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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdh1
Name: cadherin 1
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdh1affects response to substanceISOCDH1 (Homo sapiens)6480464CTDCDH1 protein affects the susceptibility to FluorouracilPMID:15352031
Cdh1decreases expressionISOCDH1 (Homo sapiens)6480464CTDFluorouracil results in decreased expression of CDH1 proteinPMID:15352031 PMID:26310874
Cdh1multiple interactionsISOCDH1 (Homo sapiens)6480464CTDresveratrol inhibits the reaction [Fluorouracil results in decreased expression of CDH1 protein]PMID:26310874
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