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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:196991
Term: 4-hydroperoxycyclophosphamide
Definition: A phosphorodiamide that is the active metabolite of the nitrogen mustard cyclophosphamide. It has potent antineoplastic and immunosuppressive properties.
Chemical ID: MESH:C011272
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxaffects foldingISOBAX (Homo sapiens)6480464CTDperfosfamide affects the folding of BAX proteinPMID:18034189
Baxincreases expressionISOBax (Mus musculus)6480464CTDperfosfamide results in increased expression of BAX proteinPMID:16488414
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDperfosfamide results in increased expression of BAXPMID:18034189
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [perfosfamide affects the folding of BAX protein]; Acetylcysteine inhibits the reaction [perfosfamide results in increased localization of BAX]; perfosfamide results in increased expression of and results in increased localization of BAXPMID:18034189
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