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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3329
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pik3r1
Name: phosphoinositide-3-kinase regulatory subunit 1
Acc ID: CHEBI:52289
Term: wortmannin
Definition: A delta-lactone that has formula C23H24O8.
Chemical ID: MESH:C009687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pik3r1multiple interactionsEXP 6480464CTDWortmannin inhibits the reaction [nonylphenol results in decreased expression of PIK3R1 protein]; Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of PIK3R1 mRNA]]PMID:27832966 PMID:32805344
Pik3r1decreases activityISOPIK3R1 (Homo sapiens)6480464CTDwortmannin results in decreased activity of PIK3R1 proteinPMID:19036708
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