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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:31767
Term: lead diacetate
Definition: A lead coordination entity in which a central lead(2+) atom is coordinated to two acetate ions.
Chemical ID: MESH:C008261
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxdecreases expressionEXP 6480464CTDlead acetate results in decreased expression of BAX mRNA; lead acetate results in decreased expression of BAX proteinPMID:23146751
Baxincreases expressionEXP 6480464CTDlead acetate results in increased expression of BAX mRNA; lead acetate results in increased expression of BAX proteinPMID:17959157 PMID:23086308 PMID:24960054 PMID:26797587 PMID:29797346 PMID:32116774 PMID:34553816 PMID:37471654
Baxmultiple interactionsEXP 6480464CTD[[lead acetate results in increased abundance of Lead] which co-treated with Carbenoxolone] results in increased expression of BAX protein; [Cadmium Chloride co-treated with lead acetate] results in increased expression of BAX protein; [lead acetate results in increased abundance of Lead] which results in increased expression of BAX protein; [sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of BAX protein; Acetylcysteine affects the reaction [lead acetate results in increased expression of BAX protein]; Ascorbic Acid inhibits the reaction [lead acetate results in increased expression of BAX protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of BAX mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of BAX protein]; Genistein affects the reaction [lead acetate results in increased expression of BAX protein]; Hemin inhibits the reaction [lead acetate results in increased expression of BAX protein]; lead acetate promotes the reaction [Zinc Oxide results in increased expression of BAX mRNA]; Ro 31-8220 promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of BAX protein]; sinapinic acid inhibits the reaction [lead acetate results in increased expression of BAX mRNA]; Tetradecanoylphorbol Acetate inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of BAX protein]; Zinc Oxide promotes the reaction [lead acetate results in increased expression of BAX mRNA]PMID:17959157 PMID:25031709 PMID:26396915 PMID:26797587 PMID:29797346 PMID:32116774 PMID:33242459 PMID:34553816 PMID:36925031 PMID:37471654
Baxaffects expressionISOBAX (Homo sapiens)6480464CTDlead acetate affects the expression of BAX proteinPMID:26542248
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDlead acetate results in increased expression of BAX proteinPMID:26498409
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDNFE2L2 protein inhibits the reaction [lead acetate results in increased expression of BAX protein]PMID:26498409
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