Pik3r1 Rat Gene (phosphoinositide-3-kinase, regulatory subunit 1 (alpha))

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Keyword

Gene:
Pik3r1 ( Rattus norvegicus )
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Description: regulatory subunit of phosphatidylinositol 3-kinase; three splice variants have been identified that regulate phosphatidylinositol 3-kinase interactions and function
Synonyms: Phosphoinositide 3-kinase p85 (other splicing variants: p55 and p50); Phosphoinositide 3-kinase regulatory subunit polypeptide 1 (p85 alpha); phosphoinositide 3-kinase p85; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1; PI3KA; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha);
ArrayIDs: D64045_s_at; U50412_at; 1370114_a_at;  (details...)
Gene Type: protein-coding

Additional Data

Candidate gene for: Bp115 - Blood pressure QTL 115

primer pair: 635169

Homologs
Homo sapiens: PIK3R1     See the Human gene in context in:     UCSC     NCBI MapViewer

Mus musculus: Pik3r1     See the Mouse gene in context in:     UCSC     NCBI MapViewer

Comparative Map Data
Species Symbol Map Name Chr. Position
Rattus norvegicus Pik3r1 genome assembly 3.1 2 32523041 - 32595719
RH 3.4 2 111
Rat Celera Assembly 2 28878690 - 28948863
RGSC genome assembly v3.4 2 32602673 - 32675350
Cytogenetic 2 q12
Mus musculus Pik3r1 Mouse genome assembly build 36.1 13 102450716 - 102538172
Cytogenetic 13 13 D1
Homo sapiens PIK3R1 human genome assembly 5 67622250 - 67633403
Human genome assembly build 36.2 5 67558218 - 67633405
Cytogenetic 5 q13.1

View comparative maps:      NCBI MapViewer

Genome
View:

Browsers:

Annotation
Molecular Function

Note Reference

activation is strongly induced by insulin 729673

activation is required for insulin-stimulated glucose transport and insulin-dependent p70S6K activation 68289

phosphorylates a variety of lipids and proteins to activate specific signaling cascades 729503

Gene Ontology

protein phosphatase binding,  protein kinase binding,  protein domain specific binding ... (details...)
Biological Process

Gene Ontology

response to cAMP,  response to glucocorticoid stimulus,  negative regulation of cell-matrix adhesion ... (details...)
Cellular Component

Gene Ontology

protein complex,  cytoplasm,  phosphoinositide 3-kinase complex ... (details...)
Disease

Ontology

Anaphylaxis,  Ovarian Neoplasms,  Insulin Resistance ... (details...)
Phenotype

Ontology

increased insulin sensitivity,  decreased circulating glucose level,  decreased mast cell number (details...)
Expression

Note Reference

expressed in hepatic, brain and renal tissues 729673

Pathway

Ontology

scatter factor/hepatocyte growth factor signaling pathway,  phosphatidylinositol 3-kinase-Akt signaling pathway,  insulin signaling pathway (details...)
Transcript structure

Note Reference

three splice variants, p85, p55 and p50 68289

Domain

Note Reference

contains SH2 domains 729673

Regulation

Note Reference

regulatory subunit of holoprotein p85 729673

Physical interaction

Note Reference

tyrosine kinase receptor binding 729673

binds to and is stimulated by phosphorylated substrates 729673

binds to insulin receptor 729673

forms a heterodimer with the p110 catalytic subunit 729673

Homology

Note Reference

alternative splice product of 55 kDa, p55alpha, has homology to p55 gamma (Pik3r3) 68289

External Links
Databases
DATABASE ID SOURCE
SMART: SH2 IPI
SMART: SH3 IPI
SMART: RhoGAP IPI
PROSITE: SH3 IPI
PROSITE: SH2 IPI
PROSITE: RHOGAP IPI
UNIPARC: UPI000013106A IPI
UNIPARC: UPI0001B7BC12 IPI
UNIPARC: UPI000002B05E IPI
UNIPARC: UPI000002B05F IPI
KEGG Report: rno:25513 ENTREZGENE
HomoloGene Group ID: 7889 ENTREZGENE
Germonline: 3329
Pfam: SH2 IPI
Pfam: SH3_1 IPI
Pfam: RhoGAP IPI
KEGG Pathway: 05215 ENTREZGENE
KEGG Pathway: 04070 ENTREZGENE
KEGG Pathway: 04810 ENTREZGENE
KEGG Pathway: 05200 ENTREZGENE
KEGG Pathway: 05212 ENTREZGENE
KEGG Pathway: 05223 ENTREZGENE
KEGG Pathway: 04722 ENTREZGENE
KEGG Pathway: 04650 ENTREZGENE
KEGG Pathway: 05218 ENTREZGENE
KEGG Pathway: 04670 ENTREZGENE
KEGG Pathway: 04630 ENTREZGENE
KEGG Pathway: 04910 ENTREZGENE
KEGG Pathway: 05214 ENTREZGENE
KEGG Pathway: 04510 ENTREZGENE
KEGG Pathway: 04666 ENTREZGENE
KEGG Pathway: 04664 ENTREZGENE
KEGG Pathway: 04012 ENTREZGENE
KEGG Pathway: 05213 ENTREZGENE
KEGG Pathway: 05210 ENTREZGENE
KEGG Pathway: 05220 ENTREZGENE
KEGG Pathway: 04062 ENTREZGENE
KEGG Pathway: 04662 ENTREZGENE
KEGG Pathway: 04210 ENTREZGENE
KEGG Pathway: 05221 ENTREZGENE
KEGG Pathway: 04150 ENTREZGENE
KEGG Pathway: 04370 ENTREZGENE
KEGG Pathway: 04930 ENTREZGENE
KEGG Pathway: 04620 ENTREZGENE
KEGG Pathway: 04660 ENTREZGENE
KEGG Pathway: 05222 ENTREZGENE
KEGG Pathway: 05211 ENTREZGENE
InterPro: SH3_domain. IPI
InterPro: SH2. IPI
InterPro: RhoGAP. IPI
InterPro: Rho_GTPase_activation_prot. IPI
InterPro: PI3kinase_P85. IPI
Ensembl Protein: ENSRNOP00000025687 IPI
Ensembl Protein: ENSRNOP00000060575 IPI
IPI: IPI00211946 IPI
IPI: IPI00949639 IPI
IPI: IPI00231821 IPI
IPI: IPI00231820 IPI
Gene3D-CATH: SH2 IPI
Gene3D-CATH: RhoGAP IPI
Entrez Gene: Pik3r1 ENTREZGENE
Ensembl Genes: ENSRNOG00000018903 IPI
TIGR: TC228818
UniProt: O55168_RAT IPI
UniProt: P85A_RAT IPI
UniProt: P85A_RAT IPI
UniProt: P85A_RAT IPI
RatMap: 41398 ENTREZGENE
Superfamily-SCOP: SH3 IPI
Superfamily-SCOP: Rho_GAP IPI
PANTHER: PI3kinase_P85 IPI
PRINTS: SH2DOMAIN. IPI
PRINTS: PI3KINASEP85. IPI
Sequences
Nucleotide: U50412 Get FASTA Search GEO Profiles
Nucleotide: NM_013005 Get FASTA Search GEO Profiles
Nucleotide: D78486 Get FASTA Search GEO Profiles
Nucleotide: D63325 Get FASTA Search GEO Profiles
Nucleotide: D64048 Get FASTA Search GEO Profiles
Nucleotide: D64045 Get FASTA Search GEO Profiles
(View all 6 Nucleotide Accessions)
Protein: BAA18933 Get FASTA
Protein: BAA24030 Get FASTA
Protein: BAA18932 Get FASTA
Protein: Q63787 Get FASTA
Protein: O55168 Get FASTA
Protein: AAC52846 Get FASTA
Protein: BAA24426 Get FASTA
Protein: NP_037137 Get FASTA
(View all 8 Protein Accessions)
Clusters
UniGene: 10599

References
Curated References
36 references in RGD related to Pik3r1

Other References
34 other references at PubMed related to Pik3r1

Database Information
RGD ID 3329
History

Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference

09-SEP-08: Pik3r1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863

14-FEB-08: Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863

08-MAY-01: Pik3r1 Phosphoinositide 3-kinase p85 WITHDRAWN Name withdrawn, does not match Human and Mouse nomenclature 62408