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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:18721
Term: 3-chloropropane-1,2-diol
Definition: A chloropropane-1,2-diol that is propane-1,2-diol substituted by a chloro group at position 3.
Chemical ID: MESH:D000517
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDalpha-Chlorohydrin results in increased expression of BAX mRNA; alpha-Chlorohydrin results in increased expression of BAX proteinPMID:30107153 PMID:33651226 PMID:34915118
Baxmultiple interactionsEXP 6480464CTD4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of BAX protein]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of BAX mRNA]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of BAX protein]PMID:30107153 PMID:33651226
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDalpha-Chlorohydrin results in increased expression of BAX mRNA; alpha-Chlorohydrin results in increased expression of BAX proteinPMID:27732882 PMID:28070108
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