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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdh1
Name: cadherin 1
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdh1decreases expressionISOCDH1 (Homo sapiens)6480464CTDNicotine results in decreased expression of CDH1 mRNA; Nicotine results in decreased expression of CDH1 proteinPMID:18844224 PMID:20061081 PMID:23219715
Cdh1multiple interactionsISOCDH1 (Homo sapiens)6480464CTDMK-886 inhibits the reaction [Nicotine results in decreased expression of CDH1 mRNA]; U 0126 inhibits the reaction [Nicotine results in decreased expression of CDH1 mRNA]PMID:20061081
Cdh1multiple interactionsISOCdh1 (Mus musculus)6480464CTD[Nicotine co-treated with Quartz] results in increased expression of CDH1 proteinPMID:36868510
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