CDH1 (cadherin 1) - Rat Genome Database

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Pathways
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Gene: CDH1 (cadherin 1) Pan paniscus
Analyze
Symbol: CDH1
Name: cadherin 1
RGD ID: 11786103
Description: ENCODES a protein that exhibits alpha-catenin binding (ortholog); beta-catenin binding (ortholog); cytoskeletal protein binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); bicellular tight junction assembly (ortholog); calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (ortholog); PARTICIPATES IN E-cadherin signaling pathway; fibroblast growth factor signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); adenoid cystic carcinoma (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN apical part of cell (ortholog); axon (ortholog); axon terminus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cadherin 1, type 1, E-cadherin (epithelial); cadherin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21878,278,865 - 78,376,726 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11684,190,211 - 84,288,055 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01649,108,745 - 49,206,347 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11668,502,399 - 68,597,748 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1668,502,584 - 68,596,488 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
adenoid cystic carcinoma  (ISO)
Animal Mammary Neoplasms  (ISO)
asthma  (ISO)
autosomal dominant dyskeratosis congenita 6  (ISO)
blepharocheilodontic syndrome 1  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
breast lobular carcinoma  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
cervix uteri carcinoma in situ  (ISO)
cleft lip  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
diabetes mellitus  (ISO)
Disease Progression  (ISO)
Ductal Carcinoma  (ISO)
endometrial cancer  (ISO)
endometrial carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
Familial Prostate Cancer  (ISO)
Fibrosis  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
GM1 gangliosidosis  (ISO)
GM1 gangliosidosis type 1  (ISO)
Helicobacter Infections  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
hereditary diffuse gastric cancer  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hypomyelinating leukodystrophy 7  (ISO)
invasive ductal carcinoma  (ISO)
invasive lobular carcinoma  (ISO)
kidney disease  (ISO)
liver cancer  (ISO)
liver cirrhosis  (ISO)
lung adenocarcinoma  (ISO)
Lymphatic Metastasis  (ISO)
Mesothelioma  (ISO)
microphthalmia  (ISO)
mucoepidermoid carcinoma  (ISO)
Mycoplasma Infections  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplasm Seeding  (ISO)
Neoplastic Cell Transformation  (ISO)
Nerve Degeneration  (ISO)
oral squamous cell carcinoma  (ISO)
orofacial cleft  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
pre-malignant neoplasm  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (ISO)
renal cell carcinoma  (ISO)
Salivary Gland Neoplasms  (ISO)
spinocerebellar ataxia 45  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
syndromic microphthalmia 5  (ISO)
thyroid gland papillary carcinoma  (ISO)
ulcerative colitis  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
adherens junction organization  (IEA)
bicellular tight junction assembly  (ISO)
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  (IEA,ISO)
canonical Wnt signaling pathway  (ISO)
cell adhesion  (IEA)
cell morphogenesis  (IEA)
cell-cell adhesion  (IEA,ISO)
cell-cell adhesion mediated by cadherin  (IEA,ISO)
cell-cell junction assembly  (IEA)
cellular response to amino acid stimulus  (ISO)
cellular response to indole-3-methanol  (IEA)
cellular response to lithium ion  (IEA)
cochlea development  (ISO)
decidualization  (ISO)
embryo implantation  (ISO)
epithelial cell morphogenesis  (ISO)
establishment of skin barrier  (ISO)
homophilic cell adhesion via plasma membrane adhesion molecules  (IEA)
in utero embryonic development  (ISO)
intestinal epithelial cell development  (ISO)
negative regulation of axon extension  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell migration  (IEA)
negative regulation of cell-cell adhesion  (IEA)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of protein localization to plasma membrane  (ISO)
negative regulation of protein processing  (ISO)
neuron projection development  (ISO)
pituitary gland development  (ISO)
positive regulation of cell-cell adhesion  (ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of protein import into nucleus  (IEA)
protein localization to plasma membrane  (IEA)
protein metabolic process  (ISO)
regulation of branching involved in salivary gland morphogenesis  (ISO)
regulation of gene expression  (IEA)
regulation of neuron migration  (ISO)
regulation of protein catabolic process at postsynapse, modulating synaptic transmission  (ISO)
regulation of protein localization  (ISO)
regulation of protein localization to cell surface  (ISO)
response to Gram-positive bacterium  (ISO)
response to heparin  (ISO)
response to toxic substance  (ISO)
response to xenobiotic stimulus  (ISO)
salivary gland cavitation  (ISO)
sensory perception of sound  (ISO)
synapse assembly  (IEA,ISO)
trophectodermal cell differentiation  (ISO)
uterine epithelium development  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CDH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21878,278,865 - 78,376,726 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11684,190,211 - 84,288,055 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01649,108,745 - 49,206,347 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11668,502,399 - 68,597,748 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1668,502,584 - 68,596,488 (+)Ensemblpanpan1.1panPan2
CDH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381668,737,292 - 68,835,537 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1668,737,292 - 68,835,537 (+)EnsemblGRCh38hg38GRCh38
GRCh371668,771,195 - 68,869,440 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361667,328,696 - 67,426,945 (+)NCBINCBI36Build 36hg18NCBI36
Build 341667,328,695 - 67,426,945NCBI
Celera1653,280,506 - 53,378,750 (+)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1654,643,861 - 54,742,830 (+)NCBIHuRef
CHM1_11670,179,154 - 70,277,601 (+)NCBICHM1_1
T2T-CHM13v2.01674,533,467 - 74,631,804 (+)NCBIT2T-CHM13v2.0
Cdh1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398107,329,982 - 107,396,879 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8107,329,983 - 107,396,878 (+)EnsemblGRCm39 Ensembl
GRCm388106,603,350 - 106,670,247 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8106,603,351 - 106,670,246 (+)EnsemblGRCm38mm10GRCm38
MGSCv378109,127,268 - 109,194,146 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368109,492,497 - 109,559,375 (+)NCBIMGSCv36mm8
Celera8110,827,793 - 110,895,640 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.18NCBI
Cdh1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81951,402,178 - 51,471,572 (+)NCBIGRCr8
mRatBN7.21934,492,371 - 34,561,775 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1934,492,371 - 34,561,775 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1941,307,916 - 41,377,323 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01941,961,239 - 42,030,653 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01944,260,374 - 44,329,781 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01938,768,467 - 38,838,395 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1938,768,467 - 38,838,395 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01949,635,965 - 49,705,893 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41936,442,693 - 36,512,091 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11936,447,573 - 36,516,972 (+)NCBI
Celera1933,919,043 - 33,988,306 (+)NCBICelera
Cytogenetic Map19q12NCBI
Cdh1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554847,782,772 - 7,860,967 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554847,782,409 - 7,861,082 (-)NCBIChiLan1.0ChiLan1.0
CDH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1580,757,508 - 80,834,878 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl580,757,508 - 80,834,878 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha580,748,132 - 80,825,726 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0581,192,046 - 81,269,949 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl581,190,208 - 81,269,990 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1581,019,133 - 81,096,989 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0580,702,291 - 80,780,290 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0581,341,865 - 81,420,857 (-)NCBIUU_Cfam_GSD_1.0
Cdh1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934940,523,052 - 40,598,579 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647518,990,474 - 19,067,203 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647518,990,529 - 19,065,954 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl618,075,480 - 18,155,986 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1618,075,487 - 18,155,986 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC103233229
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1558,578,244 - 58,679,677 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl558,578,146 - 58,679,541 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604721,315,122 - 21,416,779 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdh1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474617,483,469 - 17,557,581 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474617,480,472 - 17,557,722 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_034940548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000038178   ⟹   ENSPPAP00000015488
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1668,502,584 - 68,596,488 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000038210   ⟹   ENSPPAP00000015520
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1668,502,584 - 68,595,712 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000038211   ⟹   ENSPPAP00000015521
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1668,502,584 - 68,575,935 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000038218   ⟹   ENSPPAP00000015528
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1668,560,575 - 68,586,926 (+)Ensembl
RefSeq Acc Id: XM_034940548   ⟹   XP_034796439
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21878,278,865 - 78,376,726 (+)NCBI
NHGRI_mPanPan11684,190,211 - 84,288,055 (+)NCBI
Mhudiblu_PPA_v01649,108,745 - 49,206,347 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034796439 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000015488.1
  ENSPPAP00000015520.1
  ENSPPAP00000015521.1
  ENSPPAP00000015528.1
Reference Protein Sequences
RefSeq Acc Id: XP_034796439   ⟸   XM_034940548
RefSeq Acc Id: ENSPPAP00000015488   ⟸   ENSPPAT00000038178
RefSeq Acc Id: ENSPPAP00000015528   ⟸   ENSPPAT00000038218
RefSeq Acc Id: ENSPPAP00000015521   ⟸   ENSPPAT00000038211
RefSeq Acc Id: ENSPPAP00000015520   ⟸   ENSPPAT00000038210
Protein Domains
Cadherin


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000030865 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000038178.1 UniProtKB/TrEMBL
  ENSPPAT00000038210.1 UniProtKB/TrEMBL
  ENSPPAT00000038211.1 UniProtKB/TrEMBL
  ENSPPAT00000038218.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.900.10 UniProtKB/TrEMBL
  Cadherins UniProtKB/TrEMBL
InterPro Cadherin UniProtKB/TrEMBL
  Cadherin-like_dom UniProtKB/TrEMBL
  Cadherin-like_sf UniProtKB/TrEMBL
  Cadherin_CS UniProtKB/TrEMBL
  Cadherin_cytoplasmic-dom UniProtKB/TrEMBL
  Cadherin_pro_dom UniProtKB/TrEMBL
  Catenin-bd_sf UniProtKB/TrEMBL
NCBI Gene CDH1 ENTREZGENE
PANTHER CADHERIN-1 UniProtKB/TrEMBL
  PTHR24027 UniProtKB/TrEMBL
Pfam Cadherin UniProtKB/TrEMBL
  Cadherin_C UniProtKB/TrEMBL
  Cadherin_pro UniProtKB/TrEMBL
PRINTS CADHERIN UniProtKB/TrEMBL
PROSITE CADHERIN_1 UniProtKB/TrEMBL
  CADHERIN_2 UniProtKB/TrEMBL
SMART Cadherin_pro UniProtKB/TrEMBL
  SM00112 UniProtKB/TrEMBL
Superfamily-SCOP SSF49313 UniProtKB/TrEMBL
UniProt A0A2R9ADW7_PANPA UniProtKB/TrEMBL
  A0A2R9ADY9_PANPA UniProtKB/TrEMBL
  A0A2R9AKB2_PANPA UniProtKB/TrEMBL
  A0A2R9AKI7_PANPA UniProtKB/TrEMBL