PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1) - Rat Genome Database

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Pathways
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Gene: PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1) Pan paniscus
Analyze
Symbol: PIK3R1
Name: phosphoinositide-3-kinase regulatory subunit 1
RGD ID: 11982703
Description: ENCODES a protein that exhibits 1-phosphatidylinositol-3-kinase activity (ortholog); 1-phosphatidylinositol-3-kinase regulator activity (ortholog); ATPase binding (ortholog); INVOLVED IN B cell differentiation (ortholog); cellular response to fatty acid (ortholog); cellular response to insulin stimulus (ortholog); PARTICIPATES IN E-cadherin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH agammaglobulinemia 7 (ortholog); Alzheimer's disease (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN phosphatidylinositol 3-kinase complex (ortholog); phosphatidylinositol 3-kinase complex, class IA (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: phosphatidylinositol 3-kinase regulatory subunit alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2445,620,454 - 45,705,861 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1543,777,000 - 43,859,488 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0545,701,219 - 45,786,652 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1547,268,477 - 47,350,960 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl547,267,286 - 47,350,960 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell differentiation  (IEA,ISO)
cellular response to fatty acid  (ISO)
cellular response to insulin stimulus  (IEA,ISO)
cellular response to UV  (IEA,ISO)
cytokine-mediated signaling pathway  (IEA)
extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
glucose metabolic process  (ISO)
growth hormone receptor signaling pathway  (IEA)
insulin receptor signaling pathway  (IEA,ISO)
insulin-like growth factor receptor signaling pathway  (IEA,ISO)
interleukin-18-mediated signaling pathway  (IEA)
intracellular glucose homeostasis  (IEA)
intrinsic apoptotic signaling pathway in response to DNA damage  (IEA,ISO)
myeloid leukocyte migration  (IEA,ISO)
natural killer cell mediated cytotoxicity  (ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of blood pressure  (ISO)
negative regulation of cell adhesion  (IEA,ISO)
negative regulation of cell-cell adhesion  (ISO)
negative regulation of cell-matrix adhesion  (IEA,ISO)
negative regulation of heart rate  (ISO)
negative regulation of muscle cell apoptotic process  (ISO)
negative regulation of osteoclast differentiation  (IEA,ISO)
negative regulation of proteolysis  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of stress fiber assembly  (IEA)
osteoclast differentiation  (IEA,ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
phosphatidylinositol metabolic process  (ISO)
phosphatidylinositol phosphate biosynthetic process  (IEA)
positive regulation of cell migration  (ISO)
positive regulation of endoplasmic reticulum unfolded protein response  (IEA)
positive regulation of filopodium assembly  (IEA)
positive regulation of focal adhesion disassembly  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of lamellipodium assembly  (IEA)
positive regulation of leukocyte migration  (IEA,ISO)
positive regulation of myoblast differentiation  (ISO)
positive regulation of protein import into nucleus  (IEA)
positive regulation of protein phosphorylation  (ISO)
positive regulation of RNA splicing  (IEA)
positive regulation of smooth muscle cell proliferation  (IEA)
positive regulation of synapse assembly  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
protein import into nucleus  (IEA,ISO)
protein stabilization  (IEA)
regulation of protein localization to plasma membrane  (IEA,ISO)
regulation of stress fiber assembly  (IEA,ISO)
regulation of toll-like receptor 4 signaling pathway  (IEA)
response to amino acid  (ISO)
response to cAMP  (ISO)
response to dexamethasone  (ISO)
response to endoplasmic reticulum stress  (IEA)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to fatty acid  (ISO)
response to fructose  (ISO)
response to glucocorticoid  (ISO)
response to growth factor  (ISO)
response to insulin  (ISO)
response to iron(II) ion  (ISO)
response to nutrient  (ISO)
response to progesterone  (ISO)
response to testosterone  (ISO)
response to xenobiotic stimulus  (ISO)
response to yeast  (ISO)
signal transduction  (IEA)
transcription by RNA polymerase II  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PIK3R1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2445,620,454 - 45,705,861 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1543,777,000 - 43,859,488 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0545,701,219 - 45,786,652 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1547,268,477 - 47,350,960 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl547,267,286 - 47,350,960 (-)Ensemblpanpan1.1panPan2
PIK3R1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38568,215,756 - 68,301,821 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl568,215,740 - 68,301,821 (+)EnsemblGRCh38hg38GRCh38
GRCh37567,511,584 - 67,597,649 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36567,558,218 - 67,633,405 (+)NCBINCBI36Build 36hg18NCBI36
Build 34567,622,250 - 67,633,403NCBI
Celera564,520,829 - 64,597,175 (+)NCBICelera
Cytogenetic Map5q13.1NCBI
HuRef564,468,818 - 64,555,164 (+)NCBIHuRef
CHM1_1567,511,846 - 67,597,747 (+)NCBICHM1_1
T2T-CHM13v2.0569,037,928 - 69,124,117 (+)NCBIT2T-CHM13v2.0
Pik3r1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913101,817,269 - 101,904,725 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13101,817,071 - 101,904,725 (-)EnsemblGRCm39 Ensembl
GRCm3813101,680,761 - 101,768,217 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13101,680,563 - 101,768,217 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713102,450,716 - 102,538,172 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613102,781,018 - 102,792,904 (-)NCBIMGSCv36mm8
Celera13105,285,857 - 105,373,612 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1353.92NCBI
Pik3r1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8234,612,946 - 34,697,660 (-)NCBIGRCr8
mRatBN7.2232,878,942 - 32,963,668 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl232,882,032 - 32,963,631 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx240,014,126 - 40,099,015 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0238,073,343 - 38,158,218 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0232,921,198 - 33,006,089 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0231,742,326 - 31,826,882 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl231,745,088 - 31,826,867 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0250,891,225 - 50,965,217 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4232,602,673 - 32,675,350 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1232,523,041 - 32,595,719 (-)NCBI
Celera228,878,690 - 28,948,863 (-)NCBICelera
RH 3.4 Map2111.0RGD
Cytogenetic Map2q12NCBI
Pik3r1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554461,020,043 - 1,098,820 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554461,020,707 - 1,098,327 (-)NCBIChiLan1.0ChiLan1.0
PIK3R1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1253,447,802 - 53,527,563 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl253,448,286 - 53,524,970 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha250,408,936 - 50,489,628 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0253,951,256 - 54,032,010 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl253,960,673 - 54,031,993 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1251,011,708 - 51,092,420 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0251,791,194 - 51,871,863 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0252,678,736 - 52,759,442 (+)NCBIUU_Cfam_GSD_1.0
Pik3r1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213192,252,011 - 192,336,736 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364801,188,183 - 1,273,537 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364801,188,408 - 1,273,210 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIK3R1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1646,511,521 - 46,523,609 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11646,434,757 - 46,523,626 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21650,135,837 - 50,148,434 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3R1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1464,321,296 - 64,406,188 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl464,321,078 - 64,406,519 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604913,008,003 - 13,093,192 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pik3r1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248151,289,997 - 1,369,610 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248151,290,106 - 1,376,961 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000061644   ⟹   ENSPPAP00000038737
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl547,267,286 - 47,350,960 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000061660   ⟹   ENSPPAP00000038753
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl547,268,471 - 47,278,933 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000061670   ⟹   ENSPPAP00000038763
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl547,268,471 - 47,276,664 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000061682   ⟹   ENSPPAP00000038775
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl547,269,643 - 47,340,022 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000061685   ⟹   ENSPPAP00000038778
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl547,269,643 - 47,340,022 (-)Ensembl
RefSeq Acc Id: XM_003806793   ⟹   XP_003806841
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2445,620,454 - 45,705,861 (-)NCBI
NHGRI_mPanPan1543,777,000 - 43,859,488 (-)NCBI
Mhudiblu_PPA_v0545,701,219 - 45,786,652 (-)NCBI
PanPan1.1547,268,477 - 47,350,960 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008957496   ⟹   XP_008955744
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2445,620,454 - 45,633,394 (-)NCBI
NHGRI_mPanPan1543,777,000 - 43,786,925 (-)NCBI
Mhudiblu_PPA_v0545,704,336 - 45,714,057 (-)NCBI
PanPan1.1547,268,477 - 47,276,624 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008957505   ⟹   XP_008955753
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2445,620,454 - 45,634,354 (-)NCBI
NHGRI_mPanPan1543,777,000 - 43,787,330 (-)NCBI
Mhudiblu_PPA_v0545,701,219 - 45,715,434 (-)NCBI
PanPan1.1547,268,488 - 47,278,933 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008957510   ⟹   XP_008955758
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2445,620,454 - 45,629,759 (-)NCBI
NHGRI_mPanPan1543,777,000 - 43,783,388 (-)NCBI
Mhudiblu_PPA_v0545,701,219 - 45,710,520 (-)NCBI
PanPan1.1547,268,477 - 47,274,867 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_003806841   ⟸   XM_003806793
- Peptide Label: isoform X1
- UniProtKB: A0A2R9CKR4 (UniProtKB/TrEMBL),   A0A2R9CCP7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008955744   ⟸   XM_008957496
- Peptide Label: isoform X2
- UniProtKB: A0A2R9CCN6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008955758   ⟸   XM_008957510
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008955753   ⟸   XM_008957505
- Peptide Label: isoform X3
- UniProtKB: A0A2R9CCM8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000038753   ⟸   ENSPPAT00000061660
RefSeq Acc Id: ENSPPAP00000038775   ⟸   ENSPPAT00000061682
RefSeq Acc Id: ENSPPAP00000038778   ⟸   ENSPPAT00000061685
RefSeq Acc Id: ENSPPAP00000038763   ⟸   ENSPPAT00000061670
RefSeq Acc Id: ENSPPAP00000038737   ⟸   ENSPPAT00000061644
Protein Domains
Rho-GAP   SH2   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000042049 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000061644.1 UniProtKB/TrEMBL
  ENSPPAT00000061660.1 UniProtKB/TrEMBL
  ENSPPAT00000061670.1 UniProtKB/TrEMBL
  ENSPPAT00000061682.1 UniProtKB/TrEMBL
  ENSPPAT00000061685.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.1490 UniProtKB/TrEMBL
  1.10.555.10 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro ISH2_PIK3R1 UniProtKB/TrEMBL
  PI3K_P85_iSH2 UniProtKB/TrEMBL
  PI3K_p85alpha_SH3 UniProtKB/TrEMBL
  PI3kinase_P85_cSH2 UniProtKB/TrEMBL
  PI3kinase_P85_nSH2 UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
KEGG Report pps:100994315 UniProtKB/TrEMBL
NCBI Gene PIK3R1 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT UniProtKB/TrEMBL
  PI3K21B, ISOFORM B UniProtKB/TrEMBL
Pfam PI3K_P85_iSH2 UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
PRINTS PI3KINASEP85 UniProtKB/TrEMBL
  SH2DOMAIN UniProtKB/TrEMBL
PROSITE RHOGAP UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART RhoGAP UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF48350 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A2R9C9Z1_PANPA UniProtKB/TrEMBL
  A0A2R9CCM8 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CCN6 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CCP7 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CKR4 ENTREZGENE, UniProtKB/TrEMBL