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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fulvestrant
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Accession:CHEBI:31638 term browser browse the term
Definition:A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Synonyms:exact_synonym: 7alpha-{9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl}estra-1(10),2,4-triene-3,17beta-diol
 related_synonym: (7alpha,17beta)-7-{9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl}estra-1(10),2,4-triene-3,17-diol;   Faslodex;   Formula=C32H47F5O3S;   ICI-182780;   InChI=1S/C32H47F5O3S/c1-30-17-15-26-25-12-11-24(38)21-23(25)20-22(29(26)27(30)13-14-28(30)39)10-7-5-3-2-4-6-8-18-41(40)19-9-16-31(33,34)32(35,36)37/h11-12,21-22,26-29,38-39H,2-10,13-20H2,1H3/t22-,26-,27+,28+,29?,30+,41?/m1/s1;   InChIKey=VWUXBMIQPBEWFH-WCCTWKNTSA-N;   SMILES=C=1C=C(C=C2C1[C@]3(CC[C@@]4([C@H](CC[C@]4([C@@]3([C@@H](C2)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F)[H])[H])O)C)[H])O;   fulvestrantum
 alt_id: CHEBI:87729
 xref: CAS:129453-61-8;   DrugBank:DB00947;   Drug_Central:1255;   KEGG:D01161;   LINCS:LSM-6504
 xref_mesh: MESH:C070081
 xref: PMID:18683044;   PMID:19369092;   PMID:21319872;   PMID:21699443;   PMID:25720568;   Wikipedia:Fulvestrant


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fulvestrant term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
ISO
EXP
fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of ABCB1 protein]; fulvestrant inhibits the reaction [Genistein results in increased expression of ABCB1 protein]
Fulvestrant inhibits the reaction [estradiol 3-benzoate results in increased expression of ABCB1A mRNA]; Fulvestrant inhibits the reaction [tetrabromobisphenol A results in decreased expression of and results in decreased activity of ABCB1A protein]; Fulvestrant inhibits the reaction [Zearalenone results in increased expression of ABCB1A mRNA]
fulvestrant results in increased expression of ABCB1 protein
CTD PMID:23707492, PMID:24685904, PMID:30830211 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B multiple interactions EXP fulvestrant inhibits the reaction [estradiol 3-benzoate results in decreased expression of ABCB1B mRNA] CTD PMID:23707492 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression
ISO
EXP
fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of ABCC2 protein]; fulvestrant inhibits the reaction [Genistein results in increased expression of ABCC2 protein]
EGF protein inhibits the reaction [fulvestrant inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]]; fulvestrant inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]
fulvestrant results in increased expression of ABCC2 protein
CTD PMID:24685904, PMID:25813982 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression ISO fulvestrant results in increased expression of ABCC3 mRNA CTD PMID:15072547 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions EXP fulvestrant inhibits the reaction [estradiol 3-benzoate results in increased expression of ABCC4 mRNA]; fulvestrant inhibits the reaction [Zearalenone results in increased expression of ABCC4 mRNA] CTD PMID:23707492 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 decreases expression
multiple interactions
ISO
EXP
fulvestrant results in decreased expression of ABCC5 mRNA
fulvestrant inhibits the reaction [Zearalenone results in increased expression of ABCC5 mRNA]
CTD PMID:15072547, PMID:23707492 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
affects response to substance
ISO
EXP
fulvestrant affects the reaction [4-nonylphenol results in decreased expression of ABCG2 protein]; fulvestrant affects the reaction [bisphenol A results in decreased expression of ABCG2 protein]; fulvestrant affects the reaction [Estradiol results in decreased expression of ABCG2 protein]; fulvestrant inhibits the reaction [[Estradiol co-treated with Testosterone] results in increased expression of ABCG2 mRNA]; fulvestrant inhibits the reaction [[Estradiol co-treated with Testosterone] results in increased expression of ABCG2 protein]; fulvestrant inhibits the reaction [Estriol results in increased expression of ABCG2 mRNA]; fulvestrant inhibits the reaction [Estriol results in increased expression of ABCG2 protein]; fulvestrant inhibits the reaction [Genistein results in decreased expression of ABCG2 protein]
fulvestrant inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCG2 protein]
ABCG2 affects the susceptibility to fulvestrant
CTD PMID:17823853, PMID:24169358, PMID:24945792, PMID:26850786, PMID:27036933 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Abhd2 abhydrolase domain containing 2, acylglycerol lipase decreases expression ISO fulvestrant results in decreased expression of ABHD2 mRNA CTD PMID:26865669 NCBI chr 1:140,998,240...141,087,405
Ensembl chr 1:140,998,240...141,087,405
JBrowse link
G Acvr2b activin A receptor type 2B multiple interactions ISO fulvestrant inhibits the reaction [bisphenol A results in decreased expression of ACVR2B mRNA] CTD PMID:14994273 NCBI chr 8:128,087,308...128,126,776
Ensembl chr 8:128,087,345...128,118,746
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO fulvestrant inhibits the reaction [Estradiol results in increased expression of AGER protein] CTD PMID:15878629 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member affects response to substance ISO AGR2 protein affects the susceptibility to fulvestrant CTD PMID:20525379 NCBI chr 6:55,465,782...55,487,087
Ensembl chr 6:55,465,782...55,487,714
JBrowse link
G Agt angiotensinogen multiple interactions ISO
EXP
Fulvestrant inhibits the reaction [bisphenol A results in increased expression of AGT mRNA]
Fulvestrant inhibits the reaction [bisphenol A results in increased expression of AGT mRNA]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of AGT protein]
CTD PMID:30677511 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Ahnak AHNAK nucleoprotein decreases expression ISO fulvestrant results in decreased expression of AHNAK mRNA CTD PMID:16514628 NCBI chr 1:225,184,883...225,429,638
Ensembl chr 1:225,184,939...225,215,015
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity
ISO [fulvestrant results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; fulvestrant inhibits the reaction [Estradiol results in increased expression of AHR protein]; fulvestrant promotes the reaction [formononetin results in increased activity of AHR protein] CTD PMID:19901195, PMID:28618207, PMID:28985473 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
[Fulvestrant co-treated with 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline] inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; Fulvestrant inhibits the reaction [4,4'-hexafluorisopropylidene diphenol results in increased phosphorylation of AKT1 protein]; Fulvestrant inhibits the reaction [[bisphenol A co-treated with ESR1 protein] results in increased phosphorylation of AKT1 protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]; Fulvestrant inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; Fulvestrant inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; Fulvestrant inhibits the reaction [Diethylhexyl Phthalate results in increased phosphorylation of AKT1 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; Fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased phosphorylation of AKT1 protein]; Fulvestrant inhibits the reaction [puerarin results in increased phosphorylation of AKT1 protein]
fulvestrant results in increased phosphorylation of AKT1 protein
fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]
[Estradiol co-treated with Fulvestrant] results in increased phosphorylation of AKT1 protein; Fulvestrant inhibits the reaction [Promegestone results in increased phosphorylation of AKT1 protein]
CTD PMID:16020483, PMID:16168102, PMID:16951259, PMID:17125913, PMID:18767177, PMID:19781563, PMID:19956873, PMID:21884717, PMID:23000059, PMID:25461906, PMID:28882636, PMID:30590302, PMID:31059536 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alad aminolevulinate dehydratase increases expression ISO fulvestrant results in increased expression of ALAD mRNA CTD PMID:26865669 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO fulvestrant inhibits the reaction [[6-(1,1-dimethylallyl)naringenin binds to ESR1 protein] which results in increased activity of ALPL protein]; fulvestrant inhibits the reaction [[8-prenylnaringenin binds to ESR1 protein] which results in increased activity of ALPL protein]; fulvestrant inhibits the reaction [[Coumestrol binds to ESR1 protein] which results in increased activity of ALPL protein]; fulvestrant inhibits the reaction [[daidzein binds to ESR1 protein] which results in increased activity of ALPL protein]; fulvestrant inhibits the reaction [[Estradiol binds to ESR1 protein] which results in increased activity of ALPL protein]; fulvestrant inhibits the reaction [[Genistein binds to ESR1 protein] which results in increased activity of ALPL protein]; fulvestrant inhibits the reaction [[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein]; fulvestrant inhibits the reaction [[Zearalenone binds to ESR1 protein] which results in increased activity of ALPL protein] CTD PMID:12650720 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO fulvestrant inhibits the reaction [Quercetin results in increased secretion of APOA1 protein] CTD PMID:24963805 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apod apolipoprotein D increases expression ISO fulvestrant results in increased expression of APOD mRNA CTD PMID:16514628 NCBI chr11:72,705,204...72,726,263
Ensembl chr11:72,705,129...72,726,301
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP fulvestrant inhibits the reaction [Trenbolone Acetate analog results in increased expression of APP protein modified form] CTD PMID:25461682 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Ar androgen receptor multiple interactions
increases expression
decreases expression
decreases activity
ISO
EXP
Fulvestrant inhibits the reaction [bisphenol A promotes the reaction [EGFR protein binds to AR protein]]; Fulvestrant inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; Fulvestrant inhibits the reaction [Estradiol results in increased activity of AR protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of AR mRNA]
fulvestrant inhibits the reaction [Testosterone results in increased expression of AR mRNA]
fulvestrant results in increased expression of AR protein
fulvestrant results in decreased expression of AR mRNA
fulvestrant results in decreased activity of AR protein
CTD PMID:11867264, PMID:15026081, PMID:15316697, PMID:15925091, PMID:17823853, PMID:29383186 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Areg amphiregulin increases expression
multiple interactions
decreases expression
ISO fulvestrant results in increased expression of AREG mRNA
Fulvestrant inhibits the reaction [4,4'-hexafluorisopropylidene diphenol results in increased expression of AREG mRNA]
fulvestrant results in decreased expression of AREG mRNA
CTD PMID:15072547, PMID:16202921, PMID:16514628, PMID:26865669, PMID:31059536 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Arg1 arginase 1 multiple interactions ISO Fulvestrant inhibits the reaction [bisphenol F results in decreased expression of ARG1 mRNA]; Fulvestrant inhibits the reaction [bisphenol F results in decreased expression of ARG1 protein] CTD PMID:32044397 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Arid1a AT-rich interaction domain 1A increases expression
decreases response to substance
ISO fulvestrant results in increased expression of ARID1A protein
ARID1A gene mutant form results in decreased susceptibility to Fulvestrant
CTD PMID:24169358, PMID:31932695 NCBI chr 5:151,904,687...151,977,973
Ensembl chr 5:151,904,684...151,977,636
JBrowse link
G Arnt2 aryl hydrocarbon receptor nuclear translocator 2 increases expression ISO fulvestrant results in increased expression of ARNT2 mRNA CTD PMID:16514628 NCBI chr 1:146,399,217...146,556,437
Ensembl chr 1:146,399,217...146,556,171
JBrowse link
G Artn artemin multiple interactions
decreases response to substance
ISO ARTN protein inhibits the reaction [fulvestrant inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]; fulvestrant inhibits the reaction [Estradiol results in increased expression of ARTN mRNA]; YC137 inhibits the reaction [ARTN protein inhibits the reaction [fulvestrant inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]]
ARTN protein results in decreased susceptibility to fulvestrant
CTD PMID:20305694 NCBI chr 5:136,759,717...136,765,036
Ensembl chr 5:136,759,717...136,762,986
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression
multiple interactions
ISO fulvestrant results in decreased expression of ASNS mRNA
fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of ASNS mRNA]; fulvestrant inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ASNS mRNA]
CTD PMID:16467188, PMID:16514628 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of ATF4 mRNA]; fulvestrant inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ATF4 mRNA] CTD PMID:16467188 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta increases expression ISO fulvestrant results in increased expression of ATP5F1B mRNA CTD PMID:20211987 NCBI chr 7:2,504,708...2,511,748
Ensembl chr 7:2,504,695...2,511,749
JBrowse link
G Aurka aurora kinase A decreases expression ISO fulvestrant results in decreased expression of AURKA mRNA CTD PMID:16514628 NCBI chr 3:170,364,177...170,380,278
Ensembl chr 3:170,364,181...170,378,210
JBrowse link
G Aurkb aurora kinase B multiple interactions
decreases expression
ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of AURKB mRNA
fulvestrant results in decreased expression of AURKB mRNA
CTD PMID:19016759 NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP fulvestrant inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in decreased expression of BAD protein modified form]] CTD PMID:23419388 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO fulvestrant inhibits the reaction [Estradiol results in decreased expression of BAX protein]; fulvestrant inhibits the reaction [Methoxychlor results in decreased expression of BAX mRNA]; fulvestrant inhibits the reaction [Triclosan results in decreased expression of BAX mRNA] CTD PMID:15870704, PMID:24835555 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member affects response to substance ISO BCAR1 affects the susceptibility to fulvestrant CTD PMID:24169358 NCBI chr19:43,932,543...43,967,452
Ensembl chr19:43,932,554...43,955,783
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO
EXP
ARTN protein inhibits the reaction [Fulvestrant inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]; Fulvestrant inhibits the reaction [[aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of BCL2 protein]; Fulvestrant inhibits the reaction [alachlor results in increased expression of BCL2 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of BCL2 protein]; Fulvestrant inhibits the reaction [o,p'-DDT results in increased expression of BCL2 protein]; YC137 inhibits the reaction [ARTN protein inhibits the reaction [Fulvestrant inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]]
fulvestrant results in increased expression of BCL2 protein
[fulvestrant co-treated with Estradiol] results in increased expression of BCL2 protein
CTD PMID:10545406, PMID:15870704, PMID:16951259, PMID:20305694, PMID:31945389 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP fulvestrant inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased expression of BCL2L1 protein]] CTD PMID:23419388 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions ISO
EXP
fulvestrant inhibits the reaction [Estradiol results in increased expression of BGLAP mRNA]; fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of BGLAP mRNA]; fulvestrant inhibits the reaction [resveratrol results in increased expression of BGLAP mRNA]
fulvestrant inhibits the reaction [naringin results in increased secretion of BGLAP protein]
CTD PMID:17689939, PMID:23596885, PMID:26362186 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression
ISO
EXP
[fulvestrant co-treated with Sirolimus] results in decreased expression of BIRC5 mRNA
fulvestrant results in decreased expression of BIRC5 mRNA
CTD PMID:19016759, PMID:21980073 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Blm BLM RecQ like helicase multiple interactions ISO fulvestrant inhibits the reaction [bisphenol A results in increased expression of BLM mRNA]; fulvestrant inhibits the reaction [Estradiol results in increased expression of BLM mRNA] CTD PMID:17268063 NCBI chr 1:142,246,773...142,332,616
Ensembl chr 1:142,246,790...142,332,588
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO
EXP
fulvestrant inhibits the reaction [resveratrol promotes the reaction [ESR1 protein binds to BMP2 promoter]]; fulvestrant inhibits the reaction [resveratrol results in increased expression of BMP2 mRNA]
fulvestrant inhibits the reaction [naringin results in increased secretion of BMP2 protein]
CTD PMID:17513867, PMID:23596885 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Bmp7 bone morphogenetic protein 7 multiple interactions ISO fulvestrant inhibits the reaction [bisphenol A results in decreased expression of BMP7 mRNA] CTD PMID:14994273 NCBI chr 3:170,879,972...170,955,820
Ensembl chr 3:170,879,973...170,955,399
JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression
multiple interactions
ISO fulvestrant results in decreased expression of BRCA1 mRNA
fulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of BRCA1 mRNA]; fulvestrant inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of BRCA1 mRNA]; fulvestrant inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]; fulvestrant inhibits the reaction [o,p'-DDT results in increased expression of BRCA1 mRNA]
CTD PMID:12473173, PMID:20206645 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase multiple interactions
decreases expression
ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of BUB1 mRNA
fulvestrant results in decreased expression of BUB1 mRNA
CTD PMID:19016759 NCBI chr 3:120,373,604...120,404,910
Ensembl chr 3:120,373,604...120,404,910
JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B multiple interactions
decreases expression
ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of BUB1B mRNA
fulvestrant results in decreased expression of BUB1B mRNA
CTD PMID:19016759 NCBI chr 3:110,367,949...110,420,471
Ensembl chr 3:110,367,939...110,420,458
JBrowse link
G C3 complement C3 multiple interactions
increases expression
EXP fulvestrant inhibits the reaction [Cadmium Chloride results in increased expression of C3 mRNA]; fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of C3 mRNA]; fulvestrant inhibits the reaction [Triclosan results in increased expression of C3 mRNA]
fulvestrant results in increased expression of C3 mRNA; fulvestrant results in increased expression of C3 protein
CTD PMID:11086226, PMID:12858169, PMID:16639590, PMID:22062131 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G Ca12 carbonic anhydrase 12 multiple interactions
decreases expression
ISO fulvestrant inhibits the reaction [Genistein results in increased expression of CA12 mRNA]; fulvestrant promotes the reaction [Dexamethasone inhibits the reaction [Genistein results in increased expression of CA12 mRNA]]
fulvestrant results in decreased expression of CA12 mRNA
CTD PMID:25136773, PMID:26865669 NCBI chr 8:72,405,770...72,461,425
Ensembl chr 8:72,405,748...72,460,240
JBrowse link
G Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase multiple interactions ISO fulvestrant inhibits the reaction [Estradiol results in increased expression of CAD mRNA] CTD PMID:16675542 NCBI chr 6:26,657,507...26,680,459
Ensembl chr 6:26,657,780...26,680,284
JBrowse link
G Capn1 calpain 1 multiple interactions ISO 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [fulvestrant promotes the reaction [CAPN1 protein results in increased cleavage of and results in increased activity of CAPN1 protein]]; fulvestrant promotes the reaction [CAPN1 protein results in increased cleavage of and results in increased activity of CAPN1 protein]; GPER1 protein affects the reaction [fulvestrant promotes the reaction [CAPN1 protein results in increased cleavage of and results in increased activity of CAPN1 protein]] CTD PMID:24440569 NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322
JBrowse link
G Casp3 caspase 3 multiple interactions EXP fulvestrant affects the reaction [Trenbolone Acetate analog results in increased activity of CASP3 protein]; fulvestrant inhibits the reaction [bisphenol A results in increased activity of CASP3 protein]; fulvestrant inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased cleavage of and results in increased activity of CASP3 protein]]; fulvestrant inhibits the reaction [Estradiol results in increased activity of CASP3 protein] CTD PMID:23419388, PMID:23788033, PMID:25461682 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp4 caspase 4 increases expression ISO fulvestrant results in increased expression of CASP4 mRNA CTD PMID:12154049 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Fulvestrant inhibits the reaction [[aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of CASP9 protein] CTD PMID:31945389 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cav1 caveolin 1 multiple interactions EXP fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in increased expression of CAV1 mRNA]; fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in increased expression of CAV1 protein] CTD PMID:17091190 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Cbx1 chromobox 1 decreases expression ISO fulvestrant results in decreased expression of CBX1 mRNA CTD PMID:16514628 NCBI chr10:84,656,698...84,677,112
Ensembl chr10:84,669,914...84,675,741
JBrowse link
G Cckar cholecystokinin A receptor multiple interactions ISO Fulvestrant inhibits the reaction [bisphenol A results in increased expression of CCKAR mRNA]; Fulvestrant inhibits the reaction [Genistein results in increased expression of CCKAR mRNA]; Fulvestrant inhibits the reaction [isoliquiritigenin results in increased expression of CCKAR mRNA] CTD PMID:26789235, PMID:27702603, PMID:31593742 NCBI chr14:59,610,939...59,619,786
Ensembl chr14:59,611,434...59,619,783
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Fulvestrant inhibits the reaction [bisphenol A inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein]]; Fulvestrant inhibits the reaction [Estradiol inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein]]; Fulvestrant inhibits the reaction [Estradiol results in decreased activity of CCL2 protein]; Fulvestrant inhibits the reaction [Estrogens, Conjugated (USP) inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA]]; Fulvestrant inhibits the reaction [nonylphenol inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein]]; Fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in decreased activity of CCL2 protein] CTD PMID:10614622, PMID:17006379, PMID:31217279 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO fulvestrant results in increased expression of CCL20 mRNA CTD PMID:16298037 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO fulvestrant results in increased expression of CCL5 mRNA CTD PMID:12154049 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccn3 cellular communication network factor 3 increases expression ISO Fulvestrant results in increased expression of CCN3 mRNA; Fulvestrant results in increased expression of CCN3 protein CTD PMID:15072547, PMID:18984771 NCBI chr 7:94,375,134...94,382,154
Ensembl chr 7:94,375,020...94,383,024
JBrowse link
G Ccn5 cellular communication network factor 5 multiple interactions ISO Fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of CCN5 mRNA]; Fulvestrant inhibits the reaction [4,4'-hexafluorisopropylidene diphenol results in increased expression of CCN5 mRNA]; Fulvestrant inhibits the reaction [bis(4-hydroxyphenyl)sulfone results in increased expression of CCN5 mRNA]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of CCN5 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of CCN5 mRNA] CTD PMID:10944450, PMID:17872378, PMID:29389661 NCBI chr 3:160,207,969...160,219,316
Ensembl chr 3:160,207,913...160,219,331
JBrowse link
G Ccna1 cyclin A1 multiple interactions ISO [CDK6 affects the susceptibility to fulvestrant] which affects the expression of CCNA1 protein CTD PMID:24169358 NCBI chr 2:144,456,689...144,503,570
Ensembl chr 2:144,458,153...144,467,912
JBrowse link
G Ccna2 cyclin A2 multiple interactions
decreases expression
ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of CCNA2 mRNA; fulvestrant promotes the reaction [RB1 protein binds to CCNA2 promoter]; fulvestrant promotes the reaction [SIN3B protein binds to CCNA2 promoter]; RB1 mutant form inhibits the reaction [fulvestrant promotes the reaction [SIN3B protein binds to CCNA2 promoter]]
fulvestrant results in decreased expression of CCNA2 mRNA; fulvestrant results in decreased expression of CCNA2 protein
CTD PMID:15072547, PMID:19016759, PMID:21367843 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 multiple interactions
decreases expression
increases expression
ISO
EXP
fulvestrant inhibits the reaction [Estradiol results in increased expression of CCNB1 mRNA]
fulvestrant results in decreased expression of CCNB1 mRNA
fulvestrant results in increased expression of CCNB1 mRNA
CTD PMID:12154049, PMID:17445807, PMID:21980073 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnb2 cyclin B2 multiple interactions
decreases expression
ISO
EXP
[fulvestrant co-treated with Sirolimus] results in decreased expression of CCNB2 mRNA
fulvestrant results in decreased expression of CCNB2 mRNA
CTD PMID:19016759, PMID:21980073 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO
EXP
Fulvestrant inhibits the reaction [2,4-dihydroxybenzophenone results in increased expression of CCND1 mRNA]; Fulvestrant inhibits the reaction [2,4-dihydroxybenzophenone results in increased expression of CCND1 protein]; Fulvestrant inhibits the reaction [4,4'-hexafluorisopropylidene diphenol results in increased expression of CCND1 protein]; Fulvestrant inhibits the reaction [4-tert-octylphenol results in increased expression of CCND1 mRNA]; Fulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of CCND1 mRNA]; Fulvestrant inhibits the reaction [bis(4-hydroxyphenyl)sulfone results in increased expression of CCND1 protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of CCND1 protein]; Fulvestrant inhibits the reaction [bisphenol F results in increased expression of CCND1 protein]; Fulvestrant inhibits the reaction [Cadmium Chloride results in increased expression of CCND1 mRNA]; Fulvestrant inhibits the reaction [Cadmium Chloride results in increased expression of CCND1 protein]; Fulvestrant inhibits the reaction [cyhalothrin affects the expression of CCND1 mRNA]; Fulvestrant inhibits the reaction [cypermethrin results in increased expression of CCND1 mRNA]; Fulvestrant inhibits the reaction [cyprodinil results in increased expression of CCND1 protein]; Fulvestrant inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of CCND1 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of CCND1 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of CCND1 protein]; Fulvestrant inhibits the reaction [FGF2 protein results in increased expression of CCND1 protein]; Fulvestrant inhibits the reaction [fludioxonil results in increased expression of CCND1 protein]; Fulvestrant inhibits the reaction [Methoxychlor results in increased expression of CCND1 mRNA]; Fulvestrant inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of CCND1 protein]; Fulvestrant inhibits the reaction [nonylphenol results in increased expression of CCND1 mRNA]; Fulvestrant inhibits the reaction [o,p'-DDT results in increased expression of CCND1 mRNA]; Fulvestrant inhibits the reaction [Triclosan results in increased expression of CCND1 mRNA]
fulvestrant results in decreased expression of CCND1 mRNA; fulvestrant results in decreased expression of CCND1 protein
Fulvestrant inhibits the reaction [Cadmium Chloride results in increased expression of CCND1 mRNA]; Fulvestrant inhibits the reaction [Cadmium results in increased expression of CCND1 mRNA]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Fulvestrant co-treated with bisphenol A] results in decreased expression of CCND1 mRNA]; [Fulvestrant co-treated with bisphenol A] results in decreased expression of CCND1 mRNA; Fulvestrant inhibits the reaction [Estradiol affects the expression of CCND1 mRNA]; GPER1 protein affects the reaction [[Fulvestrant co-treated with bisphenol A] results in decreased expression of CCND1 mRNA]; RTKI cpd inhibits the reaction [[Fulvestrant co-treated with bisphenol A] results in decreased expression of CCND1 mRNA]
CTD PMID:9094091, PMID:9705214, PMID:19361625, PMID:20179196, PMID:20206645, PMID:20208560, PMID:20215421, PMID:20219890, PMID:20543978, PMID:21367843, PMID:21980073, PMID:22735500, PMID:23328252, PMID:24236210, PMID:24684733, PMID:24835555, PMID:26344002, PMID:26865669, PMID:26877835, PMID:27260121, PMID:27539251, PMID:28446726, PMID:28808208, PMID:30590302, PMID:30684532 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd3 cyclin D3 multiple interactions ISO
EXP
fulvestrant inhibits the reaction [Estradiol affects the expression of CCND3 mRNA]
fulvestrant inhibits the reaction [Cadmium Chloride results in increased expression of CCND3 mRNA]; fulvestrant inhibits the reaction [Cadmium results in increased expression of CCND3 mRNA]
CTD PMID:9094091, PMID:24236210 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Ccne1 cyclin E1 decreases expression
multiple interactions
ISO fulvestrant results in decreased expression of CCNE1 mRNA
fulvestrant inhibits the reaction [bis(4-hydroxyphenyl)sulfone results in increased expression of CCNE1 protein]; fulvestrant inhibits the reaction [bisphenol A results in increased expression of CCNE1 protein]; fulvestrant inhibits the reaction [bisphenol F results in increased expression of CCNE1 protein]; fulvestrant inhibits the reaction [cyprodinil results in increased expression of CCNE1 protein]; fulvestrant inhibits the reaction [Estradiol results in increased expression of CCNE1 protein]; fulvestrant inhibits the reaction [fludioxonil results in increased expression of CCNE1 protein]; fulvestrant inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of CCNE1 protein]
CTD PMID:20215421, PMID:26344002, PMID:27539251, PMID:28808208 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccne2 cyclin E2 decreases expression
multiple interactions
ISO fulvestrant results in decreased expression of CCNE2 mRNA
[fulvestrant co-treated with Sirolimus] results in decreased expression of CCNE2 mRNA
CTD PMID:19016759 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Ccng2 cyclin G2 increases expression ISO fulvestrant results in increased expression of CCNG2 mRNA CTD PMID:26865669 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Cd24 CD24 molecule increases expression ISO fulvestrant results in increased expression of CD24 mRNA CTD PMID:16514628 NCBI chr20:48,335,540...48,340,847
Ensembl chr20:48,335,540...48,340,846
JBrowse link
G Cd36 CD36 molecule increases expression
multiple interactions
ISO fulvestrant results in increased expression of CD36 protein
Tamoxifen inhibits the reaction [fulvestrant results in increased expression of CD36 protein]
CTD PMID:27358406 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cd44 CD44 molecule (Indian blood group) multiple interactions
decreases expression
ISO fulvestrant inhibits the reaction [Genistein results in increased expression of CD44 mRNA]
fulvestrant results in decreased expression of CD44 mRNA
CTD PMID:22553218, PMID:26865669 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cd86 CD86 molecule multiple interactions ISO fulvestrant inhibits the reaction [Diethylhexyl Phthalate inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of CD86 protein]] CTD PMID:21538406 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cdc20 cell division cycle 20 multiple interactions
decreases expression
ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of CDC20 mRNA
fulvestrant results in decreased expression of CDC20 mRNA
CTD PMID:19016759 NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015
JBrowse link
G Cdc25b cell division cycle 25B multiple interactions ISO fulvestrant inhibits the reaction [Estradiol results in increased expression of CDC25B protein] CTD PMID:20208560 NCBI chr 3:123,731,539...123,741,696
Ensembl chr 3:123,731,539...123,741,339
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO fulvestrant inhibits the reaction [2,4-dihydroxybenzophenone results in decreased expression of CDH1 protein]; fulvestrant inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CDH1 mRNA]; fulvestrant inhibits the reaction [4-tert-octylphenol results in decreased expression of CDH1 protein]; fulvestrant inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein]; fulvestrant inhibits the reaction [afimoxifene results in increased expression of CDH1 protein]; fulvestrant inhibits the reaction [bis(4-hydroxyphenyl)sulfone results in increased expression of CDH1 protein]; fulvestrant inhibits the reaction [bisphenol A results in decreased expression of CDH1 protein]; fulvestrant inhibits the reaction [bisphenol A results in increased expression of CDH1 protein]; fulvestrant inhibits the reaction [bisphenol F results in increased expression of CDH1 protein]; fulvestrant inhibits the reaction [Estradiol results in decreased expression of CDH1 protein]; fulvestrant inhibits the reaction [fludioxonil results in decreased expression of CDH1 protein]; fulvestrant inhibits the reaction [nonylphenol results in decreased expression of CDH1 protein]; fulvestrant inhibits the reaction [Triclosan results in decreased expression of CDH1 protein] CTD PMID:19593637, PMID:25690688, PMID:26407941, PMID:27145024, PMID:27539251, PMID:28284859, PMID:28808208, PMID:28844962 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO fulvestrant inhibits the reaction [2,4-dihydroxybenzophenone results in increased expression of CDH2 protein]; fulvestrant inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CDH2 mRNA]; fulvestrant inhibits the reaction [4-tert-octylphenol results in increased expression of CDH2 protein]; fulvestrant inhibits the reaction [bis(4-hydroxyphenyl)sulfone results in increased expression of CDH2 protein]; fulvestrant inhibits the reaction [bisphenol A results in increased expression of CDH2 protein]; fulvestrant inhibits the reaction [bisphenol F results in increased expression of CDH2 protein]; fulvestrant inhibits the reaction [Estradiol results in increased expression of CDH2 protein]; fulvestrant inhibits the reaction [fludioxonil results in increased expression of CDH2 protein]; fulvestrant inhibits the reaction [Triclosan results in increased expression of CDH2 protein] CTD PMID:27145024, PMID:27539251, PMID:28284859, PMID:28808208, PMID:28844962 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions
decreases expression
ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of CDK1 mRNA
fulvestrant results in decreased expression of CDK1 mRNA
CTD PMID:19016759 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk12 cyclin-dependent kinase 12 affects response to substance ISO CDK12 affects the susceptibility to fulvestrant CTD PMID:19651820 NCBI chr10:86,157,186...86,210,657
Ensembl chr10:86,157,608...86,222,707
JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression
multiple interactions
ISO fulvestrant results in increased expression of CDK2 mRNA
fulvestrant inhibits the reaction [DDT results in increased phosphorylation of and results in increased activity of CDK2 protein]; fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of and results in increased activity of CDK2 protein]
CTD PMID:9049186, PMID:20215421 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO fulvestrant inhibits the reaction [bisphenol A results in increased expression of CDK4 protein]; fulvestrant inhibits the reaction [Estradiol results in increased expression of CDK4 protein] CTD PMID:19361625 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk6 cyclin-dependent kinase 6 affects response to substance
increases expression
multiple interactions
ISO CDK6 affects the susceptibility to fulvestrant
fulvestrant results in increased expression of CDK6 protein
[CDK6 affects the susceptibility to fulvestrant] which affects the expression of CCNA1 protein; [CDK6 affects the susceptibility to fulvestrant] which affects the phosphorylation of RB1 protein
CTD PMID:24169358 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
affects response to substance
increases expression
ISO fulvestrant inhibits the reaction [ESR1 protein binds to CDKN1A promoter]; fulvestrant inhibits the reaction [Estradiol results in decreased expression of CDKN1A protein]; fulvestrant inhibits the reaction [fludioxonil results in decreased expression of CDKN1A protein]; fulvestrant inhibits the reaction [Methoxychlor results in decreased expression of CDKN1A mRNA]; fulvestrant inhibits the reaction [Triclosan results in decreased expression of CDKN1A mRNA]
CDKN1A affects the susceptibility to fulvestrant
fulvestrant results in increased expression of CDKN1A mRNA
CTD PMID:12154049, PMID:12473173, PMID:15870704, PMID:20696891, PMID:24169358, PMID:24835555, PMID:27539251 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
increases expression
ISO fulvestrant inhibits the reaction [Estradiol results in increased degradation of CDKN1B protein]
fulvestrant results in increased expression of CDKN1B protein
CTD PMID:17283133, PMID:21367843, PMID:23029392 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression EXP fulvestrant results in increased expression of CEBPD mRNA CTD PMID:21980073 NCBI chr11:89,008,008...89,009,146
Ensembl chr11:89,008,008...89,009,146
JBrowse link
G Cenpa centromere protein A decreases expression ISO fulvestrant results in decreased expression of CENPA mRNA CTD PMID:16514628 NCBI chr 6:27,072,259...27,080,863
Ensembl chr 6:27,072,166...27,080,856
JBrowse link
G Cga glycoprotein hormones, alpha polypeptide multiple interactions ISO fulvestrant inhibits the reaction [bifenthrin results in increased secretion of CGA protein]; fulvestrant inhibits the reaction [Estradiol results in increased expression of CGA protein]; fulvestrant inhibits the reaction [Zearalenone results in increased expression of CGA protein] CTD PMID:19580841, PMID:24938463 NCBI chr 5:50,362,491...50,393,368
Ensembl chr 5:50,381,244...50,393,367
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions EXP fulvestrant inhibits the reaction [bisphenol A results in increased phosphorylation of CHEK2 protein]; fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of CHEK2 protein] CTD PMID:23788033 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO fulvestrant promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of CHUK protein] CTD PMID:26220752 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Clk1 CDC-like kinase 1 increases expression ISO fulvestrant results in increased expression of CLK1 mRNA CTD PMID:12154049 NCBI chr 9:65,296,777...65,308,017
Ensembl chr 9:65,296,778...65,307,995
JBrowse link
G Clmn calmin increases expression ISO fulvestrant results in increased expression of CLMN mRNA CTD PMID:26865669 NCBI chr 6:128,473,592...128,567,267
Ensembl chr 6:128,473,570...128,567,198
JBrowse link
G Clstn1 calsyntenin 1 decreases expression ISO fulvestrant results in decreased expression of CLSTN1 mRNA CTD PMID:16514628 NCBI chr 5:166,533,262...166,601,686
Ensembl chr 5:166,533,181...166,601,684
JBrowse link
G Clu clusterin multiple interactions EXP
ISO
fulvestrant inhibits the reaction [Ethinyl Estradiol results in decreased expression of CLU mRNA]
fulvestrant inhibits the reaction [bisphenol A inhibits the reaction [Doxorubicin results in increased expression of CLU mRNA]]
CTD PMID:16639590, PMID:26320837 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cnbp CCHC-type zinc finger, nucleic acid binding protein increases expression ISO fulvestrant results in increased expression of CNBP mRNA CTD PMID:12154049 NCBI chr 4:119,747,890...119,756,787
Ensembl chr 4:119,747,911...119,756,765
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP fulvestrant inhibits the reaction [bisphenol A results in increased expression of COL1A1 mRNA] CTD PMID:27025157 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions EXP fulvestrant inhibits the reaction [bisphenol A results in increased expression of COL3A1 mRNA] CTD PMID:27025157 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO fulvestrant inhibits the reaction [bisphenol A results in decreased expression of COMT mRNA]; fulvestrant inhibits the reaction [butylbenzyl phthalate results in decreased expression of COMT mRNA]; fulvestrant inhibits the reaction [daidzein results in decreased expression of COMT mRNA]; fulvestrant inhibits the reaction [Dibutyl Phthalate results in decreased expression of COMT mRNA]; fulvestrant inhibits the reaction [Estradiol results in decreased expression of COMT mRNA]; fulvestrant inhibits the reaction [Genistein results in decreased expression of COMT mRNA] CTD PMID:18192686, PMID:18497090, PMID:24040167 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Copb2 COPI coat complex subunit beta 2 decreases expression ISO fulvestrant results in decreased expression of COPB2 mRNA CTD PMID:16514628 NCBI chr 8:106,582,339...106,603,763 JBrowse link
G Crebbp CREB binding protein multiple interactions EXP
ISO
fulvestrant inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CREBBP protein]]
fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [CREBBP protein binds to CYP11A1 gene]]; fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [CREBBP protein binds to HSD3B gene]]; fulvestrant inhibits the reaction [[TNF protein co-treated with resveratrol] promotes the reaction [CREBBP protein binds to IL6 promoter]]; fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CREBBP protein]]]
CTD PMID:18511507, PMID:24771768 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039
JBrowse link
G Csf1 colony stimulating factor 1 increases expression ISO fulvestrant results in increased expression of CSF1 mRNA CTD PMID:12154049 NCBI chr 2:210,522,370...210,550,546
Ensembl chr 2:210,522,375...210,550,560
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO fulvestrant inhibits the reaction [Diethylhexyl Phthalate inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of CD86 protein]]; fulvestrant inhibits the reaction [Diethylhexyl Phthalate inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of LY75 protein]] CTD PMID:21538406 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Csf3 colony stimulating factor 3 decreases expression ISO fulvestrant results in decreased expression of CSF3 mRNA CTD PMID:16298037 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
JBrowse link
G Csta cystatin A decreases expression ISO fulvestrant results in decreased expression of CSTA mRNA CTD PMID:15072547 NCBI chr11:67,555,792...67,566,980
Ensembl chr11:67,555,658...67,566,972
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO fulvestrant inhibits the reaction [dioscin results in increased expression of CTNNB1 mRNA] CTD PMID:24742230 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ctsb cathepsin B multiple interactions ISO fulvestrant inhibits the reaction [4-tert-octylphenol results in increased expression of CTSB mRNA]; fulvestrant inhibits the reaction [4-tert-octylphenol results in increased expression of CTSB protein]; fulvestrant inhibits the reaction [bisphenol A results in increased expression of CTSB protein]; fulvestrant inhibits the reaction [Estradiol results in increased expression of CTSB protein]; fulvestrant inhibits the reaction [Triclosan results in increased expression of CTSB protein] CTD PMID:23219593, PMID:28844962 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Ctsd cathepsin D increases expression
decreases expression
multiple interactions
ISO fulvestrant results in increased expression of CTSD mRNA
fulvestrant results in decreased expression of CTSD mRNA
Fulvestrant inhibits the reaction [1,7-diphenyl-5-heptene-3-one results in increased expression of CTSD mRNA]; Fulvestrant inhibits the reaction [4-tert-octylphenol results in increased expression of CTSD mRNA]; Fulvestrant inhibits the reaction [Benzo(a)pyrene analog results in increased expression of CTSD mRNA]; Fulvestrant inhibits the reaction [Benzo(a)pyrene results in increased expression of CTSD mRNA]; Fulvestrant inhibits the reaction [bisphenol A promotes the reaction [ESR1 protein binds to CTSD promoter]]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of CTSD protein]; Fulvestrant inhibits the reaction [cyprodinil results in increased expression of CTSD protein]; Fulvestrant inhibits the reaction [Diarylheptanoids results in increased expression of CTSD mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of CTSD protein]; Fulvestrant inhibits the reaction [Eucalyptol results in increased expression of CTSD mRNA]; Fulvestrant inhibits the reaction [fludioxonil results in increased expression of CTSD protein]; Fulvestrant inhibits the reaction [lavender oil results in increased expression of CTSD mRNA]; Fulvestrant inhibits the reaction [Limonene results in increased expression of CTSD mRNA]; Fulvestrant inhibits the reaction [linalool results in increased expression of CTSD mRNA]; Fulvestrant inhibits the reaction [linalyl acetate results in increased expression of CTSD mRNA]; Fulvestrant inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of CTSD protein]; Fulvestrant inhibits the reaction [nonylphenol promotes the reaction [ESR1 protein binds to CTSD promoter]]; Fulvestrant inhibits the reaction [nonylphenol results in increased expression of CTSD protein]; Fulvestrant inhibits the reaction [Tea Tree Oil results in increased expression of CTSD mRNA]; Fulvestrant inhibits the reaction [terpinenol-4 results in increased expression of CTSD mRNA]; Fulvestrant inhibits the reaction [Triclosan results in increased expression of CTSD protein]
CTD PMID:14750165, PMID:15072547, PMID:19365803, PMID:19654927, PMID:23219593, PMID:26344002, PMID:26407941, PMID:27366082, PMID:27539251, PMID:28844962, PMID:31393563 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Ctsh cathepsin H increases expression ISO fulvestrant results in increased expression of CTSH mRNA CTD PMID:16514628 NCBI chr 8:97,439,155...97,458,293
Ensembl chr 8:97,439,161...97,458,287
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP fulvestrant inhibits the reaction [resveratrol results in decreased expression of CXCL1 protein] CTD PMID:18277952, PMID:21192278 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO fulvestrant inhibits the reaction [bazedoxifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL10 mRNA]]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Dimethoate results in increased expression of CXCL10 mRNA]]; fulvestrant inhibits the reaction [Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL10 mRNA]]
fulvestrant inhibits the reaction [Estradiol results in increased expression of CXCL10 mRNA]
CTD PMID:15557169, PMID:19533603, PMID:23943137 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 multiple interactions ISO fulvestrant inhibits the reaction [Estradiol results in increased expression of CXCL11 mRNA] CTD PMID:15557169 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions
decreases expression
ISO fulvestrant inhibits the reaction [2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of CXCL12 mRNA]; fulvestrant inhibits the reaction [2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of CXCL12 protein]; fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of CXCL12 mRNA]; fulvestrant inhibits the reaction [4,4'-hexafluorisopropylidene diphenol results in increased expression of CXCL12 mRNA]; fulvestrant inhibits the reaction [4,4'-hexafluorisopropylidene diphenol results in increased secretion of CXCL12 protein]; fulvestrant inhibits the reaction [CXCL12 protein results in increased expression of CXCL12 mRNA]; fulvestrant inhibits the reaction [CXCL12 protein results in increased expression of EB1 mRNA]; fulvestrant inhibits the reaction [CXCL12 protein results in increased expression of PGR mRNA]; fulvestrant inhibits the reaction [Estradiol results in increased expression of CXCL12 mRNA]; fulvestrant inhibits the reaction [Estradiol results in increased expression of CXCL12 protein]; fulvestrant inhibits the reaction [Genistein results in increased expression of CXCL12 mRNA]; fulvestrant inhibits the reaction [Genistein results in increased expression of CXCL12 protein]
fulvestrant results in decreased expression of CXCL12 mRNA
CTD PMID:17872378, PMID:19584281, PMID:22549810, PMID:26435001, PMID:26865669 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO
EXP
fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of CXCL2 mRNA]]
fulvestrant inhibits the reaction [resveratrol results in decreased expression of CXCL2 protein]
CTD PMID:18277952, PMID:21192278, PMID:21501669 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of CXCL1 mRNA]] CTD PMID:21501669 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions ISO fulvestrant inhibits the reaction [bisphenol A results in increased expression of CXCR4 protein]; fulvestrant inhibits the reaction [Estradiol results in increased expression of CXCR4 protein]; fulvestrant inhibits the reaction [Triclosan results in increased expression of CXCR4 protein] CTD PMID:28844962 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cycs cytochrome c, somatic multiple interactions
increases expression
ISO
EXP
fulvestrant inhibits the reaction [Diethylstilbestrol affects the localization of CYCS protein]; fulvestrant inhibits the reaction [Estradiol affects the localization of CYCS protein]; fulvestrant inhibits the reaction [Genistein affects the localization of CYCS protein]; fulvestrant inhibits the reaction [Tamoxifen affects the localization of CYCS protein]
fulvestrant inhibits the reaction [Estradiol results in increased expression of CYCS protein]
fulvestrant results in increased expression of CYCS mRNA
CTD PMID:15994367, PMID:16924424, PMID:20211987 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions EXP
ISO
Fulvestrant inhibits the reaction [Estradiol results in decreased expression of CYP11A1 mRNA]; Fulvestrant inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CYP11A1 gene]]; Fulvestrant inhibits the reaction [FSHB protein results in increased expression of CYP11A1 protein]
fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [CREBBP protein binds to CYP11A1 gene]]; fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [NCOA1 protein binds to CYP11A1 gene]]; fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [PPARGC1A protein binds to CYP11A1 gene]]; fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CYP11A1 gene]]]; fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein results in increased expression of CYP11A1 protein]]
CTD PMID:18511507, PMID:23209616 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO fulvestrant results in increased expression of CYP17A1 mRNA
fulvestrant inhibits the reaction [DDT results in increased expression of CYP17A1 mRNA]
CTD PMID:17158782, PMID:23684557 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO fulvestrant results in decreased activity of CYP19A1 protein CTD PMID:11850205, PMID:15976552 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO [Fulvestrant results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; Fulvestrant inhibits the reaction [daidzein results in decreased expression of CYP1A1 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of CYP1A1 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of CYP1A1 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of CYP1A1 protein]; Fulvestrant inhibits the reaction [Genistein results in decreased expression of CYP1A1 mRNA]; Fulvestrant inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]]; Fulvestrant promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA]; Fulvestrant promotes the reaction [biochanin A results in increased expression of CYP1A1 mRNA]; Fulvestrant promotes the reaction [formononetin results in increased expression of CYP1A1 mRNA]; Fulvestrant promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
fulvestrant inhibits the reaction [Estradiol promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]
fulvestrant results in increased expression of CYP1A1 mRNA
CTD PMID:10619402, PMID:12093619, PMID:19460354, PMID:19901195, PMID:21513769, PMID:28618207, PMID:28985473 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression
ISO fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1B1 mRNA]; fulvestrant inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 mRNA]; fulvestrant inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 protein]; fulvestrant inhibits the reaction [Estradiol results in increased expression of CYP1B1 mRNA]; fulvestrant inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 promoter]]; fulvestrant promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1B1 mRNA]; fulvestrant promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]
fulvestrant results in increased expression of CYP1B1 mRNA
CTD PMID:16280380, PMID:19460354, PMID:20093341, PMID:21513769, PMID:28985473, PMID:29362861 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions ISO [Androstanols co-treated with fulvestrant] inhibits the reaction [DDT results in increased expression of CYP2B10 mRNA] CTD PMID:23684557 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases expression EXP fulvestrant results in increased expression of CYP2C11 mRNA CTD PMID:16837770 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions ISO fulvestrant inhibits the reaction [Estradiol results in increased expression of CYP2C29 mRNA]; fulvestrant inhibits the reaction [Methoxychlor results in increased expression of CYP2C29 mRNA] CTD PMID:16280380 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP2E1 mRNA] CTD PMID:29362861 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression EXP fulvestrant results in increased expression of CYP3A2 mRNA CTD PMID:16837770 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Ddx21 DExD-box helicase 21 decreases expression ISO fulvestrant results in decreased expression of DDX21 mRNA CTD PMID:16514628 NCBI chr20:32,213,147...32,232,632
Ensembl chr20:32,213,148...32,232,632
JBrowse link
G Dek DEK proto-oncogene multiple interactions ISO fulvestrant inhibits the reaction [Estradiol results in increased expression of DEK protein] CTD PMID:23071688 NCBI chr17:17,965,872...17,987,836
Ensembl chr17:17,965,881...17,987,834
JBrowse link
G Depp1 DEPP1, autophagy regulator decreases expression ISO fulvestrant results in decreased expression of DEPP1 mRNA CTD PMID:16298037 NCBI chr 4:148,780,330...148,784,566
Ensembl chr 4:148,782,479...148,784,562
JBrowse link
G Dhh desert hedgehog signaling molecule multiple interactions EXP fulvestrant inhibits the reaction [Ethinyl Estradiol results in decreased expression of DHH mRNA] CTD PMID:17109907 NCBI chr 7:140,575,288...140,580,783
Ensembl chr 7:140,575,288...140,580,783
JBrowse link
G Dhx9 DExH-box helicase 9 decreases expression ISO fulvestrant results in decreased expression of DHX9 mRNA CTD PMID:16514628 NCBI chr13:70,885,503...70,922,278
Ensembl chr13:70,885,504...70,922,245
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions ISO fulvestrant inhibits the reaction [cyhalothrin results in increased expression of DLG4 protein] CTD PMID:26969072 NCBI chr10:56,625,845...56,655,543
Ensembl chr10:56,627,411...56,653,599
JBrowse link
G Dmbt1 deleted in malignant brain tumors 1 increases expression
multiple interactions
ISO
EXP
fulvestrant results in increased expression of DMBT1 mRNA
fulvestrant inhibits the reaction [Estrone results in increased expression of DMBT1 mRNA]
CTD PMID:15564322 NCBI chr 1:201,620,642...201,689,905
NCBI chr 1:203,149,414...203,228,705
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 decreases expression ISO fulvestrant results in decreased expression of DNAJA1 mRNA CTD PMID:16514628 NCBI chr 5:57,028,467...57,039,378
Ensembl chr 5:57,028,467...57,039,378
JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions
decreases expression
ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of DNMT1 mRNA
Fulvestrant inhibits the reaction [bisphenol A results in decreased expression of DNMT1 mRNA]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of DNMT1 mRNA]
fulvestrant results in decreased expression of DNMT1 mRNA
CTD PMID:19016759, PMID:22131059, PMID:30892605 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha multiple interactions ISO fulvestrant inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA] CTD PMID:22131059 NCBI chr 6:28,205,375...28,346,052
Ensembl chr 6:28,235,695...28,340,577
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta multiple interactions ISO Fulvestrant inhibits the reaction [bisphenol A results in decreased expression of DNMT3B mRNA]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of DNMT3B mRNA] CTD PMID:22131059, PMID:30892605 NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786
JBrowse link
G Dnmt3l DNA methyltransferase 3 like multiple interactions ISO fulvestrant inhibits the reaction [bisphenol A results in decreased expression of DNMT3L mRNA] CTD PMID:22131059 NCBI chr20:11,344,513...11,359,090
Ensembl chr20:11,344,514...11,359,090
JBrowse link
G Dst dystonin increases expression ISO fulvestrant results in increased expression of DST mRNA CTD PMID:16202921 NCBI chr 9:37,902,336...38,296,961
Ensembl chr 9:37,902,303...38,196,273
JBrowse link
G Dynll1 dynein light chain LC8-type 1 increases expression ISO fulvestrant results in increased expression of DYNLL1 mRNA CTD PMID:12154049 NCBI chr12:47,074,200...47,076,573
Ensembl chr12:47,074,200...47,076,572
JBrowse link
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 increases expression ISO fulvestrant results in increased expression of DYRK2 mRNA CTD PMID:26865669 NCBI chr 7:61,785,423...61,816,775
Ensembl chr 7:61,786,309...61,798,729
JBrowse link
G E2f1 E2F transcription factor 1 decreases expression
multiple interactions
ISO fulvestrant results in decreased expression of E2F1 mRNA
fulvestrant inhibits the reaction [DDT results in increased expression of E2F1 mRNA]
CTD PMID:20215421, PMID:23684557 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G Ece1 endothelin converting enzyme 1 multiple interactions ISO [fulvestrant co-treated with Tamoxifen co-treated with ZD4054] results in decreased expression of ECE1 mRNA CTD PMID:19943105 NCBI chr 5:156,215,469...156,318,652
Ensembl chr 5:156,215,417...156,318,671
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO [fulvestrant co-treated with Tamoxifen co-treated with ZD4054] results in decreased expression of EDN1 mRNA CTD PMID:19943105 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Ednra endothelin receptor type A multiple interactions ISO [fulvestrant co-treated with Tamoxifen co-treated with ZD4054] results in decreased expression of EDNRA mRNA CTD PMID:19943105 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703
JBrowse link
G Efna1 ephrin A1 increases expression ISO fulvestrant results in increased expression of EFNA1 mRNA CTD PMID:15072547, PMID:26865669 NCBI chr 2:188,588,808...188,596,156
Ensembl chr 2:188,588,796...188,596,222
JBrowse link
G Egf epidermal growth factor affects activity
multiple interactions
ISO
EXP
fulvestrant affects the activity of EGF protein
fulvestrant inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein]; fulvestrant inhibits the reaction [EGF protein results in increased expression of PLAUR protein]; fulvestrant inhibits the reaction [EGF protein results in increased expression of TFF1 mRNA]
EGF protein inhibits the reaction [fulvestrant inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]]
CTD PMID:19395996, PMID:19593637, PMID:20206645, PMID:25813982 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Fulvestrant inhibits the reaction [bisphenol A promotes the reaction [EGFR protein binds to AR protein]]; Fulvestrant inhibits the reaction [bisphenol A promotes the reaction [EGFR protein binds to ESR2 protein]]; Fulvestrant inhibits the reaction [bisphenol A results in increased phosphorylation of EGFR protein]; Fulvestrant inhibits the reaction [butylbenzyl phthalate results in increased phosphorylation of EGFR protein]; Fulvestrant inhibits the reaction [Dibutyl Phthalate results in increased phosphorylation of EGFR protein] CTD PMID:22552774, PMID:29383186 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO fulvestrant inhibits the reaction [bisphenol A results in increased expression of EGR1 mRNA]; fulvestrant inhibits the reaction [bisphenol A results in increased expression of EGR1 protein]; fulvestrant inhibits the reaction [Estradiol results in increased expression of EGR1 mRNA]; fulvestrant inhibits the reaction [Estradiol results in increased expression of EGR1 protein] CTD PMID:25461906 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Egr3 early growth response 3 decreases expression ISO fulvestrant results in decreased expression of EGR3 mRNA CTD PMID:26865669 NCBI chr15:51,756,683...51,762,080
Ensembl chr15:51,756,736...51,760,722
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha decreases expression ISO fulvestrant results in decreased expression of EIF2S1 mRNA CTD PMID:16514628 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Eif5 eukaryotic translation initiation factor 5 decreases expression ISO fulvestrant results in decreased expression of EIF5 mRNA CTD PMID:16514628 NCBI chr 6:136,002,983...136,011,409
Ensembl chr 6:136,004,214...136,011,406
JBrowse link
G Elob elongin B decreases expression ISO fulvestrant results in decreased expression of ELOB mRNA CTD PMID:16514628 NCBI chr10:13,163,032...13,168,217
Ensembl chr10:13,163,036...13,168,217
JBrowse link
G Elovl5 ELOVL fatty acid elongase 5 decreases expression ISO fulvestrant results in decreased expression of ELOVL5 mRNA CTD PMID:16514628 NCBI chr 8:85,220,941...85,287,449
Ensembl chr 8:85,259,982...85,285,983
JBrowse link
G Epha1 Eph receptor A1 increases expression ISO fulvestrant results in increased expression of EPHA1 mRNA CTD PMID:12154049 NCBI chr 4:71,749,100...71,763,681
Ensembl chr 4:71,749,242...71,763,679
JBrowse link
G Epha4 Eph receptor A4 increases expression ISO fulvestrant results in increased expression of EPHA4 mRNA CTD PMID:26865669 NCBI chr 9:83,111,222...83,253,486
Ensembl chr 9:83,111,222...83,253,458
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 increases expression
affects response to substance
ISO fulvestrant results in increased expression of ERBB2 mRNA
ERBB2 affects the susceptibility to fulvestrant
CTD PMID:15072547, PMID:24169358 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 multiple interactions ISO Fulvestrant inhibits the reaction [4,4'-hexafluorisopropylidene diphenol results in increased expression of and results in increased phosphorylation of ERBB3 protein] CTD PMID:31059536 NCBI chr 7:2,989,202...3,010,610
Ensembl chr 7:2,989,340...3,010,350
JBrowse link
G Ereg epiregulin multiple interactions EXP fulvestrant inhibits the reaction [Estradiol results in decreased expression of EREG mRNA] CTD PMID:23209616 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394
JBrowse link
G Espl1 extra spindle pole bodies like 1, separase decreases expression
multiple interactions
ISO fulvestrant results in decreased expression of ESPL1 mRNA
[fulvestrant co-treated with Sirolimus] results in decreased expression of ESPL1 mRNA
CTD PMID:19016759 NCBI chr 7:143,896,890...143,923,868
Ensembl chr 7:143,897,014...143,923,868
JBrowse link
G Esr1 estrogen receptor 1 affects expression
increases expression
increases ubiquitination
multiple interactions
decreases expression
affects response to substance
affects binding
affects activity
increases degradation
decreases activity
ISO
EXP
fulvestrant affects the expression of ESR1 mRNA
Fulvestrant results in increased expression of ESR1 mRNA
fulvestrant results in increased expression of ESR1 mRNA
fulvestrant results in increased ubiquitination of ESR1 protein
5-OH-BDE-47 promotes the reaction [Fulvestrant results in decreased expression of ESR1 protein]; 6-OH-BDE-47 promotes the reaction [Fulvestrant results in decreased expression of ESR1 protein]; [Estradiol co-treated with Fulvestrant co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA; [Fulvestrant binds to and results in decreased activity of ESR1 protein] inhibits the reaction [Drugs, Chinese Herbal results in increased activity of ESR1 protein]; [Fulvestrant binds to and results in decreased activity of ESR1 protein] inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; [Fulvestrant binds to and results in decreased activity of ESR1 protein] inhibits the reaction [icaritin results in increased activity of ESR1 protein]; [Fulvestrant binds to and results in decreased activity of ESR1 protein] inhibits the reaction [Quercetin results in increased activity of ESR1 protein]; [Fulvestrant binds to and results in decreased activity of ESR1 protein] which results in decreased susceptibility to Equol; [Fulvestrant binds to and results in decreased activity of ESR1 protein] which results in decreased susceptibility to Genistein; [Fulvestrant binds to and results in increased activity of ESR1 protein] which results in increased expression of HSPB1 mRNA; [Fulvestrant co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA; [Fulvestrant results in decreased expression of ESR1 protein] which results in decreased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; AG 1879 inhibits the reaction [Fulvestrant promotes the reaction [ESR1 protein binds to IGF1R protein]]; Curcumin inhibits the reaction [Fulvestrant results in increased degradation of ESR1 protein]; Fulvestrant affects the folding of and affects the activity of ESR1 protein; Fulvestrant binds to and results in decreased activity of ESR1 protein; Fulvestrant inhibits the reaction [1,1-bis(4-hydroxyphenyl)cyclohexane results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [1,7-diphenyl-5-heptene-3-one results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; Fulvestrant inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ESR1 protein]; Fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [4,4'-bisphenol F results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [4,4'-dihydroxystilbene analog binds to and results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [4,4'-hexafluorisopropylidene diphenol results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [4,4'-hexafluorisopropylidene diphenol results in increased expression of and results in increased phosphorylation of ESR1 protein]; Fulvestrant inhibits the reaction [4,4'-thiodiphenol results in increased expression of ESR1 protein]; Fulvestrant inhibits the reaction [4-hydroxystilbene analog binds to and results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [[6-(1,1-dimethylallyl)naringenin binds to ESR1 protein] which results in increased activity of ALPL protein]; Fulvestrant inhibits the reaction [[8-prenylnaringenin binds to ESR1 protein] which results in increased activity of ALPL protein]; Fulvestrant inhibits the reaction [[Arsenic Trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; Fulvestrant inhibits the reaction [[Arsenic Trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [[bisphenol A co-treated with ESR1 protein] results in increased phosphorylation of AKT1 protein]; Fulvestrant inhibits the reaction [[Coumestrol binds to ESR1 protein] which results in increased activity of ALPL protein]; Fulvestrant inhibits the reaction [[daidzein binds to ESR1 protein] which results in increased activity of ALPL protein]; Fulvestrant inhibits the reaction [[Estradiol binds to ESR1 protein] which results in increased activity of ALPL protein]; Fulvestrant inhibits the reaction [[Estradiol co-treated with ESR1 protein] results in increased expression of NOS3 mRNA]; Fulvestrant inhibits the reaction [[fenarimol co-treated with Estradiol] results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [[Genistein binds to ESR1 protein] which results in increased activity of ALPL protein]; Fulvestrant inhibits the reaction [[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein]; Fulvestrant inhibits the reaction [[Zearalenone binds to ESR1 protein] which results in increased activity of ALPL protein]; Fulvestrant inhibits the reaction [Androstane-3,17-diol analog binds to and results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Androstane-3,17-diol binds to and results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Androstenols results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [benz(a)anthracene promotes the reaction [Estradiol results in increased activity of ESR1 protein]]; Fulvestrant inhibits the reaction [Benzo(a)pyrene promotes the reaction [Estradiol results in increased activity of ESR1 protein]]; Fulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in decreased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [bis(4-hydroxyphenyl)sulfone results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [bisphenol A promotes the reaction [ESR1 protein binds to CTSD promoter]]; Fulvestrant inhibits the reaction [bisphenol A results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of ESR1 protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased phosphorylation of ESR1 protein]; Fulvestrant inhibits the reaction [bisphenol B results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [bisphenol F results in increased expression of ESR1 protein]; Fulvestrant inhibits the reaction [butylparaben results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Cadmium Chloride results in increased expression of ESR1 protein]; Fulvestrant inhibits the reaction [Coumestrol results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Diarylheptanoids results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Diarylheptanoids results in increased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in decreased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [Diethylstilbestrol binds to and results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Dithiothreitol results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Equilin results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [ESR1 protein binds to CDKN1A promoter]; Fulvestrant inhibits the reaction [ESR1 protein binds to STUB1 protein]; Fulvestrant inhibits the reaction [ESR1 protein results in increased susceptibility to Resveratrol]; Fulvestrant inhibits the reaction [Estradiol affects the localization of ESR1 protein]; Fulvestrant inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of ESR1 protein]; Fulvestrant inhibits the reaction [Estriol results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Estrone results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [exemestane binds to and results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [fenarimol results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [fluoranthene promotes the reaction [Estradiol results in increased activity of ESR1 protein]]; Fulvestrant inhibits the reaction [Genistein results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [glyphosate results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [luteolin-7-O-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of ESR1 protein]]; Fulvestrant inhibits the reaction [Methylcholanthrene results in increased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [nonylphenol promotes the reaction [ESR1 protein binds to CTSD promoter]]; Fulvestrant inhibits the reaction [o,p'-DDT results in decreased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [prochloraz results in decreased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [Progesterone results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [propylparaben results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Resveratrol analog binds to and results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Resveratrol binds to and results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Resveratrol promotes the reaction [ESR1 protein binds to BMP2 promoter]]; Fulvestrant inhibits the reaction [Tartrazine results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Testosterone results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]]; Fulvestrant inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 promoter]]; Fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CREBBP protein]]]; Fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CYP11A1 gene]]]; Fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to HSD3B gene]]]; Fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to NCOA1 protein]]]; Fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to PPARGC1A protein]]]; Fulvestrant promotes the reaction [5-OH-BDE-47 affects the expression of ESR1 protein]; Fulvestrant promotes the reaction [6-OH-BDE-47 affects the expression of ESR1 protein]; Fulvestrant promotes the reaction [ESR1 protein binds to ESR1 protein]; Fulvestrant promotes the reaction [ESR1 protein binds to ESR2 protein]; Fulvestrant promotes the reaction [ESR1 protein binds to IGF1R protein]; Fulvestrant promotes the reaction [Estradiol results in decreased expression of ESR1 protein]; Fulvestrant promotes the reaction [Hexachlorobenzene results in decreased expression of ESR1 protein]; Fulvestrant results in decreased activity of and results in decreased expression of ESR1 protein; Fulvestrant results in increased degradation of and results in decreased expression of and results in decreased activity of ESR1 protein; KRT18 protein promotes the reaction [Fulvestrant inhibits the reaction [Estradiol results in increased activity of ESR1 protein]]; KRT18 protein promotes the reaction [Fulvestrant results in increased degradation of ESR1 protein]; KRT8 protein promotes the reaction [Fulvestrant inhibits the reaction [Estradiol results in increased activity of ESR1 protein]]; KRT8 protein promotes the reaction [Fulvestrant results in increased degradation of ESR1 protein]; RU 58668 promotes the reaction [Fulvestrant inhibits the reaction [Genistein results in increased activity of ESR1 protein]]; tyrphostin AG 1024 inhibits the reaction [Fulvestrant promotes the reaction [ESR1 protein binds to IGF1R protein]]
fulvestrant results in decreased expression of ESR1 protein
ESR1 protein mutant form affects the susceptibility to fulvestrant
fulvestrant binds to ESR1 protein
fulvestrant results in decreased expression of ESR1; fulvestrant results in decreased expression of ESR1 mRNA; fulvestrant results in decreased expression of ESR1 protein
fulvestrant affects the activity of ESR1 protein
fulvestrant results in increased degradation of ESR1 protein
1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [Fulvestrant binds to and results in decreased activity of ESR1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Fulvestrant results in increased degradation of ESR1 protein]; Fulvestrant binds to and results in decreased activity of ESR1 protein; Fulvestrant inhibits the reaction [[Ethinyl Estradiol co-treated with Triclosan] results in decreased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [bisphenol A affects the expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [bisphenol A affects the expression of ESR1 protein]; Fulvestrant inhibits the reaction [bisphenol A results in decreased phosphorylation of and affects the localization of ESR1 protein]; Fulvestrant inhibits the reaction [butylparaben results in decreased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [butylparaben results in decreased expression of ESR1 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [Ethinyl Estradiol results in decreased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [Ethinyl Estradiol results in decreased expression of ESR1 protein]; Fulvestrant inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CREBBP protein]]; Fulvestrant inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CYP11A1 gene]]; Fulvestrant inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to HSD3B gene]]; Fulvestrant inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to NCOA1 protein]]; Fulvestrant inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to PPARGC1A protein]]; Fulvestrant inhibits the reaction [isopropyl 4-hydroxybenzoate results in decreased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [isopropyl 4-hydroxybenzoate results in decreased expression of ESR1 protein]; Fulvestrant inhibits the reaction [naringin results in increased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [tributyltin affects the expression of ESR1 protein]
4-tert-octylphenol inhibits the reaction [Fulvestrant results in increased expression of ESR1 mRNA]; [bisphenol A co-treated with Fulvestrant] results in increased expression of ESR1 mRNA; bisphenol A inhibits the reaction [Fulvestrant results in increased expression of ESR1 mRNA]; Estradiol inhibits the reaction [Fulvestrant results in increased expression of ESR1 mRNA]; Fulvestrant binds to and results in decreased activity of ESR1 protein; Fulvestrant binds to and results in increased activity of ESR1 protein mutant form; Fulvestrant inhibits the reaction [4-tert-octylphenol results in decreased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [[notoginsenoside R1 co-treated with Lipopolysaccharides] results in increased expression of ESR1 protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [cyhalothrin results in increased expression of ESR1]; Fulvestrant inhibits the reaction [Diarylheptanoids binds to and affects the transport of ESR1 protein]; Fulvestrant inhibits the reaction [Diethylstilbestrol results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [dioscin results in increased expression of ESR1 protein]; Fulvestrant inhibits the reaction [ESR1 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]]; Fulvestrant inhibits the reaction [Estradiol binds to and affects the transport of ESR1 protein]; Fulvestrant inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [Estrogens results in increased expression of ESR1 protein]; Fulvestrant inhibits the reaction [octylphenol results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [tributyltin results in decreased expression of ESR1 protein]; Fulvestrant promotes the reaction [bisphenol A results in decreased expression of ESR1 protein]; Fulvestrant promotes the reaction [Estradiol results in increased expression of ESR1 protein]
fulvestrant results in increased degradation of ESR1 mRNA; fulvestrant results in increased degradation of ESR1 protein
fulvestrant results in decreased activity of ESR1 protein
CTD PMID:9048584, PMID:11174852, PMID:11518614, PMID:11867264, PMID:12441364, PMID:12612060, PMID:12650720, PMID:12927369, PMID:14742696, PMID:14750165, PMID:15130599, PMID:15236189, PMID:15319301, PMID:15475434, PMID:15537743, PMID:15842231, PMID:15899841, PMID:15950373, PMID:16010691, PMID:16037132, PMID:16076840, PMID:16202921, PMID:16280380, PMID:16489053, PMID:17003281, PMID:17203231, PMID:17299137, PMID:17513867, PMID:17716812, PMID:17872378, PMID:17974624, PMID:18028983, PMID:18417718, PMID:18511507, PMID:18634860, PMID:18635651, PMID:18677558, PMID:18767177, PMID:18973785, PMID:18976723, PMID:19264808, PMID:19270784, PMID:19339991, PMID:19340542, PMID:19351862, PMID:19427779, PMID:19435893, PMID:19460354, PMID:19477949, PMID:19496085, PMID:19570671, PMID:19620290, PMID:19654335, PMID:19654927, PMID:19723634, PMID:19815064, PMID:19879930, PMID:19913605, PMID:20061804, PMID:20179196, PMID:20206645, PMID:20208560, PMID:20209442, PMID:20211987, PMID:20215421, PMID:20219890, PMID:20362049, PMID:20419096, PMID:20435135, PMID:20543978, PMID:20599613, PMID:20696891, PMID:21367843, PMID:21873215, PMID:22403704, PMID:22558281, PMID:22562034, PMID:22613215, PMID:23170834, PMID:23183181, PMID:23208499, PMID:23213263, PMID:23261820, PMID:23552522, PMID:23557686, PMID:23562765, PMID:23596885, PMID:23810794, PMID:24440569, PMID:24742230, PMID:24782323, PMID:25012808, PMID:25074486, PMID:25136773, PMID:25534675, PMID:25616260, PMID:25752796, PMID:25819109, PMID:26812056, PMID:26865669, PMID:26867312, PMID:26877835, PMID:26944108, PMID:26969072, PMID:26988655, PMID:27260121, PMID:27366082, PMID:27880919, PMID:28571686, PMID:28711546, PMID:28882636, PMID:29421333, PMID:30061528, PMID:30195206, PMID:30682495, PMID:31059536, PMID:31381935, PMID:31388671 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 increases response to substance
increases expression
decreases expression
affects binding
affects expression
multiple interactions
ISO
EXP
ESR2 protein results in increased susceptibility to fulvestrant
fulvestrant results in increased expression of ESR2 protein
fulvestrant results in decreased expression of ESR2 mRNA alternative form
fulvestrant binds to ESR2 protein
fulvestrant affects the expression of ESR2 protein
fulvestrant binds to and results in decreased activity of ESR2 protein; fulvestrant inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]; fulvestrant inhibits the reaction [[Ethinyl Estradiol co-treated with Triclosan] results in decreased expression of ESR2 mRNA]; fulvestrant inhibits the reaction [naringin results in increased expression of ESR2 mRNA]
Estradiol inhibits the reaction [Fulvestrant results in decreased expression of ESR2 mRNA alternative form]; Fulvestrant inhibits the reaction [[[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] co-treated with bisphenol A] results in increased activity of ESR2 protein]; Fulvestrant inhibits the reaction [dioscin results in increased expression of ESR2 protein]; Fulvestrant inhibits the reaction [ESR2 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]]; Fulvestrant inhibits the reaction [Estrogens results in increased activity of ESR2 protein polymorphism]; Fulvestrant inhibits the reaction [sodium arsenite results in increased expression of ESR2 mRNA]; Fulvestrant inhibits the reaction [sodium arsenite results in increased expression of ESR2 protein]
fulvestrant results in decreased expression of ESR2 protein
6-OH-BDE-47 promotes the reaction [Fulvestrant results in decreased expression of ESR2 protein]; Fulvestrant binds to and results in decreased activity of ESR2 protein; Fulvestrant inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ESR2 protein]; Fulvestrant inhibits the reaction [3,3',4,5'-tetrahydroxystilbene results in increased activity of ESR2 protein]; Fulvestrant inhibits the reaction [[Estradiol co-treated with ESR2 protein] results in increased expression of NOS3 mRNA]; Fulvestrant inhibits the reaction [Androstane-3,17-diol analog binds to and results in increased activity of ESR2 protein]; Fulvestrant inhibits the reaction [Androstane-3,17-diol binds to and results in increased activity of ESR2 protein]; Fulvestrant inhibits the reaction [bisphenol A promotes the reaction [EGFR protein binds to ESR2 protein]]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of ESR2 mRNA]; Fulvestrant inhibits the reaction [Cadmium Chloride results in increased expression of ESR2 protein]; Fulvestrant inhibits the reaction [Diarylheptanoids results in increased activity of ESR2 protein]; Fulvestrant inhibits the reaction [diarylpropionitrile results in increased activity of ESR2 protein]; Fulvestrant inhibits the reaction [Dihydrotestosterone results in increased activity of ESR2 protein]; Fulvestrant inhibits the reaction [Dihydrotestosterone results in increased localization of ESR2 protein]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of ESR2 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of ESR2 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased localization of ESR2 protein]; Fulvestrant inhibits the reaction [Genistein results in increased expression of ESR2 protein]; Fulvestrant inhibits the reaction [luteolin-7-O-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of ESR2 protein]]; Fulvestrant inhibits the reaction [methoxyacetic acid promotes the reaction [Estradiol results in increased activity of ESR2 protein]]; Fulvestrant inhibits the reaction [Plant Preparations results in increased activity of ESR2 protein]; Fulvestrant inhibits the reaction [prochloraz results in decreased expression of ESR2 mRNA]; Fulvestrant inhibits the reaction [Resveratrol results in increased activity of ESR2 protein]; Fulvestrant inhibits the reaction [rhapontigenin analog results in increased activity of ESR2 protein]; Fulvestrant promotes the reaction [5-OH-BDE-47 results in decreased expression of ESR2 protein]; Fulvestrant promotes the reaction [6-OH-BDE-47 affects the expression of ESR2 protein]; Fulvestrant promotes the reaction [ESR1 protein binds to ESR2 protein]
CTD PMID:9048584, PMID:14742696, PMID:15103026, PMID:15130599, PMID:15171712, PMID:15537743, PMID:15950373, PMID:16202921, PMID:17003281, PMID:17203231, PMID:17638070, PMID:17692514, PMID:17935960, PMID:17974624, PMID:18973785, PMID:19270784, PMID:19570671, PMID:19654927, PMID:19913605, PMID:20061804, PMID:23261820, PMID:23596885, PMID:24685904, PMID:24742230, PMID:24782323, PMID:25752796, PMID:26867312, PMID:26944108, PMID:26988655, PMID:28013213, PMID:28356238, PMID:28571686, PMID:28882636, PMID:29383186, PMID:29421333, PMID:30682495, PMID:30684567, PMID:31381935 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Fulvestrant results in increased expression of ESRRA mRNA]; AG 1879 inhibits the reaction [Fulvestrant results in increased expression of ESRRA mRNA]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of ESRRA mRNA]; Fulvestrant promotes the reaction [SP1 protein binds to ESRRA promoter]; Fulvestrant promotes the reaction [SP3 protein binds to ESRRA promoter]; GPER1 protein promotes the reaction [Fulvestrant results in increased expression of ESRRA mRNA]; Pertussis Toxin inhibits the reaction [Fulvestrant results in increased expression of ESRRA mRNA]
fulvestrant results in increased expression of ESRRA mRNA; fulvestrant results in increased expression of ESRRA protein
CTD PMID:15968320, PMID:20211987 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725
JBrowse link
G F11r F11 receptor multiple interactions ISO Fulvestrant inhibits the reaction [diarylpropionitrile results in increased expression of F11R mRNA]; Fulvestrant inhibits the reaction [diarylpropionitrile results in increased expression of F11R protein]; Fulvestrant inhibits the reaction [estradiol 3-benzoate results in increased expression of F11R mRNA]; Fulvestrant inhibits the reaction [estradiol 3-benzoate results in increased expression of F11R protein] CTD PMID:19433574 NCBI chr13:89,826,272...89,850,151
Ensembl chr13:89,826,254...89,850,612
JBrowse link
G F2r coagulation factor II (thrombin) receptor increases expression ISO fulvestrant results in increased expression of F2R mRNA CTD PMID:12154049 NCBI chr 2:26,118,760...26,135,340
Ensembl chr 2:26,118,760...26,135,340
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO fulvestrant inhibits the reaction [bis(4-hydroxyphenyl)sulfone results in increased expression of FABP4 protein]; fulvestrant inhibits the reaction [bisphenol A results in increased expression of FABP4 protein]
fulvestrant inhibits the reaction [bisphenol A glucuronide results in increased expression of FABP4 protein]; fulvestrant inhibits the reaction [Diosgenin results in decreased expression of FABP4 mRNA]
CTD PMID:24418828, PMID:26018136, PMID:26408789, PMID:27003841 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fads1 fatty acid desaturase 1 multiple interactions ISO fulvestrant inhibits the reaction [[alpha-Linolenic Acid co-treated with Estradiol] results in increased expression of FADS1 mRNA] CTD PMID:19576517 NCBI chr 1:226,234,034...226,249,118
Ensembl chr 1:226,234,074...226,249,138
JBrowse link
G Fam102a family with sequence similarity 102, member A multiple interactions ISO fulvestrant inhibits the reaction [Estradiol results in increased expression of FAM102A mRNA] CTD PMID:14605097 NCBI chr 3:11,554,084...11,586,315
Ensembl chr 3:11,554,457...11,586,303
JBrowse link
G Farp1 FERM, ARH/RhoGEF and pleckstrin domain protein 1 multiple interactions ISO Fulvestrant inhibits the reaction [afimoxifene results in increased expression of FARP1 mRNA] CTD PMID:16849584 NCBI chr15:106,375,298...106,625,837
Ensembl chr15:106,434,177...106,625,837
JBrowse link
G Faslg Fas ligand decreases expression
increases expression
ISO fulvestrant results in decreased expression of FASLG mRNA
[fulvestrant results in increased expression of TGFB1 protein] which results in increased expression of FASLG mRNA
CTD PMID:20145137 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO fulvestrant inhibits the reaction [Norethynodrel results in increased activity of FASN protein] CTD PMID:15870863 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fbxo5 F-box protein 5 multiple interactions
decreases expression
ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of FBXO5 mRNA
fulvestrant results in decreased expression of FBXO5 mRNA
CTD PMID:19016759 NCBI chr 1:42,461,277...42,467,646
Ensembl chr 1:42,461,291...42,467,586
JBrowse link
G Fgf18 fibroblast growth factor 18 multiple interactions ISO Fulvestrant inhibits the reaction [bisphenol A results in increased expression of FGF18 mRNA] CTD PMID:30892605 NCBI chr10:18,047,109...18,082,290
Ensembl chr10:18,047,109...18,063,391
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO
EXP
fulvestrant inhibits the reaction [FGF2 protein results in increased expression of CCND1 protein]
fulvestrant inhibits the reaction [naringin results in increased expression of FGF2 mRNA]
CTD PMID:20179196, PMID:23596885 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgf9 fibroblast growth factor 9 decreases expression
multiple interactions
ISO fulvestrant results in decreased expression of FGF9 mRNA
Fulvestrant inhibits the reaction [bisphenol A results in increased expression of FGF9 mRNA]
CTD PMID:14602803, PMID:30892605 NCBI chr15:38,341,657...38,386,945
Ensembl chr15:38,341,089...38,387,316
JBrowse link
G Fhl2 four and a half LIM domains 2 decreases expression ISO fulvestrant results in decreased expression of FHL2 mRNA CTD PMID:26865669 NCBI chr 9:49,920,611...49,994,906
Ensembl chr 9:49,920,854...49,950,093
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 multiple interactions ISO [Bucladesine co-treated with fulvestrant] results in decreased expression of FKBP5 mRNA; [Bucladesine co-treated with fulvestrant] results in decreased expression of FKBP5 protein; [fulvestrant co-treated with Bucladesine] results in increased methylation of FKBP5 intron; bisphenol A promotes the reaction [[fulvestrant co-treated with Bucladesine] results in increased methylation of FKBP5 intron]; Estradiol inhibits the reaction [[Bucladesine co-treated with fulvestrant] results in decreased expression of FKBP5 mRNA] CTD PMID:26427651 NCBI chr20:7,976,704...8,097,290
Ensembl chr20:7,976,713...8,019,020
JBrowse link
G Fkbpl FKBP prolyl isomerase like increases response to substance ISO FKBPL protein results in increased susceptibility to fulvestrant CTD PMID:20103631 NCBI chr20:4,411,890...4,413,360
Ensembl chr20:4,411,876...4,413,366
JBrowse link
G Flg filaggrin multiple interactions ISO fulvestrant affects the reaction [bisphenol A affects the expression of FLG mRNA]; fulvestrant inhibits the reaction [Estradiol results in decreased expression of FLG mRNA] CTD PMID:28701262 NCBI chr 2:193,565,401...193,574,297 JBrowse link
G Flnc filamin C decreases expression ISO fulvestrant results in decreased expression of FLNC mRNA CTD PMID:16514628 NCBI chr 4:56,710,934...56,738,779
Ensembl chr 4:56,711,049...56,738,791
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
ISO Fulvestrant inhibits the reaction [Atrazine results in increased expression of FOS protein]; Fulvestrant inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA]; Fulvestrant inhibits the reaction [Cadmium results in increased expression of FOS mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of FOS mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of FOS protein]; Fulvestrant inhibits the reaction [luteolin-7-O-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of FOS protein]]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Fulvestrant co-treated with bisphenol A] results in increased expression of FOS mRNA]; [Fulvestrant co-treated with bisphenol A] results in increased expression of FOS mRNA; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of FOS mRNA]; Fulvestrant inhibits the reaction [DDT results in increased expression of FOS mRNA]; GPER1 protein affects the reaction [[Fulvestrant co-treated with bisphenol A] results in increased expression of FOS mRNA]; RTKI cpd inhibits the reaction [[Fulvestrant co-treated with bisphenol A] results in increased expression of FOS mRNA]
fulvestrant results in decreased expression of FOS mRNA
CTD PMID:10478842, PMID:15072547, PMID:17125913, PMID:20875696, PMID:21813366, PMID:23684557, PMID:25616260, PMID:28446726, PMID:30682495, PMID:31381935 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxc1 forkhead box C1 decreases expression ISO fulvestrant results in decreased expression of FOXC1 mRNA CTD PMID:26865669 NCBI chr17:33,947,501...33,951,484
Ensembl chr17:33,947,506...33,951,484
JBrowse link
G Foxm1 forkhead box M1 multiple interactions
decreases expression
ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of FOXM1 mRNA
fulvestrant results in decreased expression of FOXM1 mRNA; fulvestrant results in decreased expression of FOXM1 protein
CTD PMID:19016759, PMID:20208560 NCBI chr 4:161,685,236...161,697,633
Ensembl chr 4:161,685,258...161,696,305
JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO Fulvestrant inhibits the reaction [Cadmium Chloride results in increased expression of FOXO3 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of FOXO3 mRNA] CTD PMID:30682495 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Foxp3 forkhead box P3 increases expression
multiple interactions
ISO fulvestrant results in increased expression of FOXP3 mRNA
TGFB1 protein promotes the reaction [fulvestrant results in increased expression of FOXP3 mRNA]
CTD PMID:20145137 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP
ISO
Fulvestrant inhibits the reaction [[Estradiol co-treated with FSHB protein] results in increased stability of and results in increased expression of TGFBR3 mRNA]; Fulvestrant inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CREBBP protein]]; Fulvestrant inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CYP11A1 gene]]; Fulvestrant inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to HSD3B gene]]; Fulvestrant inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to NCOA1 protein]]; Fulvestrant inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to PPARGC1A protein]]; Fulvestrant inhibits the reaction [FSHB protein results in increased abundance of Cyclic AMP]; Fulvestrant inhibits the reaction [FSHB protein results in increased expression of CYP11A1 protein]; Fulvestrant inhibits the reaction [FSHB protein results in increased expression of HSD3B protein]
fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [CREBBP protein binds to CYP11A1 gene]]; fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [CREBBP protein binds to HSD3B gene]]; fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [NCOA1 protein binds to CYP11A1 gene]]; fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [NCOA1 protein binds to HSD3B gene]]; fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [PPARGC1A protein binds to CYP11A1 gene]]; fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [PPARGC1A protein binds to HSD3B gene]]; fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CREBBP protein]]]; fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CYP11A1 gene]]]; fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to HSD3B gene]]]; fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to NCOA1 protein]]]; fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to PPARGC1A protein]]]; fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein results in increased abundance of Progesterone]]; fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein results in increased expression of CYP11A1 protein]]; fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein results in increased expression of HSD3B protein]]
CTD PMID:15878966, PMID:18511507, PMID:25549949 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Fst follistatin increases expression ISO fulvestrant results in increased expression of FST mRNA CTD PMID:16298037 NCBI chr 2:46,537,589...46,544,813
Ensembl chr 2:46,538,700...46,544,457
JBrowse link
G Fyttd1 forty-two-three domain containing 1 decreases expression ISO fulvestrant results in decreased expression of FYTTD1 mRNA CTD PMID:16514628 NCBI chr11:71,113,931...71,136,694
Ensembl chr11:71,116,579...71,136,673
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions ISO fulvestrant inhibits the reaction [Estradiol results in increased expression of G6PDX mRNA] CTD PMID:10433208 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gabpa GA binding protein transcription factor subunit alpha increases expression ISO fulvestrant results in increased expression of GABPA mRNA CTD PMID:12154049 NCBI chr11:24,293,845...24,322,822
Ensembl chr11:24,263,281...24,322,815
JBrowse link
G Gas6 growth arrest specific 6 multiple interactions ISO fulvestrant inhibits the reaction [Estradiol results in increased expression of GAS6 mRNA]; fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in increased expression of GAS6 mRNA]; fulvestrant inhibits the reaction [Tamoxifen results in increased expression of GAS6 mRNA] CTD PMID:19429434 NCBI chr16:81,213,364...81,243,824
Ensembl chr16:81,213,364...81,243,757
JBrowse link
G Gch1 GTP cyclohydrolase 1 multiple interactions EXP fulvestrant inhibits the reaction [resveratrol results in increased expression of GCH1 protein] CTD PMID:17666920 NCBI chr15:23,935,011...23,968,971
Ensembl chr15:23,934,585...23,969,011
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions EXP fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein] CTD PMID:24437944 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gh1 growth hormone 1 multiple interactions EXP Fulvestrant inhibits the reaction [4-nonylphenol results in increased expression of GH1 mRNA]; Fulvestrant inhibits the reaction [4-nonylphenol results in increased expression of GH1 protein]; Fulvestrant inhibits the reaction [4-nonylphenol results in increased secretion of GH1 protein]; Fulvestrant inhibits the reaction [4-octylphenol results in increased expression of GH1 mRNA]; Fulvestrant inhibits the reaction [4-octylphenol results in increased secretion of GH1 protein]; Fulvestrant inhibits the reaction [4-tert-octylphenol results in increased expression of GH1 mRNA]; Fulvestrant inhibits the reaction [4-tert-octylphenol results in increased expression of GH1 protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of GH1 mRNA]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of GH1 protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased secretion of GH1 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of GH1 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased secretion of GH1 protein] CTD PMID:19145065, PMID:19463694 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression
multiple interactions
ISO fulvestrant results in decreased expression of GJA1 mRNA; fulvestrant results in decreased expression of GJA1 protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Fulvestrant results in decreased expression of GJA1 protein]; Fulvestrant promotes the reaction [NEDD4 protein binds to and results in increased ubiquitination of GJA1 protein]; MAP2K3 promotes the reaction [Fulvestrant results in decreased expression of GJA1 protein]; MAP2K6 promotes the reaction [Fulvestrant results in decreased expression of GJA1 protein]; SB 203580 inhibits the reaction [Fulvestrant promotes the reaction [NEDD4 protein binds to and results in increased ubiquitination of GJA1 protein]]; SB 203580 inhibits the reaction [Fulvestrant results in decreased expression of GJA1 mRNA]; SB 203580 inhibits the reaction [Fulvestrant results in decreased expression of GJA1 protein]
CTD PMID:29180066 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gjb2 gap junction protein, beta 2 multiple interactions ISO Fulvestrant inhibits the reaction [bisphenol A results in decreased expression of GJB2 mRNA] CTD PMID:30187510 NCBI chr15:37,377,313...37,394,494
Ensembl chr15:37,377,316...37,383,277
JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions ISO fulvestrant inhibits the reaction [Estradiol results in decreased expression of GLB1 protein] CTD PMID:17075048 NCBI chr 8:122,439,328...122,511,939
Ensembl chr 8:122,439,328...122,511,939
JBrowse link
G Gli1 GLI family zinc finger 1 increases expression EXP fulvestrant results in increased expression of GLI1 mRNA CTD PMID:20232216 NCBI chr 7:70,620,794...70,633,171
Ensembl chr 7:70,620,766...70,630,338
JBrowse link
G Gnaq G protein subunit alpha q multiple interactions EXP fulvestrant inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased expression of GNAQ protein]] CTD PMID:23419388 NCBI chr 1:233,382,778...233,622,584
Ensembl chr 1:233,382,708...233,622,786
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 multiple interactions
decreases expression
ISO fulvestrant affects the reaction [2,3',4,4',5-pentachlorobiphenyl affects the expression of GNRH1 protein]; fulvestrant affects the reaction [2,4,4',5-tetrachlorobiphenyl affects the expression of GNRH1 protein]; fulvestrant affects the reaction [2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of GNRH1 protein]; fulvestrant inhibits the reaction [Chlorpyrifos results in increased secretion of GNRH1 protein]; fulvestrant inhibits the reaction [Estradiol results in decreased expression of GNRH1 mRNA]; fulvestrant inhibits the reaction [Methoxychlor results in increased secretion of GNRH1 protein]
fulvestrant results in decreased expression of GNRH1 protein
CTD PMID:10537130, PMID:12088877, PMID:19362103 NCBI chr15:44,441,856...44,446,064
Ensembl chr15:44,442,555...44,442,875
Ensembl chr15:44,442,555...44,442,875
JBrowse link
G Golga5 golgin A5 decreases expression ISO fulvestrant results in decreased expression of GOLGA5 mRNA CTD PMID:16514628 NCBI chr 6:126,350,572...126,378,735
Ensembl chr 6:126,353,223...126,378,610
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 multiple interactions
increases expression
decreases response to substance
affects response to substance
ISO 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Fulvestrant results in increased expression of GPER1 mRNA]; [Fulvestrant co-treated with 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline] inhibits the reaction [bisphenol A results in increased expression of GPER1 mRNA]; [Fulvestrant co-treated with 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline] inhibits the reaction [Estradiol results in increased expression of GPER1 mRNA]; [Fulvestrant co-treated with 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline] inhibits the reaction [Estradiol results in increased expression of GPER1 protein]; Fulvestrant inhibits the reaction [4,4'-thiodiphenol results in increased expression of GPER1 protein]; Fulvestrant inhibits the reaction [bisphenol F results in increased expression of GPER1 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of GPER1 protein]; GPER1 protein affects the reaction [Fulvestrant promotes the reaction [CAPN1 protein results in increased cleavage of and results in increased activity of CAPN1 protein]]; GPER1 protein promotes the reaction [Fulvestrant results in increased expression of ESRRA mRNA]
GPER1 protein affects the reaction [[fulvestrant co-treated with bisphenol A] results in decreased expression of CCND1 mRNA]; GPER1 protein affects the reaction [[fulvestrant co-treated with bisphenol A] results in increased expression of FOS mRNA]
Fulvestrant results in increased expression of GPER1 mRNA; Fulvestrant results in increased expression of GPER1 protein
GPER1 mutant form results in decreased susceptibility to fulvestrant
GPER1 protein affects the susceptibility to fulvestrant
CTD PMID:20211987, PMID:24169358, PMID:24440569, PMID:25969534, PMID:27880919, PMID:28446726, PMID:28882636, PMID:30195206 NCBI chr12:17,309,122...17,315,267
Ensembl chr12:17,309,834...17,311,112
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions
decreases response to substance
ISO Fulvestrant inhibits the reaction [4,4'-hexafluorisopropylidene diphenol results in increased expression of GREB1 mRNA]; Fulvestrant inhibits the reaction [[Arsenic Trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; Fulvestrant inhibits the reaction [alpha-terpineol results in increased expression of GREB1 mRNA]; Fulvestrant inhibits the reaction [Arsenic Trioxide results in increased expression of GREB1 mRNA]; Fulvestrant inhibits the reaction [bis(4-hydroxyphenyl)sulfone results in increased expression of GREB1 mRNA]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of GREB1 mRNA]; Fulvestrant inhibits the reaction [butylparaben metabolite results in increased expression of GREB1 mRNA]; Fulvestrant inhibits the reaction [butylparaben results in increased expression of GREB1 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of GREB1 mRNA]; Fulvestrant inhibits the reaction [Eucalyptol results in increased expression of GREB1 mRNA]; Fulvestrant inhibits the reaction [isobutylparaben metabolite results in increased expression of GREB1 mRNA]; Fulvestrant inhibits the reaction [isobutylparaben results in increased expression of GREB1 mRNA]; Fulvestrant inhibits the reaction [kaempferol results in increased expression of GREB1 mRNA]; Fulvestrant inhibits the reaction [lavender oil results in increased expression of GREB1 mRNA]; Fulvestrant inhibits the reaction [Limonene results in increased expression of GREB1 mRNA]; Fulvestrant inhibits the reaction [linalool results in increased expression of GREB1 mRNA]; Fulvestrant inhibits the reaction [linalyl acetate results in increased expression of GREB1 mRNA]; Fulvestrant inhibits the reaction [Resveratrol results in increased expression of GREB1 mRNA]; Fulvestrant inhibits the reaction [Tea Tree Oil results in increased expression of GREB1 mRNA]; Fulvestrant inhibits the reaction [terpinenol-4 results in increased expression of GREB1 mRNA]
GREB1 mutant form results in decreased susceptibility to fulvestrant
CTD PMID:20846786, PMID:22558281, PMID:24169358, PMID:29389661, PMID:29945225, PMID:31393563 NCBI chr 6:41,932,941...42,002,770
Ensembl chr 6:41,932,244...42,002,819
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions EXP fulvestrant inhibits the reaction [bisphenol A results in increased phosphorylation of GRIN1 protein]; fulvestrant inhibits the reaction [estradiol 3-benzoate results in increased phosphorylation of GRIN1 protein] CTD PMID:21763338 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions EXP fulvestrant inhibits the reaction [bisphenol A results in increased phosphorylation of GRIN2B protein]; fulvestrant inhibits the reaction [estradiol 3-benzoate results in increased phosphorylation of GRIN2B protein] CTD PMID:20858508, PMID:21763338 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP
ISO
fulvestrant inhibits the reaction [gypenoside analog results in increased phosphorylation of GSK3B protein]; fulvestrant inhibits the reaction [Phytoestrogens results in increased phosphorylation of GSK3B protein]
fulvestrant inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of GSK3B protein modified form]]
CTD PMID:23170834, PMID:24726523 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gzmb granzyme B increases expression
decreases expression
ISO [fulvestrant results in increased expression of TGFB1 protein] which results in increased expression of GZMB mRNA
fulvestrant results in decreased expression of GZMB mRNA; fulvestrant results in decreased expression of GZMB protein
CTD PMID:20145137 NCBI chr15:35,413,862...35,417,293
Ensembl chr15:35,413,793...35,417,316
JBrowse link
G H2ax H2A.X variant histone multiple interactions EXP
ISO
Fulvestrant inhibits the reaction [bisphenol A results in increased expression of H2AX protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of H2AX protein]
Fulvestrant inhibits the reaction [Estradiol results in increased expression of H2AX protein modified form]; Fulvestrant inhibits the reaction [oxybenzone results in increased expression of H2AX protein modified form]; Fulvestrant inhibits the reaction [propylparaben results in increased expression of H2AX protein modified form]
CTD PMID:23788033, PMID:31939680 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G H2az1 H2A.Z variant histone 1 decreases expression ISO Fulvestrant results in decreased expression of H2AZ1 mRNA CTD PMID:20543978 NCBI chr 2:243,105,224...243,107,333
Ensembl chr 2:243,105,674...243,106,956
JBrowse link
G Hmgb1 high mobility group box 1 decreases expression ISO fulvestrant results in decreased expression of HMGB1 mRNA CTD PMID:16514628 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
multiple interactions
ISO
EXP
fulvestrant results in decreased expression of HMOX1 mRNA
fulvestrant inhibits the reaction [gypenoside analog results in increased expression of and results in increased activity of HMOX1 protein]; fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of HMOX1 protein]; fulvestrant inhibits the reaction [Phytoestrogens results in increased expression of and results in increased activity of HMOX1 protein]; fulvestrant inhibits the reaction [resveratrol results in increased expression of HMOX1 protein]
fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA]; fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]
CTD PMID:16298037, PMID:19781563, PMID:21192278, PMID:24437944, PMID:24726523 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha multiple interactions ISO fulvestrant inhibits the reaction [Estradiol results in decreased expression of HNF4A mRNA]; fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in decreased expression of HNF4A mRNA] CTD PMID:23184660 NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003
JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 decreases expression ISO fulvestrant results in decreased expression of HNRNPA2B1 mRNA CTD PMID:16514628 NCBI chr 4:81,237,496...81,241,281
Ensembl chr 4:81,237,496...81,241,282
JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 decreases expression ISO fulvestrant results in decreased expression of HNRNPH1 mRNA CTD PMID:16514628 NCBI chr10:35,872,619...35,879,911
Ensembl chr10:35,870,232...35,879,910
JBrowse link
G Hnrnpu heterogeneous nuclear ribonucleoprotein U decreases expression ISO fulvestrant results in decreased expression of HNRNPU mRNA CTD PMID:16514628 NCBI chr13:96,222,093...96,238,845
Ensembl chr13:96,225,912...96,238,572
JBrowse link
G Hoxa10 homeobox A10 multiple interactions
increases expression
ISO 4-tert-octylphenol inhibits the reaction [Fulvestrant results in increased expression of HOXA10 mRNA]; [Fulvestrant co-treated with 4-tert-octylphenol] results in decreased expression of HOXA10 mRNA; [Fulvestrant co-treated with bisphenol A] results in decreased expression of HOXA10 mRNA; bisphenol A inhibits the reaction [Fulvestrant results in increased expression of HOXA10 mRNA]; Estradiol inhibits the reaction [Fulvestrant results in increased expression of HOXA10 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of HOXA10 mRNA] CTD PMID:30061528 NCBI chr 4:82,285,940...82,295,892
Ensembl chr 4:82,285,528...82,295,470
JBrowse link
G Hoxa13 homeo box A13 multiple interactions ISO fulvestrant inhibits the reaction [Genistein results in decreased expression of HOXA13 mRNA] CTD PMID:21810550 Ensembl chr 4:82,228,017...82,229,397 JBrowse link
G Hoxa9 homeobox A9 multiple interactions ISO fulvestrant inhibits the reaction [Genistein results in decreased expression of HOXA9 mRNA] CTD PMID:21810550
G Hsf1 heat shock transcription factor 1 multiple interactions ISO fulvestrant inhibits the reaction [Estradiol results in increased expression of HSF1 mRNA] CTD PMID:12927369 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions ISO fulvestrant inhibits the reaction [bisphenol A results in increased expression of HSP90AA1 protein]; fulvestrant inhibits the reaction [Estradiol results in increased expression of HSP90AA1 protein] CTD PMID:11568360 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 decreases expression ISO fulvestrant results in decreased expression of HSP90AB1 mRNA CTD PMID:16514628 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 decreases expression
multiple interactions
ISO fulvestrant results in decreased expression of HSP90B1 mRNA
fulvestrant inhibits the reaction [bisphenol A results in increased expression of HSP90B1 protein]; fulvestrant inhibits the reaction [Estradiol results in increased expression of HSP90B1 protein]
CTD PMID:11568360, PMID:16514628 NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B multiple interactions ISO fulvestrant inhibits the reaction [bisphenol A results in increased expression of HSPA1B mRNA]; fulvestrant inhibits the reaction [Estradiol results in increased expression of HSPA1B mRNA] CTD PMID:12927369 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 decreases expression ISO fulvestrant results in decreased expression of HSPA4 mRNA CTD PMID:16514628 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO [Chlordecone co-treated with fulvestrant] results in increased expression of HSPA5 protein CTD PMID:17640991 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 decreases expression ISO fulvestrant results in decreased expression of HSPA8 mRNA CTD PMID:16514628 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions ISO [fulvestrant binds to and results in increased activity of ESR1 protein] which results in increased expression of HSPB1 mRNA; fulvestrant inhibits the reaction [Estradiol results in increased expression of HSPB1 mRNA] CTD PMID:11174852 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 decreases expression ISO fulvestrant results in decreased expression of HSPD1 mRNA CTD PMID:16514628 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO
EXP
fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of ICAM1 mRNA]]
fulvestrant inhibits the reaction [resveratrol results in decreased expression of ICAM1 protein]
CTD PMID:18277952, PMID:21192278, PMID:21501669 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Icam5 intercellular adhesion molecule 5 multiple interactions ISO fulvestrant inhibits the reaction [Estradiol results in decreased expression of ICAM5 mRNA] CTD PMID:26789235 NCBI chr 8:22,050,222...22,057,209
Ensembl chr 8:22,050,222...22,057,209
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein multiple interactions ISO fulvestrant inhibits the reaction [Estradiol results in increased expression of ID1 mRNA] CTD PMID:20031206 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein increases expression ISO fulvestrant results in increased expression of ID3 mRNA CTD PMID:26865669 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Ier3 immediate early response 3 multiple interactions ISO Fulvestrant inhibits the reaction [afimoxifene results in increased expression of IER3 mRNA] CTD PMID:16849584 NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769
JBrowse link
G Ifrd1 interferon-related developmental regulator 1 decreases expression ISO fulvestrant results in decreased expression of IFRD1 mRNA CTD PMID:16514628 NCBI chr 6:60,132,025...60,151,354
Ensembl chr 6:60,132,024...60,151,420
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions EXP fulvestrant inhibits the reaction [naringin results in increased expression of IGF1 mRNA] CTD PMID:23596885 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions
increases phosphorylation
ISO
EXP
AG 1879 inhibits the reaction [fulvestrant promotes the reaction [ESR1 protein binds to IGF1R protein]]; fulvestrant inhibits the reaction [[Hexachlorobenzene co-treated with Estradiol] results in increased expression of IGF1R protein]; fulvestrant inhibits the reaction [bisphenol A results in increased expression of IGF1R mRNA]; fulvestrant inhibits the reaction [Estradiol results in increased expression of IGF1R mRNA]; fulvestrant inhibits the reaction [Hexachlorobenzene results in increased expression of IGF1R protein]; fulvestrant promotes the reaction [ESR1 protein binds to IGF1R protein]; tyrphostin AG 1024 inhibits the reaction [fulvestrant promotes the reaction [ESR1 protein binds to IGF1R protein]]
fulvestrant inhibits the reaction [[Triclosan co-treated with Ethinyl Estradiol] results in increased expression of IGF1R mRNA]; fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of IGF1R mRNA]
fulvestrant results in increased phosphorylation of IGF1R protein
CTD PMID:19815064, PMID:19879930, PMID:23261820, PMID:23810794 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Igf2 insulin-like growth factor 2 multiple interactions EXP fulvestrant inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in decreased expression of BAD protein modified form]]; fulvestrant inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased cleavage of and results in increased activity of CASP3 protein]]; fulvestrant inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased expression of BCL2L1 protein]]; fulvestrant inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased expression of GNAQ protein]]; fulvestrant inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased expression of IGF2R protein]]; fulvestrant inhibits the reaction [dan-shen root extract results in decreased susceptibility to IGF2 protein mutant form] CTD PMID:23419388 NCBI chr 1:215,828,102...215,839,081
Ensembl chr 1:215,828,102...215,846,911
JBrowse link
G Igf2r insulin-like growth factor 2 receptor multiple interactions ISO
EXP
fulvestrant inhibits the reaction [bisphenol A results in decreased methylation of IGF2R gene]
fulvestrant inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased expression of IGF2R protein]]
CTD PMID:22131059, PMID:23419388 NCBI chr 1:48,176,095...48,264,482
Ensembl chr 1:48,176,106...48,264,477
JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 decreases expression ISO fulvestrant results in decreased expression of IGFBP4 mRNA CTD PMID:15072547 NCBI chr10:86,950,555...86,962,563
Ensembl chr10:86,950,557...86,962,578
JBrowse link
G Ihh Indian hedgehog signaling molecule multiple interactions
decreases expression
EXP fulvestrant inhibits the reaction [Ethinyl Estradiol results in decreased expression of IHH mRNA]
fulvestrant results in decreased expression of IHH mRNA
CTD PMID:17109907, PMID:20232216 NCBI chr 9:82,208,223...82,214,440
Ensembl chr 9:82,208,223...82,214,440
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO fulvestrant promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of IKBKB protein] CTD PMID:26220752 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il10 interleukin 10 multiple interactions ISO fulvestrant inhibits the reaction [[bisphenol A co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL10 protein] CTD PMID:25128825 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il17a interleukin 17A multiple interactions ISO fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of IL17A protein]] CTD PMID:21501669 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il17rb interleukin 17 receptor B multiple interactions
decreases expression
ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of IL17RB mRNA
fulvestrant results in decreased expression of IL17RB mRNA
CTD PMID:19016759 NCBI chr16:6,064,287...6,077,978
Ensembl chr16:6,064,288...6,077,978
JBrowse link
G Il18 interleukin 18 multiple interactions ISO [fulvestrant co-treated with Mifepristone] inhibits the reaction [[Progesterone co-treated with Estrogens] inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]] CTD PMID:17850464 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO fulvestrant inhibits the reaction [bisphenol A inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein]]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein]]; fulvestrant inhibits the reaction [nonylphenol inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein]] CTD PMID:10614622 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
ISO
EXP
fulvestrant results in increased expression of IL1B mRNA
fulvestrant inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]
fulvestrant inhibits the reaction [bisphenol A results in increased expression of IL1B mRNA]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Dimethoate results in increased expression of IL1B mRNA]]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of IL1B mRNA]]
fulvestrant inhibits the reaction [Estradiol inhibits the reaction [IL1B protein results in increased expression of MMP1 protein]]
CTD PMID:16298037, PMID:20600708, PMID:21501669, PMID:23943137, PMID:25738436, PMID:28500084 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il24 interleukin 24 increases expression ISO fulvestrant results in increased expression of IL24 mRNA CTD PMID:16298037 NCBI chr13:47,618,451...47,623,849
Ensembl chr13:47,618,452...47,623,849
JBrowse link
G Il4 interleukin 4 multiple interactions ISO fulvestrant inhibits the reaction [Diethylhexyl Phthalate inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of CD86 protein]]; fulvestrant inhibits the reaction [Diethylhexyl Phthalate inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of LY75 protein]] CTD PMID:21538406 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO
EXP
fulvestrant results in increased expression of IL6 mRNA
fulvestrant inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; fulvestrant inhibits the reaction [resveratrol results in decreased expression of IL6 protein]
fulvestrant inhibits the reaction [bazedoxifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA]]; fulvestrant inhibits the reaction [bisphenol A results in increased expression of IL6 mRNA]; fulvestrant inhibits the reaction [bisphenol A results in increased secretion of IL6 protein]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Dimethoate results in increased expression of IL6 mRNA]]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of IL6 mRNA]]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]; fulvestrant inhibits the reaction [Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA]]; fulvestrant inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]
Fulvestrant inhibits the reaction [[bisphenol A co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL6 protein]; Fulvestrant inhibits the reaction [[TNF protein co-treated with Resveratrol] promotes the reaction [CREBBP protein binds to IL6 promoter]]; Fulvestrant inhibits the reaction [[TNF protein co-treated with Resveratrol] promotes the reaction [NCOA2 protein binds to IL6 promoter]]; Fulvestrant inhibits the reaction [[TNF protein co-treated with Resveratrol] promotes the reaction [NCOA3 protein binds to IL6 promoter]]; Fulvestrant inhibits the reaction [[TNF protein co-treated with Resveratrol] promotes the reaction [NCOR2 protein binds to IL6 promoter]]; Fulvestrant inhibits the reaction [[TNF protein co-treated with Resveratrol] promotes the reaction [NMNAT1 protein binds to IL6 promoter]]; Fulvestrant inhibits the reaction [[TNF protein co-treated with Resveratrol] promotes the reaction [RCOR1 protein binds to IL6 promoter]]; Fulvestrant inhibits the reaction [[TNF protein co-treated with Resveratrol] promotes the reaction [RELA protein modified form binds to IL6 promoter]]; Fulvestrant inhibits the reaction [[TNF protein co-treated with Resveratrol] promotes the reaction [SIRT1 protein binds to IL6 promoter]]; Fulvestrant inhibits the reaction [Estradiol inhibits the reaction [TNF protein results in increased secretion of IL6 protein]]; Fulvestrant inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; Fulvestrant inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased secretion of IL6 protein]]
CTD PMID:16298037, PMID:18277952, PMID:19533603, PMID:21192278, PMID:21501669, PMID:23943137, PMID:24771768, PMID:25047101, PMID:25128825, PMID:25738436, PMID:28500084 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ilrun inflammation and lipid regulator with UBA-like and NBR1-like domains decreases expression ISO Fulvestrant results in decreased expression of ILRUN mRNA CTD PMID:16514628 NCBI chr20:7,331,321...7,397,588
Ensembl chr20:7,331,326...7,397,448
JBrowse link
G Ins2 insulin 2 multiple interactions ISO fulvestrant inhibits the reaction [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in increased expression of INS2 protein]; fulvestrant inhibits the reaction [[[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] co-treated with bisphenol A] results in increased activity of ESR2 protein]; fulvestrant inhibits the reaction [bisphenol A results in increased expression of INS2 protein]; fulvestrant inhibits the reaction [Estradiol results in increased expression of INS2 protein]
fulvestrant inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS protein]]
CTD PMID:18446233, PMID:26944108, PMID:28180948 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Insr insulin receptor multiple interactions EXP fulvestrant inhibits the reaction [resveratrol results in increased phosphorylation of INSR protein] CTD PMID:18426865 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 decreases expression ISO fulvestrant results in decreased expression of IQGAP1 mRNA CTD PMID:16514628 NCBI chr 1:142,525,041...142,615,673
Ensembl chr 1:142,525,046...142,615,673
JBrowse link
G Irs1 insulin receptor substrate 1 decreases expression
multiple interactions
ISO fulvestrant results in decreased expression of IRS1 mRNA
fulvestrant inhibits the reaction [[Hexachlorobenzene co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]; fulvestrant inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of IRS1 protein]
CTD PMID:15072547, PMID:19879930 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Itgam integrin subunit alpha M decreases expression ISO fulvestrant results in decreased expression of ITGAM protein CTD PMID:28811679 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itgax integrin subunit alpha X decreases expression ISO fulvestrant results in decreased expression of ITGAX protein CTD PMID:28811679 NCBI chr 1:199,555,560...199,576,948
Ensembl chr 1:199,555,722...199,576,932
JBrowse link
G Itgb1 integrin subunit beta 1 increases expression
multiple interactions
ISO fulvestrant results in increased expression of ITGB1 mRNA
Fulvestrant inhibits the reaction [bisphenol A results in increased expression of ITGB1 protein]; Fulvestrant promotes the reaction [bisphenol A results in increased expression of ITGB1 protein]
CTD PMID:12154049, PMID:25534675, PMID:30611077 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Ivl involucrin multiple interactions ISO fulvestrant affects the reaction [bisphenol A affects the expression of IVL mRNA]; fulvestrant inhibits the reaction [Estradiol results in decreased expression of IVL mRNA] CTD PMID:28701262 NCBI chr 2:192,761,171...192,773,346
Ensembl chr 2:192,761,538...192,763,577
JBrowse link
G Jak2 Janus kinase 2 decreases expression
decreases phosphorylation
multiple interactions
ISO fulvestrant results in decreased expression of JAK2 mRNA
Fulvestrant results in decreased phosphorylation of JAK2 protein
Fulvestrant inhibits the reaction [bisphenol F results in increased phosphorylation of JAK2 protein]
CTD PMID:26865669, PMID:32044397 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO Fulvestrant inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]; Fulvestrant inhibits the reaction [Cadmium results in increased expression of JUN mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of JUN mRNA]
fulvestrant results in increased expression of JUN mRNA
CTD PMID:12154049, PMID:17125913, PMID:30682495 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kcnh1 potassium voltage-gated channel subfamily H member 1 multiple interactions
decreases expression
ISO [Estradiol co-treated with fulvestrant co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA; [fulvestrant co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA; fulvestrant inhibits the reaction [Estradiol results in increased expression of KCNH1 mRNA]
fulvestrant results in decreased expression of KCNH1 mRNA
CTD PMID:19351862 NCBI chr13:110,920,712...111,232,291
Ensembl chr13:110,920,737...111,232,269
JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 multiple interactions EXP fulvestrant inhibits the reaction [Estradiol results in decreased expression of KCNMA1 mRNA alternative form]; fulvestrant inhibits the reaction [Estradiol results in decreased expression of KCNMA1 mRNA]; fulvestrant inhibits the reaction [Estradiol results in decreased expression of KCNMA1 protein] CTD PMID:16102753 NCBI chr15:344,204...1,048,849
Ensembl chr15:344,360...1,047,956
JBrowse link
G Kif20a kinesin family member 20A decreases expression ISO fulvestrant results in decreased expression of KIF20A mRNA CTD PMID:16514628 NCBI chr18:27,424,328...27,432,814
Ensembl chr18:27,424,328...27,432,814
JBrowse link
G Klf4 Kruppel like factor 4 multiple interactions EXP fulvestrant inhibits the reaction [Estradiol results in increased expression of KLF4 protein] CTD PMID:21484412 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669
JBrowse link
G Kmt5a lysine methyltransferase 5A multiple interactions ISO [fulvestrant results in increased susceptibility to bisphenol A] which results in decreased expression of KMT5A mRNA; fulvestrant inhibits the reaction [bisphenol A results in decreased expression of KMT5A mRNA]; fulvestrant inhibits the reaction [Estradiol results in decreased expression of KMT5A mRNA] CTD PMID:27114721 NCBI chr12:37,558,150...37,581,183
Ensembl chr12:37,559,770...37,574,750
JBrowse link
G Kpna2 karyopherin subunit alpha 2 decreases expression ISO fulvestrant results in decreased expression of KPNA2 mRNA CTD PMID:16514628 NCBI chr10:95,200,029...95,212,111
Ensembl chr10:95,200,030...95,212,111
JBrowse link
G Kpnb1 karyopherin subunit beta 1 decreases expression ISO fulvestrant results in decreased expression of KPNB1 mRNA CTD PMID:16514628 NCBI chr10:85,096,517...85,124,641
Ensembl chr10:85,093,841...85,124,644
JBrowse link
G Krt1 keratin 1 multiple interactions ISO fulvestrant inhibits the reaction [bisphenol A affects the expression of KRT1 mRNA]; fulvestrant inhibits the reaction [Estradiol results in decreased expression of KRT1 mRNA] CTD PMID:28701262 NCBI chr 7:143,448,318...143,453,544
Ensembl chr 7:143,448,318...143,453,544
JBrowse link
G Krt10 keratin 10 multiple interactions ISO fulvestrant inhibits the reaction [bisphenol A affects the expression of KRT10 mRNA]; fulvestrant inhibits the reaction [Estradiol results in decreased expression of KRT10 mRNA] CTD PMID:28701262 NCBI chr10:87,296,445...87,301,307
Ensembl chr10:87,296,451...87,300,736
JBrowse link
G Krt13 keratin 13 multiple interactions ISO Fulvestrant inhibits the reaction [afimoxifene results in increased expression of KRT13 mRNA] CTD PMID:16849584 NCBI chr10:88,032,130...88,036,040
Ensembl chr10:88,032,130...88,036,040
JBrowse link
G Krt18 keratin 18 multiple interactions ISO KRT18 protein promotes the reaction [fulvestrant inhibits the reaction [Estradiol results in increased activity of ESR1 protein]]; KRT18 protein promotes the reaction [fulvestrant results in increased degradation of ESR1 protein] CTD PMID:20061804 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Krt8 keratin 8 multiple interactions ISO KRT8 protein promotes the reaction [fulvestrant inhibits the reaction [Estradiol results in increased activity of ESR1 protein]]; KRT8 protein promotes the reaction [fulvestrant results in increased degradation of ESR1 protein] CTD PMID:20061804 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Kynu kynureninase increases expression ISO fulvestrant results in increased expression of KYNU mRNA CTD PMID:26865669 NCBI chr 3:28,416,926...28,566,939
Ensembl chr 3:28,416,954...28,566,928
JBrowse link
G Lefty1 left right determination factor 1 multiple interactions ISO fulvestrant inhibits the reaction [Genistein inhibits the reaction [Dexamethasone results in increased expression of LEFTY1 mRNA]] CTD PMID:25136773 NCBI chr13:99,212,778...99,217,786
Ensembl chr13:99,214,389...99,217,786
JBrowse link
G Lif LIF, interleukin 6 family cytokine decreases expression
multiple interactions
ISO Fulvestrant results in decreased expression of LIF mRNA
Fulvestrant promotes the reaction [Estradiol results in decreased expression of LIF mRNA]
CTD PMID:30061528 NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642
JBrowse link
G Lpl lipoprotein lipase multiple interactions
decreases expression
ISO Fulvestrant inhibits the reaction [bisphenol A glucuronide results in increased expression of LPL protein]; Fulvestrant inhibits the reaction [ESR1 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]]; Fulvestrant inhibits the reaction [ESR2 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of LPL mRNA]
fulvestrant results in decreased expression of LPL mRNA
CTD PMID:17974624, PMID:26018136 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Lrp5 LDL receptor related protein 5 multiple interactions ISO fulvestrant inhibits the reaction [dioscin results in increased expression of LRP5 mRNA] CTD PMID:24742230 NCBI chr 1:218,816,833...218,920,147
Ensembl chr 1:218,816,841...218,920,094
JBrowse link
G Ltf lactotransferrin multiple interactions ISO Fulvestrant inhibits the reaction [1,7-diphenyl-5-heptene-3-one results in increased expression of LTF mRNA]; Fulvestrant inhibits the reaction [Chlordecone results in increased expression of LTF mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of LTF mRNA]; Fulvestrant inhibits the reaction [o,p'-DDT results in increased expression of LTF mRNA] CTD PMID:9607801, PMID:10433208, PMID:17640991, PMID:19654927 NCBI chr 8:119,290,416...119,313,261
Ensembl chr 8:119,290,416...119,313,261
JBrowse link
G Ly75 lymphocyte antigen 75 multiple interactions ISO fulvestrant inhibits the reaction [Diethylhexyl Phthalate inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of LY75 protein]] CTD PMID:21538406 NCBI chr 3:46,369,749...46,457,182
Ensembl chr 3:46,365,165...46,457,201
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 multiple interactions
decreases expression
ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of MAD2L1 mRNA
fulvestrant results in decreased expression of MAD2L1 mRNA
CTD PMID:19016759 NCBI chr 4:97,530,993...97,543,179
Ensembl chr 4:97,531,083...97,537,086
JBrowse link
G Manf mesencephalic astrocyte-derived neurotrophic factor multiple interactions ISO fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of MANF mRNA]; fulvestrant inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MANF mRNA] CTD PMID:16467188 NCBI chr 8:115,623,175...115,626,408
Ensembl chr 8:115,623,178...115,626,380
JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 multiple interactions ISO MAP2K3 promotes the reaction [fulvestrant results in decreased expression of GJA1 protein] CTD PMID:29180066 NCBI chr10:45,089,455...45,110,802
Ensembl chr10:47,182,433...47,203,753
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 multiple interactions ISO MAP2K6 promotes the reaction [fulvestrant results in decreased expression of GJA1 protein] CTD PMID:29180066 NCBI chr10:98,707,160...98,823,054
Ensembl chr10:98,706,960...98,823,287
JBrowse link
G Map3k11 mitogen-activated protein kinase kinase kinase 11 increases expression ISO fulvestrant results in increased expression of MAP3K11 mRNA CTD PMID:12154049 NCBI chr 1:221,043,119...221,056,420
Ensembl chr 1:221,043,119...221,056,417
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
[U 0126 results in decreased phosphorylation of [MAPK3 protein co-treated with MAPK1 protein]] which results in decreased susceptibility to Fulvestrant; Fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MAPK1 protein modified form]; Fulvestrant inhibits the reaction [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]]; Fulvestrant inhibits the reaction [4,4'-hexafluorisopropylidene diphenol results in increased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [4,4'-thiodiphenol results in increased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [4-tert-octylphenol results in decreased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [[bisphenol A co-treated with Dibutyl Phthalate] results in decreased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [[bisphenol A co-treated with Diethylhexyl Phthalate] results in decreased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with bisphenol A] results in increased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [Atrazine results in increased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [bisphenol A results in decreased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Fulvestrant inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [Diethylhexyl Phthalate results in decreased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased activity of MAPK1 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of MAPK1 protein modified form]; Fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased activity of MAPK1 protein]; Fulvestrant inhibits the reaction [luteolin-7-O-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK1 protein]]; Fulvestrant inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of MAPK1 protein]
fulvestrant results in increased phosphorylation of MAPK1 protein
[Estradiol co-treated with Fulvestrant] results in increased phosphorylation of MAPK1 protein; Fulvestrant inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [4-propylphenol results in increased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [notoginsenoside R1 results in increased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [Promegestone results in increased phosphorylation of MAPK1 protein]
Fulvestrant affects the reaction [sodium arsenite affects the expression of MAPK1 mRNA]; Fulvestrant affects the reaction [sodium arsenite affects the expression of MAPK1 protein]; Fulvestrant inhibits the reaction [4-nonylphenol results in increased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased activity of MAPK1 protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [Diethylstilbestrol results in increased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [octylphenol results in increased phosphorylation of MAPK1 protein]; Fulvestrant promotes the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]
CTD PMID:14710592, PMID:15319301, PMID:15531431, PMID:16020483, PMID:16951259, PMID:17125913, PMID:17689939, PMID:18417718, PMID:19041697, PMID:20875696, PMID:20962025, PMID:21278053, PMID:22230296, PMID:24437944, PMID:24440569, PMID:24495410, PMID:25128825, PMID:25461906, PMID:25616260, PMID:26006730, PMID:26133781, PMID:27025157, PMID:27071941, PMID:27880919, PMID:28446726, PMID:28736254, PMID:28849599, PMID:29383186, PMID:30590302, PMID:30682495, PMID:30684567, PMID:31059536, PMID:31381935 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
[U 0126 results in decreased phosphorylation of [MAPK3 protein co-treated with MAPK1 protein]] which results in decreased susceptibility to Fulvestrant; Fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MAPK3 protein modified form]; Fulvestrant inhibits the reaction [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]]; Fulvestrant inhibits the reaction [4,4'-hexafluorisopropylidene diphenol results in increased phosphorylation of MAPK3 protein]; Fulvestrant inhibits the reaction [4,4'-thiodiphenol results in increased phosphorylation of MAPK3 protein]; Fulvestrant inhibits the reaction [4-tert-octylphenol results in decreased phosphorylation of MAPK3 protein]; Fulvestrant inhibits the reaction [[bisphenol A co-treated with Dibutyl Phthalate] results in decreased phosphorylation of MAPK3 protein]; Fulvestrant inhibits the reaction [[bisphenol A co-treated with Diethylhexyl Phthalate] results in decreased phosphorylation of MAPK3 protein]; Fulvestrant inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with bisphenol A] results in increased phosphorylation of MAPK3 protein]; Fulvestrant inhibits the reaction [Atrazine results in increased phosphorylation of MAPK3 protein]; Fulvestrant inhibits the reaction [bisphenol A results in decreased phosphorylation of MAPK3 protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein]; Fulvestrant inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Fulvestrant inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; Fulvestrant inhibits the reaction [Cadmium results in increased phosphorylation of MAPK3 protein]; Fulvestrant inhibits the reaction [Diethylhexyl Phthalate results in decreased phosphorylation of MAPK3 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of MAPK3 protein modified form]; Fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of MAPK3 protein]; Fulvestrant inhibits the reaction [luteolin-7-O-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK3 protein]]; Fulvestrant inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of MAPK3 protein]
fulvestrant results in increased phosphorylation of MAPK3 protein
fulvestrant inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK3 protein]; fulvestrant inhibits the reaction [4-propylphenol results in increased phosphorylation of MAPK3 protein]; fulvestrant inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein]; fulvestrant inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK3 protein]; fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of MAPK3 protein]; fulvestrant inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; fulvestrant inhibits the reaction [notoginsenoside R1 results in increased phosphorylation of MAPK3 protein]; fulvestrant inhibits the reaction [Promegestone results in increased phosphorylation of MAPK3 protein]
Fulvestrant affects the reaction [sodium arsenite affects the expression of MAPK3 mRNA]; Fulvestrant affects the reaction [sodium arsenite affects the expression of MAPK3 protein]; Fulvestrant inhibits the reaction [4-nonylphenol results in increased phosphorylation of MAPK3 protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased activity of MAPK3 protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein]; Fulvestrant inhibits the reaction [Diethylstilbestrol results in increased phosphorylation of MAPK3 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of MAPK3 protein]; Fulvestrant inhibits the reaction [octylphenol results in increased phosphorylation of MAPK3 protein]; Fulvestrant promotes the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein]
CTD PMID:15319301, PMID:15531431, PMID:16020483, PMID:17125913, PMID:17689939, PMID:18417718, PMID:19041697, PMID:20875696, PMID:20962025, PMID:21278053, PMID:22230296, PMID:24437944, PMID:24440569, PMID:24495410, PMID:25128825, PMID:25461906, PMID:25616260, PMID:26006730, PMID:26133781, PMID:27025157, PMID:27071941, PMID:27880919, PMID:28446726, PMID:28736254, PMID:28849599, PMID:29383186, PMID:30590302, PMID:30682495, PMID:30684567, PMID:31059536, PMID:31381935 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO fulvestrant results in decreased expression of MAPT protein CTD PMID:20579400 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Matr3 matrin 3 decreases expression ISO fulvestrant results in decreased expression of MATR3 mRNA CTD PMID:16514628 NCBI chr18:28,351,691...28,390,764
Ensembl chr18:28,361,283...28,390,717
JBrowse link
G Mbp myelin basic protein multiple interactions EXP fulvestrant inhibits the reaction [bisphenol A results in decreased expression of MBP protein] CTD PMID:27364615 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Mgp matrix Gla protein decreases expression ISO fulvestrant results in decreased expression of MGP mRNA CTD PMID:16514628 NCBI chr 4:170,856,783...170,860,105
Ensembl chr 4:170,856,751...170,860,225
JBrowse link
G Mical2 microtubule associated monooxygenase, calponin and LIM domain containing 2 decreases expression ISO fulvestrant results in decreased expression of MICAL2 mRNA CTD PMID:26865669 NCBI chr 1:177,048,607...177,173,729
Ensembl chr 1:177,048,655...177,173,995
JBrowse link
G Mir21 microRNA 21 multiple interactions
increases expression
ISO 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [fulvestrant results in increased expression of MIR21 mRNA]; fulvestrant inhibits the reaction [Estradiol results in decreased expression of MIR21 mRNA]; fulvestrant inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]; fulvestrant inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of MIR21 mRNA] CTD PMID:19264808, PMID:23052036, PMID:25969534 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mir30d microRNA 30d decreases expression ISO fulvestrant results in decreased expression of MIR30D mRNA CTD PMID:27481218 NCBI chr 7:109,286,463...109,286,544
Ensembl chr 7:109,286,463...109,286,544
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO fulvestrant inhibits the reaction [1,7-diphenyl-5-heptene-3-one results in increased expression of MKI67 protein]; fulvestrant inhibits the reaction [Estradiol results in increased expression of MKI67 protein]
fulvestrant inhibits the reaction [bisphenol A results in decreased expression of MKI67 mRNA]; fulvestrant inhibits the reaction [Estradiol results in increased expression of MKI67 mRNA]; fulvestrant inhibits the reaction [nonylphenol results in increased expression of MKI67 mRNA]
CTD PMID:19654927, PMID:27260121, PMID:28701262 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mme membrane metallo-endopeptidase increases expression ISO fulvestrant results in increased expression of MME mRNA CTD PMID:16202921 NCBI chr 2:153,799,203...153,880,910
Ensembl chr 2:153,803,349...153,880,738
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO fulvestrant inhibits the reaction [Estradiol inhibits the reaction [IL1B protein results in increased expression of MMP1 protein]] CTD PMID:20600708 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp15 matrix metallopeptidase 15 increases expression ISO fulvestrant results in increased expression of MMP15 mRNA CTD PMID:15072547 NCBI chr19:10,079,881...10,101,380
Ensembl chr19:10,079,765...10,101,451
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO fulvestrant inhibits the reaction [bisphenol A results in increased expression of MMP2 mRNA]; fulvestrant inhibits the reaction [bisphenol A results in increased expression of MMP2 protein]; fulvestrant inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MMP2 mRNA]; fulvestrant inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MMP2 protein]; fulvestrant inhibits the reaction [Estradiol results in decreased expression of MMP2 mRNA]; fulvestrant inhibits the reaction [Estradiol results in decreased expression of MMP2 protein]; fulvestrant inhibits the reaction [Estradiol results in increased expression of MMP2 protein]; fulvestrant inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of MMP2 mRNA]; fulvestrant inhibits the reaction [nonylphenol results in increased expression of MMP2 protein]; fulvestrant inhibits the reaction [Triclosan results in increased expression of MMP2 protein] CTD PMID:19956873, PMID:26407941, PMID:28390675, PMID:28844962 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO fulvestrant inhibits the reaction [bisphenol A results in increased expression of MMP9 mRNA]; fulvestrant inhibits the reaction [bisphenol A results in increased expression of MMP9 protein]; fulvestrant inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MMP9 mRNA]; fulvestrant inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MMP9 protein]; fulvestrant inhibits the reaction [Estradiol results in decreased expression of MMP9 mRNA]; fulvestrant inhibits the reaction [Estradiol results in decreased expression of MMP9 protein]; fulvestrant inhibits the reaction [Estradiol results in increased expression of MMP9 protein]; fulvestrant inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of MMP9 mRNA]; fulvestrant inhibits the reaction [nonylphenol results in increased expression of MMP9 protein]; fulvestrant inhibits the reaction [Triclosan results in increased expression of MMP9 protein] CTD PMID:19956873, PMID:25534675, PMID:25690688, PMID:28390675, PMID:28844962 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Fulvestrant inhibits the reaction [Resveratrol results in decreased activity of MPO protein]; Fulvestrant inhibits the reaction [Resveratrol results in decreased expression of MPO protein] CTD PMID:18277952, PMID:21192278 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases response to substance
multiple interactions
ISO MTOR results in decreased susceptibility to fulvestrant
[Sirolimus results in decreased activity of MTOR protein] which results in increased susceptibility to fulvestrant; fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of MTOR protein]
CTD PMID:19016759, PMID:23000059 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Muc1 mucin 1, cell surface associated multiple interactions
increases expression
ISO bisphenol A inhibits the reaction [Fulvestrant results in increased expression of MUC1 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of MUC1 mRNA]; Fulvestrant promotes the reaction [4-tert-octylphenol results in increased expression of MUC1 mRNA]
Fulvestrant results in increased expression of MUC1 mRNA; Fulvestrant results in increased expression of MUC1 protein
CTD PMID:30061528 NCBI chr 2:188,543,137...188,547,874
Ensembl chr 2:188,543,137...188,547,874
JBrowse link
G Myb MYB proto-oncogene, transcription factor decreases expression ISO fulvestrant results in decreased expression of MYB mRNA CTD PMID:26865669 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Mybl1 MYB proto-oncogene like 1 decreases expression ISO fulvestrant results in decreased expression of MYBL1 mRNA CTD PMID:26865669 NCBI chr 5:9,279,756...9,315,112
Ensembl chr 5:9,279,970...9,315,114
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases expression
ISO
EXP
fulvestrant inhibits the reaction [DDT results in increased expression of MYC mRNA]
Fulvestrant inhibits the reaction [1,7-diphenyl-5-heptene-3-one results in increased expression of MYC mRNA]; Fulvestrant inhibits the reaction [4,4'-hexafluorisopropylidene diphenol results in increased expression of MYC mRNA]; Fulvestrant inhibits the reaction [4,4'-hexafluorisopropylidene diphenol results in increased expression of MYC protein]; Fulvestrant inhibits the reaction [[NRG1 protein co-treated with Estradiol] results in increased expression of MYC protein]; Fulvestrant inhibits the reaction [Cadmium Chloride results in increased expression of MYC mRNA]; Fulvestrant inhibits the reaction [Cadmium Chloride results in increased expression of MYC protein]; Fulvestrant inhibits the reaction [Diarylheptanoids results in increased expression of MYC mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of MYC mRNA]
fulvestrant results in decreased expression of MYC mRNA
fulvestrant results in decreased expression of MYC mRNA; fulvestrant results in decreased expression of MYC protein
CTD PMID:15072547, PMID:19654927, PMID:20219890, PMID:21980073, PMID:23684557, PMID:24169358, PMID:26502914, PMID:27514991, PMID:30590302, PMID:31059536 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myh10 myosin heavy chain 10 multiple interactions ISO fulvestrant inhibits the reaction [Estradiol results in increased expression of MYH10 protein]; fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of MYH10 protein] CTD PMID:16901965 NCBI chr10:55,274,910...55,406,738
Ensembl chr10:55,275,411...55,406,732
JBrowse link
G Myog myogenin multiple interactions ISO fulvestrant inhibits the reaction [Benzo(a)pyrene results in decreased expression of MYOG protein] CTD PMID:24431215 NCBI chr13:51,126,459...51,129,048
Ensembl chr13:51,126,459...51,129,048
JBrowse link
G Nanog Nanog homeobox increases expression ISO fulvestrant results in increased expression of NANOG protein CTD PMID:27581495 NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268
JBrowse link
G Nars1 asparaginyl-tRNA synthetase 1 decreases expression ISO Fulvestrant results in decreased expression of NARS1 mRNA CTD PMID:16514628 NCBI chr18:59,986,350...60,002,644
Ensembl chr18:59,986,360...60,002,569
JBrowse link
G Ncaph non-SMC condensin I complex, subunit H decreases expression ISO fulvestrant results in decreased expression of NCAPH mRNA CTD PMID:16514628 NCBI chr 3:119,583,798...119,611,148
Ensembl chr 3:119,583,648...119,611,136
JBrowse link
G Ncl nucleolin decreases expression ISO fulvestrant results in decreased expression of NCL mRNA CTD PMID:16514628 NCBI chr 9:93,369,119...93,377,643
Ensembl chr 9:93,368,932...93,377,643
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO
EXP
fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [NCOA1 protein binds to CYP11A1 gene]]; fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [NCOA1 protein binds to HSD3B gene]]; fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to NCOA1 protein]]]
fulvestrant inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to NCOA1 protein]]
CTD PMID:18511507 NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO fulvestrant inhibits the reaction [[TNF protein co-treated with resveratrol] promotes the reaction [NCOA2 protein binds to IL6 promoter]] CTD PMID:24771768 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Ncoa3 nuclear receptor coactivator 3 multiple interactions ISO fulvestrant inhibits the reaction [[TNF protein co-treated with resveratrol] promotes the reaction [NCOA3 protein binds to IL6 promoter]] CTD PMID:24771768 NCBI chr 3:162,692,176...162,788,582
Ensembl chr 3:162,692,185...162,787,548
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO fulvestrant promotes the reaction [NCOR1 protein binds to TFF2 promoter] CTD PMID:20696891 NCBI chr10:48,629,121...48,772,890
Ensembl chr10:48,629,121...48,772,890
JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions ISO fulvestrant inhibits the reaction [[TNF protein co-treated with resveratrol] promotes the reaction [NCOR2 protein binds to IL6 promoter]] CTD PMID:24771768 NCBI chr12:36,871,917...37,033,701
Ensembl chr12:36,871,999...37,033,701
JBrowse link
G Ndc80 NDC80 kinetochore complex component decreases expression
multiple interactions
ISO fulvestrant results in decreased expression of NDC80 mRNA
[fulvestrant co-treated with Sirolimus] results in decreased expression of NDC80 mRNA
CTD PMID:19016759 NCBI chr 9:119,837,857...119,871,435
Ensembl chr 9:119,839,016...119,871,382
JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase multiple interactions ISO fulvestrant promotes the reaction [NEDD4 protein binds to and results in increased ubiquitination of GJA1 protein]; SB 203580 inhibits the reaction [fulvestrant promotes the reaction [NEDD4 protein binds to and results in increased ubiquitination of GJA1 protein]] CTD PMID:29180066 NCBI chr 8:79,323,408...79,408,842
Ensembl chr 8:79,323,408...79,408,833
JBrowse link
G Nefh neurofilament heavy multiple interactions EXP fulvestrant inhibits the reaction [bisphenol A results in decreased expression of NEFH protein] CTD PMID:27364615 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Nek2 NIMA-related kinase 2 multiple interactions
decreases expression
ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of NEK2 mRNA
fulvestrant results in decreased expression of NEK2 mRNA
CTD PMID:19016759 NCBI chr13:110,511,546...110,524,750
Ensembl chr13:110,511,668...110,522,769
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO
EXP
fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased localization of NFE2L2 protein]
fulvestrant inhibits the reaction [gypenoside analog affects the localization of NFE2L2 protein]; fulvestrant inhibits the reaction [Phytoestrogens affects the localization of NFE2L2 protein]
CTD PMID:19781563, PMID:24726523 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases expression
multiple interactions
ISO fulvestrant results in decreased expression of NFKBIA mRNA
fulvestrant inhibits the reaction [bisphenol A results in decreased expression of NFKBIA protein]
fulvestrant inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of NFKBIA protein]]
CTD PMID:16298037, PMID:23170834, PMID:27522653 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nkx3-1 NK3 homeobox 1 multiple interactions ISO fulvestrant inhibits the reaction [Estradiol results in increased expression of NKX3-1 mRNA]
fulvestrant inhibits the reaction [Genistein results in decreased expression of NKX3-1 mRNA]
CTD PMID:17131305, PMID:21810550 NCBI chr15:51,065,316...51,067,908
Ensembl chr15:51,065,316...51,068,421
JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 multiple interactions
decreases expression
ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of NME1 mRNA
fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of NME1 mRNA]; fulvestrant inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NME1 mRNA]
fulvestrant results in decreased expression of NME1 mRNA
CTD PMID:16467188, PMID:19016759 NCBI chr10:81,657,152...81,666,542
Ensembl chr10:81,657,153...81,666,523
JBrowse link
G Nmnat1 nicotinamide nucleotide adenylyltransferase 1 multiple interactions ISO fulvestrant inhibits the reaction [[TNF protein co-treated with resveratrol] promotes the reaction [NMNAT1 protein binds to IL6 promoter]] CTD PMID:24771768 NCBI chr 5:166,409,460...166,430,291
Ensembl chr 5:166,409,461...166,430,254
JBrowse link
G Nmrk1 nicotinamide riboside kinase 1 decreases expression ISO fulvestrant results in decreased expression of NMRK1 mRNA CTD PMID:26865669 NCBI chr 1:234,721,992...234,749,452
Ensembl chr 1:234,721,974...234,749,447
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
Fulvestrant inhibits the reaction [bisphenol A inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]]; Fulvestrant inhibits the reaction [bisphenol F results in increased expression of NOS2 mRNA]; Fulvestrant inhibits the reaction [bisphenol F results in increased expression of NOS2 protein]; Fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
Fulvestrant inhibits the reaction [Estradiol results in increased expression of NOS2 protein]; Fulvestrant inhibits the reaction [Resveratrol results in increased activity of NOS2 protein]; Fulvestrant inhibits the reaction [San'o-shashin-to affects the expression of NOS2]
CTD PMID:11583108, PMID:12860292, PMID:15256495, PMID:17666920, PMID:23615023, PMID:32044397 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases expression
ISO
EXP
[fulvestrant co-treated with MK-886] inhibits the reaction [resveratrol results in increased expression of NOS3 mRNA]; fulvestrant inhibits the reaction [[Estradiol co-treated with ESR1 protein] results in increased expression of NOS3 mRNA]; fulvestrant inhibits the reaction [[Estradiol co-treated with ESR2 protein] results in increased expression of NOS3 mRNA]; fulvestrant inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; fulvestrant inhibits the reaction [amurensin G results in increased phosphorylation of NOS3 protein]; fulvestrant inhibits the reaction [puerarin results in increased phosphorylation of NOS3 protein]
fulvestrant inhibits the reaction [Estradiol results in increased expression of NOS3 protein]
fulvestrant results in decreased expression of NOS3 protein
CTD PMID:11583108, PMID:14742696, PMID:19962728, PMID:21791144, PMID:21884717, PMID:22982565 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Npm1 nucleophosmin 1 decreases expression ISO fulvestrant results in decreased expression of NPM1 mRNA CTD PMID:16514628 NCBI chr10:18,080,949...18,091,062
Ensembl chr10:18,080,950...18,090,950
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP fulvestrant inhibits the reaction [[Estradiol co-treated with Phenylephrine] results in increased expression of NPPA protein]; fulvestrant inhibits the reaction [Estradiol results in increased expression of NPPA mRNA] CTD PMID:14718400 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nppc natriuretic peptide C multiple interactions ISO fulvestrant inhibits the reaction [Estradiol results in increased expression of NPPC mRNA] CTD PMID:9435603 NCBI chr 9:93,731,436...93,735,636
Ensembl chr 9:93,731,436...93,735,636
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of NQO1 protein] CTD PMID:24437944 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO fulvestrant inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
Fulvestrant inhibits the reaction [bisphenol A results in decreased expression of NR1H4 mRNA]
CTD PMID:25257666, PMID:30245210 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO fulvestrant results in increased activity of NR1I2 protein CTD PMID:15885729 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression ISO fulvestrant results in increased expression of NR4A1 mRNA CTD PMID:16514628 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions ISO fulvestrant inhibits the reaction [afimoxifene results in increased expression of NRF1 mRNA]; fulvestrant inhibits the reaction [Estradiol results in increased expression of NRF1 mRNA]; fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in increased expression of NRF1 mRNA]; fulvestrant inhibits the reaction [resveratrol results in increased expression of NRF1 mRNA] CTD PMID:22105178 NCBI chr 4:57,335,732...57,445,317
Ensembl chr 4:57,378,069...57,445,341
JBrowse link
G Nrg1 neuregulin 1 multiple interactions ISO fulvestrant inhibits the reaction [[NRG1 protein co-treated with Estradiol] results in increased expression of MYC protein] CTD PMID:26502914 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434
JBrowse link
G Nus1 NUS1 dehydrodolichyl diphosphate synthase subunit decreases expression ISO fulvestrant results in decreased expression of NUS1 mRNA CTD PMID:16514628 NCBI chr20:33,557,052...33,584,011
Ensembl chr20:33,557,052...33,584,010
JBrowse link
G Ocln occludin multiple interactions ISO
EXP
Fulvestrant inhibits the reaction [diarylpropionitrile results in increased expression of OCLN mRNA]; Fulvestrant inhibits the reaction [diarylpropionitrile results in increased expression of OCLN protein]; Fulvestrant inhibits the reaction [estradiol 3-benzoate results in increased expression of OCLN mRNA]; Fulvestrant inhibits the reaction [estradiol 3-benzoate results in increased expression of OCLN protein]
fulvestrant inhibits the reaction [estradiol 3-benzoate results in increased expression of OCLN mRNA]
CTD PMID:19433574 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Odc1 ornithine decarboxylase 1 affects expression EXP fulvestrant affects the expression of ODC1 mRNA CTD PMID:15925091 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Olfm1 olfactomedin 1 decreases expression ISO fulvestrant results in decreased expression of OLFM1 mRNA CTD PMID:26865669 NCBI chr 3:6,761,031...6,798,739
Ensembl chr 3:6,773,813...6,798,737
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO fulvestrant inhibits the reaction [Estradiol results in increased cleavage of PARP1 protein]; fulvestrant inhibits the reaction [Quercetin results in increased cleavage of PARP1 protein] CTD PMID:21732360 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pax5 paired box 5 increases expression ISO fulvestrant results in increased expression of PAX5 mRNA CTD PMID:12154049 NCBI chr 5:60,007,587...60,191,973
Ensembl chr 5:60,007,587...60,191,941
JBrowse link
G Pclaf PCNA clamp associated factor decreases expression ISO fulvestrant results in decreased expression of PCLAF mRNA CTD PMID:16514628 NCBI chr 8:71,514,281...71,526,182
Ensembl chr 8:71,514,281...71,526,182
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
decreases expression
ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of PCNA mRNA
fulvestrant results in decreased expression of PCNA mRNA
fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of PCNA mRNA]; fulvestrant inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PCNA mRNA]
CTD PMID:15072547, PMID:16202921, PMID:16467188, PMID:19016759 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pdgfa platelet derived growth factor subunit A multiple interactions ISO fulvestrant inhibits the reaction [Cadmium Chloride results in increased expression of PDGFA mRNA]; fulvestrant inhibits the reaction [Cadmium results in increased expression of PDGFA mRNA] CTD PMID:17125913 NCBI chr12:17,734,141...17,756,186
Ensembl chr12:17,734,133...17,755,285
JBrowse link
G Pdgfra platelet derived growth factor receptor alpha multiple interactions ISO fulvestrant inhibits the reaction [Cadmium Chloride results in increased phosphorylation of PDGFRA protein]; fulvestrant inhibits the reaction [Cadmium results in increased phosphorylation of PDGFRA protein] CTD PMID:17125913 NCBI chr14:35,527,926...35,581,130
Ensembl chr14:35,527,927...35,581,031
JBrowse link
G Pdzk1 PDZ domain containing 1 multiple interactions
decreases expression
ISO fulvestrant inhibits the reaction [Estradiol results in increased expression of PDZK1 mRNA]
fulvestrant results in decreased expression of PDZK1 mRNA
CTD PMID:14605097, PMID:26865669 NCBI chr 2:198,965,685...198,999,323
Ensembl chr 2:198,965,685...198,999,323
JBrowse link
G Per1 period circadian regulator 1 multiple interactions EXP fulvestrant inhibits the reaction [Estradiol results in increased expression of PER1 mRNA] CTD PMID:17761890 NCBI chr10:55,681,761...55,696,557
Ensembl chr10:55,687,050...55,695,994
JBrowse link
G Pgr progesterone receptor multiple interactions
decreases expression
ISO
EXP
Fulvestrant binds to and results in decreased activity of PGR protein; Fulvestrant inhibits the reaction [1,7-diphenyl-5-heptene-3-one results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PGR protein alternative form]; Fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [4,4'-hexafluorisopropylidene diphenol results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [4-hydroxy-equilenin results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [alternariol results in increased expression of PGR protein]; Fulvestrant inhibits the reaction [arsenite results in increased expression of PGR protein]; Fulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [bifenthrin results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [bis(4-hydroxyphenyl)sulfone results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [bisphenol A analog results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [chromous chloride results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [chromous chloride results in increased expression of PGR protein]; Fulvestrant inhibits the reaction [cobaltous chloride results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [cobaltous chloride results in increased expression of PGR protein]; Fulvestrant inhibits the reaction [cupric chloride results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [cupric chloride results in increased expression of PGR protein]; Fulvestrant inhibits the reaction [CXCL12 protein results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [desmethylicaritin results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [Diarylheptanoids results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [Diethylstilbestrol results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of PGR protein alternative form]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of PGR protein alternative form]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of PGR protein]; Fulvestrant inhibits the reaction [Estrogens results in increased expression of PGR protein alternative form]; Fulvestrant inhibits the reaction [Estrone results in decreased expression of PGR protein alternative form]; Fulvestrant inhibits the reaction [gamma-terpinene results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [icariin results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [icaritin results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [isobavachin results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [isobavachin results in increased expression of PGR protein]; Fulvestrant inhibits the reaction [lead chloride results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [lead chloride results in increased expression of PGR protein]; Fulvestrant inhibits the reaction [Limonene results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [linalool results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [linalyl acetate results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [Mercuric Chloride results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [Mercuric Chloride results in increased expression of PGR protein]; Fulvestrant inhibits the reaction [Mycotoxins results in increased expression of PGR protein]; Fulvestrant inhibits the reaction [nickel chloride results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [nickel chloride results in increased expression of PGR protein]; Fulvestrant inhibits the reaction [o,p'-DDT results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [pentabrominated diphenyl ether 100 results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [Tea Tree Oil results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [terpinenol-4 results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [Vanadates results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [Vanadates results in increased expression of PGR protein]; Fulvestrant inhibits the reaction [zearalenol results in increased expression of PGR protein]; Fulvestrant inhibits the reaction [Zearalenone results in increased expression of PGR protein]
Fulvestrant results in decreased expression of PGR mRNA
fulvestrant inhibits the reaction [bisphenol A results in increased expression of PGR protein]; fulvestrant inhibits the reaction [butylparaben results in increased expression of PGR mRNA]; fulvestrant inhibits the reaction [butylparaben results in increased expression of PGR protein]; fulvestrant inhibits the reaction [Cadmium Chloride results in increased expression of PGR mRNA]; fulvestrant inhibits the reaction [Estradiol results in decreased expression of PGR mRNA]; fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of PGR mRNA]; fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of PGR protein]; fulvestrant inhibits the reaction [isobutylparaben results in increased expression of PGR protein]; fulvestrant inhibits the reaction [isopropyl 4-hydroxybenzoate results in increased expression of PGR mRNA]; fulvestrant inhibits the reaction [isopropyl 4-hydroxybenzoate results in increased expression of PGR protein]
bisphenol A promotes the reaction [Fulvestrant results in decreased expression of PGR mRNA]; Estradiol promotes the reaction [Fulvestrant results in decreased expression of PGR mRNA]; Fulvestrant affects the reaction [Chlordecone results in increased expression of PGR mRNA]; Fulvestrant promotes the reaction [Estradiol results in decreased expression of PGR mRNA]
fulvestrant results in decreased expression of PGR mRNA; fulvestrant results in decreased expression of PGR protein
CTD PMID:9607801, PMID:10411312, PMID:11014213, PMID:11391616, PMID:11867264, PMID:12746304, PMID:12858169, PMID:15072547, PMID:15319301, PMID:15541416, PMID:15806153, PMID:16323292, PMID:16892383, PMID:17872378, PMID:19584281, PMID:19654335, PMID:19654927, PMID:20179196, PMID:20206645, PMID:20540524, PMID:20543978, PMID:21803136, PMID:23209616, PMID:23211298, PMID:23665424, PMID:24938463, PMID:25752796, PMID:26865669, PMID:29389661, PMID:30061528, PMID:30796839, PMID:31393563 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 increases expression ISO fulvestrant results in increased expression of PIK3R3 mRNA CTD PMID:26865669 NCBI chr 5:135,069,972...135,145,633
Ensembl chr 5:135,074,297...135,142,488
JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase increases expression ISO fulvestrant results in increased expression of PIM1 mRNA CTD PMID:16298037 NCBI chr20:8,165,423...8,169,557
Ensembl chr20:8,165,307...8,169,555
JBrowse link
G Pitx1 paired-like homeodomain 1 multiple interactions ISO fulvestrant inhibits the reaction [Genistein results in decreased expression of PITX1 mRNA]; fulvestrant inhibits the reaction [Genistein results in increased expression of PITX1 mRNA] CTD PMID:21810550, PMID:22553218 NCBI chr17:8,873,184...8,884,428
Ensembl chr17:8,878,270...8,884,423
JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions ISO fulvestrant inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PKM mRNA]; fulvestrant inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PKM protein] CTD PMID:28284859 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions
decreases expression
ISO fulvestrant inhibits the reaction [EGF protein results in increased expression of PLAUR protein]
fulvestrant results in decreased expression of PLAUR mRNA
CTD PMID:19395996, PMID:26865669 NCBI chr 1:81,328,171...81,344,954
Ensembl chr 1:81,328,183...81,344,708
JBrowse link
G Plekhf2 pleckstrin homology and FYVE domain containing 2 increases expression ISO fulvestrant results in increased expression of PLEKHF2 mRNA CTD PMID:26865669 NCBI chr 5:24,240,241...24,255,922
Ensembl chr 5:24,240,242...24,255,606
JBrowse link
G Plk1 polo-like kinase 1 multiple interactions ISO Fulvestrant inhibits the reaction [Estradiol results in increased expression of PLK1 protein]; Fulvestrant promotes the reaction [RB1 protein binds to PLK1 promoter]; Fulvestrant promotes the reaction [SIN3B protein binds to PLK1 promoter]; RB1 mutant form inhibits the reaction [Fulvestrant promotes the reaction [SIN3B protein binds to PLK1 promoter]] CTD PMID:20208560, PMID:21367843 NCBI chr 1:192,115,990...192,125,969
Ensembl chr 1:192,115,966...192,125,989
JBrowse link
G Polr2b RNA polymerase II subunit B decreases expression ISO fulvestrant results in decreased expression of POLR2B mRNA CTD PMID:16514628 NCBI chr14:33,070,104...33,107,792
Ensembl chr14:33,070,078...33,107,776
JBrowse link
G Pomc proopiomelanocortin multiple interactions EXP fulvestrant inhibits the reaction [nonylphenol promotes the reaction [POMC protein modified form results in increased secretion of Corticosterone]] CTD PMID:20837582 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Pou5f1 POU class 5 homeobox 1 multiple interactions ISO fulvestrant inhibits the reaction [Estradiol results in increased expression of POU5F1 mRNA] CTD PMID:22132214 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO fulvestrant inhibits the reaction [Diethylstilbestrol results in increased activity of PPARG protein]; fulvestrant inhibits the reaction [Diosgenin results in decreased expression of PPARG mRNA] CTD PMID:22710028, PMID:26408789 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO
EXP
Fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [PPARGC1A protein binds to CYP11A1 gene]]; Fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [PPARGC1A protein binds to HSD3B gene]]; Fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to PPARGC1A protein]]]
fulvestrant inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to PPARGC1A protein]]
CTD PMID:18511507 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D decreases expression ISO fulvestrant results in decreased expression of PPM1D mRNA CTD PMID:16514628 NCBI chr10:72,909,550...72,945,884
Ensembl chr10:72,909,550...72,945,884
JBrowse link
G Ppp1r9b protein phosphatase 1, regulatory subunit 9B multiple interactions EXP fulvestrant inhibits the reaction [Dinoprostone results in decreased expression of PPP1R9B protein] CTD PMID:23054057 NCBI chr10:82,800,704...82,816,735
Ensembl chr10:82,800,704...82,816,731
JBrowse link
G Prf1 perforin 1 decreases expression
increases expression
ISO Fulvestrant results in decreased expression of PRF1 mRNA; Fulvestrant results in decreased expression of PRF1 protein
[fulvestrant results in increased expression of TGFB1 protein] which results in increased expression of PRF1 mRNA
CTD PMID:20145137 NCBI chr20:30,915,294...30,920,804
Ensembl chr20:30,915,213...30,921,382
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit decreases expression ISO fulvestrant results in decreased expression of PRKDC mRNA CTD PMID:16514628 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
JBrowse link
G Prl prolactin multiple interactions
decreases expression
decreases secretion
ISO
EXP
[fulvestrant co-treated with Estradiol] results in increased secretion of PRL protein
Fulvestrant results in decreased expression of PRL mRNA; Fulvestrant results in decreased expression of PRL protein
fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of and results in increased secretion of PRL protein]; fulvestrant inhibits the reaction [4-nonylphenol results in increased expression of PRL mRNA]; fulvestrant inhibits the reaction [4-nonylphenol results in increased secretion of PRL protein]; fulvestrant inhibits the reaction [4-octylphenol results in increased expression of PRL mRNA]; fulvestrant inhibits the reaction [4-octylphenol results in increased secretion of PRL protein]; fulvestrant inhibits the reaction [bisphenol A results in increased expression of PRL mRNA]; fulvestrant inhibits the reaction [bisphenol A results in increased secretion of PRL protein]; fulvestrant inhibits the reaction [Cadmium Chloride results in increased expression of PRL mRNA]; fulvestrant inhibits the reaction [Cadmium results in increased expression of PRL mRNA]; fulvestrant inhibits the reaction [Estradiol results in increased expression of and results in increased secretion of PRL protein]
fulvestrant results in decreased secretion of PRL protein
CTD PMID:15950373, PMID:17909072, PMID:19463694, PMID:20419096, PMID:24236210 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Prss23 serine protease 23 decreases expression ISO fulvestrant results in decreased expression of PRSS23 mRNA CTD PMID:26865669 NCBI chr 1:153,732,528...153,742,111
Ensembl chr 1:153,732,532...153,752,541
JBrowse link
G Psen1 presenilin 1 multiple interactions EXP fulvestrant inhibits the reaction [Trenbolone Acetate analog results in decreased expression of PSEN1 protein] CTD PMID:25461682 NCBI chr 6:107,169,514...107,221,000
Ensembl chr 6:107,169,528...107,216,798
JBrowse link
G Psmd14 proteasome 26S subunit, non-ATPase 14 decreases expression ISO fulvestrant results in decreased expression of PSMD14 mRNA CTD PMID:16514628 NCBI chr 3:47,578,449...47,673,330
Ensembl chr 3:47,578,384...47,673,338
JBrowse link
G Psmd6 proteasome 26S subunit, non-ATPase 6 decreases expression ISO fulvestrant results in decreased expression of PSMD6 mRNA CTD PMID:16514628 NCBI chr15:12,407,557...12,416,153
Ensembl chr15:12,407,524...12,416,105
JBrowse link
G Psme4 proteasome activator subunit 4 decreases expression ISO fulvestrant results in decreased expression of PSME4 mRNA CTD PMID:16514628 NCBI chr14:115,166,165...115,269,041
Ensembl chr14:115,166,416...115,269,056
JBrowse link
G Ptch1 patched 1 multiple interactions EXP fulvestrant inhibits the reaction [Ethinyl Estradiol results in decreased expression of PTCH1 mRNA] CTD PMID:17109907 NCBI chr17:1,032,242...1,085,885
Ensembl chr17:1,029,048...1,093,873
JBrowse link
G Pten phosphatase and tensin homolog increases response to substance
multiple interactions
ISO PTEN protein results in increased susceptibility to fulvestrant
fulvestrant inhibits the reaction [Quercetin results in increased expression of PTEN protein]
CTD PMID:19435893, PMID:21732360 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptger4 prostaglandin E receptor 4 multiple interactions ISO fulvestrant inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of PTGER4 mRNA]] CTD PMID:24771768 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448
JBrowse link
G Ptges prostaglandin E synthase decreases expression ISO fulvestrant results in decreased expression of PTGES mRNA CTD PMID:26865669 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Fulvestrant inhibits the reaction [bisphenol F results in increased expression of PTGS2 mRNA]; Fulvestrant inhibits the reaction [bisphenol F results in increased expression of PTGS2 protein]; Fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]
Fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PTGS2 protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of PTGS2 mRNA]; Fulvestrant inhibits the reaction [Hexachlorobenzene results in increased expression of PTGS2 protein]; Fulvestrant promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PTGS2 mRNA]; Fulvestrant promotes the reaction [Chlorpyrifos results in increased expression of PTGS2 protein]
CTD PMID:15256495, PMID:20951759, PMID:21513769, PMID:26546977, PMID:32044397, PMID:32526215 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2 protein tyrosine kinase 2 increases degradation ISO fulvestrant results in increased degradation of PTK2 protein CTD PMID:24440569 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Ptprg protein tyrosine phosphatase, receptor type, G multiple interactions ISO Fulvestrant inhibits the reaction [afimoxifene results in increased expression of PTPRG mRNA] CTD PMID:16849584 NCBI chr15:12,926,056...13,633,839
Ensembl chr15:12,926,167...13,228,607
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin multiple interactions
decreases expression
ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of PTTG1 mRNA
fulvestrant results in decreased expression of PTTG1 mRNA; fulvestrant results in decreased expression of PTTG1 protein
CTD PMID:18984771, PMID:19016759 NCBI chr10:29,014,332...29,026,088
Ensembl chr10:29,020,049...29,026,002
JBrowse link
G Rab2a RAB2A, member RAS oncogene family increases expression ISO fulvestrant results in increased expression of RAB2A mRNA CTD PMID:12154049 NCBI chr 5:21,632,654...21,696,721
Ensembl chr 5:21,632,926...21,695,519
JBrowse link
G Rab30 RAB30, member RAS oncogene family multiple interactions ISO Fulvestrant inhibits the reaction [afimoxifene results in increased expression of RAB30 mRNA] CTD PMID:16849584 NCBI chr 1:157,573,344...157,667,973
Ensembl chr 1:157,573,324...157,660,008
JBrowse link
G Racgap1 Rac GTPase-activating protein 1 decreases expression ISO fulvestrant results in decreased expression of RACGAP1 mRNA CTD PMID:16514628 NCBI chr 7:141,277,303...141,308,849
Ensembl chr 7:141,277,312...141,307,233
JBrowse link
G Rad51 RAD51 recombinase multiple interactions
decreases expression
ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of RAD51 mRNA
fulvestrant results in decreased expression of RAD51 mRNA
CTD PMID:19016759 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family decreases expression ISO fulvestrant results in decreased expression of RAP1A mRNA CTD PMID:16514628 NCBI chr 2:208,193,950...208,215,186
Ensembl chr 2:208,193,954...208,215,187
JBrowse link
G Rapgefl1 Rap guanine nucleotide exchange factor like 1 decreases expression ISO fulvestrant results in decreased expression of RAPGEFL1 mRNA CTD PMID:26865669 NCBI chr10:86,749,220...86,765,677
Ensembl chr10:86,763,117...86,765,675
JBrowse link
G Rarres2 retinoic acid receptor responder 2 multiple interactions ISO fulvestrant inhibits the reaction [bisphenol A results in decreased expression of and results in decreased secretion of RARRES2 protein]; fulvestrant inhibits the reaction [tetrabromobisphenol A results in decreased expression of and results in decreased secretion of RARRES2 protein]; fulvestrant inhibits the reaction [tetrachlorodian results in decreased expression of and results in decreased secretion of RARRES2 protein] CTD PMID:29653259 NCBI chr 4:78,205,809...78,208,956
Ensembl chr 4:78,205,812...78,208,767
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
decreases phosphorylation
ISO [CDK6 affects the susceptibility to Fulvestrant] which affects the phosphorylation of RB1 protein; Fulvestrant inhibits the reaction [bis(4-hydroxyphenyl)sulfone results in increased phosphorylation of RB1 protein]; Fulvestrant promotes the reaction [RB1 protein binds to CCNA2 promoter]; Fulvestrant promotes the reaction [RB1 protein binds to PLK1 promoter]; Fulvestrant promotes the reaction [RB1 protein binds to RNR2 promoter]; RB1 mutant form inhibits the reaction [Fulvestrant promotes the reaction [SIN3B protein binds to CCNA2 promoter]]; RB1 mutant form inhibits the reaction [Fulvestrant promotes the reaction [SIN3B protein binds to PLK1 promoter]]; RB1 mutant form inhibits the reaction [Fulvestrant promotes the reaction [SIN3B protein binds to RNR2 promoter]]
fulvestrant results in decreased phosphorylation of RB1 protein
CTD PMID:21367843, PMID:24169358, PMID:30684532 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rbbp7 RB binding protein 7, chromatin remodeling factor decreases expression ISO fulvestrant results in decreased expression of RBBP7 mRNA CTD PMID:16514628 NCBI chr  X:33,648,682...33,665,821
Ensembl chr  X:33,648,682...33,665,821
JBrowse link
G Rbbp8 RB binding protein 8, endonuclease decreases expression ISO fulvestrant results in decreased expression of RBBP8 mRNA CTD PMID:26865669 NCBI chr18:3,134,630...3,227,702
Ensembl chr18:3,162,543...3,227,688
JBrowse link
G Rcl1 RNA terminal phosphate cyclase-like 1 decreases expression ISO fulvestrant results in decreased expression of RCL1 mRNA CTD PMID:26865669 NCBI chr 1:247,228,012...247,272,369
Ensembl chr 1:247,228,061...247,305,693
JBrowse link
G Rcor1 REST corepressor 1 multiple interactions ISO fulvestrant inhibits the reaction [[TNF protein co-treated with resveratrol] promotes the reaction [RCOR1 protein binds to IL6 promoter]] CTD PMID:24771768 NCBI chr 6:135,475,470...135,552,155
Ensembl chr 6:135,513,650...135,548,201
Ensembl chr 6:135,513,650...135,548,201
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO fulvestrant inhibits the reaction [[TNF protein co-treated with resveratrol] promotes the reaction [RELA protein modified form binds to IL6 promoter]]; fulvestrant inhibits the reaction [bisphenol A results in increased expression of RELA protein]; fulvestrant inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased phosphorylation of RELA protein]
Fulvestrant inhibits the reaction [sodium arsenite results in increased expression of RELA mRNA]; Fulvestrant inhibits the reaction [sodium arsenite results in increased expression of RELA protein]
CTD PMID:24771768, PMID:27522653, PMID:28390675, PMID:30684567 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rerg RAS-like, estrogen-regulated, growth-inhibitor affects response to substance ISO RERG affects the susceptibility to fulvestrant CTD PMID:24169358 NCBI chr 4:171,069,161...171,176,678
Ensembl chr 4:171,069,191...171,176,581
JBrowse link
G Ret ret proto-oncogene decreases expression ISO fulvestrant results in decreased expression of RET mRNA CTD PMID:26865669 NCBI chr 4:150,202,170...150,249,196
Ensembl chr 4:150,202,058...150,244,372
JBrowse link
G Retn resistin multiple interactions ISO fulvestrant inhibits the reaction [octylphenol results in increased expression of RETN mRNA] CTD PMID:18417718 NCBI chr12:2,201,909...2,203,649
Ensembl chr12:2,201,891...2,204,249
JBrowse link
G Rhbdf1 rhomboid 5 homolog 1 increases expression ISO fulvestrant results in increased expression of RHBDF1 mRNA CTD PMID:26865669 NCBI chr10:15,672,370...15,685,285
Ensembl chr10:15,672,382...15,685,284
JBrowse link
G Rnf4 ring finger protein 4 multiple interactions ISO fulvestrant inhibits the reaction [Diethylstilbestrol results in increased expression of RNF4 mRNA] CTD PMID:14749358 NCBI chr14:81,658,400...81,679,756
Ensembl chr14:81,660,354...81,679,082
JBrowse link
G Rpl6 ribosomal protein L6 decreases expression ISO fulvestrant results in decreased expression of RPL6 mRNA CTD PMID:16514628 NCBI chr12:40,877,578...40,882,032
Ensembl chr12:40,877,613...40,881,124
JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 decreases expression ISO fulvestrant results in decreased expression of RRM1 mRNA CTD PMID:16514628 NCBI chr 1:167,538,387...167,562,688
Ensembl chr 1:167,538,263...167,562,688
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO
EXP
fulvestrant inhibits the reaction [Estradiol results in increased expression of RUNX2 mRNA]; fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of RUNX2 mRNA]; fulvestrant inhibits the reaction [resveratrol results in increased expression of RUNX2 mRNA]
fulvestrant inhibits the reaction [naringin results in increased expression of RUNX2 mRNA]
CTD PMID:17689939, PMID:23596885, PMID:26362186 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G S100g S100 calcium binding protein G multiple interactions ISO
EXP
Fulvestrant inhibits the reaction [bisphenol A results in increased expression of S100G mRNA]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of S100G protein]; Fulvestrant inhibits the reaction [nonylphenol results in increased expression of S100G mRNA]; Fulvestrant inhibits the reaction [nonylphenol results in increased expression of S100G protein]; Fulvestrant inhibits the reaction [octylphenol results in increased expression of S100G mRNA]; Fulvestrant inhibits the reaction [octylphenol results in increased expression of S100G protein]; Fulvestrant inhibits the reaction [Progesterone results in increased expression of S100G mRNA]
fulvestrant inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of S100G mRNA]; fulvestrant inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of S100G protein]; fulvestrant inhibits the reaction [bisphenol A results in increased expression of S100G mRNA]; fulvestrant inhibits the reaction [bisphenol A results in increased expression of S100G protein]; fulvestrant inhibits the reaction [butylparaben results in increased expression of S100G mRNA]; fulvestrant inhibits the reaction [butylparaben results in increased expression of S100G protein]; fulvestrant inhibits the reaction [Estradiol results in increased expression of S100G mRNA]; fulvestrant inhibits the reaction [Estradiol results in increased expression of S100G protein]; fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of S100G mRNA]; fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of S100G protein]; fulvestrant inhibits the reaction [isobutylparaben results in increased expression of S100G protein]; fulvestrant inhibits the reaction [isopropyl 4-hydroxybenzoate results in increased expression of S100G mRNA]; fulvestrant inhibits the reaction [isopropyl 4-hydroxybenzoate results in increased expression of S100G protein]; fulvestrant inhibits the reaction [nonylphenol results in increased expression of S100G mRNA]; fulvestrant inhibits the reaction [octylphenol results in increased expression of S100G mRNA]; fulvestrant inhibits the reaction [Triclosan results in increased expression of S100G mRNA]; fulvestrant inhibits the reaction [Triclosan results in increased expression of S100G protein]
CTD PMID:15509668, PMID:17361017, PMID:17504770, PMID:19654335, PMID:22062131, PMID:23211298, PMID:23261820 NCBI chr  X:33,442,820...33,445,714
Ensembl chr  X:33,443,186...33,445,709
JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma multiple interactions ISO fulvestrant inhibits the reaction [bisphenol A results in decreased expression of SCNN1G protein] CTD PMID:27522653 NCBI chr 1:191,704,397...191,738,271
Ensembl chr 1:191,704,311...191,738,268
JBrowse link
G Serpinb2 serpin family B member 2 increases expression ISO fulvestrant results in increased expression of SERPINB2 mRNA CTD PMID:16298037 NCBI chr13:27,449,907...27,463,015
Ensembl chr13:27,449,934...27,463,010
JBrowse link
G Serpinb9 serpin family B member 9 multiple interactions ISO fulvestrant inhibits the reaction [Estradiol results in increased expression of SERPINB9 mRNA]; fulvestrant inhibits the reaction [moxestrol results in increased expression of SERPINB9 mRNA] CTD PMID:10681578, PMID:17237823 NCBI chr17:32,648,846...32,673,047
Ensembl chr17:32,650,441...32,661,865
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO Fulvestrant inhibits the reaction [bisphenol A results in increased secretion of SERPINE1 protein] CTD PMID:31230753 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sfpq splicing factor proline and glutamine rich decreases expression ISO fulvestrant results in decreased expression of SFPQ mRNA CTD PMID:16514628 NCBI chr 5:145,079,803...145,088,517
Ensembl chr 5:145,079,803...145,088,498
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 decreases expression
multiple interactions
ISO fulvestrant results in decreased expression of SGK1 mRNA
Fulvestrant inhibits the reaction [bisphenol A results in decreased expression of SGK1 protein]
CTD PMID:26865669, PMID:29605410 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Sgk3 serum/glucocorticoid regulated kinase family, member 3 decreases expression ISO fulvestrant results in decreased expression of SGK3 mRNA CTD PMID:26865669 NCBI chr 5:9,046,889...9,094,740
Ensembl chr 5:9,048,614...9,094,616
JBrowse link
G Siah2 siah E3 ubiquitin protein ligase 2 decreases expression ISO fulvestrant results in decreased expression of SIAH2 mRNA CTD PMID:26865669 NCBI chr 2:148,874,151...148,891,900
Ensembl chr 2:148,874,151...148,891,900
JBrowse link
G Sin3b SIN3 transcription regulator family member B multiple interactions ISO Fulvestrant promotes the reaction [SIN3B protein binds to CCNA2 promoter]; Fulvestrant promotes the reaction [SIN3B protein binds to PLK1 promoter]; Fulvestrant promotes the reaction [SIN3B protein binds to RNR2 promoter]; RB1 mutant form inhibits the reaction [Fulvestrant promotes the reaction [SIN3B protein binds to CCNA2 promoter]]; RB1 mutant form inhibits the reaction [Fulvestrant promotes the reaction [SIN3B protein binds to PLK1 promoter]]; RB1 mutant form inhibits the reaction [Fulvestrant promotes the reaction [SIN3B protein binds to RNR2 promoter]] CTD PMID:21367843 NCBI chr16:18,842,456...18,860,086
Ensembl chr16:18,842,456...18,860,086
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO fulvestrant inhibits the reaction [[TNF protein co-treated with resveratrol] promotes the reaction [SIRT1 protein binds to IL6 promoter]] CTD PMID:24771768 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Six1 SIX homeobox 1 multiple interactions ISO fulvestrant inhibits the reaction [Genistein results in decreased expression of SIX1 mRNA] CTD PMID:21810550 NCBI chr 6:95,929,060...95,934,296
Ensembl chr 6:95,929,060...95,934,296
JBrowse link
G Skil SKI-like proto-oncogene multiple interactions ISO fulvestrant inhibits the reaction [bisphenol A results in increased expression of SKIL protein]; fulvestrant inhibits the reaction [Estradiol results in increased expression of SKIL protein]; fulvestrant inhibits the reaction [nonylphenol results in increased expression of SKIL protein] CTD PMID:26407941 NCBI chr 2:115,862,932...115,891,304
Ensembl chr 2:115,866,701...115,891,097
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions EXP fulvestrant inhibits the reaction [bisphenol A results in decreased expression of SLC16A1 protein] CTD PMID:27364615 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions
increases expression
EXP fulvestrant inhibits the reaction [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in increased expression of SLC1A2 protein]; fulvestrant inhibits the reaction [diarylpropionitrile results in increased expression of SLC1A2 protein]
fulvestrant results in increased expression of SLC1A2 protein
CTD PMID:24782323 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644
JBrowse link
G Slc25a5 solute carrier family 25 member 5 multiple interactions ISO fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of SLC25A5 mRNA] CTD PMID:16467188 NCBI chr  X:123,404,570...123,407,637
Ensembl chr  X:123,404,518...123,407,645
JBrowse link
G Slc26a2 solute carrier family 26 member 2 decreases expression ISO fulvestrant results in decreased expression of SLC26A2 mRNA CTD PMID:16514628 NCBI chr18:56,518,999...56,534,539
Ensembl chr18:56,520,740...56,534,415
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP fulvestrant inhibits the reaction [[resveratrol results in increased localization of SLC2A4 protein] which results in increased uptake of Glucose] CTD PMID:18426865 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slc39a6 solute carrier family 39 member 6 decreases expression ISO fulvestrant results in decreased expression of SLC39A6 mRNA CTD PMID:16514628 NCBI chr18:16,523,450...16,543,992
Ensembl chr18:16,522,982...16,543,992
JBrowse link
G Slc7a5 solute carrier family 7 member 5 decreases expression ISO fulvestrant results in decreased expression of SLC7A5 mRNA CTD PMID:26865669 NCBI chr19:54,693,959...54,722,563
Ensembl chr19:54,693,959...54,722,563
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions EXP Fulvestrant inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 protein] CTD PMID:27090119 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor multiple interactions ISO fulvestrant inhibits the reaction [Genistein results in increased expression of SLPI mRNA] CTD PMID:22553218 NCBI chr 3:160,799,979...160,802,228
Ensembl chr 3:160,799,981...160,802,433
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO fulvestrant inhibits the reaction [4-nonylphenol results in decreased phosphorylation of SMAD3 protein]; fulvestrant inhibits the reaction [benzophenone results in decreased phosphorylation of SMAD3 protein]; fulvestrant inhibits the reaction [bisphenol A results in decreased phosphorylation of SMAD3 protein]; fulvestrant inhibits the reaction [Estradiol results in decreased phosphorylation of SMAD3 protein]; fulvestrant inhibits the reaction [nonylphenol results in decreased phosphorylation of SMAD3 protein] CTD PMID:24308608, PMID:26407941 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 decreases expression ISO fulvestrant results in decreased expression of SMARCA4 protein CTD PMID:24169358 NCBI chr 8:22,648,323...22,739,468
Ensembl chr 8:22,648,323...22,739,468
JBrowse link
G Smarcb1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 increases expression ISO fulvestrant results in increased expression of SMARCB1 protein CTD PMID:24169358 NCBI chr20:13,679,955...13,702,821
Ensembl chr20:13,680,716...13,704,931
JBrowse link
G Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 increases expression ISO fulvestrant results in increased expression of SMARCC1 protein CTD PMID:24169358 NCBI chr 8:118,206,678...118,326,264
Ensembl chr 8:118,206,698...118,325,537
JBrowse link
G Smarcc2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 decreases expression ISO fulvestrant results in decreased expression of SMARCC2 protein CTD PMID:24169358 NCBI chr 7:2,875,898...2,905,463
Ensembl chr 7:2,875,909...2,904,453
JBrowse link
G Smox spermine oxidase decreases expression ISO fulvestrant results in decreased expression of SMOX mRNA CTD PMID:26865669 NCBI chr 3:124,068,796...124,103,726
Ensembl chr 3:124,068,865...124,102,240
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO fulvestrant inhibits the reaction [2,4-dihydroxybenzophenone results in increased expression of SNAI1 protein]; fulvestrant inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SNAI1 mRNA]; fulvestrant inhibits the reaction [4-tert-octylphenol results in increased expression of SNAI1 protein]; fulvestrant inhibits the reaction [bisphenol A results in increased expression of SNAI1 mRNA]; fulvestrant inhibits the reaction [bisphenol A results in increased expression of SNAI1 protein]; fulvestrant inhibits the reaction [Estradiol results in increased expression of SNAI1 mRNA]; fulvestrant inhibits the reaction [Estradiol results in increased expression of SNAI1 protein]; fulvestrant inhibits the reaction [fludioxonil results in increased expression of SNAI1 protein]; fulvestrant inhibits the reaction [nonylphenol results in increased expression of SNAI1 mRNA]; fulvestrant inhibits the reaction [nonylphenol results in increased expression of SNAI1 protein]; fulvestrant inhibits the reaction [Triclosan results in increased expression of SNAI1 protein] CTD PMID:25690688, PMID:27145024, PMID:27480627, PMID:27539251, PMID:28284859, PMID:28844962 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions ISO fulvestrant inhibits the reaction [2,4-dihydroxybenzophenone results in increased expression of SNAI2 protein]; fulvestrant inhibits the reaction [4-tert-octylphenol results in increased expression of SNAI2 protein]; fulvestrant inhibits the reaction [bisphenol A results in increased expression of SNAI2 mRNA]; fulvestrant inhibits the reaction [bisphenol A results in increased expression of SNAI2 protein]; fulvestrant inhibits the reaction [Estradiol results in increased expression of SNAI2 mRNA]; fulvestrant inhibits the reaction [Estradiol results in increased expression of SNAI2 protein]; fulvestrant inhibits the reaction [nonylphenol results in increased expression of SNAI2 mRNA]; fulvestrant inhibits the reaction [Triclosan results in increased expression of SNAI2 protein] CTD PMID:25690688, PMID:27145024, PMID:28844962 NCBI chr11:90,404,421...90,406,730
Ensembl chr11:90,403,333...90,406,797
JBrowse link
G Socs1 suppressor of cytokine signaling 1 multiple interactions ISO Fulvestrant inhibits the reaction [afimoxifene results in increased expression of SOCS1 mRNA] CTD PMID:16849584 NCBI chr10:4,956,795...4,958,472
Ensembl chr10:4,957,326...4,958,461
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions
decreases expression
ISO Fulvestrant inhibits the reaction [Estradiol results in increased expression of SOCS3 mRNA]; Fulvestrant inhibits the reaction [Genistein results in increased expression of SOCS3 mRNA]
Fulvestrant results in decreased expression of SOCS3 protein
Fulvestrant inhibits the reaction [bisphenol F results in increased expression of SOCS3 mRNA]; Fulvestrant inhibits the reaction [bisphenol F results in increased expression of SOCS3 protein]
CTD PMID:16055089, PMID:32044397 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO fulvestrant results in increased expression of SOD1 mRNA CTD PMID:12154049 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP
ISO
fulvestrant inhibits the reaction [Estradiol results in increased expression of SOD2 mRNA]; fulvestrant inhibits the reaction [San'o-shashin-to affects the activity of SOD2 protein]
fulvestrant inhibits the reaction [Coumestrol results in increased expression of SOD2 protein]; fulvestrant inhibits the reaction [daidzein results in increased expression of SOD2 protein]; fulvestrant inhibits the reaction [Estradiol results in increased expression of SOD2 protein]; fulvestrant inhibits the reaction [Genistein results in increased expression of SOD2 protein]; fulvestrant inhibits the reaction [kaempferol results in increased expression of SOD2 protein]; fulvestrant inhibits the reaction [polydatin results in increased expression of SOD2 protein]; fulvestrant inhibits the reaction [pterostilbene results in increased expression of SOD2 protein]; fulvestrant inhibits the reaction [resveratrol results in increased expression of SOD2 protein]
fulvestrant inhibits the reaction [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol inhibits the reaction [Glucose results in decreased expression of and results in decreased activity of SOD2 protein]]
CTD PMID:12816884, PMID:20962025, PMID:21215799, PMID:23526725, PMID:23615023, PMID:24361291 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions EXP fulvestrant inhibits the reaction [Estradiol results in increased expression of SOD3 mRNA] CTD PMID:12816884 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Son SON DNA and RNA binding protein decreases expression ISO fulvestrant results in decreased expression of SON mRNA CTD PMID:16514628 NCBI chr11:31,806,598...31,837,769
Ensembl chr11:31,806,618...31,837,763
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO fulvestrant promotes the reaction [SP1 protein binds to ESRRA promoter] CTD PMID:20211987 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Sp3 Sp3 transcription factor multiple interactions ISO fulvestrant promotes the reaction [SP3 protein binds to ESRRA promoter] CTD PMID:20211987 NCBI chr 3:59,644,579...59,689,011
Ensembl chr 3:59,646,015...59,688,692
JBrowse link
G Sp7 Sp7 transcription factor multiple interactions ISO
EXP
fulvestrant inhibits the reaction [Estradiol results in increased expression of SP7 mRNA]; fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of SP7 mRNA]; fulvestrant inhibits the reaction [resveratrol results in increased expression of SP7 mRNA]
fulvestrant inhibits the reaction [naringin results in increased expression of SP7 mRNA]
CTD PMID:17689939, PMID:23596885, PMID:26362186 NCBI chr 7:143,957,316...143,967,488
Ensembl chr 7:143,958,858...143,967,484
JBrowse link
G Sparc secreted protein acidic and cysteine rich multiple interactions ISO fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of SPARC mRNA] CTD PMID:26362186 NCBI chr10:40,742,390...40,764,232
Ensembl chr10:40,742,400...40,764,185
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP fulvestrant inhibits the reaction [naringin results in increased secretion of SPP1 protein] CTD PMID:23596885 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO Fulvestrant inhibits the reaction [butylbenzyl phthalate results in increased phosphorylation of SRC protein]; Fulvestrant inhibits the reaction [Dibutyl Phthalate results in increased phosphorylation of SRC protein] CTD PMID:22552774 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Srsf1 serine and arginine rich splicing factor 1 decreases expression ISO fulvestrant results in decreased expression of SRSF1 mRNA CTD PMID:16514628 NCBI chr10:75,334,200...75,341,197
Ensembl chr10:75,335,146...75,341,197
JBrowse link
G Ssbp2 single-stranded DNA binding protein 2 increases expression ISO fulvestrant results in increased expression of SSBP2 mRNA CTD PMID:26865669 NCBI chr 2:20,416,795...20,707,838
Ensembl chr 2:20,431,243...20,702,515
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP
ISO
fulvestrant inhibits the reaction [Estradiol results in decreased expression of STAR mRNA]
Fulvestrant inhibits the reaction [bisphenol A results in increased expression of STAR protein]
CTD PMID:23209616, PMID:30206973 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression ISO fulvestrant results in decreased expression of STAT1 mRNA CTD PMID:16514628 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases phosphorylation
ISO Fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of STAT3 mRNA]; Fulvestrant inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of STAT3 protein modified form]; Fulvestrant inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of STAT3 protein]; Fulvestrant inhibits the reaction [luteolin-7-O-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of STAT3 protein]]
Fulvestrant inhibits the reaction [bisphenol F results in increased phosphorylation of STAT3 protein]
Fulvestrant results in decreased phosphorylation of STAT3 protein
CTD PMID:28284859, PMID:29362861, PMID:31381935, PMID:32044397 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Stk26 serine/threonine kinase 26 decreases expression ISO fulvestrant results in decreased expression of STK26 mRNA CTD PMID:16514628 NCBI chr  X:138,032,356...138,096,632
Ensembl chr  X:138,046,494...138,096,669
JBrowse link
G Stk39 serine threonine kinase 39 multiple interactions ISO fulvestrant inhibits the reaction [Estradiol results in increased expression of STK39 mRNA] CTD PMID:17131305 NCBI chr 3:54,359,449...54,625,702
Ensembl chr 3:54,359,451...54,625,414
JBrowse link
G Stmn1 stathmin 1 decreases expression ISO fulvestrant results in decreased expression of STMN1 mRNA CTD PMID:16514628 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 multiple interactions ISO fulvestrant inhibits the reaction [ESR1 protein binds to STUB1 protein] CTD PMID:16037132 NCBI chr10:15,197,754...15,200,035
Ensembl chr10:15,197,803...15,200,117
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 multiple interactions EXP fulvestrant inhibits the reaction [Estradiol results in decreased expression of SULT1E1 mRNA] CTD PMID:23209616 NCBI chr14:22,070,861...22,089,264
Ensembl chr14:22,072,024...22,089,248
JBrowse link
G Svil supervillin decreases expression ISO fulvestrant results in decreased expression of SVIL mRNA CTD PMID:26865669 NCBI chr17:55,230,298...55,425,967
Ensembl chr17:55,230,298...55,346,279
JBrowse link
G Tacc1 transforming, acidic coiled-coil containing protein 1 increases expression ISO fulvestrant results in increased expression of TACC1 mRNA; fulvestrant results in increased expression of TACC1 protein CTD PMID:15072547, PMID:18984771 NCBI chr16:71,596,970...71,681,126
Ensembl chr16:71,629,525...71,681,126
JBrowse link
G Taf9 TATA-box binding protein associated factor 9 decreases expression
increases expression
ISO fulvestrant results in decreased expression of TAF9 mRNA
fulvestrant results in increased expression of TAF9 mRNA
CTD PMID:12154049, PMID:16514628 NCBI chr 2:30,664,407...30,668,414
Ensembl chr 2:30,664,639...30,668,414
JBrowse link
G Tars1 threonyl-tRNA synthetase 1 decreases expression ISO Fulvestrant results in decreased expression of TARS1 mRNA CTD PMID:16514628 NCBI chr 2:61,394,632...61,414,115
Ensembl chr 2:61,394,770...61,414,102
JBrowse link
G Tcf19 transcription factor 19 multiple interactions
decreases expression
ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of TCF19 mRNA
fulvestrant results in decreased expression of TCF19 mRNA
CTD PMID:19016759 NCBI chr20:3,740,454...3,746,964
Ensembl chr20:3,744,395...3,746,964
JBrowse link
G Tert telomerase reverse transcriptase multiple interactions
decreases expression
ISO fulvestrant inhibits the reaction [Estradiol results in increased expression of TERT mRNA alternative form]
fulvestrant results in decreased expression of TERT mRNA alternative form
CTD PMID:19501078 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions ISO Fulvestrant inhibits the reaction [Estradiol results in increased expression of TFAM mRNA]; Fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in increased expression of TFAM mRNA] CTD PMID:22105178 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
G Tfap2a transcription factor AP-2 alpha increases expression ISO fulvestrant results in increased expression of TFAP2A mRNA CTD PMID:26865669 NCBI chr17:24,653,342...24,670,457
Ensembl chr17:24,654,902...24,670,457
JBrowse link
G Tfap2c transcription factor AP-2 gamma decreases expression ISO fulvestrant results in decreased expression of TFAP2C mRNA CTD PMID:26865669 NCBI chr 3:170,550,314...170,558,197
Ensembl chr 3:170,550,314...170,558,194
JBrowse link
G Tff1 trefoil factor 1 decreases secretion
multiple interactions
decreases expression
ISO fulvestrant results in decreased secretion of TFF1 protein
Fulvestrant inhibits the reaction [1,7-diphenyl-5-heptene-3-one results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [4,4'-hexafluorisopropylidene diphenol results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [4-hydroxy-equilenin results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [[Arsenic Trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [Arsenic Trioxide results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [benz(a)anthracene results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [butylparaben results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [Coumestrol results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [desmethylicaritin results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [Dexamethasone results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [Diarylheptanoids results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [EGF protein results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [Equilin results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of TFF1 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased secretion of TFF1 protein]; Fulvestrant inhibits the reaction [Estriol results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [Estrone results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [Flame Retardants results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [Genistein results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [hexabromocyclododecane results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [icariin results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [isobavachin results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [Methoxychlor results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [o,p'-DDT results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [Progesterone results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [propylparaben results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [Rosiglitazone results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [Tartrazine results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [Testosterone results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of TFF1 mRNA]]
fulvestrant results in decreased expression of TFF1 mRNA
CTD PMID:9276643, PMID:12473173, PMID:14750165, PMID:15072547, PMID:15525692, PMID:15541416, PMID:16202921, PMID:16514628, PMID:16892383, PMID:17453334, PMID:17872378, PMID:18310281, PMID:18700809, PMID:19654927, PMID:19838210, PMID:20206645, PMID:20208560, PMID:20540524, PMID:21457653, PMID:22558281, PMID:22562034, PMID:22643241, PMID:23056216, PMID:25321415, PMID:31059536, PMID:31939680 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Tff2 trefoil factor 2 multiple interactions
decreases expression
ISO fulvestrant promotes the reaction [NCOR1 protein binds to TFF2 promoter]
fulvestrant results in decreased expression of TFF2 mRNA
CTD PMID:20696891 NCBI chr20:9,872,669...9,876,008
Ensembl chr20:9,872,680...9,876,008
JBrowse link
G Tff3 trefoil factor 3 decreases expression ISO fulvestrant results in decreased expression of TFF3 mRNA CTD PMID:16202921 NCBI chr20:9,850,800...9,855,481
Ensembl chr20:9,850,803...9,855,481
JBrowse link
G Tfpi tissue factor pathway inhibitor multiple interactions
increases expression
decreases secretion
ISO
EXP
[Fulvestrant co-treated with Raloxifene Hydrochloride] results in increased secretion of TFPI protein; Fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in decreased expression of and results in decreased secretion of TFPI protein]
fulvestrant results in increased expression of TFPI mRNA
fulvestrant inhibits the reaction [Ethinyl Estradiol results in decreased activity of TFPI protein]; fulvestrant inhibits the reaction [norethindrone acetate results in decreased activity of TFPI protein]
fulvestrant results in decreased secretion of TFPI protein
CTD PMID:15857755, PMID:17029634, PMID:26865669 NCBI chr 3:71,852,738...71,902,127
Ensembl chr 3:71,852,744...71,893,618
JBrowse link
G Tfrc transferrin receptor increases expression ISO fulvestrant results in increased expression of TFRC mRNA CTD PMID:12154049 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tg thyroglobulin increases expression EXP fulvestrant results in increased expression of TG mRNA CTD PMID:23238275 NCBI chr 7:107,467,260...107,652,897
Ensembl chr 7:107,467,260...107,652,899
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO Fulvestrant inhibits the reaction [4-hydroxy-equilenin results in increased expression of TGFA mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of TGFA mRNA] CTD PMID:20540524 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions
ISO
EXP
[fulvestrant results in increased expression of TGFB1 protein] which results in increased expression of FASLG mRNA; [fulvestrant results in increased expression of TGFB1 protein] which results in increased expression of GZMB mRNA; [fulvestrant results in increased expression of TGFB1 protein] which results in increased expression of PRF1 mRNA; fulvestrant results in increased expression of TGFB1 protein
fulvestrant inhibits the reaction [bisphenol A results in increased expression of TGFB1 mRNA]; fulvestrant inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]
fulvestrant inhibits the reaction [[bisphenol A co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of TGFB1 protein]; fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [CREBBP protein binds to CYP11A1 gene]]; fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [CREBBP protein binds to HSD3B gene]]; fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [NCOA1 protein binds to CYP11A1 gene]]; fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [NCOA1 protein binds to HSD3B gene]]; fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [PPARGC1A protein binds to CYP11A1 gene]]; fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [PPARGC1A protein binds to HSD3B gene]]; fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CREBBP protein]]]; fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CYP11A1 gene]]]; fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to HSD3B gene]]]; fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to NCOA1 protein]]]; fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to PPARGC1A protein]]]; fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein results in increased abundance of Progesterone]]; fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein results in increased expression of CYP11A1 protein]]; fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein results in increased expression of HSD3B protein]]; TGFB1 protein promotes the reaction [fulvestrant results in increased expression of FOXP3 mRNA]
fulvestrant inhibits the reaction [Estradiol results in decreased activity of TGFB1 protein]
CTD PMID:18511507, PMID:20145137, PMID:20962747, PMID:25128825, PMID:27025157 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 multiple interactions EXP fulvestrant inhibits the reaction [[Estradiol co-treated with FSHB protein] results in increased stability of and results in increased expression of TGFBR3 mRNA] CTD PMID:15878966 NCBI chr14:3,506,416...3,680,508
Ensembl chr14:3,506,339...3,682,545
JBrowse link
G Thbs2 thrombospondin 2 decreases expression ISO fulvestrant results in decreased expression of THBS2 mRNA CTD PMID:16514628 NCBI chr 1:56,653,929...56,683,571
Ensembl chr 1:56,653,938...56,683,731
JBrowse link
G Timeless timeless circadian regulator multiple interactions
decreases expression
ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of TIMELESS mRNA
fulvestrant results in decreased expression of TIMELESS mRNA
CTD PMID:19016759 NCBI chr 7:2,643,288...2,667,329
Ensembl chr 7:2,643,288...2,667,628
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions ISO fulvestrant inhibits the reaction [bisphenol A results in increased expression of TIMP2 mRNA]; fulvestrant inhibits the reaction [bisphenol A results in increased expression of TIMP2 protein]; fulvestrant inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TIMP2 mRNA]; fulvestrant inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TIMP2 protein]; fulvestrant inhibits the reaction [Estradiol results in decreased expression of TIMP2 mRNA]; fulvestrant inhibits the reaction [Estradiol results in decreased expression of TIMP2 protein] CTD PMID:19956873 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Tlr9 toll-like receptor 9 decreases expression ISO fulvestrant results in decreased expression of TLR9 mRNA CTD PMID:28811679 NCBI chr 8:114,916,122...114,920,171
Ensembl chr 8:114,916,122...114,920,171
JBrowse link
G Tmpo thymopoietin decreases expression ISO fulvestrant results in decreased expression of TMPO mRNA CTD PMID:16514628 NCBI chr 7:31,847,412...31,872,416
Ensembl chr 7:31,847,410...31,872,423
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
[Fulvestrant results in decreased susceptibility to CpG ODN 1826] which results in decreased expression of TNF protein; Fulvestrant inhibits the reaction [bisphenol A inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]]; Fulvestrant inhibits the reaction [bisphenol A inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of TNF mRNA]; Fulvestrant inhibits the reaction [bisphenol A results in increased secretion of TNF protein]; Fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Dimethoate results in increased expression of TNF mRNA]]; Fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of TNF mRNA]]; Fulvestrant inhibits the reaction [Estradiol results in decreased activity of TNF protein]; Fulvestrant inhibits the reaction [Estrogens inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Fulvestrant inhibits the reaction [Estrogens inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
Fulvestrant inhibits the reaction [[bisphenol A co-treated with Tetradecanoylphorbol Acetate] results in increased expression of TNF protein]; Fulvestrant inhibits the reaction [[TNF protein co-treated with Resveratrol] promotes the reaction [CREBBP protein binds to IL6 promoter]]; Fulvestrant inhibits the reaction [[TNF protein co-treated with Resveratrol] promotes the reaction [NCOA2 protein binds to IL6 promoter]]; Fulvestrant inhibits the reaction [[TNF protein co-treated with Resveratrol] promotes the reaction [NCOA3 protein binds to IL6 promoter]]; Fulvestrant inhibits the reaction [[TNF protein co-treated with Resveratrol] promotes the reaction [NCOR2 protein binds to IL6 promoter]]; Fulvestrant inhibits the reaction [[TNF protein co-treated with Resveratrol] promotes the reaction [NMNAT1 protein binds to IL6 promoter]]; Fulvestrant inhibits the reaction [[TNF protein co-treated with Resveratrol] promotes the reaction [RCOR1 protein binds to IL6 promoter]]; Fulvestrant inhibits the reaction [[TNF protein co-treated with Resveratrol] promotes the reaction [RELA protein modified form binds to IL6 promoter]]; Fulvestrant inhibits the reaction [[TNF protein co-treated with Resveratrol] promotes the reaction [SIRT1 protein binds to IL6 promoter]]; Fulvestrant inhibits the reaction [Estradiol inhibits the reaction [TNF protein results in increased secretion of IL6 protein]]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of and results in increased secretion of TNF protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of TNF]; Fulvestrant inhibits the reaction [Estriol inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; Fulvestrant inhibits the reaction [Estrogens, Conjugated (USP) inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF mRNA]]; Fulvestrant inhibits the reaction [Genistein inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; Fulvestrant inhibits the reaction [nonylphenol results in increased expression of and results in increased secretion of TNF protein]; Fulvestrant inhibits the reaction [nonylphenol results in increased expression of TNF]; Fulvestrant inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; Fulvestrant inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of PTGER4 mRNA]]; Fulvestrant inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of TNFRSF11B mRNA]]; Fulvestrant inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased secretion of IL6 protein]]
Fulvestrant inhibits the reaction [bisphenol A results in increased expression of TNF mRNA]; Fulvestrant inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Fulvestrant inhibits the reaction [Resveratrol results in decreased expression of TNF protein]
CTD PMID:12547825, PMID:12860292, PMID:17850464, PMID:20056579, PMID:20962747, PMID:21192278, PMID:21501669, PMID:23943137, PMID:24039973, PMID:24771768, PMID:25047101, PMID:25128825, PMID:25738436, PMID:28500084, PMID:28811679, PMID:30677511, PMID:31217279 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B multiple interactions ISO fulvestrant inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of TNFRSF11B mRNA]]
Fulvestrant inhibits the reaction [dioscin results in increased expression of TNFRSF11B mRNA]; Fulvestrant inhibits the reaction [naringenin-6-C-glucoside results in increased expression of TNFRSF11B mRNA]
CTD PMID:21864313, PMID:24742230, PMID:24771768 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Fulvestrant inhibits the reaction [dioscin results in increased expression of TNFSF11 mRNA]; Fulvestrant inhibits the reaction [naringenin-6-C-glucoside results in decreased expression of TNFSF11 mRNA] CTD PMID:21864313, PMID:24742230 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Tnpo1 transportin 1 decreases expression ISO fulvestrant results in decreased expression of TNPO1 mRNA CTD PMID:16514628 NCBI chr 2:29,056,219...29,126,882
Ensembl chr 2:29,056,219...29,121,104
JBrowse link
G Top1 DNA topoisomerase I decreases expression ISO fulvestrant results in decreased expression of TOP1 mRNA CTD PMID:16514628 NCBI chr 3:156,635,688...156,717,686
Ensembl chr 3:156,642,464...156,717,686
JBrowse link
G Top2a DNA topoisomerase II alpha increases expression ISO fulvestrant results in increased expression of TOP2A mRNA CTD PMID:12154049 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Top2b DNA topoisomerase II beta decreases expression ISO fulvestrant results in decreased expression of TOP2B mRNA CTD PMID:16514628 NCBI chr15:10,262,972...10,319,741
Ensembl chr15:10,262,651...10,320,233
JBrowse link
G Tp53 tumor protein p53 multiple interactions
decreases expression
ISO Fulvestrant inhibits the reaction [bisphenol A results in increased phosphorylation of TP53 protein]; Fulvestrant inhibits the reaction [Estradiol affects the localization of TP53 protein]
fulvestrant results in decreased expression of TP53 protein
CTD PMID:15870704, PMID:24169358, PMID:29383186 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trak2 trafficking kinesin protein 2 decreases expression ISO fulvestrant results in decreased expression of TRAK2 mRNA CTD PMID:16514628 NCBI chr 9:65,698,706...65,763,351
Ensembl chr 9:65,698,712...65,763,273
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP fulvestrant inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein] CTD PMID:18617618 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Trpv5 transient receptor potential cation channel, subfamily V, member 5 multiple interactions ISO Fulvestrant promotes the reaction [bisphenol A results in increased expression of TRPV5 mRNA]; Fulvestrant promotes the reaction [Estradiol results in increased expression of TRPV5 protein] CTD PMID:30061528 NCBI chr 4:70,947,615...70,974,004
Ensembl chr 4:70,947,717...70,974,006
JBrowse link
G Trpv6 transient receptor potential cation channel, subfamily V, member 6 multiple interactions
increases expression
ISO [Fulvestrant co-treated with bisphenol A] results in increased expression of TRPV6 mRNA; Fulvestrant promotes the reaction [4-tert-octylphenol results in increased expression of TRPV6 mRNA]
Fulvestrant results in increased expression of TRPV6 protein
CTD PMID:30061528 NCBI chr 4:70,918,631...70,934,291
Ensembl chr 4:70,918,632...70,934,295
JBrowse link
G Tsc22d3 TSC22 domain family, member 3 multiple interactions ISO fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 mRNA]]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 protein]]; fulvestrant inhibits the reaction [Genistein inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 mRNA]]; fulvestrant promotes the reaction [Dexamethasone results in increased expression of TSC22D3 mRNA] CTD PMID:23183181, PMID:25136773 NCBI chr  X:111,884,285...111,944,693
Ensembl chr  X:111,884,295...111,887,906
JBrowse link
G Ttk Ttk protein kinase multiple interactions
decreases expression
ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of TTK mRNA
fulvestrant results in decreased expression of TTK mRNA
CTD PMID:19016759 NCBI chr 8:91,368,065...91,405,995
Ensembl chr 8:91,368,111...91,405,993
JBrowse link
G Tuba1b tubulin, alpha 1B increases expression ISO fulvestrant results in increased expression of TUBA1B mRNA CTD PMID:12154049 NCBI chr 7:140,614,746...140,617,721
Ensembl chr 7:140,614,752...140,617,721
JBrowse link
G Tubb3 tubulin, beta 3 class III multiple interactions ISO fulvestrant inhibits the reaction [Estradiol results in increased expression of TUBB3 mRNA] CTD PMID:19466750 NCBI chr19:56,220,759...56,229,813
Ensembl chr19:56,220,755...56,229,813
JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases expression ISO fulvestrant results in decreased expression of TXNRD1 mRNA CTD PMID:16514628 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO fulvestrant results in increased expression of UGT1A1 mRNA CTD PMID:15072547 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ung uracil-DNA glycosylase decreases expression ISO fulvestrant results in decreased expression of UNG mRNA CTD PMID:16514628 NCBI chr12:48,246,593...48,255,547
Ensembl chr12:48,246,569...48,254,822
JBrowse link
G Usp32 ubiquitin specific peptidase 32 decreases expression ISO fulvestrant results in decreased expression of USP32 mRNA CTD PMID:16514628 NCBI chr10:72,300,173...72,474,574
Ensembl chr10:72,300,173...72,472,675
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO
EXP
fulvestrant inhibits the reaction [Estriol inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; fulvestrant inhibits the reaction [Genistein inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]
fulvestrant inhibits the reaction [biochanin A results in decreased expression of VCAM1 protein]; fulvestrant inhibits the reaction [Ethinyl Estradiol results in decreased expression of VCAM1 protein]
CTD PMID:12547825, PMID:16223672 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vdr vitamin D receptor multiple interactions
decreases expression
ISO fulvestrant inhibits the reaction [Estradiol results in increased expression of VDR protein]; fulvestrant inhibits the reaction [Genistein results in increased expression of VDR protein]; fulvestrant inhibits the reaction [glycitein results in increased expression of VDR protein]
fulvestrant results in decreased expression of VDR protein
CTD PMID:15930183, PMID:17088408 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Fulvestrant affects the reaction [Chlorpyrifos results in increased expression of VEGFA protein]; Fulvestrant inhibits the reaction [4-tert-octylphenol results in increased secretion of VEGFA protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased secretion of VEGFA protein]; Fulvestrant inhibits the reaction [Dieldrin results in increased secretion of VEGFA protein]; Fulvestrant inhibits the reaction [Estradiol results in increased secretion of VEGFA protein]; Fulvestrant inhibits the reaction [Genistein results in increased secretion of VEGFA protein]; Fulvestrant inhibits the reaction [Hexachlorobenzene results in increased expression of VEGFA protein] CTD PMID:18252963, PMID:32526215 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vim vimentin multiple interactions ISO fulvestrant inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VIM mRNA]; fulvestrant inhibits the reaction [bisphenol A results in increased expression of VIM mRNA]; fulvestrant inhibits the reaction [bisphenol A results in increased expression of VIM protein]; fulvestrant inhibits the reaction [Estradiol results in increased expression of VIM mRNA]; fulvestrant inhibits the reaction [Estradiol results in increased expression of VIM protein]; fulvestrant inhibits the reaction [nonylphenol results in increased expression of VIM mRNA]; fulvestrant inhibits the reaction [nonylphenol results in increased expression of VIM protein] CTD PMID:25690688, PMID:26407941, PMID:28284859 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Wnt2 Wnt family member 2 decreases expression ISO fulvestrant results in decreased expression of WNT2 mRNA CTD PMID:15072547 NCBI chr 4:45,286,845...45,332,899
Ensembl chr 4:45,292,437...45,332,420
JBrowse link
G Wnt4 Wnt family member 4 multiple interactions ISO fulvestrant inhibits the reaction [Diethylstilbestrol results in increased expression of WNT4 mRNA] CTD PMID:22445810 NCBI chr 5:155,649,238...155,668,065
Ensembl chr 5:155,649,217...155,672,579
JBrowse link
G Wnt7a Wnt family member 7A multiple interactions ISO fulvestrant inhibits the reaction [Estradiol results in decreased expression of WNT7A mRNA] CTD PMID:16534752 NCBI chr 4:122,994,425...123,040,609
Ensembl chr 4:122,994,425...123,040,609
JBrowse link
G Wt1 WT1 transcription factor decreases response to substance ISO WT1 protein results in decreased susceptibility to fulvestrant CTD PMID:20204298 NCBI chr 3:95,133,221...95,180,574
Ensembl chr 3:95,133,713...95,180,564
JBrowse link
G Wwc1 WW and C2 domain containing 1 decreases expression ISO fulvestrant results in decreased expression of WWC1 mRNA CTD PMID:26865669 NCBI chr10:20,662,996...20,818,500
Ensembl chr10:20,663,541...20,818,128
JBrowse link
G Xpo1 exportin 1 decreases expression ISO fulvestrant results in decreased expression of XPO1 mRNA CTD PMID:16514628 NCBI chr14:108,007,421...108,049,088
Ensembl chr14:108,007,724...108,049,660
JBrowse link
G Xrcc5 X-ray repair cross complementing 5 decreases expression ISO fulvestrant results in decreased expression of XRCC5 mRNA CTD PMID:16514628 NCBI chr 9:79,659,275...79,748,050
Ensembl chr 9:79,659,251...79,748,078
JBrowse link
G Zfp217 zinc finger protein 217 increases expression ISO fulvestrant results in increased expression of ZNF217 mRNA CTD PMID:15072547 NCBI chr 3:166,981,419...167,022,349
Ensembl chr 3:166,983,220...166,994,286
JBrowse link
G Zfx zinc finger protein X-linked increases expression ISO fulvestrant results in increased expression of ZFX mRNA CTD PMID:12154049 NCBI chr  X:63,158,368...63,204,971
Ensembl chr  X:63,158,976...63,204,530
JBrowse link
G Zwint ZW10 interacting kinetochore protein multiple interactions
decreases expression
ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of ZWINT mRNA
fulvestrant results in decreased expression of ZWINT mRNA
CTD PMID:19016759 NCBI chr20:17,075,781...17,091,715
Ensembl chr20:17,075,771...17,091,766
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pharmaceutical 19272
          drug 19272
            antineoplastic agent 16982
              fulvestrant 509
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic polycyclic compound 16384
                                  steroid 12788
                                    hydroxy steroid 12371
                                      17-hydroxy steroid 11855
                                        17beta-hydroxy steroid 10575
                                          fulvestrant 509
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.