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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdh1
Name: cadherin 1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdh1increases expression ISOCDH1 (Homo sapiens)127284886RGDcisplatin increases expression of CDH1 protein in stomach 
Cdh1affects expressionISOCDH1 (Homo sapiens)6480464CTDCisplatin affects the expression of CDH1 mRNAPMID:23300844
Cdh1decreases expressionISOCDH1 (Homo sapiens)6480464CTDCisplatin results in decreased expression of CDH1 mRNAPMID:21618587
Cdh1increases expressionISOCDH1 (Homo sapiens)6480464CTDCisplatin results in increased expression of CDH1 proteinPMID:34687144
Cdh1multiple interactionsISOCDH1 (Homo sapiens)6480464CTD[CDH1 protein binds to ENTPD6 protein] which results in decreased susceptibility to Cisplatin; Cisplatin promotes the reaction [jinfukang results in increased expression of CDH1 mRNA]; Cisplatin promotes the reaction [SC-66 compound results in increased expression of CDH1 protein]; Cisplatin results in decreased expression of and results in decreased cleavage of CDH1 protein; jinfukang promotes the reaction [Cisplatin results in increased expression of CDH1 mRNA]; SC-66 compound promotes the reaction [Cisplatin results in increased expression of CDH1 protein]PMID:21519793 PMID:21618587 PMID:27392435 PMID:34687144
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