Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5-Hydroxythalidomide
go back to main search page
Accession:CHEBI:168639 term browser browse the term
Synonyms:exact_synonym: 2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindole-1,3-dione
 related_synonym: Formula=C13H10N2O5;   InChI=1S/C13H10N2O5/c16-6-1-2-7-8(5-6)13(20)15(12(7)19)9-3-4-10(17)14-11(9)18/h1-2,5,9,16H,3-4H2,(H,14,17,18);   InChIKey=LJBQRRQTZUJWRC-UHFFFAOYSA-N;   SMILES=O=C1NC(=O)CCC1N2C(=O)C3=C(C2=O)C=CC(O)=C3
 xref: CAS:64567-60-8;   Chemspider:4675403;   HMDB:HMDB0013871
 xref_mesh: MESH:C544471


show annotations for term's descendants           Sort by:
5-Hydroxythalidomide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 affects binding ISO 5-hydroxythalidomide binds to ALDH1A1 protein CTD PMID:27464947 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Ass1 argininosuccinate synthase 1 affects binding ISO 5-hydroxythalidomide binds to ASS1 protein CTD PMID:27464947 NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha affects binding ISO 5-hydroxythalidomide binds to ATP5F1A protein CTD PMID:27464947 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794 		JBrowse link
G Atp5me ATP synthase membrane subunit e affects binding ISO 5-hydroxythalidomide binds to ATP5ME protein CTD PMID:27464947 NCBI chr14:1,319,868...1,320,996
Ensembl chr14:1,319,868...1,321,013 		JBrowse link
G Bdh1 3-hydroxybutyrate dehydrogenase 1 affects binding ISO 5-hydroxythalidomide binds to BDH1 protein CTD PMID:27464947 NCBI chr11:69,302,534...69,343,173
Ensembl chr11:69,302,534...69,337,671 		JBrowse link
G Car3 carbonic anhydrase 3 affects binding ISO 5-hydroxythalidomide binds to CAR3 protein
5-hydroxythalidomide binds to CA3 protein		 CTD PMID:27464947 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280 		JBrowse link
G Cox6a1 cytochrome c oxidase subunit 6A1 affects binding ISO 5-hydroxythalidomide binds to COX6A1 protein CTD PMID:27464947 NCBI chr12:41,261,983...41,265,037
Ensembl chr12:41,261,967...41,265,041 		JBrowse link
G Cox6b1 cytochrome c oxidase subunit 6B1 affects binding ISO 5-hydroxythalidomide binds to COX6B1 protein CTD PMID:27464947 NCBI chr 1:85,875,080...85,884,081
Ensembl chr 1:85,875,109...85,884,001
Ensembl chr 2:85,875,109...85,884,001
Ensembl chr 5:85,875,109...85,884,001 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases metabolic processing ISO CYP2C18 protein results in increased metabolism of 5-hydroxythalidomide CTD PMID:24350712 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases abundance
multiple interactions		 ISO CYP2C19 protein results in increased abundance of 5'-hydroxythalidomide; CYP2C19 protein results in increased abundance of 5-hydroxythalidomide
[CYP2C19 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5'-hydroxythalidomide; [CYP2C19 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5-hydroxythalidomide; [CYP2C19 protein results in increased oxidation of Thalidomide] which results in increased abundance of 5'-hydroxythalidomide; [CYP2C19 protein results in increased oxidation of Thalidomide] which results in increased abundance of 5-hydroxythalidomide		 CTD PMID:20443640 PMID:24350712 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 increases metabolic processing ISO CYP2J2 protein results in increased metabolism of 5-hydroxythalidomide CTD PMID:24350712 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [CYP3A4 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5-hydroxythalidomide; CYP3A4 protein results in increased oxidation of and results in increased glutathionylation of 5-hydroxythalidomide CTD PMID:20443640 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO [CYP3A5 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5-hydroxythalidomide; CYP3A5 protein results in increased oxidation of and results in increased glutathionylation of 5-hydroxythalidomide CTD PMID:20443640 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Eno1 enolase 1 affects binding ISO 5-hydroxythalidomide binds to ENO1 protein CTD PMID:27464947 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336 		JBrowse link
G Fabp1 fatty acid binding protein 1 affects binding ISO 5-hydroxythalidomide binds to FABP1 protein CTD PMID:27464947 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Ftl1 ferritin light chain 1 affects binding ISO 5-hydroxythalidomide binds to FTL protein
5-hydroxythalidomide binds to FTL1 protein		 CTD PMID:27464947 NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
Ensembl chr 2:95,936,387...95,939,725 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 affects binding ISO 5-hydroxythalidomide binds to GSTA1 protein CTD PMID:27464947 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 affects binding ISO 5-hydroxythalidomide binds to GSTA1 protein CTD PMID:27464947 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects binding ISO 5-hydroxythalidomide binds to GSTM1 protein CTD PMID:27464947 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 affects binding ISO 5-hydroxythalidomide binds to PEBP1 protein CTD PMID:27464947 NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862 		JBrowse link
G Rgn regucalcin affects binding ISO 5-hydroxythalidomide binds to RGN protein CTD PMID:27464947 NCBI chr  X:1,619,030...1,634,456
Ensembl chr  X:1,619,032...1,634,450 		JBrowse link
G Uqcrb ubiquinol-cytochrome c reductase binding protein affects binding ISO 5-hydroxythalidomide binds to UQCRB protein CTD PMID:27464947 NCBI chr 7:63,814,784...63,820,150
Ensembl chr 7:63,814,797...63,820,150 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    chemical entity 19897
      atom 19897
        nonmetal atom 19819
          nitrogen atom 19003
            nitrogen molecular entity 19003
              organonitrogen compound 18855
                organonitrogen heterocyclic compound 18176
                  benzopyrrole 9747
                    isoindoles 1154
                      phthalimides 1017
                        5-Hydroxythalidomide 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            organic molecule 19724
                              organic cyclic compound 19514
                                organic heterocyclic compound 18893
                                  organic heteropolycyclic compound 18320
                                    organic heterobicyclic compound 17272
                                      benzopyrrole 9747
                                        isoindoles 1154
                                          phthalimides 1017
                                            5-Hydroxythalidomide 22
paths to the root