RGD Reference Report - Selective modulation of the CAP/Cbl pathway in the adipose tissue of high fat diet treated rats. - Rat Genome Database

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Selective modulation of the CAP/Cbl pathway in the adipose tissue of high fat diet treated rats.

Authors: Prada, PO  Pauli, JR  Ropelle, ER  Zecchin, HG  Carvalheira, JB  Velloso, LA  Saad, MJ 
Citation: Prada PO, etal., FEBS Lett. 2006 Sep 4;580(20):4889-94. Epub 2006 Aug 10.
RGD ID: 8554697
Pubmed: PMID:16919274   (View Abstract at PubMed)
DOI: DOI:10.1016/j.febslet.2006.08.004   (Journal Full-text)

A high-fat diet (HFD) is associated with reduced glucose uptake in muscle, but not in adipose tissue. In the present study, we investigated whether a HFD can modulate glucose uptake in adipose tissue by increasing signal transduction through the CAP/Cbl pathway, independently of the PI3-K/Akt pathway. Our results suggest that, in HFD, the differential regulation of insulin-induced glucose uptake between skeletal muscle and adipose tissue may, in part, be a consequence of the CAP/Cbl/C3G pathway, since the expression of CAP and Cbl, and also the activation of this pathway were increased in adipose tissue but not in muscle.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to nutrient levels  IEP 8554697 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Sorbs1  (sorbin and SH3 domain containing 1)

Objects referenced in this article
Gene Irs1 insulin receptor substrate 1 Rattus norvegicus
Gene Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 Rattus norvegicus

Additional Information