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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sulfinpyrazone
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Accession:CHEBI:9342 term browser browse the term
Definition:A pyrazolidine that has formula C23H20N2O3S.
Synonyms:exact_synonym: 1,2-diphenyl-4-[2-(phenylsulfinyl)ethyl]pyrazolidine-3,5-dione
 related_synonym: 1,2-Diphenyl-3,5-dioxo-4-(2-phenylsulfinylethyl)pyrazolidine;   1,2-Diphenyl-4-(2'-phenylsulfinethyl)-3,5-pyrazolidinedione;   4-(2-Benzenesulfinylethyl)-1,2-diphenylpyrazolidine-3,5-dione;   Anturane (TN);   Formula=C23H20N2O3S;   InChI=1S/C23H20N2O3S/c26-22-21(16-17-29(28)20-14-8-3-9-15-20)23(27)25(19-12-6-2-7-13-19)24(22)18-10-4-1-5-11-18/h1-15,21H,16-17H2;   InChIKey=MBGGBVCUIVRRBF-UHFFFAOYSA-N;   SMILES=O=C1C(CCS(=O)c2ccccc2)C(=O)N(N1c1ccccc1)c1ccccc1;   Sulfoxyphenylpyrazolidine
 xref: Beilstein:713597;   CAS:57-96-5;   DrugBank:DB01138;   Drug_Central:2528;   KEGG:C07317;   KEGG:D00449;   LINCS:LSM-1491
 xref_mesh: MESH:D013442
 xref: Wikipedia:Sulfinpyrazone



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sulfinpyrazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Sulfinpyrazone inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Sulfinpyrazone results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity
multiple interactions
ISO
EXP
Sulfinpyrazone results in decreased activity of ABCC1 protein
[Sulfinpyrazone results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine
CTD PMID:12893836 PMID:15044619 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity ISO Sulfinpyrazone results in decreased activity of ABCC2 protein CTD PMID:14569069 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Sulfinpyrazone results in increased expression of CYP2B6 protein CTD PMID:14977870 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Sulfinpyrazone results in decreased activity of CYP2C8 protein CTD PMID:12464242
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
increases activity
ISO Sulfinpyrazone results in increased expression of CYP3A4 mRNA
Sulfinpyrazone results in increased activity of CYP3A4 protein
CTD PMID:9512926 PMID:10219967 PMID:12065438 PMID:16837568 PMID:17954527 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions ISO Sulfinpyrazone inhibits the reaction [GSTM1 protein results in decreased susceptibility to Vincristine] CTD PMID:15044619 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Sulfinpyrazone inhibits the reaction [GSTP1 protein results in decreased susceptibility to Etoposide] CTD PMID:15999103 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO Sulfinpyrazone binds to and results in increased activity of NR1I2 protein
Sulfinpyrazone results in increased activity of NR1I2 protein
CTD PMID:12065438 PMID:14977870 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO Sulfinpyrazone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] CTD PMID:21272127 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
JBrowse link

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            renal agent 413
              uricosuric drug 398
                sulfinpyrazone 10
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    subatomic particle 20054
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                  main group element atom 19956
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                      carbon group element atom 19882
                        carbon atom 19875
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                            organic molecule 19822
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                                organic heterocyclic compound 18798
                                  organic heteromonocyclic compound 17145
                                    diazolidine 998
                                      pyrazolidines 29
                                        sulfinpyrazone 10
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