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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdh1
Name: cadherin 1
Acc ID: CHEBI:34317
Term: 3,3',4,4',5-pentachlorobiphenyl
Definition: A pentachlorobiphenyl in which the chlorines are located at the 3, 4, 5, 3', and 4' positions.
Chemical ID: MESH:C023035
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdh1decreases expressionISOCDH1 (Homo sapiens)6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CDH1 mRNAPMID:28284859
Cdh1multiple interactionsISOCDH1 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CDH1 mRNA]; AHR mRNA promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CDH1 mRNA]; fulvestrant inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CDH1 mRNA]; PKM protein promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CDH1 mRNA]; WP1066 inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CDH1 mRNA]PMID:28284859
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