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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:81584
Term: 2,2',4,4'-Tetrabromodiphenyl ether
Definition: An organobromine compound that has formula C12H6Br4O.
Chemical ID: MESH:C511295
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionISOBax (Mus musculus)6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in increased expression of BAX mRNA; 2,2',4,4'-tetrabromodiphenyl ether results in increased expression of BAX proteinPMID:25462306 PMID:25639565
Baxincreases expressionISOBAX (Homo sapiens)6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in increased expression of BAX mRNAPMID:22543052
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDepoxomicin inhibits the reaction [troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of BAX protein]]; troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of BAX protein]PMID:25639565
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDERN1 protein affects the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of BAX mRNA]PMID:22543052
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