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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdh1
Name: cadherin 1
Acc ID: CHEBI:4791
Term: endosulfan
Definition: A cyclic sulfite ester that is 1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepine 3-oxide substituted by chloro groups at positions 6, 7, 8, 9, 10 and 10.
Chemical ID: MESH:D004726
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdh1affects expressionEXP 6480464CTDEndosulfan affects the expression of CDH1 mRNAPMID:31464424
Cdh1decreases expressionEXP 6480464CTDEndosulfan results in decreased expression of CDH1 mRNAPMID:29391264
Cdh1decreases expressionISOCDH1 (Homo sapiens)6480464CTDEndosulfan results in decreased expression of CDH1 mRNA; Endosulfan results in decreased expression of CDH1 proteinPMID:22677888 PMID:22902829 PMID:28108160 PMID:32413665 PMID:36513242
Cdh1multiple interactionsISOCDH1 (Homo sapiens)6480464CTDEndosulfan inhibits the reaction [CDH1 protein binds to CTNNB1 protein]; LY2109761 inhibits the reaction [Endosulfan results in decreased expression of CDH1 protein]PMID:22902829 PMID:32413665
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