580 inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased expression of HIF1A protein]
SB 203580 results in decreased expression of HIF1A protein
CTD PMID:12482858 PMID:13679210 PMID:14695184 PMID:17082639 PMID:20152896 More... NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmga2 high mobility group AT-hook 2 multiple interactions ISO SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of HMGA2 mRNA] CTD PMID:28329830 NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO SB 203580 inhibits the reaction [Silicon Dioxide results in increased expression of HMGB1 protein] CTD PMID:27616297 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
decreases expression
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [SB 203580 inhibits the reaction [Quercetin promotes the reaction [Ethanol results in increased activity of HMOX1 protein]]]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with SB 203580] inhibits the reaction [Quercetin results in increased activity of HMOX1 protein]; SB 203580 inhibits the reaction [10-nitro-oleic acid results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [2-butenal results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [2-butenal results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Cadmium results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [gallium nitrate results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [kahweol results in increased expression of and results in increased activity of HMOX1 protein]; SB 203580 inhibits the reaction [lead acetate results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Plant Extracts results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Potassium Dichromate results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [Quercetin promotes the reaction [Ethanol results in increased activity of HMOX1 protein]]; SB 203580 inhibits the reaction [Quercetin results in increased activity of HMOX1 protein]; SB 203580 inhibits the reaction [Quercetin results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Silver results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Simvastatin results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [sodium arsenite results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Sulindac promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]]; SB 203580 inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased expression of HMOX1 protein]; SB 203580 promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin promotes the reaction [Ethanol results in increased activity of HMOX1 protein]]]
SB 203580 results in increased expression of HMOX1 mRNA
SB 203580 results in decreased expression of HMOX mRNA; SB 203580 results in decreased expression of HMOX1 mRNA
SB 203580 inhibits the reaction [Ascorbic Acid results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [aureusidin results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [diphenylarsinic acid results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Methamphetamine results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Quercetin results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [Resveratrol results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Tropisetron results in increased expression of HMOX1 protein]; SB 203580 promotes the reaction [[Paraquat results in increased abundance of Reactive Oxygen Species] which results in increased expression of HMOX1 mRNA]
SB 203580 inhibits the reaction [10-nitro-oleic acid results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [10-nitro-oleic acid results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [17-hydroxyjolkinolide B promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [Copper results in increased expression of HMOX mRNA]; SB 203580 inhibits the reaction [Dieldrin results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [farrerol results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Lead results in increased expression of HMOX mRNA]; SB 203580 inhibits the reaction [lipoteichoic acid results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Mercury results in increased expression of HMOX mRNA]; SB 203580 inhibits the reaction [Quercetin analog results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]
CTD PMID:10874044 PMID:14647439 PMID:15504750 PMID:15770161 PMID:16171798 More... NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 multiple interactions ISO SB 203580 inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA] CTD PMID:30993381 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 multiple interactions EXP SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of HSD17B3 mRNA] CTD PMID:29567110 NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554
JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions EXP SB 203580 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of HSF1 protein] CTD PMID:9822662 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B multiple interactions ISO SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of HSPA1B mRNA] CTD PMID:28329830 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO SB 203580 inhibits the reaction [Indomethacin results in increased expression of HSPA5 protein] CTD PMID:17341418 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions
decreases phosphorylation
ISO
EXP
SB 203580 inhibits the reaction [IL1B protein results in increased phosphorylation of HSPB1 protein]; SB 203580 inhibits the reaction [Methotrexate results in increased expression of HSPB1 protein]
SB 203580 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of HSPB1 protein]; SB 203580 inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of HSPB1 protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of HSPB1 protein]
SB 203580 inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of HSPB1 protein]
SB 203580 results in decreased phosphorylation of HSPB1 protein
CTD PMID:10903806 PMID:19100307 PMID:20864298 PMID:21457723 PMID:22000993 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Hspb2 heat shock protein family B (small) member 2 multiple interactions ISO SB 203580 inhibits the reaction [Fluorouracil results in increased phosphorylation of HSPB2 protein] CTD PMID:18757417 NCBI chr 8:51,093,267...51,094,864 JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions EXP SB 203580 inhibits the reaction [Particulate Matter results in increased expression of HTR2A mRNA]; SB 203580 inhibits the reaction [Particulate Matter results in increased expression of HTR2A protein] CTD PMID:31199065 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO
EXP
SB 203580 inhibits the reaction [Chenodeoxycholic Acid results in increased expression of ICAM1 mRNA]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]; SB 203580 inhibits the reaction [Particulate Matter results in increased expression of ICAM1 mRNA]; SB 203580 inhibits the reaction [TNF results in increased expression of ICAM1 protein]; SB 203580 inhibits the reaction [Vehicle Emissions results in increased expression of ICAM1 mRNA]; SB 203580 inhibits the reaction [Vehicle Emissions results in increased expression of ICAM1 protein]
SB 203580 inhibits the reaction [resveratrol results in decreased expression of ICAM1 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of ICAM1 protein]
CTD PMID:10792388 PMID:16582018 PMID:19020780 PMID:21192278 PMID:22226621 More... NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP
[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with SB 203580] inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; [SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] results in decreased susceptibility to [IL1B protein co-treated with IFNG protein]; SB 203580 inhibits the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]; SB 203580 inhibits the reaction [[IL12A protein binds to IL12B protein] which results in increased expression of IFNG protein]; SB 203580 inhibits the reaction [deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]]; SB 203580 inhibits the reaction [IFNG protein results in increased expression of CYP27B1 mRNA]; SB 203580 inhibits the reaction [IFNG protein results in increased phosphorylation of CEBPB protein]; SB 203580 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]
[SB 203580 co-treated with Manganese] inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; SB 203580 inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [[IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased abundance of Nitric Oxide]; SB 203580 inhibits the reaction [[IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NOS2 protein]; SB 203580 inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; SB 203580 inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of NOS2 protein]; SB 203580 inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; SB 203580 inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; SB 203580 inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]]
SB 203580 inhibits the reaction [[Polysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]
CTD PMID:10903806 PMID:10952721 PMID:12911628 PMID:16307444 PMID:16355272 More... NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO SB 203580 inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of and results in decreased secretion of IGF1 protein]] CTD PMID:26254549 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf2 insulin-like growth factor 2 multiple interactions
decreases response to substance
ISO SB 203580 inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]
SB 203580 results in decreased susceptibility to IGF2 protein
CTD PMID:24055520 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO
EXP
SB 203580 inhibits the reaction [Lipopolysaccharides results in increased activity of IKBKB protein]
SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of IKBKB protein]
CTD PMID:16765938 PMID:19616567 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Il10 interleukin 10 multiple interactions ISO SB 203580 inhibits the reaction [Drugs, Chinese Herbal results in increased secretion of IL10 protein]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]; SB 203580 inhibits the reaction [Methotrexate results in increased expression of IL10 protein]; SB 203580 inhibits the reaction [Poly I-C results in increased secretion of IL10 protein]; SB 203580 inhibits the reaction [Polysaccharides results in increased secretion of IL10 protein]; SB 203580 inhibits the reaction [Zymosan results in increased secretion of IL10 protein]
SB 203580 inhibits the reaction [Folic Acid promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL10 protein]]; SB 203580 inhibits the reaction [Folic Acid results in increased secretion of IL10 protein]; SB 203580 inhibits the reaction [Fungal Polysaccharides results in increased secretion of IL10 protein]; SB 203580 inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL10 protein]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA]
CTD PMID:15894585 PMID:17698565 PMID:19100307 PMID:21135123 PMID:21586572 More... NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il11 interleukin 11 multiple interactions ISO SB 203580 inhibits the reaction [Formaldehyde results in increased expression of IL11 mRNA]; SB 203580 inhibits the reaction [Formaldehyde results in increased secretion of IL11 protein] CTD PMID:22138297 NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129
JBrowse link
G Il12a interleukin 12A multiple interactions ISO SB 203580 inhibits the reaction [[IL12A protein binds to IL12B protein] which results in increased expression of IFNG protein]; SB 203580 inhibits the reaction [Drugs, Chinese Herbal results in increased secretion of [IL12A protein binds to IL12B protein]]; SB 203580 inhibits the reaction [Polysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]
SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]
CTD PMID:10952721 PMID:11006016 PMID:15894585 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B multiple interactions ISO SB 203580 inhibits the reaction [[IL12A protein binds to IL12B protein] which results in increased expression of IFNG protein]; SB 203580 inhibits the reaction [Drugs, Chinese Herbal results in increased secretion of [IL12A protein binds to IL12B protein]]; SB 203580 inhibits the reaction [Drugs, Chinese Herbal results in increased secretion of IL12B protein]; SB 203580 inhibits the reaction [nickel sulfate results in increased secretion of IL12B protein]; SB 203580 inhibits the reaction [Polysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]; SB 203580 inhibits the reaction [Polysaccharides results in increased secretion of IL12B protein]
SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]
CTD PMID:10952721 PMID:11006016 PMID:15778123 PMID:15894585 PMID:19101624 More... NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 decreases expression ISO SB 203580 results in decreased expression of IL13RA2 mRNA CTD PMID:20660070 NCBI chr  X:111,002,590...111,074,053
Ensembl chr  X:111,002,592...111,072,381
JBrowse link
G Il17a interleukin 17A multiple interactions ISO SB 203580 inhibits the reaction [IL17A protein promotes the reaction [TNF protein results in increased expression of IL6 mRNA]]; SB 203580 inhibits the reaction [IL17A protein results in increased expression of CCL2 protein]; SB 203580 inhibits the reaction [IL17A protein results in increased expression of CXCL8 protein]; SB 203580 inhibits the reaction [IL17A protein results in increased expression of IL6 protein] CTD PMID:12016129 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il18 interleukin 18 multiple interactions ISO SB 203580 inhibits the reaction [IL18 protein results in increased expression of PTEN mRNA]; SB 203580 inhibits the reaction [IL18 protein results in increased phosphorylation of and results in increased activity of RELA protein]; SB 203580 inhibits the reaction [IL18 protein results in increased phosphorylation of ATF2 protein] CTD PMID:18215737 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO SB 203580 inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]; SB 203580 inhibits the reaction [IL1A protein results in increased secretion of IL6 protein]; SB 203580 inhibits the reaction [IL1A results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [IL1A results in increased expression of PTGS2 protein] CTD PMID:14742690 PMID:15728660 PMID:16532021 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO
EXP
[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with SB 203580] inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; [SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [IL1B protein results in increased chemical synthesis of Nitrites]; [SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] results in decreased susceptibility to [IL1B protein co-treated with IFNG protein]; SB 203580 affects the reaction [IL1B results in increased expression of CXCL8 protein]; SB 203580 analog inhibits the reaction [IL1B results in increased expression of MMP13 mRNA]; SB 203580 analog inhibits the reaction [IL1B results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]; SB 203580 inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of and results in increased secretion of CRP protein]; SB 203580 inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL1B mRNA]; SB 203580 inhibits the reaction [APP protein results in increased expression of and results in increased cleavage of IL1B protein]; SB 203580 inhibits the reaction [deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]]; SB 203580 inhibits the reaction [IL1B protein results in decreased expression of TNFRSF11B protein]; SB 203580 inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; SB 203580 inhibits the reaction [IL1B protein results in increased expression of CXCL8 protein]; SB 203580 inhibits the reaction [IL1B protein results in increased expression of F3 protein]; SB 203580 inhibits the reaction [IL1B protein results in increased expression of FOS mRNA]; SB 203580 inhibits the reaction [IL1B protein results in increased expression of IL6 protein]; SB 203580 inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [IL1B protein results in increased phosphorylation of ELK1 protein]; SB 203580 inhibits the reaction [IL1B protein results in increased phosphorylation of FOS protein]; SB 203580 inhibits the reaction [IL1B protein results in increased phosphorylation of HSPB1 protein]; SB 203580 inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; SB 203580 inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; SB 203580 inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; SB 203580 inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; SB 203580 inhibits the reaction [IL1B results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [Methotrexate results in increased expression of IL1B protein]; SB 203580 inhibits the reaction [Mustard Gas results in increased expression of IL1B protein]; SB 203580 inhibits the reaction [T-2 Toxin promotes the reaction [IL1B protein results in increased secretion of CXCL8 protein]]; SB 203580 promotes the reaction [bufalin results in increased expression of IL1B mRNA]
SB 203580 results in decreased expression of IL1B protein
SB 203580 inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]; SB 203580 inhibits the reaction [Fungal Polysaccharides results in increased expression of IL1B mRNA]; SB 203580 inhibits the reaction [IL1B protein results in increased expression of IL6 protein]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; SB 203580 inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of and results in increased secretion of IL1B protein]]
SB 203580 inhibits the reaction [2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid inhibits the reaction [ACE2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]]; SB 203580 inhibits the reaction [7-Ala-angiotensin (1-7) inhibits the reaction [ACE2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]]; SB 203580 inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [Acrolein results in increased cleavage of IL1B protein]; SB 203580 inhibits the reaction [Acrolein results in increased expression of and results in increased secretion of IL1B protein]; SB 203580 inhibits the reaction [CLDN2 protein results in increased expression of IL1B mRNA]; SB 203580 inhibits the reaction [CLDN2 protein results in increased expression of IL1B protein]; SB 203580 inhibits the reaction [lead acetate results in increased expression of IL1B protein]; SB 203580 inhibits the reaction [Particulate Matter results in increased expression of IL1B mRNA]; SB 203580 inhibits the reaction [T-2 Toxin results in increased expression of IL1B mRNA]
CTD PMID:10704466 PMID:10712238 PMID:10903806 PMID:11854442 PMID:15251176 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions ISO SB 203580 affects the reaction [Methotrexate results in increased expression of IL2 protein]; SB 203580 inhibits the reaction [norcantharidin inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2 protein]] CTD PMID:19100307 PMID:21075198 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il27 interleukin 27 multiple interactions ISO SB 203580 inhibits the reaction [nickel sulfate results in increased expression of IL27 mRNA] CTD PMID:30421605 NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582
JBrowse link
G Il4 interleukin 4 multiple interactions ISO
EXP
SB 203580 inhibits the reaction [Methadone results in increased expression of IL4 mRNA]; SB 203580 inhibits the reaction [Methotrexate results in decreased expression of IL4 protein]; SB 203580 inhibits the reaction [Morphine results in increased expression of IL4 mRNA]
SB 203580 inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased expression of IL4 mRNA]; SB 203580 promotes the reaction [dinitrophenyl-human serum albumin conjugate results in increased secretion of IL4 protein]
CTD PMID:10611455 PMID:19100307 PMID:23965172 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases secretion
decreases expression
ISO
EXP
magnolin promotes the reaction [SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA]]; magnolin promotes the reaction [SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL6 protein]]; SB 203580 affects the reaction [Methotrexate results in decreased expression of IL6 protein]; SB 203580 inhibits the reaction [7-ketocholesterol results in increased expression of IL6 mRNA]; SB 203580 inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of and results in increased secretion of CRP protein]; SB 203580 inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of IL6 protein]; SB 203580 inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA]; SB 203580 inhibits the reaction [cobaltous chloride results in increased secretion of IL6 protein]; SB 203580 inhibits the reaction [EDN1 protein results in increased expression of IL6 mRNA]; SB 203580 inhibits the reaction [hexabromocyclododecane results in increased expression of IL6 protein]; SB 203580 inhibits the reaction [IL17A protein promotes the reaction [TNF protein results in increased expression of IL6 mRNA]]; SB 203580 inhibits the reaction [IL17A protein results in increased expression of IL6 protein]; SB 203580 inhibits the reaction [IL1A protein results in increased secretion of IL6 protein]; SB 203580 inhibits the reaction [IL1B protein results in increased expression of IL6 protein]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; SB 203580 inhibits the reaction [melamine results in increased expression of IL6 mRNA]; SB 203580 inhibits the reaction [Mustard Gas results in increased expression of IL6 protein]; SB 203580 inhibits the reaction [Mustard Gas results in increased secretion of IL6 protein]; SB 203580 inhibits the reaction [nickel sulfate results in increased secretion of IL6 protein]; SB 203580 inhibits the reaction [OSM protein results in increased expression of and results in increased secretion of IL6 protein]; SB 203580 inhibits the reaction [OSM protein results in increased expression of IL6 mRNA]; SB 203580 inhibits the reaction [Particulate Matter results in increased expression of IL6 mRNA]; SB 203580 inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]; SB 203580 inhibits the reaction [pentabromodiphenyl ether results in increased expression of IL6 protein]; SB 203580 inhibits the reaction [Poly I-C results in increased secretion of IL6 protein]; SB 203580 inhibits the reaction [tetrabromobisphenol A results in increased expression of IL6 protein]; SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA]; SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL6 protein]; SB 203580 inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; SB 203580 inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of IL6 mRNA]; SB 203580 inhibits the reaction [Vehicle Emissions results in increased secretion of IL6 protein]; SB 203580 inhibits the reaction [Zymosan results in increased secretion of IL6 protein]; SB 203580 promotes the reaction [magnolin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA]]; SB 203580 promotes the reaction [magnolin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL6 protein]]; SB 203580 results in decreased susceptibility to [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]
SB 203580 inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased secretion of IL6 protein]]; SB 203580 inhibits the reaction [[Paraquat results in increased abundance of Reactive Oxygen Species] which results in increased secretion of IL6 protein]; SB 203580 inhibits the reaction [Adenosine Triphosphate promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased secretion of IL6 protein]]; SB 203580 inhibits the reaction [cobaltous chloride results in increased secretion of IL6 protein]; SB 203580 inhibits the reaction [diphenylarsinic acid results in increased secretion of IL6 protein]; SB 203580 inhibits the reaction [lead acetate results in increased expression of IL6 protein]; SB 203580 inhibits the reaction [Resveratrol results in decreased expression of IL6 protein]; SB 203580 inhibits the reaction [Tropisetron results in decreased expression of IL6 protein]
SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of IL6 mRNA]; SB 203580 inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; SB 203580 inhibits the reaction [cobaltous chloride results in increased expression of IL6 protein]; SB 203580 inhibits the reaction [deoxynivalenol results in increased expression of IL6 mRNA]; SB 203580 inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; SB 203580 inhibits the reaction [Fungal Polysaccharides results in increased secretion of IL6 protein]; SB 203580 inhibits the reaction [IL1B protein results in increased expression of IL6 protein]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; SB 203580 inhibits the reaction [Particulate Matter promotes the reaction [Tobacco Smoke Pollution results in increased expression of IL6 mRNA]]; SB 203580 inhibits the reaction [Particulate Matter results in increased expression of IL6 mRNA]; SB 203580 inhibits the reaction [Tobacco Smoke Pollution promotes the reaction [Particulate Matter results in increased expression of IL6 mRNA]]; SB 203580 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of IL6 mRNA]
SB 203580 results in decreased secretion of IL6 protein
SB 203580 results in decreased expression of IL6 protein
CTD PMID:1970628 PMID:10704466 PMID:12016129 PMID:12794122 PMID:15251176 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins2 insulin 2 multiple interactions ISO [SB 203580 co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein] CTD PMID:11574405 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Insr insulin receptor multiple interactions EXP SB 203580 inhibits the reaction [oleoylethanolamide affects the phosphorylation of and affects the activity of INSR protein] CTD PMID:19345745 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Irgm immunity-related GTPase M multiple interactions ISO SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of IRGM1 mRNA] CTD PMID:28329830 NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO SB 203580 inhibits the reaction [bisphenol A results in increased expression of IRS1 protein modified form] CTD PMID:29793316 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Itga2 integrin subunit alpha 2 multiple interactions ISO SB 203580 inhibits the reaction [benz(a)anthracene results in increased expression of ITGA2 mRNA]; SB 203580 inhibits the reaction [benzo(k)fluoranthene results in increased expression of ITGA2 mRNA]; SB 203580 inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of ITGA2 mRNA] CTD PMID:21635667 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO SB 203580 inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of ITGAM protein]] CTD PMID:26254549 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Itgb6 integrin subunit beta 6 multiple interactions ISO SB 203580 inhibits the reaction [TGFB1 protein results in increased expression of ITGB6 mRNA] CTD PMID:21303922 NCBI chr 3:45,046,295...45,170,532
Ensembl chr 3:45,048,044...45,121,671
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO
EXP
SB 203580 inhibits the reaction [benz(a)anthracene results in increased expression of JUN mRNA]; SB 203580 inhibits the reaction [benzo(k)fluoranthene results in increased expression of JUN mRNA]; SB 203580 inhibits the reaction [Glucose results in increased phosphorylation of JUN protein]; SB 203580 inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of JUN mRNA]
SB 203580 inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]; SB 203580 promotes the reaction [diphenylarsinic acid results in increased expression of and results in increased phosphorylation of JUN protein]
SB 203580 inhibits the reaction [icariin results in increased expression of JUN protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of JUN protein]
CTD PMID:11035063 PMID:15252869 PMID:18423597 PMID:19002563 PMID:19132243 More... NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO SB 203580 inhibits the reaction [TGFB1 protein affects the localization of JUNB protein]; SB 203580 inhibits the reaction [TGFB1 protein results in increased expression of JUNB mRNA] CTD PMID:21303922 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Kitlg KIT ligand decreases expression ISO SB 203580 results in decreased expression of SCF protein CTD PMID:15585325 NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214
JBrowse link
G Klf4 Kruppel like factor 4 multiple interactions ISO SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of KLF4 mRNA] CTD PMID:28329830 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
JBrowse link
G Klf5 Kruppel-like factor 5 multiple interactions ISO SB 203580 inhibits the reaction [TGFB1 protein results in decreased expression of KLF5 mRNA]
SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of KLF5 mRNA]
CTD PMID:21712382 PMID:28329830 NCBI chr15:76,060,320...76,079,445
Ensembl chr15:76,064,258...76,079,445
JBrowse link
G Klf6 Kruppel-like factor 6 multiple interactions ISO [Arachidonic Acid co-treated with SB 203580] results in decreased expression of KLF6 mRNA; SB 203580 promotes the reaction [Arachidonic Acid promotes the reaction [CYP2E1 protein results in increased expression of KLF6 mRNA]]; SB 203580 promotes the reaction [CYP2E1 protein results in increased expression of KLF6 mRNA] CTD PMID:22486562 NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570
JBrowse link
G Krt1 keratin 1 multiple interactions
decreases expression
ISO SB 203580 inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]; SB 203580 inhibits the reaction [Calcium results in increased expression of KRT1 protein]; SB 203580 inhibits the reaction [Mustard Gas results in increased expression of KRT1 mRNA]; SB 203580 inhibits the reaction [Mustard Gas results in increased expression of KRT1 protein]
SB 203580 results in decreased expression of KRT1 mRNA; SB 203580 results in decreased expression of KRT1 protein
CTD PMID:21524694 NCBI chr 7:132,976,618...132,981,844
Ensembl chr 7:132,976,620...132,981,844
JBrowse link
G Krt18 keratin 18 multiple interactions ISO SB 203580 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of KRT18 protein] CTD PMID:22960429 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
JBrowse link
G Krt8 keratin 8 multiple interactions ISO SB 203580 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of KRT8 protein] CTD PMID:22960429 NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase decreases activity ISO SB 203580 results in decreased activity of LCK protein CTD PMID:10998351 NCBI chr 5:141,888,319...141,916,992
Ensembl chr 5:141,888,326...141,903,794
JBrowse link
G Lep leptin multiple interactions
decreases response to substance
ISO SB 203580 inhibits the reaction [LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR protein]]; SB 203580 inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA]
SB 203580 results in decreased susceptibility to LEP protein
CTD PMID:16996477 PMID:19849856 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lepr leptin receptor affects response to substance ISO LEPR protein affects the susceptibility to SB 203580 CTD PMID:22933112 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Lif LIF, interleukin 6 family cytokine multiple interactions ISO SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of LIF mRNA] CTD PMID:28329830 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
JBrowse link
G Loricrin loricrin cornified envelope precursor protein multiple interactions
decreases expression
ISO SB 203580 inhibits the reaction [Calcium results in increased expression of LORICRIN mRNA]; SB 203580 inhibits the reaction [Calcium results in increased expression of LORICRIN protein]; SB 203580 inhibits the reaction [Mustard Gas results in increased expression of LORICRIN mRNA]; SB 203580 inhibits the reaction [Mustard Gas results in increased expression of LORICRIN protein]
SB 203580 results in decreased expression of LORICRIN protein
CTD PMID:21524694 NCBI chr 2:177,558,062...177,559,980
Ensembl chr 2:177,558,252...177,559,807
JBrowse link
G Lrp1 LDL receptor related protein 1 multiple interactions
increases expression
ISO SB 203580 inhibits the reaction [tanshinone results in decreased expression of LRP1 mRNA]
SB 203580 results in increased expression of LRP1 mRNA
CTD PMID:21165580 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
JBrowse link
G Lta4h leukotriene A4 hydrolase multiple interactions ISO SB 203580 inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of LTA4H mRNA] CTD PMID:20382172 NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600
JBrowse link
G Ltc4s leukotriene C4 synthase multiple interactions ISO SB 203580 inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of LTC4S mRNA] CTD PMID:20382172 NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651
JBrowse link
G Lyz2 lysozyme 2 multiple interactions ISO SB 203580 inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein]; SB 203580 inhibits the reaction [Heme analog results in increased secretion of LYZ protein] CTD PMID:23355332 NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 multiple interactions EXP SB 203580 inhibits the reaction [MAP2K6 protein results in decreased expression of EP300 protein] CTD PMID:15767673 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
SB 203580 inhibits the reaction [4-vinyl-2,6-dimethoxyphenol results in decreased phosphorylation of MAPK1 protein]; SB 203580 inhibits the reaction [Dinitrochlorobenzene results in decreased phosphorylation of MAPK1 protein]; SB 203580 inhibits the reaction [Estradiol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SB 203580 inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; SB 203580 inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SB 203580 inhibits the reaction [Thimerosal results in decreased phosphorylation of MAPK1 protein]; SB 203580 promotes the reaction [bufalin results in increased phosphorylation of MAPK1 protein]; SB 203580 promotes the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]; SB 203580 promotes the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]
SB 203580 results in increased phosphorylation of MAPK1 protein
[pyrazolanthrone co-treated with SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Quercetin results in increased phosphorylation of MAPK1 protein]; SB 203580 inhibits the reaction [esculetin results in increased phosphorylation of MAPK1 protein]; SB 203580 inhibits the reaction [Quercetin results in increased phosphorylation of MAPK1 protein]; SB 203580 promotes the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; SB 203580 promotes the reaction [Iron results in increased phosphorylation of MAPK1 protein]
SB 203580 promotes the reaction [Anisomycin results in increased phosphorylation of MAPK1 protein]; SB 203580 promotes the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]; SB 203580 promotes the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]; SB 203580 promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:9671412 PMID:10712238 PMID:10993886 PMID:12547826 PMID:15588916 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk11 mitogen-activated protein kinase 11 multiple interactions
decreases expression
increases expression
decreases activity
ISO
EXP
Cadmium Chloride inhibits the reaction [SB 203580 results in decreased expression of MAPK11 mRNA]; Cadmium Chloride inhibits the reaction [SB 203580 results in increased expression of MAPK11 protein]; SB 203580 inhibits the reaction [Cadmium Chloride results in increased expression of MAPK11 protein]; SB 203580 inhibits the reaction [MAPK11 protein results in increased phosphorylation of SOD2 protein]
SB 203580 results in decreased activity of MAPK11 protein
CTD PMID:10998351 PMID:19757093 PMID:24376630 PMID:24465521 NCBI chr 7:120,218,471...120,225,488
Ensembl chr 7:120,218,478...120,225,395
JBrowse link
G Mapk12 mitogen-activated protein kinase 12 decreases expression ISO SB 203580 results in decreased expression of MAPK12 mRNA CTD PMID:19757093 NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664
JBrowse link
G Mapk13 mitogen activated protein kinase 13 multiple interactions ISO [SB 203580 co-treated with Cadmium Chloride] results in increased expression of MAPK13 mRNA CTD PMID:19757093 NCBI chr20:6,835,277...6,845,500
Ensembl chr20:6,835,320...6,844,222
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions
decreases activity
ISO
EXP
MAPK14 protein mutant form inhibits the reaction [SB 203580 inhibits the reaction [arsenite results in increased phosphorylation of EIF4E protein]]; SB 203580 inhibits the reaction [11,11'-dideoxyverticilin results in increased expression of and results in increased phosphorylation of MAPK14 protein]; SB 203580 inhibits the reaction [benz(a)anthracene results in increased phosphorylation of MAPK14 protein]; SB 203580 inhibits the reaction [benzo(k)fluoranthene results in increased phosphorylation of MAPK14 protein]; SB 203580 inhibits the reaction [Cadmium Chloride results in decreased expression of MAPK14 mRNA]; SB 203580 inhibits the reaction [Cadmium results in increased phosphorylation of MAPK14 protein]; SB 203580 inhibits the reaction [cinnamaldehyde results in increased phosphorylation of MAPK14 protein]; SB 203580 inhibits the reaction [dracorhodin analog results in increased phosphorylation of MAPK14 protein]; SB 203580 inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK14 protein]; SB 203580 inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]; SB 203580 inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased phosphorylation of MAPK14 protein]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK14 protein]; SB 203580 inhibits the reaction [Methotrexate results in increased phosphorylation of MAPK14 protein]; SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein]]
[SB 203580 results in decreased activity of MAPK14 protein] which results in decreased susceptibility to Doxorubicin; SB 203580 inhibits the reaction [[Methionine deficiency co-treated with Cysteine deficiency] results in increased activity of MAPK14 protein]; SB 203580 inhibits the reaction [Acrolein results in increased phosphorylation of MAPK14 protein]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased activity of MAPK14 protein]; SB 203580 inhibits the reaction [INS1 protein results in increased activity of MAPK14 protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased activity of MAPK14 protein]; SB 203580 promotes the reaction [dibenzo(a,l)pyrene results in increased phosphorylation of MAPK14 protein]
[SB 203580 results in decreased activity of MAPK14 protein] inhibits the reaction [[octanoic acid co-treated with Dexamethasone] results in increased expression of CAV1 protein]; [SB 203580 results in decreased activity of MAPK14 protein] inhibits the reaction [[octanoic acid co-treated with Dexamethasone] results in increased expression of PPARG protein alternative form]; SB 203580 affects the reaction [MAPK14 protein affects the reaction [sodium arsenite results in increased activity of MAPKAPK2 protein]]; SB 203580 inhibits the reaction [1-dodecylsulfonyl-5N,6O-oxomethylidenenojirimycin results in increased phosphorylation of MAPK14 protein]
CTD PMID:8971075 PMID:9647221 PMID:10704466 PMID:10998351 PMID:11709198 More... NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
SB 203580 inhibits the reaction [4-vinyl-2,6-dimethoxyphenol results in decreased phosphorylation of MAPK3 protein]; SB 203580 inhibits the reaction [Dinitrochlorobenzene results in decreased phosphorylation of MAPK3 protein]; SB 203580 inhibits the reaction [Estradiol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SB 203580 inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; SB 203580 inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SB 203580 inhibits the reaction [Thimerosal results in decreased phosphorylation of MAPK3 protein]; SB 203580 promotes the reaction [bufalin results in increased phosphorylation of MAPK3 protein]; SB 203580 promotes the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein]; SB 203580 promotes the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]
SB 203580 results in increased phosphorylation of MAPK3 protein
[Oxaliplatin co-treated with SB 203580] results in decreased phosphorylation of MAPK3 protein; [pyrazolanthrone co-treated with SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Quercetin results in increased phosphorylation of MAPK3 protein]; SB 203580 inhibits the reaction [esculetin results in increased phosphorylation of MAPK3 protein]; SB 203580 inhibits the reaction [Quercetin results in increased phosphorylation of MAPK3 protein]; SB 203580 promotes the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; SB 203580 promotes the reaction [Iron results in increased phosphorylation of MAPK3 protein]
SB 203580 promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:10712238 PMID:10993886 PMID:12547826 PMID:15588916 PMID:17172471 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
decreases activity
EXP
ISO
SB 203580 promotes the reaction [Acrolein results in increased phosphorylation of MAPK8 protein]
SB 203580 results in increased phosphorylation of MAPK8 protein
SB 203580 inhibits the reaction [4-vinyl-2,6-dimethoxyphenol results in increased phosphorylation of MAPK8 protein]; SB 203580 inhibits the reaction [cinnamaldehyde results in increased phosphorylation of MAPK8 protein]; SB 203580 inhibits the reaction [Oxygen deficiency results in increased activity of MAPK8 protein]; SB 203580 inhibits the reaction [polyhexamethyleneguanidine results in increased phosphorylation of MAPK8 protein]; SB 203580 promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK8 protein]; SB 203580 promotes the reaction [nickel sulfate results in increased phosphorylation of MAPK8 protein]
SB 203580 results in decreased activity of MAPK8 protein
CTD PMID:12487375 PMID:13679210 PMID:15964311 PMID:16818652 PMID:18089842 More... NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO SB 203580 inhibits the reaction [4-vinyl-2,6-dimethoxyphenol results in increased phosphorylation of MAPK9 protein]; SB 203580 promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK9 protein] CTD PMID:16818652 PMID:30653946 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 multiple interactions
increases phosphorylation
decreases expression
decreases phosphorylation
ISO
EXP
SB 203580 inhibits the reaction [Arsenic Trioxide results in increased activity of MAPKAPK2 protein]; SB 203580 inhibits the reaction [arsenite results in increased activity of MAPKAPK2 protein]; SB 203580 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPKAPK2 protein]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPKAPK2 protein]; SB 203580 inhibits the reaction [LY 303511 results in increased phosphorylation of MAPKAPK2 protein]; SB 203580 inhibits the reaction [Methotrexate results in increased expression of MAPKAPK2 protein]; SB 203580 inhibits the reaction [Mustard Gas results in increased phosphorylation of and results in increased activity of MAPKAPK2 protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased activity of MAPKAPK2 protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of MAPKAPK2 protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPKAPK2 protein]; SB 203580 inhibits the reaction [Sodium Fluoride results in increased phosphorylation of MAPKAPK2 protein]; SB 203580 inhibits the reaction [Sorbitol results in increased phosphorylation of MAPKAPK2 protein]; SB 203580 inhibits the reaction [Tretinoin results in increased phosphorylation of MAPKAPK2 protein]
SB 203580 results in increased phosphorylation of MAPKAPK2 protein
SB 203580 results in decreased expression of MAPKAPK2 protein modified form
SB 203580 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPKAPK2 protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased activity of MAPKAPK2 protein]
SB 203580 affects the reaction [MAPK14 protein affects the reaction [sodium arsenite results in increased activity of MAPKAPK2 protein]]; SB 203580 inhibits the reaction [arsenite results in increased phosphorylation of MAPKAPK2 protein]; SB 203580 inhibits the reaction [Ethanol results in increased phosphorylation of MAPKAPK2 protein]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased activity of MAPKAPK2 protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased activity of MAPKAPK2 protein]; SB 203580 inhibits the reaction [trovafloxacin results in increased phosphorylation of MAPKAPK2 protein]
SB 203580 results in decreased phosphorylation of MAPKAPK2 protein
CTD PMID:9288946 PMID:9545260 PMID:9822662 PMID:9877156 PMID:10704466 More... NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457
JBrowse link
G Mapkapk3 MAPK activated protein kinase 3 multiple interactions ISO SB 203580 inhibits the reaction [sodium arsenite results in increased activity of MAPKAPK3 protein] CTD PMID:12547826 NCBI chr 8:107,929,754...107,963,638
Ensembl chr 8:107,929,762...107,963,568
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO
EXP
SB 203580 inhibits the reaction [Acrolein results in increased phosphorylation of MAPT protein]; SB 203580 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of MAPT protein]
SB 203580 inhibits the reaction [cyanoginosin LR results in increased localization of MAPT protein]; SB 203580 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of MAPT protein]
CTD PMID:12605413 PMID:22000993 PMID:23929704 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mef2c myocyte enhancer factor 2C multiple interactions ISO SB 203580 inhibits the reaction [icariin affects the localization of MEF2C protein]; SB 203580 inhibits the reaction [icariin results in increased expression of MEF2C mRNA] CTD PMID:18423597 NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880
JBrowse link
G Mir143 microRNA 143 multiple interactions ISO SB 203580 inhibits the reaction [TGFB1 protein results in increased expression of MIR143] CTD PMID:21712382 NCBI chr18:55,101,006...55,101,110
Ensembl chr18:55,101,006...55,101,110
JBrowse link
G Mir145 microRNA 145 multiple interactions ISO SB 203580 inhibits the reaction [TGFB1 protein results in increased expression of MIR145] CTD PMID:21712382 NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727
JBrowse link
G Mir328 microRNA 328 increases expression
multiple interactions
ISO SB 203580 results in increased expression of MIR328 mRNA
resveratrol promotes the reaction [SB 203580 results in increased expression of MIR328 mRNA]
CTD PMID:25605016 NCBI chr19:33,184,766...33,184,849
Ensembl chr19:33,184,766...33,184,849
JBrowse link
G Mitf melanocyte inducing transcription factor multiple interactions ISO SB 203580 inhibits the reaction [Cannabidiol results in increased expression of MITF mRNA] CTD PMID:28601556 NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145
JBrowse link
G Mknk1 MAPK interacting serine/threonine kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MKNK1 protein]]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with SB 203580] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MKNK1 protein]; SB 203580 inhibits the reaction [Anisomycin results in increased activity of MKNK1 protein]; SB 203580 inhibits the reaction [arsenite results in increased activity of MKNK1 protein]; SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MKNK1 protein]; SB 203580 promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MKNK1 protein]]
[SB 203580 co-treated with U 0126] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MKNK1 protein]
CTD PMID:9545260 PMID:12781867 PMID:16431125 NCBI chr 5:129,318,128...129,357,641
Ensembl chr 5:129,318,170...129,357,639
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO SB 203580 inhibits the reaction [2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of and results in increased activity of MMP1 protein]; SB 203580 inhibits the reaction [benzo(k)fluoranthene results in increased expression of MMP1 mRNA]; SB 203580 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of MMP1 protein]; SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP1 protein] CTD PMID:20004183 PMID:21635667 PMID:24469321 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO
EXP
SB 203580 analog inhibits the reaction [IL1B results in increased expression of MMP13 mRNA]; SB 203580 inhibits the reaction [S100A4 protein results in increased expression of MMP13 protein]; SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP13 protein]
SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of MMP13 mRNA]
SB 203580 inhibits the reaction [gadolinium chloride results in increased expression of MMP13 mRNA]; SB 203580 inhibits the reaction [halofuginone results in increased expression of MMP13 mRNA]
CTD PMID:12493575 PMID:16489207 PMID:16948116 PMID:19656660 PMID:20004183 More... NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
affects expression
decreases expression
ISO
EXP
brazilein promotes the reaction [SB 203580 results in decreased expression of and results in decreased activity of MMP2 protein]; SB 203580 affects the reaction [U 0126 promotes the reaction [Plant Extracts results in decreased expression of MMP2 protein]]; SB 203580 inhibits the reaction [benz(a)anthracene results in increased expression of MMP2 mRNA]; SB 203580 inhibits the reaction [Glucose promotes the reaction [Air Pollutants results in increased activity of MMP2 protein]]; SB 203580 inhibits the reaction [Glucose promotes the reaction [Particulate Matter results in increased activity of MMP2 protein]]; SB 203580 inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of MMP2 mRNA]; SB 203580 inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]; SB 203580 inhibits the reaction [taiwanin E results in decreased expression of MMP2 protein]; SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP2 protein]; SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 mRNA]; SB 203580 promotes the reaction [brazilein results in decreased expression of and results in decreased activity of MMP2 protein]; SB 203580 promotes the reaction [resveratrol results in decreased expression of and results in decreased activity of MMP2 protein]; SB 203580 promotes the reaction [resveratrol results in decreased expression of MMP2]; SB 203580 results in decreased expression of and results in decreased activity of MMP2 protein
SB 203580 affects the expression of MMP2 mRNA; SB 203580 affects the expression of MMP2 protein
SB 203580 results in decreased expression of MMP2
CTD PMID:16575906 PMID:20599481 PMID:21635667 PMID:23707804 PMID:24841706 More... NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp25 matrix metallopeptidase 25 multiple interactions ISO SB 203580 inhibits the reaction [benzo(k)fluoranthene results in increased expression of MMP25 mRNA] CTD PMID:21635667 NCBI chr10:12,661,297...12,676,119 JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 protein] CTD PMID:20004183 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
decreases activity
ISO
EXP
[kahweol acetate co-treated with SB 203580] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of and results in increased activity of MMP9 protein]; SB 203580 inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]; SB 203580 inhibits the reaction [Arsenic Trioxide results in increased expression of MMP9 mRNA]; SB 203580 inhibits the reaction [Arsenic Trioxide results in increased expression of MMP9 protein]; SB 203580 inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of MMP9 mRNA]; SB 203580 inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased secretion of MMP9 protein]; SB 203580 inhibits the reaction [Glucose promotes the reaction [Air Pollutants results in increased activity of MMP9 protein]]; SB 203580 inhibits the reaction [Glucose promotes the reaction [Particulate Matter results in increased activity of MMP9 protein]]; SB 203580 inhibits the reaction [hydroquinone results in increased secretion of MMP9 protein]; SB 203580 inhibits the reaction [Oxidopamine results in increased expression of MMP9 mRNA]; SB 203580 inhibits the reaction [taiwanin E results in decreased expression of MMP9 protein]; SB 203580 inhibits the reaction [tetrabromobisphenol A results in increased expression of MMP9 mRNA]; SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of and results in increased activity of MMP9 protein]; SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]; SB 203580 inhibits the reaction [thymoquinone results in decreased expression of MMP9 protein]; SB 203580 inhibits the reaction [TNF protein results in increased expression of and results in increased activity of MMP9 protein]; SB 203580 promotes the reaction [ovatodiolide results in decreased activity of MMP9 protein]; SB 203580 promotes the reaction [Resveratrol results in decreased expression of MMP9]; SB 203580 promotes the reaction [Resveratrol results in increased expression of and results in increased activity of MMP9 protein]
SB 203580 results in decreased expression of MMP9 mRNA; SB 203580 results in decreased expression of MMP9 protein
SB 203580 results in decreased activity of MMP9 protein
SB 203580 inhibits the reaction [Doxorubicin results in increased activity of MMP9 protein]; SB 203580 inhibits the reaction [Doxorubicin results in increased expression of MMP9 mRNA]; SB 203580 inhibits the reaction [gadolinium chloride results in increased expression of MMP9 mRNA]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased activity of MMP9 protein]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of MMP9 protein]; SB 203580 inhibits the reaction [T-2 Toxin results in increased expression of MMP9 mRNA]; SB 203580 promotes the reaction [U 0126 inhibits the reaction [Lipopolysaccharides results in increased activity of MMP9 protein]]; U 0126 promotes the reaction [SB 203580 inhibits the reaction [Lipopolysaccharides results in increased activity of MMP9 protein]]
SB 203580 inhibits the reaction [Leukotriene B4 results in increased expression of MMP9 protein]; SB 203580 inhibits the reaction [Leukotriene C4 results in increased expression of MMP9 protein]; SB 203580 inhibits the reaction [Leukotriene D4 results in increased expression of MMP9 protein]; SB 203580 inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of MMP9 protein]
CTD PMID:12493575 PMID:15657063 PMID:15728660 PMID:16213474 PMID:16683234 More... NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases activity
EXP
ISO
SB 203580 inhibits the reaction [Resveratrol results in decreased activity of MPO protein]; SB 203580 inhibits the reaction [Tropisetron results in decreased activity of MPO protein]
SB 203580 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased activity of MPO protein]; SB 203580 inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]
SB 203580 results in decreased activity of MPO protein
CTD PMID:17368305 PMID:21192278 PMID:23285267 PMID:27920472 PMID:32033504 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO SB 203580 promotes the reaction [Copper results in increased activity of MT1 promoter] CTD PMID:14576086 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Mt3 metallothionein 3 multiple interactions ISO SB 203580 inhibits the reaction [Cadmium results in increased expression of MT3] CTD PMID:21783819 NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158
JBrowse link
G Mtmr10 myotubularin related protein 10 multiple interactions ISO SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of MTMR10 mRNA] CTD PMID:28329830 NCBI chr 1:117,859,355...117,910,839
Ensembl chr 1:117,859,267...117,910,849
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP SB 203580 inhibits the reaction [fenvalerate results in decreased phosphorylation of MTOR protein] CTD PMID:31734597 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Muc4 mucin 4, cell surface associated multiple interactions ISO SB 203580 inhibits the reaction [Particulate Matter results in increased expression of MUC4 mRNA]; SB 203580 inhibits the reaction [Particulate Matter results in increased expression of MUC4 protein]; SB 203580 inhibits the reaction [Vehicle Emissions results in increased expression of MUC4 mRNA]; SB 203580 inhibits the reaction [Vehicle Emissions results in increased expression of MUC4 protein] CTD PMID:28049186 NCBI chr11:68,008,245...68,053,229 JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO SB 203580 inhibits the reaction [EGF protein results in increased secretion of MUC5AC protein]; SB 203580 inhibits the reaction [polyhexamethyleneguanidine results in increased expression of MUC5AC mRNA]; SB 203580 inhibits the reaction [polyhexamethyleneguanidine results in increased expression of MUC5AC protein]; SB 203580 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MUC5AC mRNA] CTD PMID:20971882 PMID:22766066 PMID:30935901 NCBI chr 1:196,864,375...196,896,475 JBrowse link
G Myh7 myosin heavy chain 7 affects expression EXP SB 203580 affects the expression of MYH7 mRNA CTD PMID:21084678 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Myocd myocardin multiple interactions ISO SB 203580 inhibits the reaction [TGFB1 protein results in increased expression of MYOCD mRNA] CTD PMID:21712382 NCBI chr10:49,833,219...49,928,806
Ensembl chr10:49,836,641...49,927,627
JBrowse link
G Myod1 myogenic differentiation 1 multiple interactions ISO SB 203580 inhibits the reaction [bakuchiol results in increased expression of MYOD1 protein] CTD PMID:26902638 NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554
JBrowse link
G Myog myogenin multiple interactions ISO SB 203580 inhibits the reaction [bakuchiol results in increased expression of MYOG protein] CTD PMID:26902638 NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO SB 203580 inhibits the reaction [arsenic trioxide results in increased phosphorylation of and affects the localization of NCF1 protein] CTD PMID:18424721 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase multiple interactions ISO SB 203580 inhibits the reaction [fulvestrant promotes the reaction [NEDD4 protein binds to and results in increased ubiquitination of GJA1 protein]] CTD PMID:29180066 NCBI chr 8:73,384,095...73,468,951
Ensembl chr 8:73,383,695...73,468,951
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO SB 203580 affects the reaction [NFE2L2 protein affects the reaction [sodium arsenite affects the expression of NFATC1 protein]]; SB 203580 affects the reaction [sodium arsenite affects the expression of NFATC1 protein] CTD PMID:30742845 NCBI chr18:74,046,421...74,156,041
Ensembl chr18:74,046,904...74,156,028
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [SB 203580 inhibits the reaction [Quercetin affects the localization of NFE2L2 protein]]; [SB 203580 co-treated with Cycloheximide] inhibits the reaction [Quercetin results in decreased expression of NFE2L2 protein]; [SB 203580 co-treated with Quercetin] results in increased expression of NFE2L2 protein; Cycloheximide inhibits the reaction [[SB 203580 co-treated with Quercetin] results in increased expression of NFE2L2 protein]; Cycloheximide inhibits the reaction [SB 203580 affects the reaction [Quercetin affects the localization of NFE2L2 protein]]; SB 203580 affects the reaction [Quercetin affects the localization of NFE2L2 protein]; SB 203580 inhibits the reaction [gallium nitrate results in increased activity of NFE2L2 protein]; SB 203580 inhibits the reaction [Quercetin affects the localization of and results in increased activity of NFE2L2 protein]; SB 203580 inhibits the reaction [Quercetin affects the localization of NFE2L2 protein]; SB 203580 inhibits the reaction [Quercetin results in decreased expression of NFE2L2 protein]; SB 203580 promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin affects the localization of NFE2L2 protein]]
SB 203580 inhibits the reaction [aureusidin affects the localization of NFE2L2 protein]; SB 203580 inhibits the reaction [Chitosan analog inhibits the reaction [Doxorubicin affects the localization of NFE2L2 protein]]; SB 203580 inhibits the reaction [Curcumin affects the localization of NFE2L2 protein]
SB 203580 affects the reaction [[NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of ATP6V0D2 mRNA]]; SB 203580 affects the reaction [[NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of CTSK mRNA]]; SB 203580 affects the reaction [NFE2L2 protein affects the reaction [sodium arsenite affects the expression of NFATC1 protein]]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone affects the localization of NFE2L2 protein]; SB 203580 inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 mRNA]; SB 203580 inhibits the reaction [farrerol affects the localization of NFE2L2 protein]; SB 203580 promotes the reaction [[Plant Extracts co-treated with Ethanol] results in increased expression of and affects the localization of NFE2L2 protein]
CTD PMID:17433488 PMID:17640564 PMID:18586083 PMID:22197970 PMID:22488045 More... NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO SB 203580 inhibits the reaction [Paraquat affects the localization of [NFKB1 protein binds to RELA protein]]; SB 203580 inhibits the reaction [Paraquat promotes the reaction [endotoxin, Escherichia coli affects the localization of [NFKB1 protein binds to RELA protein]]]
SB 203580 inhibits the reaction [indoleacetic acid affects the localization of NFKB1 protein]
CTD PMID:16919916 PMID:30324315 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases expression
ISO
EXP
SB 203580 inhibits the reaction [icariin results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; SB 203580 inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
SB 203580 results in decreased expression of NFKBIA protein
SB 203580 promotes the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; SB 203580 promotes the reaction [Iron results in increased phosphorylation of NFKBIA protein]
SB 203580 inhibits the reaction [1,2,5,8-tetrahydroxy anthraquinone results in increased expression of NFKBIA protein]; SB 203580 inhibits the reaction [Glucose results in increased phosphorylation of NFKBIA protein]
CTD PMID:17172471 PMID:18423597 PMID:19132243 PMID:23707484 PMID:33030807 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ngf nerve growth factor multiple interactions
decreases activity
EXP SB 203580 inhibits the reaction [pentaacetyl geniposide results in increased expression of NGF mRNA]; SB 203580 inhibits the reaction [pentaacetyl geniposide results in increased expression of NGF protein]
SB 203580 results in decreased activity of NGF protein
CTD PMID:9733710 PMID:17651887 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Ngfr nerve growth factor receptor multiple interactions EXP SB 203580 inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR mRNA]; SB 203580 inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR protein] CTD PMID:17651887 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO
EXP
SB 203580 inhibits the reaction [APP protein results in increased expression of NLRP3 protein]
SB 203580 inhibits the reaction [Acrolein results in increased expression of NLRP3 protein]
CTD PMID:28004443 PMID:31639409 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
increases degradation
ISO
EXP
SB 203580 inhibits the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]; SB 203580 inhibits the reaction [deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]]; SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein]
SB 203580 results in decreased expression of NOS2 mRNA; SB 203580 results in decreased expression of NOS2 protein
SB 203580 inhibits the reaction [[IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NOS2 protein]; SB 203580 inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of NOS2 protein]; SB 203580 inhibits the reaction [cobaltous chloride results in increased expression of NOS2 protein]; SB 203580 inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; SB 203580 inhibits the reaction [Particulate Matter results in increased expression of NOS2 mRNA]
SB 203580 results in increased degradation of NOS2 mRNA
1-dodecylsulfonyl-5N,6O-oxomethylidenenojirimycin promotes the reaction [SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; SB 203580 inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; SB 203580 inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; SB 203580 inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of NOS2 mRNA]; SB 203580 inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; SB 203580 inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; SB 203580 inhibits the reaction [Methoxychlor results in increased expression of NOS2 mRNA]; SB 203580 inhibits the reaction [S100B protein results in increased expression of NOS2 mRNA]; SB 203580 inhibits the reaction [S100B protein results in increased expression of NOS2 protein]; SB 203580 inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOS2 protein]]
CTD PMID:11518563 PMID:12911628 PMID:14734799 PMID:15979571 PMID:16307444 More... NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO SB 203580 inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of NOS3 protein] CTD PMID:11788791 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Notch1 notch receptor 1 multiple interactions ISO SB 203580 inhibits the reaction [o,p'-DDT results in increased activity of NOTCH1 protein] CTD PMID:18791200 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP SB 203580 inhibits the reaction [Lead results in increased expression of NOX1 mRNA]; SB 203580 inhibits the reaction [Mercuric Chloride results in increased expression of NOX1 mRNA] CTD PMID:23415682 PMID:25596430 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP SB 203580 inhibits the reaction [Lead results in increased expression of NOX4 mRNA] CTD PMID:25596430 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Nppa natriuretic peptide A affects secretion
multiple interactions
EXP SB 203580 affects the secretion of NPPA protein
SB 203580 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; SB 203580 promotes the reaction [Sunitinib results in increased expression of NPPA mRNA]
CTD PMID:10727428 PMID:21084678 PMID:24247421 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nppb natriuretic peptide B affects expression
decreases expression
multiple interactions
EXP SB 203580 affects the expression of NPPB protein
SB 203580 results in decreased expression of NPPB mRNA
SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of NPPB protein]
CTD PMID:21084678 PMID:22224641 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
decreases expression
ISO SB 203580 inhibits the reaction [Particulate Matter analog results in increased expression of NQO1 mRNA]; SB 203580 inhibits the reaction [Particulate Matter analog results in increased expression of NQO1 protein]; SB 203580 inhibits the reaction [Plant Extracts results in increased expression of NQO1 protein]; SB 203580 inhibits the reaction [Quercetin results in increased expression of NQO1 mRNA]; SB 203580 inhibits the reaction [Vehicle Emissions analog results in increased expression of NQO1 mRNA]; SB 203580 inhibits the reaction [Vehicle Emissions analog results in increased expression of NQO1 protein]
SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NQO1 mRNA]; SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of NQO1 mRNA]; SB 203580 promotes the reaction [Copper results in increased expression of NQO1 mRNA]; SB 203580 promotes the reaction [Lead results in increased expression of NQO1 mRNA]
SB 203580 results in decreased expression of NQO1 mRNA
CTD PMID:16920990 PMID:18752316 PMID:27454768 PMID:28329830 PMID:30626086 More... NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression ISO SB 203580 results in increased expression of NR1H3 mRNA CTD PMID:19883121 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO SB 203580 inhibits the reaction [deacylcortivazol results in increased phosphorylation of NR3C1 protein]; SB 203580 inhibits the reaction [Dexamethasone results in increased phosphorylation of NR3C1 protein] CTD PMID:15817653 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of NR4A1 mRNA] CTD PMID:28329830 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
JBrowse link
G Ocln occludin multiple interactions ISO SB 203580 inhibits the reaction [Arsenic Trioxide results in decreased expression of OCLN protein]; SB 203580 inhibits the reaction [Clopidogrel results in decreased expression of OCLN protein]
SB 203580 inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of OCLN protein]
CTD PMID:23220562 PMID:23761298 PMID:27818224 PMID:32683294 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 multiple interactions ISO SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of OLR1 mRNA] CTD PMID:28329830 NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 multiple interactions ISO SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of OSGIN1 mRNA] CTD PMID:28329830 NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516
JBrowse link
G Osm oncostatin M multiple interactions ISO SB 203580 inhibits the reaction [OSM protein results in increased expression of and results in increased secretion of IL6 protein]; SB 203580 inhibits the reaction [OSM protein results in increased expression of IL6 mRNA] CTD PMID:21548952 NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313
JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions ISO SB 203580 promotes the reaction [PARK7 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased secretion of Dinoprostone]]; SB 203580 promotes the reaction [PARK7 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]] CTD PMID:26691871 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO SB 203580 inhibits the reaction [1,4-naphthoquinone analog results in increased cleavage of PARP1 protein]; SB 203580 inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased cleavage of PARP1 protein]; SB 203580 inhibits the reaction [[ESR1 protein results in increased susceptibility to Quercetin] which results in increased cleavage of PARP1 protein]; SB 203580 inhibits the reaction [[ESR2 protein results in increased susceptibility to Estradiol] which results in increased cleavage of PARP1 protein]; SB 203580 inhibits the reaction [[ESR2 protein results in increased susceptibility to Quercetin] which results in increased cleavage of PARP1 protein]; SB 203580 inhibits the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein]; SB 203580 inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]; SB 203580 inhibits the reaction [Emodin results in increased cleavage of PARP1 protein]; SB 203580 inhibits the reaction [Lapatinib inhibits the reaction [sodium arsenite results in decreased cleavage of PARP1 protein]]; SB 203580 inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]; SB 203580 inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein]; SB 203580 inhibits the reaction [Tamoxifen results in increased cleavage of PARP1 protein]; SB 203580 promotes the reaction [[sodium arsenite co-treated with TNF protein] results in increased cleavage of PARP1 protein] CTD PMID:14645110 PMID:16328441 PMID:16843435 PMID:19194971 PMID:19777565 More... NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions EXP SB 203580 inhibits the reaction [Buthionine Sulfoximine results in increased expression of PCK1 mRNA] CTD PMID:16960379 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO SB 203580 inhibits the reaction [Lapatinib inhibits the reaction [sodium arsenite results in increased expression of PCNA protein]] CTD PMID:32890875 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO SB 203580 inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]; SB 203580 results in decreased susceptibility to [PDGFB protein binds to PDGFB protein]
SB 203580 promotes the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]
CTD PMID:9671412 PMID:15728660 PMID:23457620 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions ISO [SB 203580 co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein]; SB 203580 inhibits the reaction [[Glucose co-treated with sodium arsenite] affects the localization of PDX1 protein]; SB 203580 inhibits the reaction [Glucose affects the localization of PDX1 protein]; SB 203580 inhibits the reaction [Glucose results in increased phosphorylation of and results in increased activity of PDX1 protein]; SB 203580 inhibits the reaction [sodium arsenite affects the localization of PDX1 protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of PDX1 protein] CTD PMID:9873045 PMID:11574405 NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064
JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 multiple interactions ISO SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of PHLDA1 mRNA] CTD PMID:28329830 NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861
JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions ISO
EXP
SB 203580 inhibits the reaction [Capsaicin results in increased phosphorylation of PLA2G4A protein]
SB 203580 inhibits the reaction [Hydrogen Peroxide results in decreased expression of PLA2G4A mRNA]
CTD PMID:15683734 PMID:19959817 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Pla2g7 phospholipase A2 group VII multiple interactions ISO SB 203580 inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PLA2G7 mRNA]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of PLA2G7 protein] CTD PMID:21176638 PMID:21432021 NCBI chr 9:17,362,214...17,404,476
Ensembl chr 9:17,362,225...17,404,476
JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions ISO SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of PLAUR mRNA] CTD PMID:28329830 NCBI chr 1:80,053,441...80,068,384
Ensembl chr 1:80,050,324...80,068,595
JBrowse link
G Pld1 phospholipase D1 multiple interactions ISO SB 203580 inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of PLD1 mRNA]; SB 203580 inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of PLD1 protein] CTD PMID:26763395 NCBI chr 2:110,849,205...111,047,692
Ensembl chr 2:110,893,608...111,047,692
JBrowse link
G Pld2 phospholipase D2 multiple interactions ISO SB 203580 inhibits the reaction [PLD2 protein promotes the reaction [epigallocatechin gallate results in increased expression of PTGS2 protein]] CTD PMID:15210717 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808
JBrowse link
G Pomc proopiomelanocortin multiple interactions EXP SB 203580 inhibits the reaction [POMC protein modified form results in increased secretion of Corticosterone] CTD PMID:20837582 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Postn periostin multiple interactions EXP SB 203580 inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]; SB 203580 inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA] CTD PMID:15121739 PMID:17485602 NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions ISO SB 203580 inhibits the reaction [Indomethacin results in increased expression of PPARD protein] CTD PMID:17341418 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
decreases expression
ISO
EXP
[SB 203580 results in decreased activity of MAPK14 protein] inhibits the reaction [[octanoic acid co-treated with Dexamethasone] results in increased expression of PPARG protein alternative form]
SB 203580 inhibits the reaction [Ethanol results in decreased expression of PPARG protein]
SB 203580 results in increased expression of PPARG mRNA; SB 203580 results in increased expression of PPARG protein
SB 203580 results in decreased expression of PPARG mRNA; SB 203580 results in decreased expression of PPARG protein
CTD PMID:14984747 PMID:23603106 PMID:24412557 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Pram1 PML-RARA regulated adaptor molecule 1 multiple interactions ISO SB 203580 inhibits the reaction [Cadmium Chloride affects the localization of PRAM1 protein] CTD PMID:12508112 NCBI chr 7:14,428,548...14,438,081 JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO SB 203580 inhibits the reaction [sodium arsenate results in increased expression of PRDX1 protein] CTD PMID:11796722 NCBI chr 5:130,147,276...130,162,850
Ensembl chr 5:130,147,204...130,162,856
JBrowse link
G Prdx2 peroxiredoxin 2 multiple interactions ISO SB 203580 inhibits the reaction [Formaldehyde results in decreased expression of PRDX2 protein] CTD PMID:20347000 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO [SB 203580 co-treated with Quercetin] results in increased phosphorylation of PRKAA1 protein CTD PMID:24535669 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
JBrowse link
G Procr protein C receptor multiple interactions ISO SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased cleavage of PROCR protein] CTD PMID:24632454 NCBI chr 3:144,254,596...144,258,863
Ensembl chr 3:144,254,380...144,258,903
JBrowse link
G Psen1 presenilin 1 multiple interactions ISO [PSEN1 protein affects the susceptibility to SB 203580] affects the reaction [Cycloheximide results in decreased expression of RBPJ protein] CTD PMID:22302987 NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO SB 203580 inhibits the reaction [IL18 protein results in increased expression of PTEN mRNA] CTD PMID:18215737 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptgds prostaglandin D2 synthase multiple interactions ISO SB 203580 inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of PTGDS mRNA] CTD PMID:20382172 NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833
JBrowse link
G Ptges2 prostaglandin E synthase 2 multiple interactions ISO SB 203580 inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of PTGES2 mRNA] CTD PMID:20382172 NCBI chr 3:15,690,501...15,697,688
Ensembl chr 3:15,690,501...15,697,688
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
ISO
EXP
SB 203580 analog inhibits the reaction [IL1B results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of PTGS2 protein]; SB 203580 inhibits the reaction [[methanandamide results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]; SB 203580 inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [Aflatoxin B1 results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [Aspirin results in decreased degradation of PTGS2 mRNA]; SB 203580 inhibits the reaction [Aspirin results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [Aspirin results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [Benzene results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [Ceramides results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [Chlorpyrifos results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [EDN1 protein results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [epigallocatechin gallate results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [IL1A results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [IL1A results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [IL1B results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [Lapatinib inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]]; SB 203580 inhibits the reaction [manganese chloride results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [Melitten results in decreased expression of PTGS2 protein]; SB 203580 inhibits the reaction [methanandamide results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [methylmercuric chloride results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [PLD2 protein promotes the reaction [epigallocatechin gallate results in increased expression of PTGS2 protein]]; SB 203580 inhibits the reaction [sodium arsenite results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [Sodium Fluoride results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [Styrene results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [Toluene results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [VEGFA protein results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [VEGFA protein results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [Zinc results in increased expression of PTGS2 protein]
SB 203580 inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [AGT protein results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [cadmium sulfate results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [cadmium sulfate results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [epigallocatechin gallate results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [lead acetate results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [Lead results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [manganese chloride results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [Mercuric Chloride results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]
SB 203580 results in decreased expression of PTGS2 mRNA; SB 203580 results in decreased expression of PTGS2 protein
SB 203580 inhibits the reaction [1-bromopropane results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [[Cadmium Chloride results in increased expression of PTGS2 mRNA] which results in increased abundance of Dinoprostone]; SB 203580 inhibits the reaction [[Cadmium Chloride results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; SB 203580 inhibits the reaction [Cadmium Chloride results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [Cadmium Chloride results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [deoxynivalenol results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [deoxynivalenol results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [deoxynivalenol results in increased stability of PTGS2 mRNA]; SB 203580 inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [Nickel results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [nonylphenol results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 protein]
CTD PMID:11527419 PMID:11854442 PMID:12377986 PMID:12911628 PMID:14742690 More... NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptx3 pentraxin 3 multiple interactions ISO SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of PTX3 mRNA] CTD PMID:28329830 NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323
JBrowse link
G Rad51 RAD51 recombinase multiple interactions ISO SB 203580 inhibits the reaction [ochratoxin A results in decreased expression of RAD51]; SB 203580 inhibits the reaction [Prodigiosin results in decreased expression of RAD51 mRNA] CTD PMID:22579953 PMID:24525463 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO SB 203580 inhibits the reaction [FGF2 protein results in increased phosphorylation of RB1 protein] CTD PMID:15249425 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rbm4 RNA binding motif protein 4 multiple interactions ISO SB 203580 inhibits the reaction [sodium arsenite affects the localization of RBM4 protein] CTD PMID:17284590 NCBI chr 1:202,078,442...202,087,506
Ensembl chr 1:202,085,279...202,105,380
JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region multiple interactions ISO [PSEN1 protein affects the susceptibility to SB 203580] affects the reaction [Cycloheximide results in decreased expression of RBPJ protein] CTD PMID:22302987 NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353
JBrowse link
G Reg3g regenerating family member 3 gamma multiple interactions EXP SB 203580 inhibits the reaction [AGT protein results in increased expression of REG3G mRNA]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of REG3G mRNA] CTD PMID:27798352 NCBI chr 4:110,922,805...110,927,803
Ensembl chr 4:110,924,168...110,926,723
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
SB 203580 affects the reaction [sodium arsenite affects the expression of RELA protein]; SB 203580 inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein]; SB 203580 inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of RELA protein]; SB 203580 inhibits the reaction [chrysin results in increased activity of RELA protein]; SB 203580 inhibits the reaction [deoxynivalenol results in increased activity of RELA protein]; SB 203580 inhibits the reaction [Galactose affects the localization of RELA protein]; SB 203580 inhibits the reaction [IL18 protein results in increased phosphorylation of and results in increased activity of RELA protein]; SB 203580 inhibits the reaction [Mustard Gas results in increased phosphorylation of RELA protein]; SB 203580 inhibits the reaction [vanadyl sulfate results in increased activity of RELA protein]
SB 203580 inhibits the reaction [Acrolein results in increased phosphorylation of RELA protein]; SB 203580 inhibits the reaction [Cyclosporine affects the localization of RELA protein]; SB 203580 inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of RELA protein]
SB 203580 inhibits the reaction [endotoxin, Escherichia coli results in increased activity of RELA protein]; SB 203580 inhibits the reaction [icariin results in increased expression of and affects the localization of RELA protein]; SB 203580 inhibits the reaction [Paraquat affects the localization of [NFKB1 protein binds to RELA protein]]; SB 203580 inhibits the reaction [Paraquat promotes the reaction [endotoxin, Escherichia coli affects the localization of [NFKB1 protein binds to RELA protein]]]
CTD PMID:10873158 PMID:16919916 PMID:18215737 PMID:18423597 PMID:18457675 More... NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rest RE1-silencing transcription factor multiple interactions ISO SB 203580 inhibits the reaction [Sodium Glutamate results in increased expression of REST mRNA] CTD PMID:16782274 NCBI chr14:30,859,109...30,879,828
Ensembl chr14:30,862,553...30,894,354
JBrowse link
G Retn resistin multiple interactions
decreases expression
ISO SB 203580 inhibits the reaction [octylphenol results in increased expression of RETN protein]
SB 203580 results in decreased expression of RETN protein
CTD PMID:18417718 NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620
JBrowse link
G Rnd3 Rho family GTPase 3 multiple interactions ISO SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of RND3 mRNA] CTD PMID:28329830 NCBI chr 3:35,571,929...35,589,283
Ensembl chr 3:35,571,143...35,589,327
JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 multiple interactions ISO
EXP
[U 0126 co-treated with SB 203580] inhibits the reaction [sodium arsenite results in increased activity of RPS6KA5 protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased activity of RPS6KA5 protein]
SB 203580 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KA5 protein]
CTD PMID:12547826 PMID:15522277 NCBI chr 6:119,828,823...120,006,190
Ensembl chr 6:119,828,846...120,006,224
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO SB 203580 promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; Sodium Salicylate inhibits the reaction [SB 203580 promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]] CTD PMID:10993886 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions EXP [pyrazolanthrone co-treated with SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Quercetin results in increased expression of RUNX2 mRNA]; SB 203580 inhibits the reaction [cobaltous chloride results in increased expression of RUNX2 mRNA] CTD PMID:26136938 PMID:31472278 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G S100a4 S100 calcium-binding protein A4 multiple interactions ISO SB 203580 inhibits the reaction [S100A4 protein results in increased expression of MMP13 protein] CTD PMID:16948116 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
JBrowse link
G S100b S100 calcium binding protein B multiple interactions ISO SB 203580 inhibits the reaction [S100B protein results in increased expression of NOS2 mRNA]; SB 203580 inhibits the reaction [S100B protein results in increased expression of NOS2 protein] CTD PMID:16376947 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
JBrowse link
G Sele selectin E multiple interactions ISO SB 203580 inhibits the reaction [Chenodeoxycholic Acid results in increased expression of SELE mRNA] CTD PMID:16582018 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Serpinb2 serpin family B member 2 multiple interactions ISO SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of SERPINB2 mRNA] CTD PMID:28329830 NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO SB 203580 inhibits the reaction [cupric oxide results in increased expression of SERPINE1 mRNA] CTD PMID:20171267 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Serpinh1 serpin family H member 1 decreases expression
multiple interactions
ISO SB 203580 results in decreased expression of SERPINH1 mRNA
SB 203580 inhibits the reaction [Oxygen deficiency results in increased expression of SERPINH1 mRNA]
CTD PMID:13679210 NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801
JBrowse link
G Sesn2 sestrin 2 multiple interactions ISO [SB 203580 co-treated with Quercetin] results in increased expression of SESN2 protein CTD PMID:24535669 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO SB 203580 inhibits the reaction [Hydrogen Peroxide affects the localization of SIRT1 protein]
SB 203580 inhibits the reaction [icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 mRNA]]; SB 203580 inhibits the reaction [icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 protein]]
CTD PMID:19303870 PMID:25512378 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slc20a1 solute carrier family 20 member 1 multiple interactions ISO SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of SLC20A1 mRNA] CTD PMID:28329830 NCBI chr 3:116,427,095...116,441,049
Ensembl chr 3:116,427,098...116,441,051
JBrowse link
G Slc6a2 solute carrier family 6 member 2 multiple interactions ISO SB 203580 inhibits the reaction [Cocaine results in increased expression of SLC6A2 protein] CTD PMID:25724654 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357
JBrowse link
G Slc7a1 solute carrier family 7 member 1 multiple interactions ISO SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of SLC7A1 mRNA] CTD PMID:28329830 NCBI chr12:6,628,214...6,703,849
Ensembl chr12:6,628,007...6,703,849
JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions ISO SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of SLC7A11 mRNA] CTD PMID:28329830 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP [SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Paraquat results in increased phosphorylation of SMAD2 protein]; SB 203580 inhibits the reaction [Paraquat results in increased phosphorylation of SMAD2 protein] CTD PMID:25873302 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO SB 203580 inhibits the reaction [TGFB2 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:18253093 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO SB 203580 inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI1 mRNA]; SB 203580 inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI1 protein]; SB 203580 inhibits the reaction [benz(a)anthracene results in increased expression of SNAI1 mRNA]; SB 203580 inhibits the reaction [benzo(k)fluoranthene results in increased expression of SNAI1 mRNA]; SB 203580 inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of SNAI1 mRNA]; SB 203580 inhibits the reaction [thymoquinone results in decreased expression of SNAI1 protein] CTD PMID:21635667 PMID:27060453 PMID:33396024 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions ISO SB 203580 inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI2 protein] CTD PMID:33396024 NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO
EXP
SB 203580 inhibits the reaction [MAPK11 protein results in increased phosphorylation of SOD2 protein]
SB 203580 inhibits the reaction [[Paraquat results in increased abundance of Reactive Oxygen Species] which results in increased expression of SOD2 mRNA]
CTD PMID:24376630 PMID:24465521 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sox9 SRY-box transcription factor 9 multiple interactions ISO SB 203580 inhibits the reaction [resveratrol results in increased expression of SOX9] CTD PMID:24841706 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO SB 203580 inhibits the reaction [Hydrogen Peroxide promotes the reaction [SP1 protein results in increased expression of CAV1 protein]] CTD PMID:17108117 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Sp7 Sp7 transcription factor multiple interactions EXP SB 203580 inhibits the reaction [cobaltous chloride results in increased expression of SP7 mRNA]; SB 203580 inhibits the reaction [cobaltous chloride results in increased expression of SP7 protein] CTD PMID:31472278 NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP SB 203580 inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein] CTD PMID:19356721 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP SB 203580 inhibits the reaction [fenvalerate results in decreased expression of SQSTM1 protein] CTD PMID:31734597 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Srf serum response factor multiple interactions ISO SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of SRF protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of SRF protein]; SB 203580 inhibits the reaction [TGFB1 protein results in increased expression of SRF protein] CTD PMID:12660819 PMID:21712382 NCBI chr 9:14,426,453...14,435,734
Ensembl chr 9:14,426,472...14,435,733
JBrowse link
G Srrt serrate, RNA effector molecule multiple interactions ISO SB 203580 inhibits the reaction [sodium arsenite results in increased expression of SRRT protein] CTD PMID:26404762 NCBI chr12:19,392,578...19,406,098 JBrowse link
G Ssb small RNA binding exonuclease protection factor La multiple interactions ISO SB 203580 inhibits the reaction [SSB protein results in increased secretion of CXCL8 protein] CTD PMID:25915936 NCBI chr 3:54,616,616...54,626,203
Ensembl chr 3:54,616,619...54,626,203
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions
increases expression
ISO
EXP
SB 203580 inhibits the reaction [LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR protein]]
SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of STAR mRNA]; SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of STAR protein]
SB 203580 results in increased expression of STAR mRNA; SB 203580 results in increased expression of STAR protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [SB 203580 promotes the reaction [sodium arsenite results in increased expression of STAR mRNA]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [SB 203580 results in increased expression of STAR mRNA]; [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with SB 203580] inhibits the reaction [perfluorooctane sulfonic acid inhibits the reaction [[CRTC2 protein binds to CREB1 protein modified form] which binds to STAR promoter]]; [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with SB 203580] inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of STAR protein]; SB 203580 inhibits the reaction [perfluorooctane sulfonic acid inhibits the reaction [[CRTC2 protein binds to CREB1 protein modified form] which binds to STAR promoter]]; SB 203580 inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of STAR protein]; SB 203580 promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR mRNA]; SB 203580 promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR protein]; SB 203580 promotes the reaction [sodium arsenite results in increased expression of STAR mRNA]; SB 203580 promotes the reaction [sodium arsenite results in increased expression of STAR protein]
CTD PMID:15713539 PMID:19849856 PMID:29567110 PMID:33359577 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO SB 203580 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]; SB 203580 inhibits the reaction [nickel sulfate results in increased phosphorylation of STAT1 protein] CTD PMID:16355272 PMID:20525893 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation
ISO SB 203580 inhibits the reaction [1,2,5,8-tetrahydroxy anthraquinone results in decreased phosphorylation of STAT3 protein]; SB 203580 inhibits the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of STAT3 protein]
SB 203580 results in increased phosphorylation of STAT3 protein
CTD PMID:30871965 PMID:33030807 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions ISO SB 203580 affects the reaction [JTE 907 affects the phosphorylation of STAT5A protein] CTD PMID:30552973 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
JBrowse link
G Sts steroid sulfatase multiple interactions ISO SB 203580 inhibits the reaction [IGF2 protein results in increased expression of STS mRNA] CTD PMID:24055520 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO SB 203580 inhibits the reaction [Gallic Acid results in increased expression of SULT1A1 protein] CTD PMID:16308312 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Sumo1 small ubiquitin-like modifier 1 multiple interactions ISO SB 203580 inhibits the reaction [Cadmium Chloride affects the localization of SUMO1 protein] CTD PMID:12508112 NCBI chr 9:61,078,790...61,108,697
Ensembl chr 9:61,077,435...61,108,761
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP SB 203580 inhibits the reaction [GR 73632 promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]] CTD PMID:18809416 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tac4 tachykinin precursor 4 multiple interactions EXP SB 203580 inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TAC4 mRNA] CTD PMID:22384199 NCBI chr10:80,207,824...80,216,156
Ensembl chr10:80,207,610...80,216,156
JBrowse link
G Taf4b TATA-box binding protein associated factor 4b multiple interactions ISO SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of TAF4B mRNA] CTD PMID:28329830 NCBI chr18:5,952,737...6,086,408
Ensembl chr18:5,952,769...6,068,307
JBrowse link
G Tert telomerase reverse transcriptase multiple interactions ISO [pyrazolanthrone co-treated with SB 203580 co-treated with U 0126] inhibits the reaction [Isothiocyanates results in increased expression of TERT mRNA] CTD PMID:23382840 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561
JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO SB 203580 affects the reaction [deoxynivalenol affects the expression of TFF1 mRNA] CTD PMID:30854615 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Tff2 trefoil factor 2 multiple interactions ISO SB 203580 affects the reaction [deoxynivalenol affects the expression of TFF2 mRNA] CTD PMID:30854615 NCBI chr20:9,215,750...9,219,619
Ensembl chr20:9,215,761...9,219,619
JBrowse link
G Tff3 trefoil factor 3 multiple interactions ISO SB 203580 affects the reaction [deoxynivalenol affects the expression of TFF3 mRNA] CTD PMID:30854615 NCBI chr20:9,193,259...9,197,969
Ensembl chr20:9,193,262...9,198,054
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP
SB 203580 analog inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein]; SB 203580 inhibits the reaction [Asbestos, Serpentine results in increased secretion of TGFB1 protein]; SB 203580 inhibits the reaction [TGFB1 protein affects the localization of JUNB protein]; SB 203580 inhibits the reaction [TGFB1 protein results in decreased expression of CCND1 protein]; SB 203580 inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; SB 203580 inhibits the reaction [TGFB1 protein results in decreased expression of KLF5 mRNA]; SB 203580 inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; SB 203580 inhibits the reaction [TGFB1 protein results in increased expression of CNN1 protein]; SB 203580 inhibits the reaction [TGFB1 protein results in increased expression of ITGB6 mRNA]; SB 203580 inhibits the reaction [TGFB1 protein results in increased expression of JUNB mRNA]; SB 203580 inhibits the reaction [TGFB1 protein results in increased expression of MIR143]; SB 203580 inhibits the reaction [TGFB1 protein results in increased expression of MIR145]; SB 203580 inhibits the reaction [TGFB1 protein results in increased expression of MYOCD mRNA]; SB 203580 inhibits the reaction [TGFB1 protein results in increased expression of SRF protein]; SB 203580 inhibits the reaction [TGFB1 protein results in increased phosphorylation of ATF2 protein]
SB 203580 inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of and results in decreased secretion of IGF1 protein]]; SB 203580 inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of and results in increased secretion of IL1B protein]]; SB 203580 inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of and results in increased secretion of TNF protein]]; SB 203580 inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of ITGAM protein]]; SB 203580 inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOS2 protein]]
SB 203580 inhibits the reaction [[Calcitriol co-treated with TGFB1 protein] results in increased secretion of VEGFA protein]; SB 203580 inhibits the reaction [TGFB1 protein results in increased secretion of VEGFA protein]; SB 203580 inhibits the reaction [Vehicle Emissions results in increased expression of TGFB1 mRNA]
CTD PMID:11591817 PMID:12649123 PMID:16598785 PMID:21303922 PMID:21712382 More... NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions ISO SB 203580 inhibits the reaction [TGFB2 protein results in increased expression of COL1A1 mRNA]; SB 203580 inhibits the reaction [TGFB2 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:18253093 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP SB 203580 inhibits the reaction [fenvalerate results in decreased expression of TH protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of TH protein] CTD PMID:9288946 PMID:31734597 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Thbs1 thrombospondin 1 multiple interactions ISO SB 203580 inhibits the reaction [Fluorouracil results in increased expression of THBS1 mRNA] CTD PMID:18757417 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO SB 203580 inhibits the reaction [Dronabinol results in increased expression of TIMP1 protein]; SB 203580 inhibits the reaction [methanandamide results in increased expression of TIMP1 protein]; SB 203580 inhibits the reaction [thymoquinone results in increased expression of TIMP1 protein] CTD PMID:18159069 PMID:27060453 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions ISO SB 203580 inhibits the reaction [thymoquinone results in increased expression of TIMP2 protein] CTD PMID:27060453 NCBI chr10:103,541,199...103,590,611 JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO SB 203580 inhibits the reaction [clopidogrel results in decreased expression of TJP1 protein]
SB 203580 inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of TJP1 protein]
CTD PMID:23220562 PMID:23761298 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA] CTD PMID:12888452 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
increases expression
decreases response to substance
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [SB 203580 inhibits the reaction [Lead results in increased expression of and results in increased stability of TNF mRNA]]; [pirinixic acid co-treated with SB 203580] inhibits the reaction [TNF protein results in decreased expression of APOA1 mRNA]; SB 203580 inhibits the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]; SB 203580 inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA]; SB 203580 inhibits the reaction [Asbestos, Crocidolite results in increased expression of TNF mRNA]; SB 203580 inhibits the reaction [Buthionine Sulfoximine promotes the reaction [TNF protein results in increased expression of CCL5 protein]]; SB 203580 inhibits the reaction [DDT results in increased expression of TNF mRNA]; SB 203580 inhibits the reaction [deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]]; SB 203580 inhibits the reaction [IL17A protein promotes the reaction [TNF protein results in increased expression of IL6 mRNA]]; SB 203580 inhibits the reaction [Lead results in increased expression of and results in increased stability of TNF mRNA]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; SB 203580 inhibits the reaction [Methotrexate results in decreased expression of TNF protein]; SB 203580 inhibits the reaction [Mustard Gas results in increased expression of TNF protein]; SB 203580 inhibits the reaction [Mustard Gas results in increased secretion of TNF protein]; SB 203580 inhibits the reaction [nonylphenol results in increased expression of and results in increased secretion of TNF protein]; SB 203580 inhibits the reaction [nonylphenol results in increased expression of TNF]; SB 203580 inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; SB 203580 inhibits the reaction [Shiga Toxin results in increased expression of TNF protein]; SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF mRNA]; SB 203580 inhibits the reaction [TNF protein results in increased expression of and results in increased activity of MMP9 protein]; SB 203580 inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; SB 203580 inhibits the reaction [TNF protein results in increased expression of F3 mRNA]; SB 203580 inhibits the reaction [TNF protein results in increased expression of FOS mRNA]; SB 203580 inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; SB 203580 inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of ALOX5 protein]; SB 203580 inhibits the reaction [TNF protein results in increased phosphorylation of EIF4E protein]; SB 203580 inhibits the reaction [TNF results in increased expression of CCL2 protein]; SB 203580 inhibits the reaction [TNF results in increased expression of ICAM1 protein]; SB 203580 promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lead results in increased expression of and results in increased stability of TNF mRNA]]; SB 203580 promotes the reaction [[sodium arsenite co-treated with TNF protein] results in increased cleavage of PARP1 protein]; SB 203580 promotes the reaction [bufalin results in increased expression of TNF mRNA]; SB 203580 promotes the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; SB 203580 promotes the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; SB 203580 promotes the reaction [Zymosan results in increased secretion of TNF protein]
SB 203580 inhibits the reaction [2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid inhibits the reaction [ACE2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]]; SB 203580 inhibits the reaction [7-Ala-angiotensin (1-7) inhibits the reaction [ACE2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]]; SB 203580 inhibits the reaction [lead acetate results in increased expression of TNF protein]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; SB 203580 inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]]; SB 203580 inhibits the reaction [Particulate Matter results in increased expression of TNF mRNA]; SB 203580 inhibits the reaction [Resveratrol results in decreased expression of TNF protein]
SB 203580 results in decreased expression of TNF protein
[SB 203580 co-treated with U 0126] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; SB 203580 inhibits the reaction [[Polysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]; SB 203580 inhibits the reaction [Cisplatin results in increased expression of TNF mRNA]; SB 203580 inhibits the reaction [Cisplatin results in increased expression of TNF protein]; SB 203580 inhibits the reaction [cobaltous chloride results in increased expression of TNF protein]; SB 203580 inhibits the reaction [CPG-oligonucleotide results in increased secretion of TNF protein]; SB 203580 inhibits the reaction [deoxynivalenol promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; SB 203580 inhibits the reaction [deoxynivalenol promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; SB 203580 inhibits the reaction [deoxynivalenol results in increased expression of TNF mRNA]; SB 203580 inhibits the reaction [deoxynivalenol results in increased secretion of TNF protein]; SB 203580 inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; SB 203580 inhibits the reaction [endotoxin, Escherichia coli results in increased expression of TNF protein]; SB 203580 inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; SB 203580 inhibits the reaction [Mercuric Chloride results in increased expression of TNF mRNA]; SB 203580 inhibits the reaction [Paraquat promotes the reaction [endotoxin, Escherichia coli results in increased expression of TNF protein]]; SB 203580 inhibits the reaction [Paraquat results in increased expression of TNF protein]; SB 203580 inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of and results in increased secretion of TNF protein]]; SB 203580 inhibits the reaction [TNF protein results in increased expression of CCL11 protein]; SB 203580 inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; SB 203580 inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; SB 203580 promotes the reaction [PARK7 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]
SB 203580 results in increased expression of TNF mRNA
SB 203580 results in decreased susceptibility to TNF protein
CTD PMID:1970628 PMID:9545260 PMID:9799232 PMID:10712238 PMID:10779545 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfaip6 TNF alpha induced protein 6 decreases expression ISO SB 203580 results in decreased expression of TNFAIP6 mRNA CTD PMID:20660070 NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B multiple interactions
decreases expression
ISO SB 203580 inhibits the reaction [IL1B protein results in decreased expression of TNFRSF11B protein]; SB 203580 promotes the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of TNFRSF11B mRNA]
SB 203580 inhibits the reaction [Alprostadil results in increased secretion of TNFRSF11B protein]; SB 203580 inhibits the reaction [Dinoprost results in increased expression of and results in increased secretion of TNFRSF11B protein]; SB 203580 inhibits the reaction [Dinoprostone results in increased secretion of TNFRSF11B protein]; SB 203580 inhibits the reaction [FGF2 protein results in increased secretion of TNFRSF11B protein]; SB 203580 inhibits the reaction [Prostaglandin D2 results in increased secretion of TNFRSF11B protein]
SB 203580 results in decreased expression of TNFRSF11B mRNA
CTD PMID:20660070 PMID:22727857 PMID:24333336 PMID:24813642 PMID:25234201 More... NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions ISO SB 203580 inhibits the reaction [Cisplatin results in increased expression of TNFRSF1A protein] CTD PMID:15701814 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B multiple interactions ISO SB 203580 inhibits the reaction [Cisplatin results in increased expression of TNFRSF1B protein] CTD PMID:15701814 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
JBrowse link
G Tnfsf10 TNF superfamily member 10 increases response to substance ISO SB 203580 results in increased susceptibility to TNFSF10 protein CTD PMID:19497411 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO [SB 203580 co-treated with CSF1R protein co-treated with TNFSF11 protein] results in decreased expression of ATP6V0D2 mRNA; [SB 203580 co-treated with CSF1R protein co-treated with TNFSF11 protein] results in decreased expression of CTSK mRNA; [SB 203580 co-treated with sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in decreased expression of ATP6V0D2 mRNA; [SB 203580 co-treated with sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in decreased expression of CTSK mRNA; SB 203580 affects the reaction [[NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of ATP6V0D2 mRNA]]; SB 203580 affects the reaction [[NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of CTSK mRNA]]; SB 203580 inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 mRNA]; SB 203580 inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA] CTD PMID:30742845 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP
ISO
SB 203580 inhibits the reaction [dibenzo(a,l)pyrene results in increased phosphorylation of TP53 protein]
SB 203580 inhibits the reaction [deoxynivalenol results in increased phosphorylation of and results in increased activity of TRP53 protein]; SB 203580 inhibits the reaction [Ethanol results in increased expression of and results in increased phosphorylation of TP53 protein]
SB 203580 inhibits the reaction [[Cisplatin co-treated with fisetin] results in increased phosphorylation of TP53 protein]; SB 203580 inhibits the reaction [[sodium arsenite co-treated with Vitamin K 3] results in increased phosphorylation of TP53 protein]; SB 203580 inhibits the reaction [Curcumin results in increased phosphorylation of TP53 protein]; SB 203580 inhibits the reaction [Pyrogallol results in increased expression of TP53 protein]; SB 203580 inhibits the reaction [S-allylcysteine results in increased phosphorylation of TP53 protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased expression of TP53 protein]; SB 203580 inhibits the reaction [Sulindac affects the localization of TP53 protein]
CTD PMID:15734884 PMID:15976193 PMID:16005925 PMID:17136320 PMID:19020741 More... NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tpp2 tripeptidyl peptidase 2 multiple interactions ISO SB 203580 inhibits the reaction [Etoposide affects the localization of TPP2 protein] CTD PMID:20643100 NCBI chr 9:46,046,712...46,128,157
Ensembl chr 9:46,046,632...46,128,157
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP SB 203580 inhibits the reaction [GR 73632 results in increased phosphorylation of TRPV1 protein] CTD PMID:18809416 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 increases expression EXP SB 203580 results in increased expression of TSC22D1 mRNA CTD PMID:26464165 NCBI chr15:51,750,489...51,850,958
Ensembl chr15:51,749,510...51,850,958
JBrowse link
G Twist1 twist family bHLH transcription factor 1 multiple interactions ISO SB 203580 inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TWIST1 mRNA]; SB 203580 inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TWIST1 protein]; SB 203580 inhibits the reaction [thymoquinone results in decreased expression of TWIST1 protein] CTD PMID:27060453 PMID:33396024 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of TXNRD1 mRNA] CTD PMID:28329830 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Tymp thymidine phosphorylase decreases expression
multiple interactions
ISO SB 203580 results in decreased expression of TYMP mRNA
SB 203580 inhibits the reaction [salinomycin results in increased expression of TYMP mRNA]; SB 203580 promotes the reaction [[tanespimycin co-treated with salinomycin] results in decreased expression of TYMP mRNA]
CTD PMID:30796972 NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874
JBrowse link
G Tyr tyrosinase multiple interactions ISO SB 203580 inhibits the reaction [Cannabidiol results in increased activity of TYR protein]; SB 203580 inhibits the reaction [Cannabidiol results in increased expression of TYR mRNA]
SB 203580 inhibits the reaction [[resorcinol co-treated with Cycloheximide] results in increased expression of TYR protein]; SB 203580 inhibits the reaction [resorcinol results in decreased activity of TYR protein]
CTD PMID:28601556 PMID:29621941 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
JBrowse link
G Tyrp1 tyrosinase-related protein 1 multiple interactions ISO SB 203580 inhibits the reaction [Cannabidiol results in increased expression of TYRP1 mRNA] CTD PMID:28601556 NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516
JBrowse link
G Ucp3 uncoupling protein 3 multiple interactions ISO SB 203580 inhibits the reaction [Oxygen deficiency results in increased expression of UCP3 protein] CTD PMID:18579531 NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO SB 203580 inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA] CTD PMID:17256720 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Vasp vasodilator-stimulated phosphoprotein multiple interactions ISO SB 203580 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of VASP protein] CTD PMID:24677693 NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO SB 203580 inhibits the reaction [Chenodeoxycholic Acid results in increased expression of VCAM1 mRNA]; SB 203580 inhibits the reaction [EDN1 protein results in increased expression of VCAM1 mRNA]; SB 203580 inhibits the reaction [melamine results in increased expression of VCAM1 mRNA]
SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of VCAM1 mRNA]; SB 203580 inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
CTD PMID:16582018 PMID:18457675 PMID:22915474 PMID:28329830 PMID:28483571 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression
decreases activity
ISO
EXP
SB 203580 inhibits the reaction [4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased expression of VEGFA mRNA]; SB 203580 inhibits the reaction [4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased expression of VEGFA protein]; SB 203580 inhibits the reaction [4-tert-octylphenol results in increased secretion of VEGFA protein]; SB 203580 inhibits the reaction [butylbenzyl phthalate results in increased secretion of VEGFA protein]; SB 203580 inhibits the reaction [Dieldrin results in increased secretion of VEGFA protein]; SB 203580 inhibits the reaction [Estradiol results in increased secretion of VEGFA protein]; SB 203580 inhibits the reaction [Genistein results in increased secretion of VEGFA protein]; SB 203580 inhibits the reaction [Lapatinib inhibits the reaction [sodium arsenite results in increased expression of VEGFA protein]]; SB 203580 inhibits the reaction [Melitten results in decreased expression of VEGFA protein]; SB 203580 inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; SB 203580 inhibits the reaction [sodium arsenite results in increased expression of VEGFA mRNA]; SB 203580 inhibits the reaction [sodium arsenite results in increased expression of VEGFA protein]; SB 203580 inhibits the reaction [Troglitazone results in increased expression of VEGFA mRNA]; SB 203580 inhibits the reaction [Troglitazone results in increased expression of VEGFA protein]; SB 203580 inhibits the reaction [VEGFA protein affects the localization of ETS1 protein]; SB 203580 inhibits the reaction [VEGFA protein results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [VEGFA protein results in increased expression of PTGS2 protein]
SB 203580 inhibits the reaction [[Calcitriol co-treated with TGFB1 protein] results in increased secretion of VEGFA protein]; SB 203580 inhibits the reaction [Calcitriol results in increased secretion of VEGFA protein]; SB 203580 inhibits the reaction [TGFB1 protein results in increased secretion of VEGFA protein]
SB 203580 results in decreased expression of VEGFA mRNA; SB 203580 results in decreased expression of VEGFA protein
SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of VEGFA mRNA]; SB 203580 inhibits the reaction [arsenic trioxide results in increased expression of VEGFA mRNA]
SB 203580 results in decreased activity of VEGFA protein
CTD PMID:12482858 PMID:13679210 PMID:16598785 PMID:18252963 PMID:18596194 More... NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vim vimentin multiple interactions ISO SB 203580 inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of VIM mRNA]; SB 203580 inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of VIM protein]; SB 203580 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of VIM protein]; SB 203580 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VIM protein] CTD PMID:22960429 PMID:26971374 PMID:33396024 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP SB 203580 inhibits the reaction [Oxygen deficiency results in increased phosphorylation of and results in increased activity of XDH protein] CTD PMID:11278616 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO SB 203580 results in decreased expression of XIAP protein CTD PMID:30801954 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A multiple interactions EXP SB 203580 inhibits the reaction [Silicon Dioxide results in increased expression of ZC3H12A protein] CTD PMID:26865670 NCBI chr 5:137,376,562...137,385,351
Ensembl chr 5:137,376,564...137,385,351
JBrowse link
G Zfp36 zinc finger protein 36 multiple interactions ISO SB 203580 inhibits the reaction [isoeugenol results in increased expression of ZFP36 protein] CTD PMID:21969073 NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        pharmaceutical 19329
          drug 19329
            protective agent 16496
              neuroprotective agent 15502
                SB 203580 420
Path 2
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  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic heterocyclic compound 18591
                                  heteroarene 16530
                                    monocyclic heteroarene 13437
                                      azole 12628
                                        diazole 8394
                                          imidazoles 7687
                                            SB 203580 420
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