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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:6954
Term: Mitotane
Definition: null
Chemical ID: MESH:D008939
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDMitotane analog results in increased expression of BAX mRNA; Mitotane results in increased expression of BAX mRNAPMID:23485034
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[Doxorubicin co-treated with Vincristine co-treated with Etoposide co-treated with Mitotane] results in decreased expression of BAX proteinPMID:9815696
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