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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdh1
Name: cadherin 1
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdh1multiple interactionsISOCDH1 (Homo sapiens)6480464CTD[AG 1879 co-treated with Fulvestrant] inhibits the reaction [Chlorpyrifos results in decreased expression of and affects the localization of CDH1 protein]; Fulvestrant inhibits the reaction [2,4-dihydroxybenzophenone results in decreased expression of CDH1 protein]; Fulvestrant inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CDH1 mRNA]; Fulvestrant inhibits the reaction [4-tert-octylphenol results in decreased expression of CDH1 protein]; Fulvestrant inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein]; Fulvestrant inhibits the reaction [afimoxifene results in increased expression of CDH1 protein]; Fulvestrant inhibits the reaction [bisphenol A results in decreased expression of CDH1 protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of CDH1 protein]; Fulvestrant inhibits the reaction [bisphenol F results in increased expression of CDH1 protein]; Fulvestrant inhibits the reaction [bisphenol S results in increased expression of CDH1 protein]; Fulvestrant inhibits the reaction [Chlorpyrifos results in decreased expression of CDH1 protein]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of CDH1 protein]; Fulvestrant inhibits the reaction [fludioxonil results in decreased expression of CDH1 protein]; Fulvestrant inhibits the reaction [nonylphenol results in decreased expression of CDH1 protein]; Fulvestrant inhibits the reaction [Triclosan results in decreased expression of CDH1 protein]PMID:19593637 PMID:25690688 PMID:26407941 PMID:27145024 PMID:27539251 PMID:28284859 PMID:28808208 PMID:28844962 PMID:32956863
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