GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bax | decreases expression | EXP | | 6480464 | CTD | Cadmium results in decreased expression of BAX protein | PMID:23741317 | Bax | increases expression | EXP | | 6480464 | CTD | Cadmium results in increased expression of BAX mRNA; Cadmium results in increased expression of BAX protein | PMID:20455018 PMID:23577223 PMID:25388156 PMID:25808797 PMID:37342552 PMID:37949422 | Bax | multiple interactions | EXP | | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein; [cadmium nitrate results in increased abundance of Cadmium] which results in increased expression of BAX mRNA; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein]; bergenin inhibits the reaction [Cadmium results in increased expression of BAX protein]; dendropanoxide inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein]; gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein]; Lithium inhibits the reaction [Cadmium results in increased expression of BAX protein]; MIR34A mRNA affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein]; pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein]; pinostrobin inhibits the reaction [Cadmium results in increased expression of BAX mRNA]; Silymarin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein] | PMID:20455018 PMID:28413886 PMID:33031904 PMID:34558789 PMID:34767868 PMID:36718047 PMID:37342552 PMID:37949422 | Bax | decreases expression | ISO | Bax (Mus musculus) | 6480464 | CTD | Cadmium results in decreased expression of BAX protein | PMID:22356713 | Bax | increases cleavage | ISO | Bax (Mus musculus) | 6480464 | CTD | Cadmium results in increased cleavage of BAX protein | PMID:29982767 | Bax | increases expression | ISO | Bax (Mus musculus) | 6480464 | CTD | Cadmium results in increased expression of BAX mRNA | PMID:26187450 | Bax | increases expression | ISO | BAX (Homo sapiens) | 6480464 | CTD | Cadmium results in increased expression of BAX mRNA | PMID:15016657 PMID:27687512 PMID:28507149 | Bax | multiple interactions | ISO | Bax (Mus musculus) | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein; MT2A protein inhibits the reaction [Cadmium results in increased cleavage of BAX protein] | PMID:29982767 PMID:33359024 | Bax | multiple interactions | ISO | BAX (Homo sapiens) | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein; [Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased expression of BAX protein; Luteolin affects the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased expression of BAX protein]; MT2A protein inhibits the reaction [Cadmium results in increased expression of BAX mRNA]; NR4A1 mutant form inhibits the reaction [Cadmium results in increased expression of BAX mRNA] | PMID:15016657 PMID:28507149 PMID:29115570 PMID:37300854 | |
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