Cdh1 (cadherin 1) - Rat Genome Database

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Gene: Cdh1 (cadherin 1) Rattus norvegicus
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Symbol: Cdh1
Name: cadherin 1
RGD ID: 69279
Description: Enables beta-catenin binding activity and protein tyrosine kinase binding activity. Involved in several processes, including nervous system development; regulation of protein catabolic process at postsynapse, modulating synaptic transmission; and response to Gram-positive bacterium. Is active in glutamatergic synapse and postsynapse. Used to study hepatocellular carcinoma and lung adenocarcinoma. Biomarker of pulmonary fibrosis and urinary bladder cancer. Human ortholog(s) of this gene implicated in several diseases, including blepharocheilodontic syndrome 1; breast cancer (multiple); carcinoma (multiple); cervix uteri carcinoma in situ; and reproductive organ cancer (multiple). Orthologous to human CDH1 (cadherin 1); PARTICIPATES IN E-cadherin signaling pathway; fibroblast growth factor signaling pathway; endometrial cancer pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (R)-carnitine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cadherin-1; E-cadherin; epithelial cadherin; uvomorulin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81951,402,178 - 51,471,572 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1951,402,034 - 51,471,565 (+)EnsemblGRCr8
mRatBN7.21934,492,371 - 34,561,775 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1934,492,371 - 34,561,775 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1941,307,916 - 41,377,323 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01941,961,239 - 42,030,653 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01944,260,374 - 44,329,781 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01938,768,467 - 38,838,395 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1938,768,467 - 38,838,395 (+)Ensemblrn6Rnor6.0
Rnor_5.01949,635,965 - 49,705,893 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41936,442,693 - 36,512,091 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1933,919,043 - 33,988,306 (+)NCBICelera
RGSC_v3.11936,447,573 - 36,516,972 (+)NCBI
Cytogenetic Map19q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
adenoid cystic carcinoma  (ISO)
Animal Mammary Neoplasms  (ISO)
asthma  (ISO)
blepharocheilodontic syndrome 1  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
breast lobular carcinoma  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
cervix uteri carcinoma in situ  (ISO)
cleft lip  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
developmental and epileptic encephalopathy 16  (ISO)
diabetes mellitus  (ISO)
Disease Progression  (ISO)
DOORS syndrome  (ISO)
Ductal Carcinoma  (ISO)
early myoclonic encephalopathy  (ISO)
endometrial cancer  (ISO)
endometrial carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
Experimental Liver Cirrhosis  (IEP)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
familial adenomatous polyposis 2  (ISO)
Familial Prostate Cancer  (ISO)
Fibrosis  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
GM1 gangliosidosis type 1  (ISO)
Helicobacter Infections  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (IDA,ISO)
hereditary breast ovarian cancer syndrome  (ISO)
hereditary diffuse gastric cancer  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hypomyelinating leukodystrophy 7  (ISO)
invasive ductal carcinoma  (ISO)
invasive lobular carcinoma  (ISO)
kidney disease  (ISO)
liver cancer  (ISO)
liver cirrhosis  (ISO)
lung adenocarcinoma  (IDA)
Lymphatic Metastasis  (ISO)
Mesothelioma  (ISO)
microphthalmia  (ISO)
mucoepidermoid carcinoma  (ISO)
Mycoplasma Infections  (ISO)
Myoclonic Epilepsy, Familial Infantile  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplasm Seeding  (ISO)
Neoplastic Cell Transformation  (ISO)
Nerve Degeneration  (ISO)
oral squamous cell carcinoma  (ISO)
orofacial cleft  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
papillary thyroid carcinoma  (ISO)
pre-malignant neoplasm  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (IEP,ISO)
renal cell carcinoma  (ISO)
Salivary Gland Neoplasms  (ISO)
spinocerebellar ataxia 45  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
syndromic microphthalmia 5  (ISO)
ulcerative colitis  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (IEP,ISO)
Uterine Cervical Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-schisandrin B  (EXP,ISO)
(+)-sesamin  (ISO)
(+)-Tetrandrine  (ISO)
(-)-citrinin  (ISO)
(-)-demecolcine  (ISO)
(-)-ephedrine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-carnitine  (EXP)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,4-dithiothreitol  (ISO)
1-nitropyrene  (ISO)
11-deoxycorticosterone  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-Dihydroxybenzophenone  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-deoxy-D-glucose  (ISO)
2-Ethylhexanoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
26-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-dihydroxybenzaldehyde  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxyhexenal  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
8'-apo-beta,psi-caroten-8'-al  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
[6]-Shogaol  (ISO)
acadesine  (ISO)
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylonitrile  (ISO)
acteoside  (ISO)
adenine  (EXP,ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (ISO)
aldrin  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-4-oxoretinol  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
allopurinol  (ISO)
alpha-naphthoflavone  (ISO)
alpha-pinene  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
AM-251  (ISO)
ametryn  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
Ammothamnine  (ISO)
andrographolide  (ISO)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antroquinonol  (ISO)
apocynin  (ISO)
arecoline  (ISO)
aristolochic acid A  (ISO)
aristolochic acids  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
aspartame  (ISO)
atorvastatin  (ISO)
atorvastatin calcium  (EXP)
atrazine  (EXP)
aucubin  (ISO)
Azaspiracid  (ISO)
Azoxymethane  (EXP,ISO)
bafilomycin A1  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
benzophenanthridine  (ISO)
berberine  (ISO)
beta-carotene  (ISO)
beta-lapachone  (ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
blebbistatin  (ISO)
bleomycin A2  (EXP,ISO)
bosutinib  (ISO)
bromodichloromethane  (EXP)
Bufotalin  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
butein  (ISO)
Butylbenzyl phthalate  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
capsaicin  (ISO)
captopril  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carboxy-PTIO  (ISO)
carvedilol  (EXP)
celecoxib  (ISO)
CHIR 99021  (ISO)
chlordecone  (ISO)
chlorogenic acid  (ISO)
chloropicrin  (ISO)
chloroquine  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
chrysin  (ISO)
ciglitazone  (EXP,ISO)
ciguatoxin CTX1B  (ISO)
Cirsimarin  (ISO)
cisatracurium  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cryptotanshinone  (ISO)
CU-CPT22  (ISO)
curcumin  (ISO)
cycloheximide  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cyprodinil  (ISO)
cytochalasin D  (ISO)
D-glucose  (ISO)
dapagliflozin  (EXP)
DAPT  (ISO)
DDE  (ISO)
DDT  (ISO)
deguelin  (ISO)
delphinidin  (ISO)
deoxycholic acid  (ISO)
desferrioxamine B  (ISO)
desipramine  (ISO)
Destruxin B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
diclofenac  (EXP,ISO)
Dictamnine  (ISO)
dieckol  (ISO)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (EXP,ISO)
dimethylarsinic acid  (EXP)
Diosbulbin B  (ISO)
dioxygen  (ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
embelin  (ISO)
emodin  (EXP)
endosulfan  (EXP,ISO)
entinostat  (ISO)
eplerenone  (ISO)
epoxiconazole  (ISO)
epoxomicin  (ISO)
ergosta-4,6,8(14),22-tetraen-3-one  (ISO)
erlotinib hydrochloride  (EXP,ISO)
ethanol  (ISO)
everolimus  (ISO)
Evodiamine  (ISO)
fenbendazole  (ISO)
fenthion  (ISO)
ferric oxide  (EXP,ISO)
ferrostatin-1  (ISO)
ferulic acid  (ISO)
finasteride  (EXP)
fisetin  (ISO)
flubendazole  (ISO)
fludioxonil  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
furfural  (ISO)
gamma-aminobutyric acid  (ISO)
gefitinib  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
geraniol  (EXP)
Ginkgoic acid  (ISO)
ginsenoside Rg1  (ISO)
glabridin  (ISO)
glucose  (ISO)
glycidol  (EXP)
glycidyl methacrylate  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
goralatide  (ISO)
gossypol  (ISO)
GSK2193874  (ISO)
GW 4064  (ISO)
harmaline  (ISO)
hemin  (EXP)
heptachlor  (ISO)
hexachlorobenzene  (EXP)
Honokiol  (ISO)
hydrogen peroxide  (ISO)
hydroxyflutamide  (ISO)
icariside II  (ISO)
imidacloprid  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
inulin  (ISO)
iprodione  (ISO)
irinotecan  (ISO)
isobutanol  (ISO)
isoorientin  (ISO)
isopimaric acid  (ISO)
isoprene  (ISO)
isorhamnetin  (ISO)
isorhapontigenin  (ISO)
ivermectin  (ISO)
jaspamide  (ISO)
ketamine  (EXP,ISO)
L-1,4-dithiothreitol  (ISO)
L-citrulline  (ISO)
L-methionine  (ISO)
lapatinib  (ISO)
latrunculin A  (ISO)
lead diacetate  (EXP,ISO)
leupeptin  (EXP)
limonin  (ISO)
linalool  (ISO)
lipopolysaccharide  (ISO)
liraglutide  (ISO)
lithium atom  (EXP)
lithium chloride  (ISO)
lithium hydride  (EXP)
lithocholic acid  (ISO)
loliolide  (ISO)
losartan  (ISO)
lupeol  (ISO)
luteolin  (ISO)
LY294002  (ISO)
lycopene  (ISO)
mangiferin  (ISO)
masoprocol  (ISO)
mebendazole  (ISO)
melatonin  (ISO)
melittin  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
metformin  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (EXP)
methoxychlor  (EXP)
methylarsonic acid  (EXP)
methylmercury chloride  (EXP,ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
mithramycin  (ISO)
MK-2206  (ISO)
ML-7  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (EXP)
monocrotaline  (ISO)
monosodium L-glutamate  (ISO)
morusin  (ISO)
Muraglitazar  (EXP)
myriocin  (ISO)
N(6),N(6)-dimethyladenine  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
neomycin  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nitric oxide  (ISO)
nitrofen  (EXP)
NMS-873  (ISO)
Nonylphenol  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
Ophiopogonin D  (ISO)
oridonin  (ISO)
Osajin  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP,ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-menthan-3-ol  (ISO)
p-tert-Amylphenol  (ISO)
Pachymic acid  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parecoxib  (ISO)
patulin  (EXP)
pelargonidin  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
Pervanadate  (ISO)
phenobarbital  (ISO)
phenol red  (ISO)
phenylmercury acetate  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pifithrin-alpha hydrobromide  (ISO)
pinostrobin  (ISO)
pirfenidone  (EXP,ISO)
pirinixic acid  (ISO)
plerixafor  (ISO)
poly(guanylic acid)  (EXP)
poly(I:C)  (ISO)
Pomiferin  (ISO)
potassium iodide  (EXP)
procyanidin B2  (ISO)
procymidone  (ISO)
propiconazole  (EXP,ISO)
propofol  (ISO)
prostaglandin E2  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
pyrrolidine dithiocarbamate  (ISO)
pyrvinium  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quercitrin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
reactive oxygen species  (ISO)
reparixin  (ISO)
resveratrol  (ISO)
RGFP966  (ISO)
ridaforolimus  (ISO)
rolipram  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
roxadustat  (ISO)
ruxolitinib  (ISO)
S-allylcysteine  (ISO)
Salinomycin  (ISO)
salubrinal  (ISO)
sanguinarine  (ISO)
SB 203580  (ISO)
SB 290157  (ISO)
SB 431542  (ISO)
Selamectin  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (ISO)
Shikonin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sinensetin  (ISO)
Sinomenine  (ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
solasodine  (ISO)
Sophoricoside  (ISO)
sorafenib  (ISO)
sorbinil  (ISO)
stattic  (ISO)
streptozocin  (EXP)
sulfasalazine  (ISO)
sulforaphane  (EXP,ISO)
sulindac sulfide  (ISO)
Sunset Yellow FCF  (EXP)
Swertiamarin  (EXP)
syringin  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
taraxasterol  (ISO)
teprenone  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetraethylenepentamine  (ISO)
tetraphene  (ISO)
thalidomide  (ISO)
theaflavin  (ISO)
thioacetamide  (EXP)
thymoquinone  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
tolfenamic acid  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP,ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimethylarsine oxide  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
Tubeimoside II  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
ubiquinone-0  (ISO)
undecane  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (EXP,ISO)
verapamil  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vinyl carbamate  (ISO)
vorinostat  (ISO)
vortioxetine  (ISO)
warfarin  (ISO)
withaferin A  (ISO)
wortmannin  (ISO)
WP1066  (ISO)
XAV939  (ISO)
Y-27632  (EXP,ISO)
Yessotoxin  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
adherens junction organization  (IBA,IEA,ISO)
bicellular tight junction assembly  (ISO)
calcium-dependent cell-cell adhesion  (IBA,ISO)
cell adhesion  (IEA)
cell migration  (IBA)
cell morphogenesis  (IBA)
cell-cell adhesion  (IEA,ISO,TAS)
cell-cell adhesion mediated by cadherin  (IBA,IEA,ISO)
cell-cell junction assembly  (IBA)
cellular response to amino acid stimulus  (ISO)
cellular response to indole-3-methanol  (IEA,ISO)
cellular response to lithium ion  (IEA,ISO)
cochlea development  (ISO)
decidualization  (ISO)
desmosome assembly  (IEA,ISO,ISS)
embryo implantation  (ISO)
epithelial cell morphogenesis  (ISO)
establishment of skin barrier  (ISO)
homophilic cell-cell adhesion  (IEA)
in utero embryonic development  (ISO)
intestinal epithelial cell development  (ISO)
negative regulation of axon extension  (IMP)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell migration  (IEA,ISO)
negative regulation of cell-cell adhesion  (IEA,ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of protein localization to plasma membrane  (ISO)
negative regulation of protein processing  (ISO)
neuron projection development  (IEP)
pituitary gland development  (IEP)
positive regulation of cell-cell adhesion  (ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of protein import into nucleus  (IEA,ISO)
positive regulation of protein localization  (IEA,ISO,ISS)
protein localization to plasma membrane  (IEA,ISO)
regulation of axonogenesis  (IEA)
regulation of branching involved in salivary gland morphogenesis  (ISO)
regulation of gene expression  (IEA,ISO,ISS)
regulation of neuron migration  (ISO)
regulation of protein catabolic process at postsynapse, modulating synaptic transmission  (IDA,IEP,IMP)
regulation of protein localization  (ISO)
regulation of protein localization to cell surface  (ISO)
response to Gram-positive bacterium  (IEP)
response to heparin  (IEP)
response to toxic substance  (IEP)
response to xenobiotic stimulus  (IEP)
salivary gland cavitation  (ISO)
sensory perception of sound  (ISO)
synapse assembly  (IBA,IEA,IMP)
trophectodermal cell differentiation  (ISO)
uterine epithelium development  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. In utero exposure to tributyltin alters the expression of e-cadherin and localization of claudin-1 in intercellular junctions of the rat ventral prostate. Barthelemy J, etal., Mol Reprod Dev. 2007 Apr;74(4):455-67.
2. Expression of E-cadherin and other paracellular junction genes is decreased in iron-loaded hepatocytes. Bilello JP, etal., Am J Pathol 2003 Apr;162(4):1323-38.
3. Chemically induced mouse liver tumors are resistant to treatment with atorvastatin. Braeuning A, etal., BMC Cancer. 2014 Oct 15;14:766. doi: 10.1186/1471-2407-14-766.
4. Fer kinase/FerT and adherens junction dynamics in the testis: an in vitro and in vivo study. Chen YM, etal., Biol Reprod. 2003 Aug;69(2):656-72. Epub 2003 Apr 16.
5. Catenins in the rat epididymis: their expression and regulation in adulthood and during postnatal development. DeBellefeuille S, etal., Endocrinology. 2003 Nov;144(11):5040-9. doi: 10.1210/en.2002-0139. Epub 2003 Aug 13.
6. Investigation of the effects of heparin and low molecular weight heparin on E-cadherin and laminin expression in rat pregnancy by immunohistochemistry. Erden O, etal., Hum Reprod. 2006 Nov;21(11):3014-8. Epub 2006 Sep 22.
7. Biological relevance of E-cadherin-catenin complex proteins in primary epithelial ovarian tumours. Faleiro-Rodrigues C, etal., Gynecol Obstet Invest. 2005;60(2):75-83. Epub 2005 Mar 21.
8. Differential regulation of cadherins and catenins during axonal reorganization in the adult rat CNS. Fasen K, etal., J Neuropathol Exp Neurol 2002 Oct;61(10):903-13.
9. Cleft lip/palate and CDH1/E-cadherin mutations in families with hereditary diffuse gastric cancer. Frebourg T, etal., J Med Genet. 2006 Feb;43(2):138-42. Epub 2005 Apr 14.
10. APC(Cdh1) mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity. Fu AK, etal., Nat Neurosci. 2011 Feb;14(2):181-9. doi: 10.1038/nn.2715. Epub 2010 Dec 26.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Nuclear E-cadherin and VHL immunoreactivity are prognostic indicators of clear-cell renal cell carcinoma. Gervais ML, etal., Lab Invest. 2007 Dec;87(12):1252-64. Epub 2007 Oct 1.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells. Gorski JA, etal., Mol Biol Cell. 2005 Aug;16(8):3574-90. Epub 2005 Jun 1.
15. Significance of an E-cadherin gene promoter polymorphism for risk and disease severity of prostate cancer in a Japanese population. Goto T, etal., Urology. 2007 Jul;70(1):127-30.
16. A switch from E-cadherin to N-cadherin expression indicates epithelial to mesenchymal transition and is of strong and independent importance for the progress of prostate cancer. Gravdal K, etal., Clin Cancer Res. 2007 Dec 1;13(23):7003-11.
17. Loss of expression of chromosome 16q genes DPEP1 and CTCF in lobular carcinoma in situ of the breast. Green AR, etal., Breast Cancer Res Treat. 2008 Jan 23;.
18. Evidence of a novel docetaxel sensitizer, garlic-derived S-allylmercaptocysteine, as a treatment option for hormone refractory prostate cancer. Howard EW, etal., Int J Cancer. 2008 Jan 8;.
19. Effect of miR-182 on hepatic fibrosis induced by Schistosomiasis japonica by targeting FOXO1 through PI3K/AKT signaling pathway. Huang Y, etal., J Cell Physiol. 2018 Oct;233(10):6693-6704. doi: 10.1002/jcp.26469. Epub 2018 Apr 25.
20. E-cadherin gene polymorphisms in asthma patients using inhaled corticosteroids. Ierodiakonou D, etal., Eur Respir J. 2011 May 3.
21. Expression of E-cadherin in human ductal breast cancer carcinoma in situ, invasive carcinomas, their lymph node metastases, their distant metastases, carcinomas with recurrence and in recurrence. Jeschke U, etal., Anticancer Res. 2007 Jul-Aug;27(4A):1969-74.
22. Reduced expression of E-cadherin and p120-catenin and elevated expression of PLC-gamma1 and PIKE are associated with aggressiveness of oral squamous cell carcinoma. Jiang Y, etal., Int J Clin Exp Pathol. 2015 Aug 1;8(8):9042-51. eCollection 2015.
23. Multiple cadherin superfamily members with unique expression profiles are produced in rat testis. Johnson KJ, etal., Endocrinology 2000 Feb;141(2):675-83.
24. p250GAP is a novel player in the Cdh1-APC/Smurf1 pathway of axon growth regulation. Kannan M, etal., PLoS One. 2012;7(11):e50735. doi: 10.1371/journal.pone.0050735. Epub 2012 Nov 30.
25. E-cadherin expression is inversely proportional to tumor size in experimental liver metastases. Karube H, etal., J Surg Res 2002 Jul;106(1):173-8.
26. The prognostic value of E-cadherin, alpha-, beta- and gamma-catenin in bladder cancer patients who underwent radical cystectomy. Kashibuchi K, etal., Int J Urol. 2007 Sep;14(9):789-94.
27. Aberrant DNA methylation of E-cadherin and p16 genes in rat lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine. Kato A, etal., Mol Carcinog. 2006 Feb;45(2):106-11.
28. Bifidobacterium bifidum improves intestinal integrity in a rat model of necrotizing enterocolitis. Khailova L, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Aug 27.
29. Changes in E- and N-cadherin expression in developing rat adenohypophysis. Kikuchi M, etal., Anat Rec (Hoboken). 2007 May;290(5):486-90.
30. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Kim KK, etal., Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13180-5. Epub 2006 Aug 21.
31. Rab8B GTPase and junction dynamics in the testis. Lau AS and Mruk DD, Endocrinology. 2003 Apr;144(4):1549-63.
32. Calcitonin down-regulates E-cadherin expression in rodent uterine epithelium during implantation. Li Q, etal., J Biol Chem 2002 Nov 29;277(48):46447-55.
33. E-cadherin gene polymorphisms and haplotype associated with the occurrence of epithelial ovarian cancer in Chinese. Li Y, etal., Gynecol Oncol. 2007 Nov 20;.
34. Ginkgolic acid (GA) suppresses gastric cancer growth by inducing apoptosis and suppressing STAT3/JAK2 signaling regulated by ROS. Liang JR and Yang H, Biomed Pharmacother. 2020 May;125:109585. doi: 10.1016/j.biopha.2019.109585. Epub 2020 Feb 25.
35. Germline E-cadherin mutations in familial lobular breast cancer. Masciari S, etal., J Med Genet. 2007 Nov;44(11):726-31. Epub 2007 Jul 27.
36. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
37. Relationship between decreased expression of squamous cell carcinoma antigen 2 and E-cadherin in primary cervical cancer lesions and lymph node metastasis. Murakami A, etal., Oncol Rep. 2008 Jan;19(1):99-104.
38. CD2AP contributes to cell migration and adhesion in cultured gastric epithelium. Mustonen H, etal., Biochem Biophys Res Commun. 2005 Jul 1;332(2):426-32.
39. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
40. E-cadherin expression during urothelial carcinogenesis induced by N-butyl-N-(4-hydroxybutyl) nitrosamine in rats. Oliveira PA, etal., J Exp Clin Cancer Res. 2006 Sep;25(3):425-32.
41. Epicardial-myocardial signaling directing coronary vasculogenesis. Olivey HE and Svensson EC, Circ Res. 2010 Mar 19;106(5):818-32. doi: 10.1161/CIRCRESAHA.109.209197.
42. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
43. Genetic changes of the E-cadherin and APC tumour suppressor genes in clear cell renal cell carcinoma. Pecina-SLaus N, etal., Pathology. 2004 Apr;36(2):145-51.
44. Fast dissociation kinetics between individual E-cadherin fragments revealed by flow chamber analysis. Perret E, etal., EMBO J 2002 Jun 3;21(11):2537-46.
45. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
46. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
47. FGF-1 reverts epithelial-mesenchymal transition induced by TGF-{beta}1 through MAPK/ERK kinase pathway. Ramos C, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Aug;299(2):L222-31. Epub 2010 May 21.
48. GOA pipeline RGD automated data pipeline
49. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
50. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
51. Overexpression of E-cadherin protein in metastatic breast cancer cells in bone. Saha B, etal., Anticancer Res. 2007 Nov-Dec;27(6B):3903-8.
52. Overexpression of E-cadherin and beta-catenin proteins in metastatic prostate cancer cells in bone. Saha B, etal., Prostate. 2008 Jan 1;68(1):78-84.
53. Evidence for a role of E-cadherin in suppressing liver carcinogenesis in mice and men. Schneider MR, etal., Carcinogenesis. 2014 Aug;35(8):1855-62. doi: 10.1093/carcin/bgu109. Epub 2014 May 19.
54. Matrix metalloproteinases 2 and 9, E-cadherin, and beta-catenin expression in endometriosis, low-grade endometrial carcinoma and non-neoplastic eutopic endometrium. Shaco-Levy R, etal., Eur J Obstet Gynecol Reprod Biol. 2008 Feb 22;.
55. DNA methyltransferase 1 expression and promoter methylation of E-cadherin in mucoepidermoid carcinoma. Shieh YS, etal., Cancer. 2005 Sep 1;104(5):1013-21.
56. Methylation of p15(INK4b) and E-cadherin genes is independently correlated with poor prognosis in acute myeloid leukemia. Shimamoto T, etal., Leuk Res. 2005 Jun;29(6):653-9. Epub 2005 Jan 19.
57. Evaluation of candidate methylation markers to detect cervical neoplasia. Shivapurkar N, etal., Gynecol Oncol. 2007 Dec;107(3):549-53. Epub 2007 Sep 25.
58. Comparative expression patterns of T-, N-, E-cadherins, beta-catenin, and polysialic acid neural cell adhesion molecule in rat cochlea during development: implications for the nature of Kolliker's organ. Simonneau L, etal., J Comp Neurol 2003 Apr 28;459(2):113-26.
59. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
60. Cadherin regulates dendritic spine morphogenesis. Togashi H, etal., Neuron 2002 Jul 3;35(1):77-89.
61. CpG site hypermethylation of E-cadherin and Connexin26 genes in hepatocellular carcinomas induced by a choline-deficient L-Amino Acid-defined diet in rats. Tsujiuchi T, etal., Mol Carcinog. 2007 Apr;46(4):269-74.
62. Cyclosporin-induced downregulation of the expression of E-cadherin during proliferation of edentulous gingival epithelium in rats. Tu HP, etal., J Periodontol. 2006 May;77(5):832-9.
63. RUNX3 site-specific hypermethylation predicts papillary thyroid cancer recurrence. Wang D, etal., Am J Cancer Res. 2014 Nov 19;4(6):725-37. eCollection 2014.
64. Clinicopathological and prognostic significance of CDH1 hypermethylation in hepatocellular carcinoma: a meta-analysis. Wu X, etal., Cancer Manag Res. 2019 Jan 17;11:857-864. doi: 10.2147/CMAR.S179710. eCollection 2019.
65. Elevated Orai1 and STIM1 expressions upregulate MACC1 expression to promote tumor cell proliferation, metabolism, migration, and invasion in human gastric cancer. Xia J, etal., Cancer Lett. 2016 Oct 10;381(1):31-40. doi: 10.1016/j.canlet.2016.07.014. Epub 2016 Jul 16.
66. Diagnostic and prognostic impact of beta-catenin alterations in pediatric liver tumors. Yamaoka H, etal., Oncol Rep. 2006 Mar;15(3):551-6.
67. Biologic Evaluation of Diabetes and Local Recurrence in Non-Small Cell Lung Cancer. Yang X, etal., Pathol Oncol Res. 2017 Jan;23(1):73-77. doi: 10.1007/s12253-016-0086-1. Epub 2016 Jul 13.
68. Reduced expression of E-cadherin/catenin complex in hepatocellular carcinomas. Zhai B, etal., World J Gastroenterol. 2008 Oct 7;14(37):5665-73. doi: 10.3748/wjg.14.5665.
69. [Detection of free tumor-related DNA in the serum of breast cancer patients] Zhang JJ, etal., Zhonghua Zhong Liu Za Zhi. 2007 Aug;29(8):609-13.
70. AMD3100 inhibits epithelial-mesenchymal transition, cell invasion, and metastasis in the liver and the lung through blocking the SDF-1α/CXCR4 signaling pathway in prostate cancer. Zhu WB, etal., J Cell Physiol. 2019 Jul;234(7):11746-11759. doi: 10.1002/jcp.27831. Epub 2018 Dec 7.
Additional References at PubMed
PMID:1639850   PMID:2519616   PMID:7806582   PMID:8582267   PMID:8853988   PMID:9864371   PMID:9950951   PMID:10460003   PMID:10868478   PMID:11121423   PMID:11197537   PMID:11340163  
PMID:11511678   PMID:11706048   PMID:12060406   PMID:12460580   PMID:12655059   PMID:12695331   PMID:12937339   PMID:14595118   PMID:14758363   PMID:15023525   PMID:15057752   PMID:15084279  
PMID:15148305   PMID:15192701   PMID:15195140   PMID:15263019   PMID:15292239   PMID:15630473   PMID:15739225   PMID:15771627   PMID:15775979   PMID:15788452   PMID:15994295   PMID:16153441  
PMID:16199027   PMID:16275913   PMID:16338932   PMID:16368433   PMID:16418220   PMID:16466397   PMID:16510873   PMID:16682529   PMID:16733663   PMID:16882694   PMID:16955247   PMID:16973135  
PMID:17130295   PMID:17138661   PMID:17344476   PMID:17392463   PMID:17544522   PMID:17605082   PMID:17620337   PMID:17666436   PMID:17762162   PMID:17982281   PMID:18279593   PMID:18287078  
PMID:18423437   PMID:18551621   PMID:18593713   PMID:18604197   PMID:18692037   PMID:18794329   PMID:18816447   PMID:18818692   PMID:19038973   PMID:19114658   PMID:19258396   PMID:19289495  
PMID:19403558   PMID:19590041   PMID:19623612   PMID:19646884   PMID:19653274   PMID:19956566   PMID:20016102   PMID:20086044   PMID:20089884   PMID:20091493   PMID:20103531   PMID:20116244  
PMID:20189993   PMID:20190754   PMID:20190755   PMID:20215345   PMID:20237282   PMID:20548288   PMID:20551175   PMID:20637190   PMID:20705680   PMID:20859650   PMID:20881055   PMID:21300292  
PMID:21377456   PMID:21399649   PMID:21406566   PMID:21464233   PMID:21572446   PMID:21724833   PMID:21853397   PMID:21925491   PMID:21991325   PMID:22114281   PMID:22288108   PMID:22378759  
PMID:22549778   PMID:22766025   PMID:22841714   PMID:23080431   PMID:23112161   PMID:23266329   PMID:23273176   PMID:23376485   PMID:23434913   PMID:23533145   PMID:23637336   PMID:23727062  
PMID:23824574   PMID:23990464   PMID:24001804   PMID:24036311   PMID:24046456   PMID:24191021   PMID:24385580   PMID:24634235   PMID:24725409   PMID:25138274   PMID:25468996   PMID:25579424  
PMID:25617501   PMID:25651564   PMID:25801296   PMID:25988855   PMID:26116661   PMID:26287173   PMID:26498254   PMID:26599499   PMID:26658992   PMID:27816814   PMID:27942853   PMID:28169360  
PMID:28169407   PMID:28213972   PMID:28301459   PMID:28711656   PMID:30639848   PMID:30677437   PMID:30982971   PMID:31785347   PMID:31889022   PMID:32336545   PMID:32842802   PMID:33390855  
PMID:34852269   PMID:37792794  


Genomics

Comparative Map Data
Cdh1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81951,402,178 - 51,471,572 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1951,402,034 - 51,471,565 (+)EnsemblGRCr8
mRatBN7.21934,492,371 - 34,561,775 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1934,492,371 - 34,561,775 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1941,307,916 - 41,377,323 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01941,961,239 - 42,030,653 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01944,260,374 - 44,329,781 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01938,768,467 - 38,838,395 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1938,768,467 - 38,838,395 (+)Ensemblrn6Rnor6.0
Rnor_5.01949,635,965 - 49,705,893 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41936,442,693 - 36,512,091 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1933,919,043 - 33,988,306 (+)NCBICelera
RGSC_v3.11936,447,573 - 36,516,972 (+)NCBI
Cytogenetic Map19q12NCBI
CDH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381668,737,292 - 68,835,537 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1668,737,292 - 68,835,540 (+)Ensemblhg38GRCh38
GRCh371668,771,195 - 68,869,440 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361667,328,696 - 67,426,945 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341667,328,695 - 67,426,945NCBI
Celera1653,280,506 - 53,378,750 (+)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1654,643,861 - 54,742,830 (+)NCBIHuRef
CHM1_11670,179,154 - 70,277,601 (+)NCBICHM1_1
T2T-CHM13v2.01674,533,467 - 74,631,804 (+)NCBIT2T-CHM13v2.0
Cdh1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398107,329,982 - 107,396,879 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8107,329,983 - 107,396,878 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm388106,603,350 - 106,670,247 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8106,603,351 - 106,670,246 (+)Ensemblmm10GRCm38
MGSCv378109,127,268 - 109,194,146 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368109,492,497 - 109,559,375 (+)NCBIMGSCv36mm8
Celera8110,827,793 - 110,895,640 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.18NCBI
Cdh1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554847,782,772 - 7,860,967 (-)Ensembl
ChiLan1.0NW_0049554847,782,409 - 7,861,082 (-)NCBIChiLan1.0ChiLan1.0
CDH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21878,278,865 - 78,376,726 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11684,190,211 - 84,288,055 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01649,108,745 - 49,206,347 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11668,502,399 - 68,597,748 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1668,502,584 - 68,596,488 (+)EnsemblpanPan2panpan1.1
CDH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1580,757,508 - 80,834,878 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl580,757,508 - 80,834,878 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha580,748,132 - 80,825,726 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0581,192,046 - 81,269,949 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl581,190,208 - 81,269,990 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1581,019,133 - 81,096,989 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0580,702,291 - 80,780,290 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0581,341,865 - 81,420,857 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cdh1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934940,523,052 - 40,598,579 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647518,990,474 - 19,067,203 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647518,990,529 - 19,065,954 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl618,075,480 - 18,155,986 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1618,075,487 - 18,155,986 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CDH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1558,578,244 - 58,679,677 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl558,578,146 - 58,679,541 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604721,315,122 - 21,416,779 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdh1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474617,483,469 - 17,557,581 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474617,480,472 - 17,557,722 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cdh1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11726,323,024 - 26,391,331 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cdh1
540 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:168
Count of miRNA genes:139
Interacting mature miRNAs:150
Transcripts:ENSRNOT00000027346
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)193128753251431640Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)194072709254856850Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)194072709254856850Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)194072709254856850Rat

Markers in Region
D19Rat46  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81951,431,501 - 51,431,640 (+)Marker Load Pipeline
mRatBN7.21934,521,694 - 34,521,833 (+)MAPPERmRatBN7.2
Rnor_6.01938,798,321 - 38,798,459NCBIRnor6.0
Rnor_5.01949,665,819 - 49,665,957UniSTSRnor5.0
RGSC_v3.41936,472,016 - 36,472,155RGDRGSC3.4
RGSC_v3.41936,472,017 - 36,472,155UniSTSRGSC3.4
Celera1933,948,364 - 33,948,502UniSTS
RGSC_v3.11936,476,898 - 36,477,036RGD
RH 3.4 Map19293.3RGD
RH 3.4 Map19293.3UniSTS
RH 2.0 Map19421.3RGD
SHRSP x BN Map1923.6499RGD
FHH x ACI Map1929.06RGD
Cytogenetic Map19q12UniSTS
RH127400  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21934,561,554 - 34,561,738 (+)MAPPERmRatBN7.2
Rnor_6.01938,838,175 - 38,838,358NCBIRnor6.0
Rnor_5.01949,705,673 - 49,705,856UniSTSRnor5.0
RGSC_v3.41936,511,871 - 36,512,054UniSTSRGSC3.4
Celera1933,988,086 - 33,988,269UniSTS
RH 3.4 Map19312.5UniSTS
Cytogenetic Map19q12UniSTS
Cdh1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21934,492,366 - 34,492,472 (+)MAPPERmRatBN7.2
Rnor_6.01938,768,463 - 38,768,568NCBIRnor6.0
Rnor_5.01949,635,961 - 49,636,066UniSTSRnor5.0
RGSC_v3.41936,442,689 - 36,442,794UniSTSRGSC3.4
Celera1933,919,039 - 33,919,144UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 158 91 90 59 82 59 6 345 181 11 137 81 92 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000027346   ⟹   ENSRNOP00000027346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1951,402,034 - 51,471,565 (+)Ensembl
mRatBN7.2 Ensembl1934,492,371 - 34,561,775 (+)Ensembl
Rnor_6.0 Ensembl1938,768,467 - 38,838,395 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095534   ⟹   ENSRNOP00000078622
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1934,539,775 - 34,561,775 (+)Ensembl
RefSeq Acc Id: NM_031334   ⟹   NP_112624
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81951,402,178 - 51,471,572 (+)NCBI
mRatBN7.21934,492,371 - 34,561,775 (+)NCBI
Rnor_6.01938,768,467 - 38,838,395 (+)NCBI
Rnor_5.01949,635,965 - 49,705,893 (+)NCBI
RGSC_v3.41936,442,693 - 36,512,091 (+)RGD
Celera1933,919,043 - 33,988,306 (+)RGD
Sequence:
RefSeq Acc Id: XM_063278314   ⟹   XP_063134384
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81951,402,655 - 51,471,572 (+)NCBI
RefSeq Acc Id: NP_112624   ⟸   NM_031334
- Peptide Label: precursor
- UniProtKB: O35794 (UniProtKB/Swiss-Prot),   Q9JIV9 (UniProtKB/Swiss-Prot),   Q9R0T4 (UniProtKB/Swiss-Prot),   A6IYX4 (UniProtKB/TrEMBL),   A0A8I6G230 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027346   ⟸   ENSRNOT00000027346
Ensembl Acc Id: ENSRNOP00000078622   ⟸   ENSRNOT00000095534
RefSeq Acc Id: XP_063134384   ⟸   XM_063278314
- Peptide Label: isoform X1
- UniProtKB: A6IYX5 (UniProtKB/TrEMBL)
Protein Domains
Cadherin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R0T4-F1-model_v2 AlphaFold Q9R0T4 1-886 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701113
Promoter ID:EPDNEW_R11637
Type:multiple initiation site
Name:Cdh1_1
Description:cadherin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01938,768,466 - 38,768,526EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69279 AgrOrtholog
BioCyc Gene G2FUF-5777 BioCyc
Ensembl Genes ENSRNOG00000020151 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027346 ENTREZGENE
  ENSRNOT00000027346.3 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.900.10 UniProtKB/Swiss-Prot
  Cadherins UniProtKB/Swiss-Prot
InterPro Cadherin UniProtKB/Swiss-Prot
  Cadherin-like_dom UniProtKB/Swiss-Prot
  Cadherin-like_sf UniProtKB/Swiss-Prot
  Cadherin_CS UniProtKB/Swiss-Prot
  Cadherin_cytoplasmic-dom UniProtKB/Swiss-Prot
  Cadherin_pro_dom UniProtKB/Swiss-Prot
  Catenin_binding_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:83502 UniProtKB/Swiss-Prot
NCBI Gene 83502 ENTREZGENE
PANTHER CADHERIN-1 UniProtKB/Swiss-Prot
  PTHR24027 UniProtKB/Swiss-Prot
Pfam Cadherin UniProtKB/Swiss-Prot
  Cadherin_C UniProtKB/Swiss-Prot
  Cadherin_pro UniProtKB/Swiss-Prot
PhenoGen Cdh1 PhenoGen
PRINTS CADHERIN UniProtKB/Swiss-Prot
PROSITE CADHERIN_1 UniProtKB/Swiss-Prot
  CADHERIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020151 RatGTEx
SMART Cadherin_pro UniProtKB/Swiss-Prot
  SM00112 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49313 UniProtKB/Swiss-Prot
TIGR TC221496
UniProt A0A8I6G230 ENTREZGENE
  A6IYX4 ENTREZGENE, UniProtKB/TrEMBL
  A6IYX5 ENTREZGENE, UniProtKB/TrEMBL
  CADH1_RAT UniProtKB/Swiss-Prot
  O35794 ENTREZGENE
  Q9JIV9 ENTREZGENE
  Q9R0T4 ENTREZGENE
UniProt Secondary O35794 UniProtKB/Swiss-Prot
  Q9JIV9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Cdh1  cadherin 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction decreased expression in the uterine epithelium may facilitate blastocyst implatation 632464
gene_product member of the cadherin family of homophilic adhesion molecules 632464