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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:29073
Term: L-ascorbic acid
Definition: The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.
Chemical ID: MESH:D001205
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxmultiple interactionsEXP 6480464CTDAscorbic Acid inhibits the reaction [Humic Substances results in increased expression of BAX protein]; Ascorbic Acid inhibits the reaction [lead acetate results in increased expression of BAX protein]; Ascorbic Acid inhibits the reaction [Potassium Dichromate affects the localization of BAX protein]; Ascorbic Acid inhibits the reaction [Potassium Dichromate results in increased expression of BAX protein]; Ascorbic Acid inhibits the reaction [Streptozocin results in increased expression of BAX protein]PMID:17959157 PMID:18683188 PMID:18758938 PMID:21262251
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDAscorbic Acid inhibits the reaction [glycidamide results in increased expression of BAX mRNA]PMID:32632975
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[Arsenic Trioxide co-treated with Ascorbic Acid co-treated with Disulfiram] results in increased expression of BAX protein; [juglone co-treated with Ascorbic Acid] results in increased expression of BAX protein; Ascorbic Acid inhibits the reaction [deoxynivalenol results in increased expression of BAX protein]; Ascorbic Acid inhibits the reaction [Silicon Dioxide results in increased expression of BAX mRNA]; Ascorbic Acid inhibits the reaction [Silicon Dioxide results in increased expression of BAX protein]PMID:17166419 PMID:22245848 PMID:24126434 PMID:29992683
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