Bax (BCL2 associated X, apoptosis regulator) - Rat Genome Database

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Gene: Bax (BCL2 associated X, apoptosis regulator) Rattus norvegicus
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Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
RGD ID: 2192
Description: Enables BH domain binding activity; heat shock protein binding activity; and protein-folding chaperone binding activity. Involved in several processes, including mitochondrion organization; regulation of apoptotic process; and response to anesthetic. Located in several cellular components, including cytosol; mitochondrial outer membrane; and perinuclear region of cytoplasm. Used to study brain glioma; endometriosis; morphine dependence; and pre-malignant neoplasm. Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); heart disease (multiple); lung disease (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; ataxia telangiectasia; colon adenocarcinoma; and colorectal cancer. Orthologous to human BAX (BCL2 associated X, apoptosis regulator); PARTICIPATES IN intrinsic apoptotic pathway; ceramide signaling pathway; syndecan signaling pathway; INTERACTS WITH (+)-catechin; (+)-pilocarpine; (+)-sesamin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: apoptosis regulator BAX; Bcl2-associated X protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Bax-ps2  
Allele / Splice: Bax_v1 ; Bax_v2
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,076,472 - 105,081,906 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1105,076,473 - 105,086,429 (-)EnsemblGRCr8
mRatBN7.2195,940,001 - 95,945,407 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,938,808 - 95,945,368 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1101,325,431 - 101,330,837 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,798,107 - 109,803,513 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,088,504 - 103,093,910 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,451,801 - 101,457,207 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,451,802 - 101,457,207 (-)Ensemblrn6Rnor6.0
Rnor_5.01102,530,747 - 102,536,153 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4195,933,023 - 95,938,176 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera190,195,913 - 90,201,319 (-)NCBICelera
RGSC_v3.1196,011,133 - 96,016,287 (-)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome 1  (IEP)
acute kidney failure  (IEP,ISO)
Acute Lung Injury  (IEP)
acute lymphoblastic leukemia  (ISO)
acute myocardial infarction  (IEP)
Adrenal Insufficiency  (IEP)
Alzheimer's disease  (IEP,ISO)
amyotrophic lateral sclerosis  (ISO)
anti-basement membrane glomerulonephritis  (IEP)
ataxia telangiectasia  (ISO)
brain glioma  (IDA,IEP)
Brain Hypoxia-Ischemia  (IEP)
Brain Injuries  (IEP)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
bronchopulmonary dysplasia  (IEP)
Burns  (IEP)
Cerebral Hemorrhage  (ISO)
cervical squamous cell carcinoma  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Intermittent Hypoxia  (IEP)
clear cell renal cell carcinoma  (ISO)
colon adenocarcinoma  (ISO)
colon carcinoma  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (IEP)
dementia  (IEP)
depressive disorder  (IEP)
Diabetic Cardiomyopathies  (ISO)
dilated cardiomyopathy  (IEP)
endometriosis  (IDA)
Endotoxemia  (IEP)
Esophageal Neoplasms  (ISO)
Experimental Arthritis  (IEP)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Mammary Neoplasms  (IDA,IEP)
Fetal Growth Retardation  (IEP)
Gastrointestinal Hemorrhage  (IEP)
genetic disease  (ISO)
glaucoma  (IEP)
heart disease  (IEP)
hepatocellular carcinoma  (IEP)
human immunodeficiency virus infectious disease  (ISO)
Huntington's disease  (IEP)
Hyperplasia  (ISO)
hypertension  (IEP)
impotence  (IEP)
intermittent claudication  (IEP)
intestinal disease  (IEP)
Intestinal Neoplasms  (ISO)
ischemia  (ISO)
Kashin-Beck Disease  (ISO)
Kidney Reperfusion Injury  (IEP)
Knee Osteoarthritis  (IEP)
leiomyoma  (IEP)
Liver Reperfusion Injury  (IEP,ISO)
Lung Injury  (IEP)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (IEP,ISO)
macular degeneration  (ISO)
male infertility  (ISO)
Microsatellite Instability  (ISO)
middle cerebral artery infarction  (IEP)
morphine dependence  (IDA)
Multi-Infarct Dementia  (IEP)
myocardial infarction  (ISO)
Myocardial Ischemia  (IEP)
Myocardial Reperfusion Injury  (IEP,ISO)
Neoplasm Metastasis  (ISO)
Nerve Degeneration  (ISO)
Optic Nerve Injuries  (IEP)
osteoarthritis  (ISO)
osteoporosis  (IEP)
polycystic ovary syndrome  (ISO)
post-traumatic stress disorder  (IEP)
Postoperative Cognitive Dysfunction  (IEP)
pre-malignant neoplasm  (IDA)
Premature Aging  (ISO)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
prion disease  (ISO)
prostate cancer  (ISO)
prostate carcinoma  (ISO)
Prostatic Neoplasms  (ISO)
Reperfusion Injury  (IEP)
Retina Reperfusion Injury  (IEP)
retinal degeneration  (IEP)
rheumatic heart disease  (IEP)
Right Ventricular Hypertrophy  (IEP)
Sarcopenia  (IEP)
scrapie  (ISO)
Spinal Cord Injuries  (IEP)
status epilepticus  (IEP)
stomach cancer  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
teratoma  (ISO)
Testis Reperfusion Injury  (IEP)
thyroiditis  (IEP)
toxoplasmosis  (IEP)
transient cerebral ischemia  (IEP)
Transplant Rejection  (IEP)
type 2 diabetes mellitus  (IEP,ISO)
urinary bladder cancer  (ISO)
Ventricular Remodeling  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-(S)-ar-turmerone  (ISO)
(+)-catechin  (EXP,ISO)
(+)-dexrazoxane  (ISO)
(+)-pilocarpine  (EXP)
(+)-sesamin  (EXP,ISO)
(+)-taxifolin  (EXP)
(+)-Tetrandrine  (ISO)
(+)-trans-(S)-allethrin  (ISO)
(-)-anisomycin  (ISO)
(-)-bornyl-caffeate  (EXP)
(-)-citrinin  (ISO)
(-)-ephedrine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-gambogic acid  (ISO)
(-)-matairesinol  (ISO)
(-)-noscapine  (ISO)
(-)-selegiline  (ISO)
(1->4)-beta-D-glucan  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(20S)-ginsenoside Rh2  (ISO)
(E)-thiamethoxam  (ISO)
(E,E)-germacrone  (ISO)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (EXP)
(R)-salsolinol  (EXP)
(R,R)-tramadol  (EXP)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(R,S)-Scoulerine  (ISO)
(S)-(-)-perillyl alcohol  (ISO)
(S)-amphetamine  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
(S)-ropivacaine  (EXP,ISO)
(Z)-3-butylidenephthalide  (EXP,ISO)
(Z)-ligustilide  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,3-dichloropropan-2-ol  (ISO)
1,3-dinitrobenzene  (EXP,ISO)
1,3-thiazolidine-2,4-dione  (ISO)
1,4-benzoquinone  (ISO)
1,4-naphthoquinone  (ISO)
1-(4'-hydroxy-3'-methoxyphenyl)-7-phenyl-3-heptanone  (ISO)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP,ISO)
1-hydroxy-1-norresistomycin  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropropane  (EXP)
1-nitropyrene  (ISO)
11-deoxycorticosterone  (EXP)
16,16-dimethylprostaglandin E2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
1H-pyrazole  (ISO)
2''-galloylhyperin  (ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2,5-hexanedione  (EXP,ISO)
2,6-diaminotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-acetamidophenol  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-aminoethoxydiphenylborane  (EXP)
2-chloroethanol  (EXP)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxy-17beta-estradiol  (EXP,ISO)
2-nitro-p-phenylenediamine  (EXP)
2-nitrofluorene  (EXP)
2-nitropropane  (EXP)
2-tert-butylhydroquinone  (EXP,ISO)
20-hydroxyecdysone  (ISO)
20-hydroxypregn-4-en-3-one  (ISO)
25-hydroxycholesterol  (ISO)
3',4',7-trihydroxyisoflavone  (ISO)
3',4'-dimethoxyflavone  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-Dichlorobenzidine  (ISO)
3,3'-diindolylmethane  (ISO)
3,4,8-Trimethyl-1H,2H,3H-imidazo[4,5-F]quinoxalin-2-imine  (ISO)
3,4-dihydroxybenzoic acid  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,7-dihydropurine-6-thione  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (EXP,ISO)
3-methylcholanthrene  (EXP)
3-nitropropanoic acid  (EXP)
3-phenoxybenzoic acid  (ISO)
3-phenylprop-2-enal  (EXP,ISO)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP,ISO)
4-acetylaminofluorene  (EXP)
4-amino-1,8-naphthalimide  (ISO)
4-aminopyridine  (EXP)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxy-TEMPO  (EXP,ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (ISO)
4-methylthioamphetamine  (ISO)
4-Nerolidylcatechol  (ISO)
4-nitro-1,2-phenylenediamine  (EXP)
4-nitro-m-cresol  (ISO)
4-nitrophenol  (ISO)
4-nonylphenol  (EXP,ISO)
4-octylphenol  (ISO)
4-phenylbutyric acid  (EXP,ISO)
4-vinylcyclohexene dioxide  (EXP)
5-aminolevulinic acid  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (ISO)
5-bromo-2'-deoxyuridine  (ISO)
5-fluorouracil  (EXP,ISO)
5-Hydroxycapric acid  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
5-methoxypsoralen  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
7,8-dihydroxycoumarin  (ISO)
7-ketocholesterol  (EXP)
8'-apo-beta,psi-caroten-8'-al  (ISO)
8-Br-cAMP  (ISO)
8-OH-DPAT  (ISO)
9,10-anthraquinone  (ISO)
9,10-phenanthroquinone  (ISO)
9-aminoacridine  (ISO)
9-cis-retinoic acid  (ISO)
9-Methoxycamptothecin  (ISO)
[6]-Shogaol  (ISO)
AB-Fubinaca  (ISO)
abamectin  (EXP)
Abemaciclib  (ISO)
ABT-737  (ISO)
acadesine  (EXP)
acetaldehyde  (ISO)
acetamide  (EXP)
acetamiprid  (EXP)
acetic acid  (EXP)
acetochlor  (ISO)
acetylsalicylic acid  (EXP,ISO)
aconitine  (EXP,ISO)
acridine orange  (ISO)
acridine orange free base  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
actinomycin D  (EXP,ISO)
adefovir pivoxil  (ISO)
adenosine  (ISO)
Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate]  (ISO)
afatinib  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
afzelechin  (EXP)
agomelatine  (EXP)
AH23848  (ISO)
alachlor  (EXP)
alantolactone  (ISO)
alborixin  (ISO)
albuterol  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldicarb  (EXP)
alendronic acid  (ISO)
all-trans-acitretin  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
allethrin  (EXP,ISO)
allicin  (ISO)
allopurinol  (EXP)
alloxan  (EXP)
Allyl chloride  (EXP)
Aloe emodin  (ISO)
alpha,alpha-trehalose  (EXP)
alpha-amanitin  (ISO)
alpha-D-galactose  (EXP,ISO)
alpha-mangostin  (ISO)
alpha-naphthoflavone  (EXP,ISO)
alpha-pinene  (ISO)
alpha-Spinasterol  (ISO)
alpha-Zearalanol  (ISO)
Alpinetin  (ISO)
alpinumisoflavone  (ISO)
aluminium atom  (EXP,ISO)
aluminium(0)  (EXP,ISO)
alvocidib  (ISO)
ambrisentan  (ISO)
amentoflavone  (ISO)
amidotrizoic acid  (ISO)
amifostine  (ISO)
amino acid  (ISO)
aminoguanidine  (ISO)
amiodarone  (ISO)
amitriptyline  (EXP)
amlexanox  (ISO)
amlodipine  (EXP,ISO)
ammonium chloride  (EXP)
Ammothamnine  (ISO)
amodiaquine  (ISO)
amosite asbestos  (ISO)
amphetamine  (ISO)
amphibole asbestos  (ISO)
ampicillin  (ISO)
amsacrine  (ISO)
andrographolide  (ISO)
Anemoside B4  (ISO)
anethole  (EXP)
angiotensin II  (ISO)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
anthracene  (ISO)
antimony(0)  (ISO)
antimycin A  (ISO)
Antrocin  (ISO)
apigenin  (EXP,ISO)
apocynin  (EXP,ISO)
aprepitant  (ISO)
arachidonic acid  (ISO)
arecoline  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (EXP,ISO)
Aroclor 1254  (EXP,ISO)
arotinoid acid  (ISO)
arsane  (EXP,ISO)
arsenic acid  (ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
Arsenobetaine  (ISO)
arsenous acid  (EXP,ISO)
artesunate  (EXP,ISO)
asarone  (ISO)
asbestos  (ISO)
asiatic acid  (EXP,ISO)
asoxime chloride  (EXP)
aspartame  (EXP,ISO)
Aspidin  (ISO)
astaxanthin  (ISO)
astilbin  (ISO)
astragaloside IV  (ISO)
Atipamezole  (EXP)
atorvastatin calcium  (ISO)
Atractylenolide III  (ISO)
Atranorin  (ISO)
atrasentan  (EXP)
atrazine  (EXP,ISO)
atropine  (EXP)
auranofin  (ISO)
aurantio-obtusin  (ISO)
aureusidin  (ISO)
Auriculasin  (ISO)
azadirachtin A  (ISO)
azide  (EXP,ISO)
azilsartan  (ISO)
Azoxymethane  (EXP)
azoxystrobin  (ISO)
bafilomycin A1  (EXP,ISO)
baicalein  (ISO)
baicalin  (EXP,ISO)
Bay-K-8644  (ISO)
beauvericin  (ISO)
benazepril  (EXP)
benomyl  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzothiazoles  (ISO)
berberine  (EXP,ISO)
Berberrubine  (ISO)
Bergenin  (EXP,ISO)
beta-carotene  (ISO)
beta-D-fructofuranose 1,6-bisphosphate  (ISO)
beta-Elemonic acid  (ISO)
beta-ionone  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
Beta-Solamarine  (ISO)
Betanin  (EXP)
betaxolol  (ISO)
betulin  (ISO)
betulinic acid  (ISO)
Betulonic acid  (ISO)
bexarotene  (ISO)
bicalutamide  (ISO)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (EXP,ISO)
boric acid  (EXP,ISO)
boron atom  (EXP)
bortezomib  (ISO)
bosentan  (ISO)
brassinin  (ISO)
brazilin  (ISO)
brequinar  (ISO)
bromocriptine  (EXP)
bromuconazole  (EXP)
brucine  (ISO)
Brusatol  (EXP,ISO)
bucladesine  (ISO)
Bufotalin  (ISO)
bupivacaine  (ISO)
buprofezin  (ISO)
buserelin  (ISO)
buta-1,3-diene  (ISO)
butane  (ISO)
butein  (ISO)
Butralin  (EXP)
Butylbenzyl phthalate  (ISO)
butyric acid  (EXP,ISO)
C.I. Natural Red 20  (EXP)
cabazitaxel  (ISO)
cadmium acetate  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium nitrate  (EXP)
cadmium sulfate  (ISO)
cadmium sulfide  (ISO)
cadmium telluride  (ISO)
caffeine  (EXP,ISO)
cajanol  (ISO)
calcidiol  (ISO)
Calcimycin  (ISO)
calcitriol  (EXP,ISO)
calcium oxalate  (ISO)
Calpeptin  (ISO)
calycosin-7-O-beta-D-glucoside  (ISO)
calyculin A  (ISO)
camalexin  (ISO)
camptothecin  (EXP,ISO)
canagliflozin  (EXP)
candesartan  (EXP)
cannabidiol  (ISO)
cantharidin  (EXP,ISO)
capsaicin  (ISO)
capsazepine  (ISO)
captan  (ISO)
carbachol  (ISO)
carbamate ester  (ISO)
carbamazepine  (ISO)
carbendazim  (EXP)
CARBENOXOLONE  (EXP,ISO)
carbidopa  (ISO)
carbofuran  (EXP)
carbon disulfide  (ISO)
carbon nanotube  (EXP,ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carboplatin  (ISO)
carmustine  (ISO)
carnosic acid  (ISO)
carnosine  (EXP,ISO)
Carnosol  (ISO)
carvacrol  (EXP)
carvedilol  (EXP,ISO)
casticin  (EXP,ISO)
CEDRELONE  (ISO)
cefalotin  (ISO)
cefotaxime  (ISO)
celastrol  (EXP,ISO)
celecoxib  (ISO)
ceric oxide  (ISO)
ceritinib  (ISO)
cetrorelix  (EXP,ISO)
chalcones  (ISO)
chelerythrine  (EXP)
chelidonine  (ISO)
chenodeoxycholic acid  (EXP)
Chikusetsusaponin-V  (ISO)
CHIR 99021  (ISO)
chitosan  (EXP,ISO)
chlorambucil  (ISO)
chlordecone  (ISO)
chloroacetaldehyde  (ISO)
chloroacetic acid  (ISO)
chlorogenic acid  (EXP,ISO)
chloroprocaine  (ISO)
chloroquine  (EXP,ISO)
chlorothalonil  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
choline  (EXP,ISO)
chromium atom  (ISO)
chromium(3+) trichloride  (ISO)
chromium(6+)  (EXP,ISO)
chrysazin  (ISO)
chrysene  (ISO)
chrysin  (EXP,ISO)
chrysin 5,7-dimethyl ether  (EXP)
chrysophanol  (ISO)
cidofovir anhydrous  (ISO)
ciglitazone  (EXP,ISO)
cilnidipine  (EXP,ISO)
cilostazol  (EXP,ISO)
cimetidine  (ISO)
Cinobufagin  (ISO)
Cinobufotalin  (ISO)
ciprofloxacin  (ISO)
Cirsimarin  (ISO)
cisplatin  (EXP,ISO)
Citreoviridin  (EXP,ISO)
citric acid  (ISO)
citronellal  (EXP)
clavulone II  (ISO)
clobetasol  (ISO)
clodronic acid  (ISO)
clofibrate  (EXP)
clonazepam  (EXP)
clorgyline  (ISO)
clozapine  (EXP,ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cobalt(2+) sulfate  (EXP)
cobicistat  (ISO)
cocaine  (EXP,ISO)
codeinone  (ISO)
coenzyme Q10  (EXP,ISO)
colistin  (EXP,ISO)
concanamycin A  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (EXP,ISO)
coptisine  (ISO)
cordycepin  (EXP,ISO)
corilagin  (EXP)
corosolic acid  (EXP,ISO)
corticosterone  (EXP)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (EXP,ISO)
crocin-1  (EXP,ISO)
crotonaldehyde  (EXP)
cryptolepine  (ISO)
crystal violet  (ISO)
CU-O LINKAGE  (ISO)
cucurbitacin B  (ISO)
cucurbitacin E  (EXP,ISO)
cudraflavone B  (ISO)
curcumin  (EXP,ISO)
cyanamide  (EXP)
Cyanoginosin  (EXP)
cycloastragenol  (EXP)
cyclohexanols  (EXP)
cycloheximide  (EXP)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyflufenamid  (ISO)
cyfluthrin  (ISO)
cyhalothrin  (EXP)
cylindrospermopsin  (EXP)
cypermethrin  (EXP,ISO)
cytarabine  (EXP,ISO)
cytochalasin B  (ISO)
D-fructofuranose 1,6-bisphosphate  (ISO)
D-glucose  (EXP,ISO)
D-mannitol  (ISO)
D-penicillamine  (ISO)
dactolisib  (ISO)
daidzein  (ISO)
dantrolene  (ISO)
dapagliflozin  (EXP)
dapoxetine  (EXP)
DAPT  (EXP)
daunorubicin  (EXP,ISO)
DDE  (EXP,ISO)
decabromodiphenyl ether  (ISO)
deferiprone  (ISO)
deguelin  (ISO)
dehydrocostus lactone  (ISO)
dehydroepiandrosterone  (EXP,ISO)
delphinidin  (ISO)
demethoxycurcumin  (ISO)
demethoxyfumitremorgin C  (ISO)
Dendrobine  (ISO)
deoxycholic acid  (EXP)
deoxynivalenol  (ISO)
Deoxyschizandrin  (ISO)
desferrioxamine B  (EXP,ISO)
Destruxin B  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (EXP)
dextran sulfate  (ISO)
dextromethorphan  (EXP)
Di-n-hexyl phthalate  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl disulfide  (EXP,ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazepam  (EXP)
diazinon  (EXP,ISO)
diazoxide  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibenzoylmethane  (ISO)
Dibromoacetonitrile  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
dichlorvos  (EXP)
dichromium trioxide  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
Dictamnine  (ISO)
dideuterium oxide  (ISO)
Didymin  (ISO)
dieckol  (ISO)
dieldrin  (EXP)
diepoxybutane  (ISO)
diethanolamine  (EXP,ISO)
diethyl phthalate  (EXP,ISO)
diethyl sulfate  (ISO)
diethylstilbestrol  (EXP,ISO)
difenoconazole  (EXP)
dihydroactinidiolide  (ISO)
diiodine  (ISO)
diisobutyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethomorph  (EXP)
Dimethyl phthalate  (EXP)
dimethyl sulfoxide  (EXP,ISO)
dimethylarsinic acid  (EXP,ISO)
dimethylarsinous acid  (ISO)
dioscin  (ISO)
diosgenin  (EXP)
diosmin  (ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
dithionite(2-)  (EXP,ISO)
dizocilpine maleate  (EXP,ISO)
dobutamine  (ISO)
Dodecyl gallate  (ISO)
domoic acid  (ISO)
donepezil hydrochloride  (ISO)
dopamine  (ISO)
dorsomorphin  (EXP,ISO)
doxazosin  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
drimenol  (ISO)
ebselen  (EXP)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (EXP)
echinacoside  (ISO)
Echinocystic acid  (ISO)
edaravone  (EXP,ISO)
elemental boron  (EXP)
elemental selenium  (EXP,ISO)
ellagic acid  (EXP,ISO)
ellipticine  (ISO)
embelin  (ISO)
emodin  (EXP,ISO)
empagliflozin  (EXP)
enalapril  (EXP)
endosulfan  (EXP,ISO)
entacapone  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
epichlorohydrin  (ISO)
epoxiconazole  (ISO)
epoxomicin  (ISO)
erdosteine  (EXP,ISO)
eriocitrin  (ISO)
eritoran  (ISO)
erlotinib hydrochloride  (ISO)
erythromycin estolate  (EXP)
esculetin  (ISO)
esketamine  (ISO)
ethanol  (EXP,ISO)
Ethyl icosapentate  (ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (EXP)
ethylene glycol  (EXP)
etoposide  (ISO)
eugenol  (ISO)
EUK-134  (ISO)
everolimus  (EXP)
Evodiamine  (ISO)
excitatory amino acid agonist  (EXP,ISO)
farrerol  (ISO)
fasudil  (EXP)
favipiravir  (EXP)
febuxostat  (EXP)
fenbendazole  (ISO)
fenhexamid  (ISO)
fenitrothion  (EXP)
fenofibrate  (EXP)
fenpyroximate  (ISO)
fenthion  (ISO)
fenvalerate  (EXP)
ferric oxide  (EXP,ISO)
ferrosoferric oxide  (ISO)
ferrostatin-1  (EXP,ISO)
ferrous oxide  (ISO)
ferulic acid  (EXP)
finasteride  (EXP)
fipronil  (EXP)
fisetin  (EXP,ISO)
flavanone  (ISO)
flavanones  (ISO)
flavokawain B  (ISO)
flavones  (EXP,ISO)
flavonoids  (ISO)
fluazinam  (ISO)
flumethrin  (ISO)
fluoranthene  (ISO)
fluoxetine  (EXP,ISO)
flutamide  (EXP,ISO)
flutriafol  (EXP)
fluvastatin  (EXP)
folic acid  (EXP,ISO)
folpet  (ISO)
fomepizole  (ISO)
formaldehyde  (EXP,ISO)
formononetin  (EXP,ISO)
Forsythiaside  (ISO)
fraxetin  (ISO)
fructose  (EXP,ISO)
fucoxanthin  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP,ISO)
furosemide  (EXP)
Fusarenone X  (ISO)
Gaillardin  (ISO)
galactose  (EXP,ISO)
galangin  (ISO)
galanthamine  (EXP)
galanthamine Trifluoroacetic acid  (EXP)
Galbanic acid  (ISO)
gallein  (EXP)
gallic acid  (EXP,ISO)
gallium nitrate  (ISO)
gamma-hexachlorocyclohexane  (EXP,ISO)
gamma-tocopherol  (ISO)
Ganoderic acid A  (ISO)
Gastrodin  (EXP,ISO)
gefitinib  (EXP,ISO)
gemcitabine  (ISO)
Genipin  (ISO)
Geniposide  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
Gentiopicrin  (ISO)
geraniol  (EXP,ISO)
geranyl acetate  (ISO)
gingerol  (ISO)
ginkgetin  (ISO)
Ginkgoic acid  (ISO)
Ginkgolide C  (EXP)
ginsenoside Rd  (EXP)
ginsenoside Re  (EXP,ISO)
ginsenoside Rg1  (EXP,ISO)
ginsenoside Rg2  (EXP)
Ginsenoside Rg5  (ISO)
glabridin  (ISO)
gliotoxin  (ISO)
glucaric acid  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glyburide  (EXP)
glycerol  (EXP)
glycine betaine  (EXP)
glycoursodeoxycholic acid  (EXP)
glycyrrhetinate  (EXP,ISO)
glycyrrhetinic acid  (EXP,ISO)
glycyrrhizinic acid  (ISO)
glyoxylic acid  (ISO)
glyphosate  (EXP,ISO)
gold atom  (EXP,ISO)
gold(0)  (EXP,ISO)
gossypol  (EXP,ISO)
graphene oxide  (ISO)
graphite  (ISO)
Grifolin  (ISO)
GSK2656157  (EXP)
GW 6471  (ISO)
Gyrophoric acid  (ISO)
haloperidol  (EXP)
halothane  (ISO)
Harpagoside  (ISO)
hellebrigenin  (ISO)
hemin  (EXP,ISO)
heparin  (ISO)
herbacetin  (EXP)
hesperetin  (EXP,ISO)
hesperidin  (EXP,ISO)
hexadecanoic acid  (EXP,ISO)
hexaflumuron  (EXP)
hexane  (EXP)
hinokiflavone  (ISO)
histamine  (EXP)
homocysteine  (EXP,ISO)
Honokiol  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxamic acid  (ISO)
hydroxychloroquine  (ISO)
hydroxytyrosol  (EXP)
hydroxyurea  (ISO)
hymexazol  (EXP)
hyperforin  (EXP,ISO)
hypoxanthine  (ISO)
icariin  (EXP)
icariside II  (ISO)
ICI 118551  (ISO)
idarubicin  (ISO)
idelalisib  (ISO)
ifosfamide  (ISO)
Ile(5)-angiotensin II  (ISO)
imidacloprid  (EXP)
Imipenem-cilastatin  (EXP)
indirubin  (ISO)
indirubin-3'-monoxime  (ISO)
indocyanine green  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
inositol  (ISO)
Inotodiol  (ISO)
iodoacetic acid  (ISO)
iohexol  (EXP,ISO)
iopamidol  (ISO)
Ioversol  (EXP)
irbesartan  (EXP,ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron dextran  (EXP,ISO)
iron(0)  (ISO)
iron(2+) sulfate (anhydrous)  (EXP)
iron(III) nitrilotriacetate  (EXP)
isocarbophos  (ISO)
isoflavones  (EXP)
isoflurane  (EXP,ISO)
isoliquiritigenin  (ISO)
isoniazide  (EXP,ISO)
isopimaric acid  (ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
jaceosidin  (ISO)
JBIR-99  (ISO)
juglone  (ISO)
Jujuboside A  (EXP,ISO)
kaempferol  (EXP,ISO)
kahweol  (ISO)
kainic acid  (EXP,ISO)
ketamine  (EXP,ISO)
keto-D-fructose 1,6-bisphosphate  (ISO)
ketoconazole  (ISO)
KN-93  (ISO)
Kukoamine B  (ISO)
L-ascorbic acid  (EXP,ISO)
L-cystathionine  (ISO)
L-gamma-glutamyl-L-cysteine  (EXP)
L-glutamic acid  (EXP,ISO)
L-methionine  (EXP,ISO)
L-serine  (ISO)
lactucin  (ISO)
lapatinib  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (EXP,ISO)
Leonurine  (EXP,ISO)
leptomycin B  (ISO)
letrozole  (EXP)
leukotriene B4  (ISO)
leupeptin  (ISO)
leuprolide  (ISO)
Licochalcone A  (ISO)
Licochalcone B  (ISO)
lidocaine  (EXP,ISO)
lignan  (ISO)
linalool  (ISO)
linderalactone  (ISO)
linsidomine  (ISO)
linuron  (EXP)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (ISO)
liraglutide  (EXP,ISO)
lithium atom  (EXP,ISO)
lithium chloride  (EXP,ISO)
lithium hydride  (EXP,ISO)
lithocholic acid  (EXP,ISO)
Longikaurin A  (ISO)
lonidamine  (ISO)
losartan  (EXP)
lovastatin  (EXP,ISO)
lupeol  (EXP,ISO)
Lupiwighteone  (ISO)
lupulone  (ISO)
lutein  (ISO)
luteolin  (EXP,ISO)
Luteolin 7-methyl ether  (EXP)
luteolin 7-O-beta-D-glucoside  (ISO)
LY294002  (EXP,ISO)
lycopene  (EXP,ISO)
maculosin  (ISO)
madecassoside  (ISO)
magnesium dichloride  (EXP,ISO)
magnesium oxide  (ISO)
Magnolol  (ISO)
malathion  (EXP,ISO)
malvidin  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (EXP,ISO)
masoprocol  (ISO)
mebendazole  (ISO)
mechlorethamine  (ISO)
medroxyprogesterone acetate  (ISO)
mefenamic acid  (ISO)
meglumine amidotrizoate  (ISO)
MeIQx  (ISO)
melamine  (ISO)
melatonin  (EXP,ISO)
melittin  (ISO)
meloxicam  (ISO)
melphalan  (ISO)
memantine  (ISO)
menadione  (EXP,ISO)
mercaptopurine  (ISO)
mercury atom  (EXP,ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
mesalamine  (EXP)
metaproterenol  (ISO)
metformin  (EXP,ISO)
methadone  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methomyl  (ISO)
methotrexate  (EXP,ISO)
methoxsalen  (ISO)
methoxyacetic acid  (EXP)
methoxychlor  (ISO)
methyl caffeate  (ISO)
methyl methanesulfonate  (ISO)
methylene blue  (EXP)
methylglyoxal  (EXP,ISO)
methylisothiazolinone  (ISO)
methyllycaconitine  (EXP)
methylmercury chloride  (EXP,ISO)
methylparaben  (ISO)
methylphenidate  (EXP)
methylseleninic acid  (EXP)
methyltestosterone  (EXP)
metiram  (ISO)
metrafenone  (ISO)
mevinphos  (EXP)
microcystin  (EXP)
microcystin RR  (ISO)
microcystin-LR  (EXP,ISO)
mifepristone  (ISO)
minocycline  (EXP,ISO)
mirtazapine  (ISO)
misoprostol  (EXP)
mitomycin C  (ISO)
Mitoquinone  (ISO)
Mitotane  (EXP,ISO)
MitoTEMPO  (ISO)
mitoxantrone  (ISO)
MK-2206  (ISO)
ML-7  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (EXP,ISO)
monocrotophos  (EXP)
monoethyl phthalate  (ISO)
monosodium L-glutamate  (EXP,ISO)
montelukast  (ISO)
morin  (EXP,ISO)
Morindone  (ISO)
morphine  (EXP,ISO)
Morroniside  (EXP,ISO)
morusin  (ISO)
Muconic dialdehyde  (ISO)
mycophenolic acid  (ISO)
myricetin  (ISO)
myricitrin  (ISO)
myristicin  (ISO)
myxothiazol  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N,N-dimethylformamide  (ISO)
N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide  (EXP,ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (EXP,ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-D-aspartic acid  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP)
N-methylnicotinate  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N-phosphocreatine  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP,ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
naloxone  (ISO)
naphthalene  (ISO)
naringin  (EXP,ISO)
navitoclax  (ISO)
Neferine  (EXP)
neoastilbin  (ISO)
neocuproine  (ISO)
Neoisoliquiritin  (ISO)
neomycin  (ISO)
nerolidol  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nickel ferrite  (ISO)
nickel sulfate  (EXP,ISO)
niclosamide  (ISO)
nicorandil  (EXP,ISO)
nicotinamide  (EXP,ISO)
nicotine  (EXP,ISO)
nifedipine  (EXP,ISO)
Niflumic acid  (ISO)
nigericin  (ISO)
nilotinib  (EXP,ISO)
nimesulide  (ISO)
nimodipine  (EXP,ISO)
nitenpyram  (ISO)
Nitidine  (ISO)
nitrates  (ISO)
nitrendipine  (EXP)
nitric oxide  (EXP,ISO)
nitrofen  (EXP)
nitrogen dioxide  (EXP,ISO)
nitroprusside  (EXP,ISO)
Nivalenol  (ISO)
NMN zwitterion  (ISO)
NMS-873  (ISO)
nobiletin  (EXP,ISO)
nocodazole  (ISO)
Nonylphenol  (EXP,ISO)
Norbinaltorphimine  (ISO)
NORCANTHARIDIN  (ISO)
norfloxacin  (ISO)
norwogonin  (EXP,ISO)
notoginsenoside R1  (EXP,ISO)
NS-398  (ISO)
Nutlin-3  (ISO)
o-cresol  (EXP)
O-methyleugenol  (ISO)
Obacunone  (ISO)
ochratoxin A  (EXP,ISO)
Octicizer  (ISO)
octreotide  (EXP)
octyl gallate  (ISO)
okadaic acid  (EXP,ISO)
olanzapine  (EXP)
olaparib  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
olesoxime  (ISO)
oleuropein  (EXP,ISO)
oligopeptide  (ISO)
olmesartan  (ISO)
Olmesartan medoxomil  (EXP)
oltipraz  (ISO)
omacetaxine mepesuccinate  (ISO)
omeprazole  (ISO)
Ophiopogonin D  (ISO)
orciprenaline  (ISO)
organoselenium compound  (EXP)
oridonin  (EXP)
orlistat  (EXP)
ortho-Aminoazotoluene  (ISO)
osthole  (EXP,ISO)
ouabain  (ISO)
oxalic acid  (ISO)
oxaliplatin  (EXP,ISO)
oxidopamine  (EXP,ISO)
oxybenzone  (EXP)
oxybuprocaine  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (EXP,ISO)
paeoniflorin  (EXP,ISO)
Paeonol  (ISO)
palmatine  (ISO)
Palmitic acid(d3)  (ISO)
Panaxynol  (EXP)
Panduratin A  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (EXP,ISO)
paraquat  (EXP,ISO)
parathion-methyl  (EXP)
Parthenin  (ISO)
parthenolide  (ISO)
patulin  (ISO)
pefloxacin  (ISO)
penconazole  (ISO)
pendimethalin  (EXP)
Pendulone  (ISO)
pentane  (ISO)
Pentoxifylline  (EXP)
perfluorodecanoic acid  (ISO)
perfluoroheptanoic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (EXP)
pergolide  (ISO)
perifosine  (ISO)
perillyl alcohol  (ISO)
permethrin  (EXP)
peroxynitrous acid  (EXP)
pexidartinib  (ISO)
PF-3758309  (ISO)
phenanthrene  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP,ISO)
phenylhydrazine  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
PhIP  (ISO)
phloretin  (EXP)
phloroglucinol  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosphatidylcholine  (ISO)
phosphoramide mustard  (EXP)
physcion  (ISO)
phytol  (ISO)
phytosphingosine  (ISO)
piclamilast  (EXP)
picolinic acid  (EXP)
pifithrin-alpha hydrobromide  (EXP,ISO)
pinostrobin  (EXP,ISO)
pioglitazone  (EXP)
piperazine  (ISO)
piperine  (ISO)
piperonyl butoxide  (EXP)
pirarubicin  (ISO)
pirinixic acid  (EXP)
PK-11195  (ISO)
platinum  (ISO)
platinum(0)  (ISO)
platycodin D  (ISO)
poly(I:C)  (ISO)
Polygodial  (ISO)
polymyxin B2  (ISO)
polysulfur  (ISO)
ponatinib  (ISO)
Ponicidin  (ISO)
porphyrins  (ISO)
potassium bromate  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP,ISO)
potassium iodide  (EXP)
Pramanicin  (ISO)
Pranoprofen  (ISO)
pravastatin  (ISO)
prednisone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
proanthocyanidin  (EXP,ISO)
probenecid  (ISO)
probucol  (EXP)
prochloraz  (ISO)
procyanidin  (ISO)
procyanidin B2  (ISO)
procymidone  (EXP,ISO)
prodigiosin  (EXP)
progesterone  (EXP,ISO)
propacetamol  (ISO)
propiconazole  (EXP)
propionic acid  (EXP)
propofol  (EXP,ISO)
propranolol  (EXP,ISO)
propylparaben  (ISO)
prostaglandin E2  (EXP,ISO)
Protolichesterinic acid  (ISO)
protosappanin A  (EXP)
psoralen  (ISO)
pterostilbene  (ISO)
puerarin  (EXP,ISO)
Pulsatilla saponin D  (ISO)
punicalagin  (EXP,ISO)
purine-6-thiol  (ISO)
purmorphamine  (EXP)
puromycin  (ISO)
pyrene  (ISO)
pyrethrins  (EXP,ISO)
Pyridostigmine bromide  (EXP,ISO)
pyridoxine  (ISO)
pyrroles  (ISO)
pyrrolidine dithiocarbamate  (EXP)
pyrroloquinoline quinone  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
quercetin 4'-O-beta-D-glucopyranoside  (ISO)
quercitrin  (EXP)
quetiapine fumarate  (EXP)
quinacrine  (ISO)
quinazolines  (ISO)
quinoline yellow  (ISO)
quinolinic acid  (EXP)
rac-lactic acid  (ISO)
raloxifene  (ISO)
ramipril  (EXP)
ranitidine  (EXP,ISO)
razoxane  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (ISO)
rebaudioside A  (ISO)
remdesivir  (ISO)
reserpine  (EXP)
resolvin D1  (EXP)
resveratrol  (EXP,ISO)
Rhein  (ISO)
riboflavin  (ISO)
rifampicin  (ISO)
rimonabant  (ISO)
rivastigmine  (EXP)
Ro 31-8220  (EXP)
robinin  (EXP)
rocaglamide  (ISO)
roflumilast  (EXP,ISO)
rolipram  (EXP)
Roridin A  (ISO)
rosmarinic acid  (EXP,ISO)
rosuvastatin calcium  (EXP)
rotenone  (EXP,ISO)
rottlerin  (ISO)
royal jelly  (EXP)
rubitecan  (ISO)
ruthenium atom  (EXP)
ruthenium red  (ISO)
rutin  (EXP,ISO)
ruxolitinib  (ISO)
RV 538  (ISO)
ryanodine  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
S-nitrosoglutathione  (ISO)
saccharin  (EXP)
safrole  (ISO)
Salidroside  (EXP,ISO)
Salinomycin  (ISO)
salubrinal  (EXP,ISO)
Salvianolic acid A  (EXP)
salvianolic acid B  (EXP,ISO)
Sanggenon C  (EXP,ISO)
sanguinarine  (EXP,ISO)
sappanchalcone  (ISO)
sarin  (EXP,ISO)
sarpogrelate  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (EXP,ISO)
SCH 23390  (ISO)
scoparone  (ISO)
scopolamine  (EXP,ISO)
scopoletin  (EXP)
scutellarin  (ISO)
selenium atom  (EXP,ISO)
selenocystine  (ISO)
semilicoisoflavone B  (ISO)
serpentine asbestos  (ISO)
Sesamol  (ISO)
sesquiterpene  (ISO)
sevoflurane  (EXP,ISO)
Shikonin  (EXP)
sibutramine  (ISO)
sildenafil citrate  (EXP)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
silmitasertib  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sinapic acid  (EXP)
sirolimus  (ISO)
sirtinol  (ISO)
SNX-2112  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium azide  (EXP)
sodium chloride  (EXP,ISO)
sodium cholate  (ISO)
sodium chromate  (ISO)
sodium dichromate  (EXP)
sodium disulfite  (ISO)
sodium fluoride  (EXP,ISO)
sodium nitrite  (EXP)
sodium propionate  (ISO)
Soman  (EXP,ISO)
Sophoricoside  (ISO)
sorafenib  (ISO)
spermine  (ISO)
sphingosine 1-phosphate  (ISO)
Spiroquinazoline  (ISO)
squalene  (EXP)
Squamocin  (ISO)
staurosporine  (EXP,ISO)
sterigmatocystin  (ISO)
steviol  (ISO)
stevioside  (ISO)
stilbenoid  (ISO)
streptozocin  (EXP,ISO)
styrene  (ISO)
styrene oxide  (EXP,ISO)
succimer  (EXP)
succinic acid  (ISO)
sucrose  (EXP)
sulfaphenazole  (ISO)
sulfasalazine  (EXP,ISO)
sulforaphane  (ISO)
sulfur atom  (ISO)
sulfur dioxide  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sulpiride  (ISO)
surfactin  (ISO)
surfactin C  (ISO)
Swertiamarin  (EXP,ISO)
syringic acid  (EXP,ISO)
syringin  (ISO)
T-2 toxin  (EXP,ISO)
tacrine  (EXP,ISO)
tacrolimus hydrate  (EXP,ISO)
tadalafil  (EXP)
talazoparib  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
Tariquidar  (ISO)
taurine  (EXP)
tauroursodeoxycholic acid  (EXP,ISO)
tazarotene  (ISO)
tebuconazole  (EXP,ISO)
telmisartan  (EXP)
temozolomide  (ISO)
terazosin  (ISO)
Terfenadine  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetrahydrocurcumin  (ISO)
tetrahydropalmatine  (ISO)
tetramethylpyrazine  (ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (EXP)
thapsigargin  (EXP,ISO)
theaflavin  (EXP)
Theaflavin 3,3'-digallate  (EXP,ISO)
thiamethoxam  (ISO)
thiamine(1+) chloride  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP,ISO)
thiostrepton  (ISO)
Thiotepa  (ISO)
thiourea  (ISO)
thymidine  (ISO)
thymol  (EXP,ISO)
thymol sulfate(1-)  (EXP,ISO)
thymoquinone  (EXP,ISO)
Tiron  (ISO)
titanium dioxide  (EXP,ISO)
tocopherol  (ISO)
tomelukast  (EXP)
Tomentosin  (ISO)
toosendanin  (ISO)
topotecan  (ISO)
Torularhodin  (ISO)
torulene  (ISO)
tramadol  (EXP)
trametinib  (ISO)
tranexamic acid  (ISO)
trans-anethole  (EXP)
trans-cinnamic acid  (EXP)
tranylcypromine  (EXP)
triadimefon  (EXP)
triamcinolone acetonide  (EXP)
triazoles  (ISO)
tributylstannane  (EXP,ISO)
Tributyltin oxide  (ISO)
tricetin  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triciribine  (ISO)
triclosan  (EXP,ISO)
trifluoperazine  (ISO)
trilobatin  (EXP)
trimethylamine N-oxide  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
tris(picolinato)chromium  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
tropisetron  (EXP)
Tubeimoside I  (ISO)
tungsten  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (EXP,ISO)
umbelliferone  (EXP,ISO)
uranium atom  (ISO)
urethane  (ISO)
uridine  (ISO)
Urolithin A  (EXP,ISO)
ursodeoxycholic acid  (EXP,ISO)
ursolic acid  (ISO)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
vanadyl sulfate  (ISO)
vancomycin  (EXP)
veliparib  (ISO)
vemurafenib  (ISO)
venetoclax  (ISO)
venlafaxine hydrochloride  (EXP)
venom  (ISO)
verapamil  (ISO)
Vernodalin  (ISO)
Vernodalol  (ISO)
verteporfin  (EXP)
Vicanicin  (ISO)
vildagliptin  (EXP)
vinclozolin  (ISO)
vincristine  (EXP,ISO)
vindesine  (ISO)
Vinpocetine  (EXP)
vitamin D  (ISO)
vitamin E  (EXP,ISO)
vitexin  (ISO)
vorinostat  (EXP,ISO)
vortioxetine  (EXP)
VX nerve agent  (ISO)
wedelolactone  (ISO)
withaferin A  (EXP)
wogonin  (ISO)
wortmannin  (EXP,ISO)
xanthohumol  (EXP)
Xanthorrhizol  (ISO)
XAV939  (ISO)
XMU-MP-1  (ISO)
Y-27632  (EXP)
ytterbium  (ISO)
yttrium chloride  (EXP)
zearalenone  (EXP,ISO)
zebularine  (ISO)
zerumbone  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP,ISO)
zinc molecular entity  (ISO)
zinc oxide  (EXP,ISO)
zinc protoporphyrin  (EXP,ISO)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zingerone  (EXP,ISO)
zingiberene  (EXP)
ziram  (EXP)
zoledronic acid  (ISO)
zolmitriptan  (EXP)
zoxamide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic mitochondrial changes  (IEA,ISO,ISS)
apoptotic process  (IEA,ISO)
apoptotic process involved in blood vessel morphogenesis  (ISO)
apoptotic process involved in embryonic digit morphogenesis  (ISO)
apoptotic signaling pathway  (IEA,ISO,ISS)
B cell apoptotic process  (IEA,ISO,ISS)
B cell homeostasis  (ISO)
B cell homeostatic proliferation  (ISO)
B cell negative selection  (ISO)
B cell receptor apoptotic signaling pathway  (IEA,ISO)
blood vessel remodeling  (ISO)
cell population proliferation  (ISO)
cellular respiration  (IDA)
cellular response to hydrogen peroxide  (IEP)
cellular response to stress  (IEA)
cellular response to UV  (ISO)
cellular response to virus  (IEA,ISO)
cerebral cortex development  (IEP,ISO)
development of secondary sexual characteristics  (ISO)
DNA damage response  (ISO)
ectopic germ cell programmed cell death  (ISO)
establishment or maintenance of transmembrane electrochemical gradient  (IEA,ISO,ISS)
execution phase of apoptosis  (IEA,ISO)
extrinsic apoptotic signaling pathway  (IEA,ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IBA,ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
fertilization  (ISO)
germ cell development  (ISO)
glial cell apoptotic process  (IEP)
glycosphingolipid metabolic process  (ISO)
homeostasis of number of cells  (ISO)
homeostasis of number of cells within a tissue  (ISO)
hypothalamus development  (ISO)
inner mitochondrial membrane organization  (IDA)
intrinsic apoptotic signaling pathway  (IEA,ISO,ISS)
intrinsic apoptotic signaling pathway by p53 class mediator  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (IBA,IEA,ISO,ISS)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (ISO)
kidney development  (ISO)
leukocyte homeostasis  (ISO)
limb morphogenesis  (ISO)
male gonad development  (ISO)
mitochondrial fragmentation involved in apoptotic process  (IEA,ISO,ISS)
mitochondrial fusion  (IBA,IEA,ISO,ISS)
mitochondrial membrane organization  (IEA)
mitochondrion organization  (ISO)
myeloid cell homeostasis  (ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of endoplasmic reticulum calcium ion concentration  (ISO)
negative regulation of fibroblast proliferation  (ISO)
negative regulation of mitochondrial membrane potential  (IEA,ISO,ISS)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of peptidyl-serine phosphorylation  (ISO)
nervous system development  (ISO)
neuron apoptotic process  (ISO)
neuron migration  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
outer mitochondrial membrane organization  (IDA)
ovarian follicle development  (IEA,IEP,ISO)
positive regulation of apoptotic DNA fragmentation  (IEA,ISO)
positive regulation of apoptotic process  (IDA,IEA,IMP,ISO,ISS)
positive regulation of apoptotic process involved in mammary gland involution  (ISO)
positive regulation of B cell apoptotic process  (ISO)
positive regulation of calcium ion transport into cytosol  (ISO)
positive regulation of developmental pigmentation  (ISO)
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (IEA,ISO,ISS)
positive regulation of mitochondrial membrane permeability involved in apoptotic process  (ISO)
positive regulation of neuron apoptotic process  (IBA,IEA,ISO,ISS)
positive regulation of protein-containing complex assembly  (IEA,ISO,ISS)
positive regulation of release of cytochrome c from mitochondria  (IEA,ISO,ISS)
positive regulation of release of sequestered calcium ion into cytosol  (ISO)
post-embryonic camera-type eye morphogenesis  (ISO)
post-embryonic development  (ISO)
protein insertion into mitochondrial membrane  (ISO)
regulation of apoptotic process  (IEA,ISO)
regulation of cell cycle  (ISO)
regulation of mammary gland epithelial cell proliferation  (ISO)
regulation of mitochondrial membrane permeability involved in apoptotic process  (ISO)
regulation of mitochondrial membrane permeability involved in programmed necrotic cell death  (ISO)
regulation of mitochondrial membrane potential  (IEA,ISO,ISS)
regulation of neuron apoptotic process  (IEP,ISO)
regulation of nitrogen utilization  (ISO)
release of cytochrome c from mitochondria  (IBA,IDA,IEA,ISO)
release of matrix enzymes from mitochondria  (IEA,ISO,ISS)
response to anesthetic  (IEP)
response to axon injury  (ISO)
response to cocaine  (IEP)
response to copper ion  (IEP)
response to corticosterone  (IEP)
response to gamma radiation  (ISO)
response to hypoxia  (IEP)
response to insulin-like growth factor stimulus  (IEP)
response to ionizing radiation  (ISO)
response to ischemia  (IEP)
response to salt stress  (ISO)
response to toxic substance  (IEA,ISO,ISS)
response to wounding  (ISO)
response to xenobiotic stimulus  (IEP)
retina development in camera-type eye  (ISO)
retinal cell programmed cell death  (ISO)
Sertoli cell proliferation  (ISO)
sex differentiation  (ISO)
spermatid differentiation  (ISO)
spermatogenesis  (ISO)
supramolecular fiber organization  (IEA,ISO)
swimming behavior  (IEP)
T cell homeostatic proliferation  (ISO)
thymocyte apoptotic process  (ISO)
vagina development  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Bax interacts with the voltage-dependent anion channel and mediates ethanol-induced apoptosis in rat hepatocytes. Adachi M, etal., Am J Physiol Gastrointest Liver Physiol. 2004 Sep;287(3):G695-705. Epub 2004 Mar 25.
2. The Bcl-2 apoptotic switch in cancer development and therapy. Adams JM and Cory S, Oncogene. 2007 Feb 26;26(9):1324-37.
3. Bax mutation and overexpression inversely correlate with immature phenotype and prognosis of childhood germ cell tumors. Addeo R, etal., Oncol Rep. 2007 May;17(5):1155-61.
4. Lung injury after ischemia-reperfusion of small intestine in rats involves apoptosis of type II alveolar epithelial cells mediated by TNF-alpha and activation of Bid pathway. An S, etal., Apoptosis. 2007 Nov;12(11):1989-2001. doi: 10.1007/s10495-007-0125-1.
5. Neutrophil gelatinase-associated lipocalin (NGAL) may play a protective role against rats ischemia/reperfusion renal injury via inhibiting tubular epithelial cell apoptosis. An S, etal., Ren Fail. 2013;35(1):143-9. doi: 10.3109/0886022X.2012.741877. Epub 2012 Nov 15.
6. Bax and heart mitochondria: uncoupling and inhibition of respiration without permeability transition. Appaix F, etal., Biochim Biophys Acta 2002 Dec 2;1556(2-3):155-67.
7. Myocardial fibrosis and apoptosis, but not inflammation, are present in long-term experimental diabetes. Ares-Carrasco S, etal., Am J Physiol Heart Circ Physiol. 2009 Oct 9.
8. Elevated caspase and AIF gene expression correlate with progression of sarcopenia during aging in male F344BN rats. Baker DJ and Hepple RT, Exp Gerontol. 2006 Nov;41(11):1149-56. Epub 2006 Oct 6.
9. Cardioprotective role of growth/differentiation factor 1 in post-infarction left ventricular remodelling and dysfunction. Bao MW, etal., J Pathol. 2015 Jul;236(3):360-72. doi: 10.1002/path.4523. Epub 2015 Mar 30.
10. Bax and Bid act in synergy to bring about T11TS-mediated glioma apoptosis via the release of mitochondrial cytochrome c and subsequent caspase activation. Bhattacharjee M, etal., Int Immunol. 2008 Dec;20(12):1489-505. Epub 2008 Oct 17.
11. T11TS Treatment Augments Apoptosis of Glioma Associated Brain Endothelial Cells, Hint Toward Anti-Angiogenic Action in Glioma. Bhattacharya D, etal., J Cell Physiol. 2017 Mar;232(3):526-539. doi: 10.1002/jcp.25447. Epub 2016 Jun 21.
12. Differential profile of Nix upregulation and translocation during hypoxia/ischaemia in vivo versus in vitro. Birse-Archbold JL, etal., J Cereb Blood Flow Metab. 2005 Oct;25(10):1356-65.
13. Chemopreventive effect of a novel oleanane triterpenoid in a chemically induced rodent model of breast cancer. Bishayee A, etal., Int J Cancer. 2013 Sep 1;133(5):1054-63. doi: 10.1002/ijc.28108. Epub 2013 Mar 29.
14. ZFP36 protects lungs from intestinal I/R-induced injury and fibrosis through the CREBBP/p53/p21/Bax pathway. Cao Y, etal., Cell Death Dis. 2021 Jul 8;12(7):685. doi: 10.1038/s41419-021-03950-y.
15. Bax translocates to mitochondria of heart cells during simulated ischaemia: involvement of AMP-activated and p38 mitogen-activated protein kinases. Capano M and Crompton M, Biochem J. 2006 Apr 1;395(1):57-64.
16. Role of p97/Valosin-containing protein (VCP) and Jab1/CSN5 in testicular ischaemia-reperfusion injury. Cayli S, etal., J Mol Histol. 2016 Feb;47(1):91-100. doi: 10.1007/s10735-016-9652-9. Epub 2016 Jan 11.
17. Significance of Bcl-2 and Bax proteins in cervical carcinogenesis: an immunohistochemical study in squamous cell carcinoma and squamous intraepithelial lesions. Cheah PL and Looi LM, Malays J Pathol. 2006 Jun;28(1):1-5.
18. Induction of Bcl-2 and Bax was related to hyperphosphorylation of tau and neuronal death induced by okadaic acid in rat brain. Chen LQ, etal., Anat Rec A Discov Mol Cell Evol Biol. 2005 Dec;287(2):1236-45.
19. Interfering effect and mechanism of neuregulin on experimental dementia model in rats. Chen Y, etal., Behav Brain Res. 2011 Sep 23;222(2):321-5. doi: 10.1016/j.bbr.2011.03.063. Epub 2011 Apr 5.
20. Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease. Chiesa R, etal., Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):238-43. doi: 10.1073/pnas.0406173102. Epub 2004 Dec 23.
21. Peroxisome proliferator-activated receptors gamma/mitochondrial uncoupling protein 2 signaling protects against seizure-induced neuronal cell death in the hippocampus following experimental status epilepticus. Chuang YC, etal., J Neuroinflammation. 2012 Jul 31;9:184.
22. [Effects of BNP preconditioning on myocardial cell apoptosis and expressions of bcl-2 and Bax during myocardial ischemia-reperfusion injury in rats]. Deng YJ, etal., Zhonghua Yi Xue Za Zhi. 2010 Dec 28;90(48):3431-4.
23. Cocaine exposure in vitro induces apoptosis in fetal locus coeruleus neurons by altering the Bax/Bcl-2 ratio and through caspase-3 apoptotic signaling. Dey S, etal., Neuroscience. 2007 Jan 19;144(2):509-21. Epub 2006 Nov 3.
24. [The changes of inducible nitric oxide synthase activity and apoptosis-related gene expression in endotoxemia-induced rat diaphragm]. Fang YY, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2013 May;29(3):209-12.
25. BAG3 protein is overexpressed in human glioblastoma and is a potential target for therapy. Festa M, etal., Am J Pathol. 2011 Jun;178(6):2504-12. Epub 2011 May 10.
26. The timing of re-institution of good blood glucose control affects apoptosis and expression of Bax and Bcl-2 in the retina of diabetic rats. Gao XY, etal., Mol Biol Rep. 2008 Nov 8.
27. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
28. Expression and Prognostic Significance of EP300, TP53 and BAX in Clear Cell Renal Cell Carcinoma. Godlewski J, etal., Anticancer Res. 2017 Jun;37(6):2927-2937. doi: 10.21873/anticanres.11646.
29. Gastroprotection studies of Schiff base zinc (II) derivative complex against acute superficial hemorrhagic mucosal lesions in rats. Golbabapour S, etal., PLoS One. 2013 Sep 13;8(9):e75036. doi: 10.1371/journal.pone.0075036. eCollection 2013.
30. Expression and localisation of Bcl-2 and Bax proteins in developing rat ovary. Gursoy E, etal., Res Vet Sci. 2008 Feb;84(1):56-61. Epub 2007 Jun 13.
31. Apoptosis repressor with caspase recruitment domain protects against cell death by interfering with Bax activation. Gustafsson AB, etal., J Biol Chem. 2004 May 14;279(20):21233-8. Epub 2004 Mar 5.
32. Effects of soy protein isolate consumption on prostate cancer biomarkers in men with HGPIN, ASAP, and low-grade prostate cancer. Hamilton-Reeves JM, etal., Nutr Cancer. 2008 Jan-Feb;60(1):7-13.
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165. Rho-kinase-dependent pathway mediates the hepatoprotective effects of sorafenib against ischemia/reperfusion liver injury in rats with nonalcoholic steatohepatitis. Yang YY, etal., Liver Transpl. 2012 Nov;18(11):1371-83. doi: 10.1002/lt.23520.
166. Protective effect of curcumin on chemotherapy-induced intestinal dysfunction. Yao Q, etal., Int J Clin Exp Pathol. 2013 Oct 15;6(11):2342-9. eCollection 2013.
167. Neonatal bronchopulmonary dysplasia increases neuronal apoptosis in the hippocampus through the HIF-1alpha and p53 pathways. Yin R, etal., Respir Physiol Neurobiol. 2016 Jan;220:81-7. doi: 10.1016/j.resp.2015.09.011. Epub 2015 Sep 30.
168. Titanium dioxide induces apoptotic cell death through reactive oxygen species-mediated Fas upregulation and Bax activation. Yoo KC, etal., Int J Nanomedicine. 2012;7:1203-14. doi: 10.2147/IJN.S28647. Epub 2012 Mar 5.
169. Influence of age or circadian time on Bcl-2 and Bax mRNA expression in the rat hippocampus after corticosterone exposure. Yoshimura A, etal., Brain Res Bull. 2007 Jul 12;73(4-6):254-8. Epub 2007 Apr 10.
170. Changes of inflammation and apoptosis in adrenal gland after experimental injury in rats with acute necrotizing pancreatitis. Yu J, etal., Inflammation. 2012 Feb;35(1):11-22.
171. Angiotension II receptor 1 blocker modifies the expression of apoptosis-related proteins and transforming growth factor-beta1 in prostate tissue of spontaneously hypertensive rats. Yu W, etal., BJU Int. 2007 Nov;100(5):1161-5. Epub 2007 Sep 3.
172. [Effects of TX0201 abstracted from heart-regulating formula on spatial learning and regulation of Bax mRNA, Bcl-2 mRNA level in brain of rat with Alzheimer's disease] Yu ZH, etal., Zhongguo Zhong Yao Za Zhi. 2007 May;32(9):839-42.
173. Gastrodin Ameliorates Acute Rejection via IRE1α/TRAF2/NF-κB in Rats Receiving Liver Allografts. Yuan F, etal., Biomed Res Int. 2019 Nov 20;2019:9276831. doi: 10.1155/2019/9276831. eCollection 2019.
174. Gingerol ameliorates neuronal damage induced by hypoxia-reoxygenation via the miR-210/brain-derived neurotrophic factor axis. Zhai Y, etal., Kaohsiung J Med Sci. 2022 Apr;38(4):367-377. doi: 10.1002/kjm2.12486. Epub 2021 Dec 28.
175. Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia. Zhang G, etal., J Ethnopharmacol. 2008 Feb 12;115(3):441-8. Epub 2007 Oct 25.
176. Bax gene silencing: a potential intervention in aluminum-induced neural cell death. Zhang QL, etal., J Biol Regul Homeost Agents. 2010 Jan-Mar;24(1):7-17.
177. Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis. Zhang X, etal., Autophagy. 2011 Apr;7(4):412-25. Epub 2011 Apr 1.
178. ARC protects rat cardiomyocytes against oxidative stress through inhibition of caspase-2 mediated mitochondrial pathway. Zhang YQ and Herman B, J Cell Biochem. 2006 Oct 1;99(2):575-88.
179. [Effects of hydrogen-rich saline on endoplasmic reticulum stress during myocardial ischemia-reperfusion in rats]. Zhao Y, etal., Zhonghua Yi Xue Za Zhi. 2014 Oct 21;94(38):3024-8.
Additional References at PubMed
PMID:1558161   PMID:7650488   PMID:7828536   PMID:7834748   PMID:8358790   PMID:8625820   PMID:8631771   PMID:8798452   PMID:8816704   PMID:8918887   PMID:9008714   PMID:9056387  
PMID:9096145   PMID:9111042   PMID:9176392   PMID:9219694   PMID:9241272   PMID:9388232   PMID:9454845   PMID:9454852   PMID:9553144   PMID:9560217   PMID:9660918   PMID:9699561  
PMID:9843949   PMID:9988273   PMID:10201940   PMID:10363969   PMID:10464378   PMID:10479688   PMID:10486519   PMID:10597216   PMID:10618441   PMID:10620504   PMID:10639175   PMID:10683286  
PMID:10744634   PMID:10762311   PMID:10884318   PMID:10894153   PMID:10931486   PMID:10995754   PMID:11060313   PMID:11146002   PMID:11146504   PMID:11150333   PMID:11163212   PMID:11226327  
PMID:11350920   PMID:11369777   PMID:11413548   PMID:11604501   PMID:11717344   PMID:11784036   PMID:11836241   PMID:11864976   PMID:11906913   PMID:11912183   PMID:11980919   PMID:12009022  
PMID:12097139   PMID:12184852   PMID:12198774   PMID:12499352   PMID:12529375   PMID:12591359   PMID:12606450   PMID:12715101   PMID:12810599   PMID:12847083   PMID:12910269   PMID:12917363  
PMID:12925707   PMID:12925958   PMID:12943686   PMID:12952892   PMID:12959737   PMID:12967636   PMID:14502238   PMID:14507967   PMID:14517300   PMID:14517994   PMID:14522999   PMID:14561915  
PMID:14614769   PMID:14623868   PMID:14625274   PMID:14651853   PMID:14660547   PMID:14729675   PMID:14752510   PMID:14754538   PMID:14769861   PMID:14871028   PMID:14963330   PMID:15051517  
PMID:15102863   PMID:15138279   PMID:15214043   PMID:15219885   PMID:15304216   PMID:15309723   PMID:15342910   PMID:15351738   PMID:15356200   PMID:15469889   PMID:15499375   PMID:15525785  
PMID:15528359   PMID:15545017   PMID:15574493   PMID:15578100   PMID:15581613   PMID:15590655   PMID:15590937   PMID:15613488   PMID:15637643   PMID:15680329   PMID:15705586   PMID:15719136  
PMID:15753097   PMID:15776018   PMID:15796810   PMID:15869495   PMID:15901672   PMID:15944391   PMID:15947791   PMID:15955981   PMID:15967824   PMID:15989966   PMID:16055554   PMID:16103918  
PMID:16113678   PMID:16121936   PMID:16133871   PMID:16195771   PMID:16199525   PMID:16227588   PMID:16270031   PMID:16302269   PMID:16307838   PMID:16424160   PMID:16446153   PMID:16459353  
PMID:16462759   PMID:16469926   PMID:16535832   PMID:16535844   PMID:16551891   PMID:16571598   PMID:16571718   PMID:16608847   PMID:16642033   PMID:16733793   PMID:16735463   PMID:16751333  
PMID:16824930   PMID:16893972   PMID:16937528   PMID:16967487   PMID:17005564   PMID:17024184   PMID:17035996   PMID:17052454   PMID:17068116   PMID:17077143   PMID:17107997   PMID:17184147  
PMID:17192424   PMID:17227955   PMID:17234627   PMID:17244737   PMID:17289999   PMID:17318810   PMID:17428862   PMID:17464193   PMID:17615176   PMID:17668322   PMID:17823127   PMID:17897919  
PMID:18195012   PMID:18201675   PMID:18279588   PMID:18308723   PMID:18308842   PMID:18401532   PMID:18436203   PMID:18497705   PMID:18547146   PMID:18563323   PMID:18601975   PMID:18614015  
PMID:18614344   PMID:18655197   PMID:18687331   PMID:18751719   PMID:18788994   PMID:18806094   PMID:18835031   PMID:18852517   PMID:18923682   PMID:19029045   PMID:19062087   PMID:19074440  
PMID:19125405   PMID:19139267   PMID:19189070   PMID:19224578   PMID:19229825   PMID:19323382   PMID:19399403   PMID:19481735   PMID:19483283   PMID:19694802   PMID:19696693   PMID:19702087  
PMID:19767770   PMID:19788070   PMID:19805544   PMID:19806804   PMID:19833151   PMID:19862336   PMID:19887447   PMID:19936637   PMID:19946888   PMID:19951548   PMID:20021812   PMID:20021825  
PMID:20092675   PMID:20093356   PMID:20128384   PMID:20137712   PMID:20360684   PMID:20448358   PMID:20457187   PMID:20458337   PMID:20465949   PMID:20541605   PMID:20671748   PMID:20684272  
PMID:20840861   PMID:20850011   PMID:20965838   PMID:20969598   PMID:21062263   PMID:21126425   PMID:21158042   PMID:21158059   PMID:21161433   PMID:21171385   PMID:21199865   PMID:21262771  
PMID:21347840   PMID:21384157   PMID:21391123   PMID:21404022   PMID:21414921   PMID:21483632   PMID:21500593   PMID:21660956   PMID:21672380   PMID:21726169   PMID:21748659   PMID:21803450  
PMID:21845871   PMID:21903151   PMID:21914402   PMID:21951169   PMID:21964438   PMID:22001368   PMID:22094093   PMID:22106416   PMID:22198199   PMID:22260021   PMID:22357517   PMID:22369161  
PMID:22493254   PMID:22650024   PMID:22668016   PMID:22903551   PMID:22947864   PMID:22978712   PMID:22982225   PMID:22998365   PMID:22999929   PMID:23074209   PMID:23151725   PMID:23239445  
PMID:23374347   PMID:23376485   PMID:23402272   PMID:23433337   PMID:23686888   PMID:23714208   PMID:23744079   PMID:23858059   PMID:23984821   PMID:24228092   PMID:24269759   PMID:24287037  
PMID:24298554   PMID:24326522   PMID:24633814   PMID:24743739   PMID:24935577   PMID:24938610   PMID:24978397   PMID:25397408   PMID:25403402   PMID:25820554   PMID:25861655   PMID:26012958  
PMID:26125843   PMID:26299946   PMID:26400280   PMID:26497033   PMID:26818429   PMID:26854628   PMID:26949185   PMID:27098698   PMID:27109989   PMID:27166426   PMID:27320597   PMID:27526155  
PMID:27645924   PMID:27666568   PMID:27690136   PMID:27818197   PMID:27830683   PMID:27919736   PMID:28000380   PMID:28263293   PMID:28266762   PMID:28388366   PMID:29243771   PMID:29412156  
PMID:29531808   PMID:30100066   PMID:30488170   PMID:30592279   PMID:31148189   PMID:31392537   PMID:31583941   PMID:32735924   PMID:32920758   PMID:33710703   PMID:33794264   PMID:34020532  
PMID:34411492   PMID:34617183   PMID:36299606   PMID:37831754   PMID:38396011  


Genomics

Comparative Map Data
Bax
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,076,472 - 105,081,906 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1105,076,473 - 105,086,429 (-)EnsemblGRCr8
mRatBN7.2195,940,001 - 95,945,407 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,938,808 - 95,945,368 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1101,325,431 - 101,330,837 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,798,107 - 109,803,513 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,088,504 - 103,093,910 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,451,801 - 101,457,207 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,451,802 - 101,457,207 (-)Ensemblrn6Rnor6.0
Rnor_5.01102,530,747 - 102,536,153 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4195,933,023 - 95,938,176 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera190,195,913 - 90,201,319 (-)NCBICelera
RGSC_v3.1196,011,133 - 96,016,287 (-)NCBI
Cytogenetic Map1q22NCBI
BAX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,954,875 - 48,961,798 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1948,954,815 - 48,961,798 (+)Ensemblhg38GRCh38
GRCh371949,458,132 - 49,465,055 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,149,929 - 54,156,867 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341954,149,928 - 54,156,866NCBI
Celera1946,325,480 - 46,332,409 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,835,055 - 45,841,975 (+)NCBIHuRef
CHM1_11949,460,326 - 49,467,266 (+)NCBICHM1_1
T2T-CHM13v2.01951,949,757 - 51,956,683 (+)NCBIT2T-CHM13v2.0
Bax
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,111,124 - 45,116,332 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,111,121 - 45,116,322 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38745,461,695 - 45,466,903 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,461,697 - 45,466,898 (-)Ensemblmm10GRCm38
MGSCv37752,717,065 - 52,722,268 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36745,329,744 - 45,334,864 (-)NCBIMGSCv36mm8
Celera740,917,745 - 40,922,946 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.32NCBI
Bax
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,695,960 - 1,700,244 (-)Ensembl
ChiLan1.0NW_0049555591,695,960 - 1,700,246 (-)NCBIChiLan1.0ChiLan1.0
BAX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,059,801 - 55,066,754 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11956,985,941 - 56,992,885 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01945,955,926 - 45,962,870 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11954,793,594 - 54,800,466 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1954,793,594 - 54,800,468 (-)EnsemblpanPan2panpan1.1
BAX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,423,388 - 107,426,464 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,422,424 - 107,426,464 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1106,945,329 - 106,949,006 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01107,947,413 - 107,951,165 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,947,430 - 107,951,107 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,614,952 - 107,618,629 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,261,311 - 107,264,988 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,096,913 - 108,100,590 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bax
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,349,880 - 21,355,462 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366642,967,865 - 2,973,820 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366642,968,103 - 2,973,652 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BAX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,222,336 - 54,228,147 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1654,222,341 - 54,228,150 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,100,514 - 50,106,337 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BAX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,186,028 - 42,193,105 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607322,071,985 - 22,079,701 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bax
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248325,050,222 - 5,055,506 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248325,050,222 - 5,068,565 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Bax
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12154,044,388 - 154,049,903 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Bax
57 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:52
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000028328
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat

Markers in Region
PMC114802P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2897,646,552 - 97,647,024 (+)MAPPERmRatBN7.2
mRatBN7.21086,532,320 - 86,532,859 (+)MAPPERmRatBN7.2
Rnor_6.01089,509,784 - 89,510,322NCBIRnor6.0
Rnor_6.08104,949,278 - 104,949,749NCBIRnor6.0
Rnor_5.01089,307,349 - 89,307,887UniSTSRnor5.0
Rnor_5.08104,395,475 - 104,395,946UniSTSRnor5.0
RGSC_v3.41090,628,148 - 90,628,686UniSTSRGSC3.4
RGSC_v3.48102,144,412 - 102,144,883UniSTSRGSC3.4
Celera897,086,649 - 97,087,120UniSTS
Celera1085,255,228 - 85,255,766UniSTS
Cytogenetic Map8q31UniSTS
Cytogenetic Map10q32.1UniSTS
Cytogenetic Map1q31.2UniSTS
PMC30226P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2897,646,629 - 97,646,985 (+)MAPPERmRatBN7.2
mRatBN7.21086,532,407 - 86,532,820 (+)MAPPERmRatBN7.2
Rnor_6.01089,509,871 - 89,510,283NCBIRnor6.0
Rnor_6.08104,949,355 - 104,949,710NCBIRnor6.0
Rnor_5.01089,307,436 - 89,307,848UniSTSRnor5.0
Rnor_5.08104,395,552 - 104,395,907UniSTSRnor5.0
RGSC_v3.41090,628,235 - 90,628,647UniSTSRGSC3.4
RGSC_v3.48102,144,489 - 102,144,844UniSTSRGSC3.4
Celera897,086,726 - 97,087,081UniSTS
Celera1085,255,315 - 85,255,727UniSTS
Cytogenetic Map8q31UniSTS
Cytogenetic Map10q32.1UniSTS
Cytogenetic Map1q31.2UniSTS
Bax  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,943,650 - 95,944,822 (+)MAPPERmRatBN7.2
Rnor_6.01101,455,451 - 101,456,622NCBIRnor6.0
Rnor_5.01102,534,397 - 102,535,568UniSTSRnor5.0
RGSC_v3.4195,936,509 - 95,937,680UniSTSRGSC3.4
Celera190,199,563 - 90,200,734UniSTS
Cytogenetic Map1q31.2UniSTS
GDB:632822  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,532,279 - 86,532,860 (+)MAPPERmRatBN7.2
Rnor_6.01089,509,743 - 89,510,323NCBIRnor6.0
Rnor_5.01089,307,308 - 89,307,888UniSTSRnor5.0
RGSC_v3.41090,628,107 - 90,628,687UniSTSRGSC3.4
Celera1085,255,187 - 85,255,767UniSTS
Cytogenetic Map10q32.1UniSTS
Cytogenetic Map1q31.2UniSTS
BARC0009  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2897,646,559 - 97,646,989 (+)MAPPERmRatBN7.2
Rnor_6.08104,949,285 - 104,949,714NCBIRnor6.0
Rnor_5.08104,395,482 - 104,395,911UniSTSRnor5.0
RGSC_v3.48102,144,419 - 102,144,848UniSTSRGSC3.4
Celera897,086,656 - 97,087,085UniSTS
Cytogenetic Map8q31UniSTS
Cytogenetic Map1q31.2UniSTS
Bax  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81105,080,120 - 105,081,061 (+)Marker Load Pipeline
mRatBN7.2195,943,649 - 95,944,590 (+)MAPPERmRatBN7.2
Rnor_6.01101,455,450 - 101,456,390NCBIRnor6.0
Rnor_5.01102,534,396 - 102,535,336UniSTSRnor5.0
RGSC_v3.4195,936,508 - 95,937,448UniSTSRGSC3.4
Celera190,199,562 - 90,200,502UniSTS
Cytogenetic Map1q31.2UniSTS
Bax  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,532,629 - 86,532,776 (+)MAPPERmRatBN7.2
Rnor_6.01089,510,093 - 89,510,239NCBIRnor6.0
Rnor_5.01089,307,658 - 89,307,804UniSTSRnor5.0
RGSC_v3.41090,628,457 - 90,628,603UniSTSRGSC3.4
Celera1085,255,537 - 85,255,683UniSTS
Cytogenetic Map10q32.1UniSTS
Cytogenetic Map1q31.2UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000028328   ⟹   ENSRNOP00000028328
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1105,076,473 - 105,081,892 (-)Ensembl
mRatBN7.2 Ensembl195,938,808 - 95,945,368 (-)Ensembl
Rnor_6.0 Ensembl1101,451,802 - 101,457,207 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087061   ⟹   ENSRNOP00000075080
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1101,451,802 - 101,457,126 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000169825   ⟹   ENSRNOP00000107192
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1105,076,473 - 105,086,429 (-)Ensembl
RefSeq Acc Id: NM_017059   ⟹   NP_058755
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,076,472 - 105,081,878 (-)NCBI
mRatBN7.2195,940,001 - 95,945,407 (-)NCBI
Rnor_6.01101,451,801 - 101,457,207 (-)NCBI
Rnor_5.01102,530,747 - 102,536,153 (-)NCBI
RGSC_v3.4195,933,023 - 95,938,176 (-)RGD
Celera190,195,913 - 90,201,319 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063281064   ⟹   XP_063137134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,076,474 - 105,081,906 (-)NCBI
RefSeq Acc Id: NP_058755   ⟸   NM_017059
- UniProtKB: G3V8T9 (UniProtKB/TrEMBL),   A0A8I6GCB5 (UniProtKB/TrEMBL),   A6JB34 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075080   ⟸   ENSRNOT00000087061
Ensembl Acc Id: ENSRNOP00000028328   ⟸   ENSRNOT00000028328
RefSeq Acc Id: XP_063137134   ⟸   XM_063281064
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000107192   ⟸   ENSRNOT00000169825
Protein Domains
Bcl-2 Bcl-2 homology region 1-3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63690-F1-model_v2 AlphaFold Q63690 1-192 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690043
Promoter ID:EPDNEW_R565
Type:initiation region
Name:Bax_1
Description:BCL2 associated X, apoptosis regulator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01101,457,158 - 101,457,218EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2192 AgrOrtholog
BioCyc Gene G2FUF-59682 BioCyc
Ensembl Genes ENSRNOG00000020876 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000028328 ENTREZGENE
Gene3D-CATH 1.10.437.10 UniProtKB/Swiss-Prot
InterPro Bcl-2_BH1-3 UniProtKB/Swiss-Prot
  Bcl2-like UniProtKB/Swiss-Prot
  Bcl2_BH1_motif_CS UniProtKB/Swiss-Prot
  Bcl2_BH2_motif_CS UniProtKB/Swiss-Prot
  Bcl2_BH3_motif_CS UniProtKB/Swiss-Prot
  Blc2-like_sf UniProtKB/Swiss-Prot
  Blc2_fam UniProtKB/Swiss-Prot
NCBI Gene 24887 ENTREZGENE
PANTHER PTHR11256 UniProtKB/Swiss-Prot
  PTHR11256:SF42 UniProtKB/Swiss-Prot
Pfam Bcl-2 UniProtKB/Swiss-Prot
PharmGKB BAX RGD
PhenoGen Bax PhenoGen
PRINTS BCL2FAMILY UniProtKB/Swiss-Prot
PROSITE BCL2_FAMILY UniProtKB/Swiss-Prot
  BH1 UniProtKB/Swiss-Prot
  BH2 UniProtKB/Swiss-Prot
  BH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020876 RatGTEx
SMART BCL UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56854 UniProtKB/Swiss-Prot
UniProt A0A8I6GCB5 ENTREZGENE
  A0ABK0LZ45_RAT UniProtKB/TrEMBL
  A6JB34 ENTREZGENE, UniProtKB/TrEMBL
  BAX_RAT UniProtKB/Swiss-Prot
  G3V8T9 ENTREZGENE, UniProtKB/TrEMBL
  Q63690 ENTREZGENE
  Q9JKL3_RAT UniProtKB/TrEMBL
UniProt Secondary Q62995 UniProtKB/Swiss-Prot
  Q64383 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-22 Bax  BCL2 associated X, apoptosis regulator  Bax  Bcl2-associated X protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Bax  bcl2-associated X protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization mainly distributed in cytosol but translocating to the outer membrane during apoptosis signaling 70241
gene_cellular_localization level in mitochondria is unchanged with age 70304
gene_process Bax/Bax homodimers induce pores in the outer membrane and enhance apoptosis by mediating the release of cytochrome c 70303
gene_process required for the cell death of cerebellar granule neurons mediated by Dp5 and other BH-3 only proteins 70303
gene_process produces large pores in the outer membrane, inhibits some segments of the respiratory chain in the inner membrane and uncouples the inner mitochondrial membrane by increasing proton leak without opening the permeability transition pore (PTP) 628373
gene_process permeabilizes the outer mitochondrial membrane and triggers the release of cytochrome c and reduces the respiration rate 628373