RGD Reference Report - The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. - Rat Genome Database

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.

Authors: Engelman, JA  Luo, J  Cantley, LC 
Citation: Engelman JA, etal., Nat Rev Genet. 2006 Aug;7(8):606-19.
RGD ID: 2290476
Pubmed: PMID:16847462   (View Abstract at PubMed)
DOI: DOI:10.1038/nrg1879   (Journal Full-text)

Phosphatidylinositol 3-kinases (PI3Ks) evolved from a single enzyme that regulates vesicle trafficking in unicellular eukaryotes into a family of enzymes that regulate cellular metabolism and growth in multicellular organisms. In this review, we examine how the PI3K pathway has evolved to control these fundamental processes, and how this pathway is in turn regulated by intricate feedback and crosstalk mechanisms. In light of the recent advances in our understanding of the function of PI3Ks in the pathogenesis of diabetes and cancer, we discuss the exciting therapeutic opportunities for targeting this pathway to treat these diseases.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Breast Neoplasms  TAS 2290476; 2290476; 2290476 RGD 
Breast Neoplasms  ISOAKT2 (Homo sapiens)2290476; 2290476 RGD 
Breast Neoplasms  ISOPIK3CA (Homo sapiens)2290476; 2290476 RGD 
Breast Neoplasms  ISOPTEN (Homo sapiens)2290476; 2290476 RGD 
Colonic Neoplasms  TAS 2290476 RGD 
Colonic Neoplasms  ISOPIK3R1 (Homo sapiens)2290476; 2290476 RGD 
Gastrointestinal Neoplasms  TAS 2290476; 2290476 RGD 
Gastrointestinal Neoplasms  ISOPIK3CA (Homo sapiens)2290476; 2290476 RGD 
Gastrointestinal Neoplasms  ISOPTEN (Homo sapiens)2290476; 2290476 RGD 
glioblastoma  TAS 2290476 RGD 
glioblastoma  ISOPTEN (Homo sapiens)2290476; 2290476 RGD 
hepatocellular carcinoma  TAS 2290476 RGD 
hepatocellular carcinoma  ISOPIK3CA (Homo sapiens)2290476; 2290476 RGD 
high grade glioma  TAS 2290476 RGD 
high grade glioma  ISOPIK3CA (Homo sapiens)2290476; 2290476 RGD 
Lung Neoplasms  TAS 2290476 RGD 
Lung Neoplasms  ISOPIK3CA (Homo sapiens)2290476; 2290476 RGD 
melanoma  TAS 2290476 RGD 
melanoma  ISOPTEN (Homo sapiens)2290476; 2290476 RGD 
Ovarian Neoplasms  TAS 2290476; 2290476; 2290476 RGD 
Ovarian Neoplasms  ISOAKT2 (Homo sapiens)2290476; 2290476 RGD 
Ovarian Neoplasms  ISOPIK3CA (Homo sapiens)2290476; 2290476 RGD 
Ovarian Neoplasms  ISOPIK3R1 (Homo sapiens)2290476; 2290476 RGD 
pancreatic cancer  TAS 2290476 RGD 
pancreatic cancer  ISOAKT2 (Homo sapiens)2290476; 2290476 RGD 
Prostatic Neoplasms  TAS 2290476 RGD 
Prostatic Neoplasms  ISOPTEN (Homo sapiens)2290476; 2290476 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Akt2  (AKT serine/threonine kinase 2)
Pik3ca  (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha)
Pik3r1  (phosphoinositide-3-kinase regulatory subunit 1)
Pten  (phosphatase and tensin homolog)

Genes (Mus musculus)
Akt2  (thymoma viral proto-oncogene 2)
Pik3ca  (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)
Pik3r1  (phosphoinositide-3-kinase regulatory subunit 1)
Pten  (phosphatase and tensin homolog)

Genes (Homo sapiens)
AKT2  (AKT serine/threonine kinase 2)
PIK3CA  (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)
PIK3R1  (phosphoinositide-3-kinase regulatory subunit 1)
PTEN  (phosphatase and tensin homolog)


Additional Information