RGD Reference Report - Significance of an E-cadherin gene promoter polymorphism for risk and disease severity of prostate cancer in a Japanese population. - Rat Genome Database

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Significance of an E-cadherin gene promoter polymorphism for risk and disease severity of prostate cancer in a Japanese population.

Authors: Goto, T  Nakano, M  Ito, S  Ehara, H  Yamamoto, N  Deguchi, T 
Citation: Goto T, etal., Urology. 2007 Jul;70(1):127-30.
RGD ID: 2289493
Pubmed: PMID:17656222   (View Abstract at PubMed)
DOI: DOI:10.1016/j.urology.2007.03.036   (Journal Full-text)

OBJECTIVES: To explore the significance of an E-cadherin gene promoter polymorphism for risk and disease severity of prostate cancer in a Japanese population. METHODS: We enrolled 200 patients with sporadic prostate cancer and 159 control patients with benign prostatic hyperplasia in this case-control study. The -160C/A polymorphism in the E-cadherin gene promoter was genotyped by polymerase chain reaction-restriction fragment length analysis. RESULTS: The C/C, C/A, and A/A genotypes were observed in 58%, 39%, and 3% of patients, respectively, whereas the C/C, C/A, and A/A genotypes were observed in 75%, 25%, and 0.63% of control subjects, respectively. Japanese men carrying the A allele and A/A genotype had 1.88-fold (95% confidence interval [CI], 1.25 to 2.84) and 9.03-fold (95% CI, 1.50 to 172.36) higher risks, respectively, for prostate cancer than did carriers of the C allele and C/C genotype. There was no significant association between the polymorphism and clinical stage or pathologic grade. CONCLUSIONS: The presence of the A allele of the -160C/A polymorphism in the E-cadherin gene may be a risk factor for prostate cancer in the Japanese population.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
prostate cancer susceptibilityIAGP 2289493DNA:polymorphism:promoter:-160C>A (human)RGD 
prostate cancer susceptibilityISOCDH1 (Homo sapiens)2289493; 2289493DNA:polymorphism:promoter:-160C>A (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cdh1  (cadherin 1)

Genes (Mus musculus)
Cdh1  (cadherin 1)

Genes (Homo sapiens)
CDH1  (cadherin 1)


Additional Information