EGF-ERBB signalling: towards the systems level.
Authors:
Citri, A Yarden, Y
Citation:
Citri A and Yarden Y, Nat Rev Mol Cell Biol. 2006 Jul;7(7):505-16.
Pubmed:
(View Article at PubMed) PMID:16829981
DOI:
Full-text: DOI:10.1038/nrm1962
Signalling through the ERBB/HER receptors is intricately involved in human cancer and already serves as a target for several cancer drugs. Because of its inherent complexity, it is useful to envision ERBB signalling as a bow-tie-configured, evolvable network, which shares modularity, redundancy and control circuits with robust biological and engineered systems. Because network fragility is an inevitable trade-off of robustness, systems-level understanding is expected to generate therapeutic opportunities to intercept aberrant network activation.
Annotation
Molecular Pathway Annotations
RGD Objects Annotated
Genes (Rattus norvegicus)
Cbl (Cbl proto-oncogene, E3 ubiquitin protein ligase) Erbb3 (v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)) Grb2 (growth factor receptor bound protein 2)
Pik3r1 (phosphoinositide-3-kinase, regulatory subunit 1 (alpha)) Ptprj (protein tyrosine phosphatase, receptor type, J) Shc1 (SHC (Src homology 2 domain containing) transforming protein 1)
Sos1 (Son of sevenless homolog 1 (Drosophila)) Sos2 (son of sevenless homolog 2 (Drosophila))
Genes (Mus musculus)
Cbl (Casitas B-lineage lymphoma) Erbb3 (v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)) Grb2 (growth factor receptor bound protein 2)
Pik3r1 (phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)) Ptprj (protein tyrosine phosphatase, receptor type, J) Shc1 (src homology 2 domain-containing transforming protein C1)
Sos1 (son of sevenless homolog 1 (Drosophila)) Sos2 (son of sevenless homolog 2 (Drosophila))
Genes (Homo sapiens)
CBL (Cbl proto-oncogene, E3 ubiquitin protein ligase) ERBB3 (v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)) GRB2 (growth factor receptor-bound protein 2)
PIK3R1 (phosphoinositide-3-kinase, regulatory subunit 1 (alpha)) PTPRJ (protein tyrosine phosphatase, receptor type, J) SHC1 (SHC (Src homology 2 domain containing) transforming protein 1)
SOS1 (son of sevenless homolog 1 (Drosophila)) SOS2 (son of sevenless homolog 2 (Drosophila))
Additional Information
RGD Object Information
RGD ID:
2317988
Created:
2010-05-05
Species:
All Species
Last Modified:
2010-05-05
Status:
ACTIVE