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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:4791
Term: endosulfan
Definition: A cyclic sulfite ester that is 1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepine 3-oxide substituted by chloro groups at positions 6, 7, 8, 9, 10 and 10.
Chemical ID: MESH:D004726
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxaffects expressionEXP 6480464CTDEndosulfan affects the expression of BAX mRNAPMID:31464424
Baxdecreases expressionISOBax (Mus musculus)6480464CTDEndosulfan results in decreased expression of BAX proteinPMID:22515965
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDEndosulfan results in increased expression of BAX proteinPMID:29705383 PMID:36513242
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[Atrazine co-treated with Chlorpyrifos co-treated with Endosulfan] results in decreased expression of BAX proteinPMID:22515965
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