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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:16330
Term: 17beta-hydroxy-5alpha-androstan-3-one
Definition: A 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5.
Chemical ID: MESH:D013196
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxmultiple interactionsEXP 6480464CTDDihydrotestosterone inhibits the reaction [Testosterone deficiency results in increased expression of BAX mRNA]; Dihydrotestosterone inhibits the reaction [Testosterone deficiency results in increased expression of BAX protein]PMID:20850791
Baxdecreases expressionISOBAX (Homo sapiens)6480464CTDDihydrotestosterone results in decreased expression of BAX proteinPMID:26804032
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDDihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]PMID:27132804
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