Apoe (apolipoprotein E) - Rat Genome Database

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Gene: Apoe (apolipoprotein E) Rattus norvegicus
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Symbol: Apoe
Name: apolipoprotein E
RGD ID: 2138
Description: Enables several functions, including amyloid-beta binding activity; hydroxyapatite binding activity; and phospholipid binding activity. Involved in several processes, including cellular response to alcohol; neurogenesis; and regulation of lipid metabolic process. Located in several cellular components, including endosome; microtubule; and neuronal cell body. Is extrinsic component of external side of plasma membrane. Part of several cellular components, including discoidal high-density lipoprotein particle; low-density lipoprotein particle; and triglyceride-rich plasma lipoprotein particle. Used to study artery disease (multiple); familial hyperlipidemia (multiple); glomerulosclerosis; middle cerebral artery infarction; and steatotic liver disease (multiple). Biomarker of several diseases, including glomerulonephritis (multiple); hyperhomocysteinemia; hypertension; sciatic neuropathy; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); biliary tract cancer (multiple); eye disease (multiple); and familial hyperlipidemia (multiple). Orthologous to human APOE (apolipoprotein E); PARTICIPATES IN altered lipoprotein metabolic pathway; lipoprotein metabolic pathway; Alzheimer's disease pathway; INTERACTS WITH (+)-schisandrin B; (25R)-cholest-5-ene-3beta,26-diol; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: apo-E; APOEA
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Apoeem8Mcwi ; Apoeem7Mcwi ; Apoeem9Mcwi ; Apoeem1Sage ; Apoeem1Ejt
Genetic Models: SD-Apoeem1Ejt ; SS-Apoeem7Mcwi ; SS-Apoeem8Mcwi ; SS-Apoeem9Mcwi ; SD-Apoeem1Sage
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,481,889 - 88,485,816 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl188,481,385 - 88,485,855 (-)EnsemblGRCr8
mRatBN7.2179,353,924 - 79,357,852 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,353,916 - 79,357,932 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx184,748,825 - 84,752,747 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0193,300,176 - 93,304,099 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,503,931 - 86,507,854 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,612,894 - 80,616,820 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,612,895 - 80,617,057 (-)Ensemblrn6Rnor6.0
Rnor_5.0181,878,372 - 81,882,298 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4179,003,634 - 79,006,387 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera173,813,122 - 73,817,046 (-)NCBICelera
RGSC_v3.1179,081,854 - 79,083,684 (-)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
adenocarcinoma  (ISO)
age related macular degeneration 1  (ISO)
Alzheimer's disease  (IEP,ISO)
Alzheimer's disease 2  (ISO)
Alzheimer's disease 3  (ISO)
Alzheimer's disease 4  (ISO)
Alzheimer's Disease, Familial, 3, with Spastic Paraparesis and Apraxia  (ISO)
amyloidosis  (ISO)
amyotrophic lateral sclerosis  (ISO)
angle-closure glaucoma  (ISO)
anxiety disorder  (ISO)
aortic atherosclerosis  (IMP)
Apolipoprotein E, Deficiency or Defect of  (ISO)
arteriosclerosis  (ISO)
atherosclerosis  (IMP,ISO)
atopic dermatitis  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
beta thalassemia  (ISO)
bile duct cancer  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
Broad-Betalipoproteinemia  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
carotid stenosis  (ISO)
cerebral amyloid angiopathy  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholelithiasis  (ISO)
cholestasis  (ISO)
Chronic Brain Injury  (ISO)
Chronic Cerebral Hypoperfusion  (IEP)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
cognitive disorder  (ISO)
Cognitive Dysfunction  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (IMP,ISO)
Coronary Disease  (ISO)
Coumarin Sensitivity  (ISO)
dementia  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
Disease Progression  (ISO)
Dysbetalipoproteinemia due to Defect in Apolipoprotein E-d  (ISO)
Dyslipidemias  (ISO)
Emphysema  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
exfoliation syndrome  (ISO)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Diabetes Mellitus  (IEP)
Experimental Mammary Neoplasms  (ISO)
familial combined hyperlipidemia  (ISO)
Familial Hyperbeta- and Prebetalipoproteinemia  (ISO)
familial hypercholesterolemia  (IMP,ISO)
familial hyperlipidemia  (IDA,IMP,ISO)
fetal alcohol spectrum disorder  (ISO)
Fetal Growth Retardation  (IEP)
Fibrosis  (ISO)
Floating-Betalipoproteinemia  (ISO)
gallbladder cancer  (ISO)
Genetic Translocation  (ISO)
glaucoma  (ISO)
glomerulonephritis  (ISO)
glomerulosclerosis  (IDA,IEP)
Habitual Abortions  (ISO)
Hearing Loss  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex  (ISO)
Herpes Simplex Encephalitis  (ISO)
herpes simplex virus keratitis  (ISO)
Hypercholesterolemia  (IMP,ISO)
hyperhomocysteinemia  (IEP)
Hyperlipemia with Familial Hypercholesterolemic Xanthomatosis  (ISO)
Hyperlipoproteinemia Type II  (ISO)
hyperlipoproteinemia type III  (ISO)
hypertension  (IEP,ISO)
Hypertriglyceridemia  (IMP,ISO)
hyperuricemia  (ISO)
hypothyroidism  (IEP)
kidney failure  (ISO)
Klebsiella Infections  (ISO)
Kuhnt-Junius degeneration  (ISO)
left ventricular failure  (ISO)
Lewy body dementia  (ISO)
Lipoprotein Glomerulopathy  (ISO)
low tension glaucoma  (ISO)
lung carcinoma  (ISO)
Lung Neoplasms  (ISO)
macular degeneration  (ISO)
malaria  (ISO)
membranous glomerulonephritis  (IEP)
Memory Disorders  (ISO)
Mercury Poisoning  (ISO)
metabolic dysfunction-associated steatotic liver disease  (IDA)
middle cerebral artery infarction  (IDA)
multiple myeloma  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Neoplasm Metastasis  (ISO)
nephrotic syndrome  (ISO)
Nerve Degeneration  (ISO)
Neurobehavioral Manifestations  (ISO)
obesity  (ISO)
open-angle glaucoma  (ISO)
pancreatic cancer  (ISO)
Parkinson's disease  (ISO)
Peripheral Nerve Injuries  (IEP,ISO)
Plaque, Atherosclerotic  (ISO)
Pregnancy Complications, Infectious  (IEP)
Presenile and Senile Dementia  (ISO)
primary cutaneous amyloidosis  (ISO)
primary open angle glaucoma  (ISO)
proteinuria  (ISO)
psoriasis  (ISO)
Puromycin Aminonucleoside Nephrosis  (IEP)
relapsing-remitting multiple sclerosis  (ISO)
retinal disease  (ISO)
schizophrenia  (IEA,ISO)
sciatic neuropathy  (IEP)
sea-blue histiocytosis  (ISO)
sensorineural hearing loss  (ISO)
Sjogren's syndrome  (ISO)
sleep apnea  (ISO)
Spinal Cord Injuries  (IEP,ISO)
Splenomegaly  (ISO)
Spontaneous Abortions  (ISO)
steatotic liver disease  (IMP,ISO)
stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
transient cerebral ischemia  (IEP)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Vascular System Injuries  (IEP,ISO)
Venous Thrombosis  (ISO)
warfarin resistance  (ISO)
warfarin sensitivity  (ISO)
Wilson disease  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
(25R)-cholest-5-ene-3beta,26-diol  (EXP)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
11-dehydro-thromboxane B2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-arachidonoylglycerol  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
26-hydroxycholesterol  (EXP)
3',5'-cyclic GMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-Nitrobenzanthrone  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxy-TEMPO  (ISO)
5-aza-2'-deoxycytidine  (EXP)
6-oxoprostaglandin F1alpha  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
8-epi-prostaglandin F2alpha  (ISO)
Abemaciclib  (ISO)
acenocoumarol  (ISO)
acetamide  (EXP)
acetylcholine  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphibole asbestos  (EXP)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
atorvastatin calcium  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
bezafibrate  (EXP,ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
BQ 123  (ISO)
Brodifacoum  (EXP)
Butylbenzyl phthalate  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
capsaicin  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
cerium trichloride  (ISO)
cetirizine  (ISO)
cetrorelix  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
chloroquine  (EXP,ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP,ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
clotrimazole  (EXP)
cobalt atom  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corosolic acid  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP,ISO)
D-glucose  (ISO)
DDE  (ISO)
DDT  (ISO)
Deoxycorticosterone acetate  (EXP)
deoxynivalenol  (ISO)
desogestrel  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP,ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
dipyridamole  (ISO)
diquat  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
enalapril  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (EXP)
erianin  (ISO)
ethanol  (EXP,ISO)
ethanolamine  (EXP)
Evodiamine  (ISO)
felodipine  (ISO)
fenvalerate  (EXP)
Fexofenadine hydrochloride  (ISO)
flusilazole  (ISO)
flutamide  (EXP)
fluvastatin  (ISO)
folic acid  (ISO)
folpet  (ISO)
fructose  (ISO)
furan  (EXP)
Ganoderic acid A  (ISO)
gemfibrozil  (EXP)
genistein  (ISO)
gentamycin  (EXP)
gingerol  (ISO)
ginkgolide B  (ISO)
glucose  (ISO)
glutathione  (ISO)
glycidol  (EXP)
glyphosate  (ISO)
GW 3965  (EXP,ISO)
GW 4064  (ISO)
GW 7647  (ISO)
hexadecanoic acid  (ISO)
high-density lipoprotein cholesterol  (ISO)
hydrazine  (EXP)
hydrogen peroxide  (EXP)
hydroquinone  (EXP)
imisopasem manganese  (ISO)
indometacin  (ISO)
iron atom  (ISO)
iron dichloride  (ISO)
iron(0)  (ISO)
isotretinoin  (ISO)
ivabradine  (ISO)
ivermectin  (ISO)
kaempferol  (ISO)
kainic acid  (ISO)
ketamine  (EXP,ISO)
ketoconazole  (EXP)
kuwanone G  (ISO)
L-ascorbic acid  (EXP)
lansoprazole  (ISO)
lanthanum trichloride  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lovastatin  (ISO)
mechlorethamine  (EXP)
menadione  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methimazole  (EXP)
methyl beta-cyclodextrin  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monosodium L-glutamate  (EXP,ISO)
morphine  (EXP)
Morroniside  (ISO)
myricitrin  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
nitrofen  (EXP)
Nivalenol  (ISO)
NONOate(1-)  (ISO)
notoginsenoside R1  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oleic acid  (ISO)
oxaliplatin  (EXP)
oxybenzone  (ISO)
ozone  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paricalcitol  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
Phenelzine  (ISO)
phenobarbital  (EXP)
phenylephrine  (ISO)
phenytoin  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
phytosterols  (ISO)
pirinixic acid  (EXP)
potassium chloride  (EXP)
probucol  (ISO)
propamocarb  (ISO)
propanal  (ISO)
Pyridostigmine bromide  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
rotenone  (ISO)
Salvianolic acid A  (ISO)
sarin  (EXP,ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sevoflurane  (EXP,ISO)
simvastatin  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
streptozocin  (EXP,ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
superoxide  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
taurocholic acid  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
theaflavin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
topotecan  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP)
Trihexyphenidyl  (ISO)
trimellitic anhydride  (ISO)
triolein  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
Tropicamide  (ISO)
trovafloxacin  (ISO)
Tungsten carbide  (ISO)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vanadyl sulfate  (EXP)
varenicline  (ISO)
vitamin E  (ISO)
vitamin K  (ISO)
vitexin  (ISO)
warfarin  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acylglycerol homeostasis  (IBA)
AMPA glutamate receptor clustering  (ISO)
amyloid precursor protein metabolic process  (IEA,ISO)
artery development  (ISO)
artery morphogenesis  (ISO)
blood vessel development  (ISO)
calcium ion homeostasis  (ISO)
cellular oxidant detoxification  (IEA)
cellular response to cholesterol  (IEP)
cellular response to ethanol  (IEP)
cellular response to growth factor stimulus  (IEP)
cellular response to interleukin-1  (IEP)
cellular response to lipoprotein particle stimulus  (IEA,ISO)
cholesterol catabolic process  (ISO)
cholesterol efflux  (IBA,IEA,ISO,ISS)
cholesterol homeostasis  (IEA,ISO)
cholesterol metabolic process  (IBA,IEA,ISO)
chylomicron remnant clearance  (IEA,ISO,ISS)
circulatory system development  (ISO)
fatty acid homeostasis  (IEA,ISO)
fatty acid metabolic process  (ISO)
G protein-coupled receptor signaling pathway  (IEA,ISO)
gene expression  (ISO)
high-density lipoprotein particle assembly  (IEA,ISO,ISS)
high-density lipoprotein particle clearance  (IEA,ISO)
high-density lipoprotein particle remodeling  (IEA,ISO)
host-mediated activation of viral process  (IEA,ISO)
intermediate-density lipoprotein particle clearance  (IEA,ISO,ISS)
intracellular calcium ion homeostasis  (ISO)
lipid homeostasis  (ISO)
lipid metabolic process  (ISO)
lipid transport  (IDA,IEA)
lipid transport involved in lipid storage  (ISO)
lipoprotein biosynthetic process  (IEA,ISO,ISS)
lipoprotein catabolic process  (ISO)
lipoprotein metabolic process  (IDA,IEA,ISO)
locomotory exploration behavior  (IEA,ISO)
long-chain fatty acid transport  (IEA,ISO)
long-term memory  (IEA,ISO)
low-density lipoprotein particle remodeling  (ISO)
maintenance of location in cell  (ISO)
melanosome organization  (IEA,ISO,ISS)
negative regulation of amyloid fibril formation  (ISO,ISS)
negative regulation of amyloid-beta formation  (IEA,ISO)
negative regulation of blood coagulation  (IEA,ISO)
negative regulation of blood vessel endothelial cell migration  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of cholesterol biosynthetic process  (IDA,IEA,ISO)
negative regulation of cholesterol efflux  (ISO)
negative regulation of dendritic spine development  (ISO)
negative regulation of dendritic spine maintenance  (ISO)
negative regulation of endothelial cell migration  (IEA,ISO)
negative regulation of endothelial cell proliferation  (IEA,ISO)
negative regulation of gene expression  (ISO)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of lipid biosynthetic process  (ISO)
negative regulation of lipid metabolic process  (IEA)
negative regulation of lipid transport across blood-brain barrier  (ISO)
negative regulation of long-term synaptic potentiation  (IEA,ISO)
negative regulation of MAPK cascade  (IEA,ISO)
negative regulation of neuron projection development  (IEA,ISO)
negative regulation of phospholipid efflux  (ISO)
negative regulation of platelet activation  (IEA,ISO)
negative regulation of platelet-derived growth factor receptor signaling pathway  (IEA,ISO)
negative regulation of postsynaptic membrane organization  (ISO)
negative regulation of protein metabolic process  (IEA,ISO)
negative regulation of protein secretion  (IEA,ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of triglyceride metabolic process  (ISO)
neuron projection development  (IEA,ISO)
neuron projection regeneration  (TAS)
nitric oxide-cGMP-mediated signaling  (IEA,ISO)
NMDA glutamate receptor clustering  (ISO)
oligodendrocyte differentiation  (IEP)
peripheral nervous system axon regeneration  (IEP)
phospholipid efflux  (IBA,IEA,ISO)
positive regulation of amyloid-beta clearance  (ISO,ISS)
positive regulation of amyloid-beta formation  (ISO)
positive regulation of axon extension  (IDA)
positive regulation of cholesterol efflux  (IEA,ISO)
positive regulation of cholesterol metabolic process  (IEA,ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of dendritic spine maintenance  (ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of endocytosis  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of lipid biosynthetic process  (IEA,ISO)
positive regulation of lipid transport across blood-brain barrier  (IEA,ISO)
positive regulation of lipoprotein transport  (IEA,ISO)
positive regulation of low-density lipoprotein particle receptor catabolic process  (IEA,ISO)
positive regulation of membrane protein ectodomain proteolysis  (IEA,ISO)
positive regulation of neurofibrillary tangle assembly  (ISO)
positive regulation of neuron projection development  (IEA,ISO)
positive regulation of nitric oxide biosynthetic process  (IEA,ISO)
positive regulation of phospholipid efflux  (IEA,ISO)
positive regulation of presynaptic membrane organization  (ISO)
protein import  (IEA,ISO)
receptor-mediated endocytosis  (IEA,ISO)
regulation of amyloid fibril formation  (IEA,ISO)
regulation of amyloid precursor protein catabolic process  (IEA,ISO)
regulation of amyloid-beta clearance  (IEA,ISO)
regulation of apoptotic process  (ISO)
regulation of behavioral fear response  (IEA,ISO)
regulation of Cdc42 protein signal transduction  (IEA,ISO)
regulation of cellular response to very-low-density lipoprotein particle stimulus  (IEA,ISO)
regulation of cholesterol metabolic process  (IEA,ISO)
regulation of gene expression  (ISO)
regulation of innate immune response  (ISO)
regulation of plasma lipoprotein particle levels  (ISO)
regulation of proteasomal protein catabolic process  (IEA,ISO)
regulation of protein metabolic process  (IEA,ISO)
regulation of protein-containing complex assembly  (IEA,ISO)
regulation of synapse organization  (ISO)
regulation of triglyceride metabolic process  (IDA,IEA)
response to caloric restriction  (IEA,ISO)
response to D-galactosamine  (IEP)
response to dietary excess  (ISO)
response to ethanol  (IEP)
response to insulin  (IEP)
response to oxidative stress  (ISO)
response to retinoic acid  (IEP)
response to tumor necrosis factor  (IEP)
response to zinc ion  (IEP)
reverse cholesterol transport  (IEA,ISO)
signal transduction  (ISO)
triglyceride homeostasis  (ISO)
triglyceride metabolic process  (IEA,ISO)
triglyceride-rich lipoprotein particle clearance  (IEA,ISO,ISS)
vasodilation  (ISO)
very-low-density lipoprotein particle clearance  (IEA,ISO,ISS)
very-low-density lipoprotein particle remodeling  (IEA,ISO)
virion assembly  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
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141. Cell surface "blanket" of apolipoprotein E on rat adrenocortical cells. Williams DL, etal., J Lipid Res. 1995 Apr;36(4):745-58.
142. Apolipoprotein E-epsilon 4 protects against severe liver disease caused by hepatitis C virus. Wozniak MA, etal., Hepatology. 2002 Aug;36(2):456-63.
143. Role of apolipoprotein E in lipoprotein metabolism and in the process of atherosclerosis. Yamada N, etal., J Atheroscler Thromb. 1995;2 Suppl 1:S29-33.
144. Genetic risk for coronary artery disease in individuals with or without type 2 diabetes. Yamada Y, etal., Mol Genet Metab. 2004 Apr;81(4):282-90.
145. Genetic risk for atherothrombotic cerebral infarction in individuals stratified by sex or conventional risk factors for atherosclerosis. Yamaguchi S, etal., Int J Mol Med. 2006 Nov;18(5):871-83.
146. Confounding effect of obstructive jaundice in the interpretation of proteomic plasma profiling data for pancreatic cancer. Yan L, etal., J Proteome Res. 2009 Jan;8(1):142-8.
147. Effects of apolipoprotein E genotypes on the development of exfoliation syndrome. Yilmaz A, etal., Exp Eye Res. 2005 Jun;80(6):871-5.
148. Investigation of the relationship between apolipoprotein E gene polymorphisms and hepatitis B virus infection in northern China. Yin Z, etal., Clin Chem Lab Med. 2010 Dec;48(12):1803-7. doi: 10.1515/CCLM.2010.354. Epub 2010 Oct 20.
149. [A study on the association of apolipoprotein E genotypes with primary open-angle glaucoma and primary angle-closure glaucoma in northeast of China]. Yuan HP, etal., Zhonghua Yan Ke Za Zhi. 2007 May;43(5):416-20.
150. Endogenous adipocyte apolipoprotein E is colocalized with caveolin at the adipocyte plasma membrane. Yue L and Mazzone T, J Lipid Res. 2011 Mar;52(3):489-98. Epub 2010 Dec 16.
151. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Zhang SH, etal., Science 1992 Oct 16;258(5081):468-71.
152. Hyperlipidemia induces typical atherosclerosis development in Ldlr and Apoe deficient rats. Zhao Y, etal., Atherosclerosis. 2018 Apr;271:26-35. doi: 10.1016/j.atherosclerosis.2018.02.015. Epub 2018 Feb 12.
153. Identification of differentially expressed proteins in rats with spinal cord injury during the transitional phase using an iTRAQ-based quantitative analysis. Zhou H, etal., Gene. 2018 Jul 20. pii: S0378-1119(18)30820-5. doi: 10.1016/j.gene.2018.07.050.
154. Less gelatinases is associated with apolipoprotein E accumulation in glomerulosclerosis rats. Zhou TB, etal., Histol Histopathol. 2012 Feb;27(2):249-56.
155. All-trans retinoic acid can regulate the expressions of gelatinases and apolipoprotein E in glomerulosclerosis rats. Zhou TB, etal., Vascul Pharmacol. 2011 Nov-Dec;55(5-6):169-77. Epub 2011 Sep 2.
Additional References at PubMed
PMID:210174   PMID:210175   PMID:1384047   PMID:1423598   PMID:1530612   PMID:1911868   PMID:1917954   PMID:2280190   PMID:2745454   PMID:2762297   PMID:3020048   PMID:3771793  
PMID:3797247   PMID:4066713   PMID:6190813   PMID:7566652   PMID:7592957   PMID:7635945   PMID:7683668   PMID:7766086   PMID:7798939   PMID:8071364   PMID:8089103   PMID:8127890  
PMID:8185566   PMID:8245722   PMID:8300609   PMID:8340399   PMID:8647961   PMID:8773783   PMID:8939961   PMID:8995232   PMID:9003062   PMID:9186920   PMID:9240444   PMID:9300780  
PMID:9325076   PMID:9488694   PMID:9649566   PMID:9685360   PMID:9788969   PMID:9826706   PMID:11120757   PMID:11162594   PMID:11305869   PMID:11551841   PMID:11553788   PMID:12042316  
PMID:12401887   PMID:12870266   PMID:12950167   PMID:13130124   PMID:14595002   PMID:14741101   PMID:14754908   PMID:15269218   PMID:15489334   PMID:15654758   PMID:15866734   PMID:15950758  
PMID:16230502   PMID:16273551   PMID:16376010   PMID:16443932   PMID:16497717   PMID:16502470   PMID:16524875   PMID:16802110   PMID:16805831   PMID:16935699   PMID:17012232   PMID:17126342  
PMID:17154273   PMID:17305370   PMID:17326667   PMID:17336988   PMID:17720994   PMID:18288929   PMID:18360691   PMID:18377911   PMID:18559657   PMID:19056867   PMID:19362542   PMID:19382209  
PMID:19414061   PMID:19717566   PMID:19816508   PMID:19946888   PMID:20005821   PMID:20456011   PMID:20458337   PMID:20551380   PMID:21593558   PMID:21630459   PMID:21700703   PMID:21784977  
PMID:22206666   PMID:22516433   PMID:22637583   PMID:22674573   PMID:22871113   PMID:23103361   PMID:23142051   PMID:23376485   PMID:23533145   PMID:23620513   PMID:23640054   PMID:23658023  
PMID:23676495   PMID:23741427   PMID:23845000   PMID:24154541   PMID:24259049   PMID:24328732   PMID:24345162   PMID:24412220   PMID:24446231   PMID:24769233   PMID:24814386   PMID:25015123  
PMID:25122793   PMID:25207746   PMID:25778834   PMID:26397958   PMID:26545012   PMID:26782580   PMID:27044754   PMID:27068509   PMID:27277003   PMID:27477018   PMID:27559042   PMID:27683909  
PMID:28111074   PMID:28164773   PMID:28356228   PMID:29336888   PMID:30303984   PMID:30958617   PMID:31432127   PMID:33564035   PMID:33575839   PMID:33932558   PMID:34575848   PMID:36104381  
PMID:37081644   PMID:37658943   PMID:38393618   PMID:38772427  


Genomics

Comparative Map Data
Apoe
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,481,889 - 88,485,816 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl188,481,385 - 88,485,855 (-)EnsemblGRCr8
mRatBN7.2179,353,924 - 79,357,852 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,353,916 - 79,357,932 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx184,748,825 - 84,752,747 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0193,300,176 - 93,304,099 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,503,931 - 86,507,854 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,612,894 - 80,616,820 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,612,895 - 80,617,057 (-)Ensemblrn6Rnor6.0
Rnor_5.0181,878,372 - 81,882,298 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4179,003,634 - 79,006,387 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera173,813,122 - 73,817,046 (-)NCBICelera
RGSC_v3.1179,081,854 - 79,083,684 (-)NCBI
Cytogenetic Map1q21NCBI
APOE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381944,905,796 - 44,909,393 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1944,903,787 - 44,909,396 (+)Ensemblhg38GRCh38
GRCh371945,409,053 - 45,412,650 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,100,879 - 50,104,490 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341950,100,878 - 50,104,489NCBI
Celera1942,213,361 - 42,216,972 (+)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1941,839,825 - 41,843,436 (+)NCBIHuRef
CHM1_11945,411,793 - 45,415,404 (+)NCBICHM1_1
T2T-CHM13v2.01947,730,492 - 47,734,089 (+)NCBIT2T-CHM13v2.0
Apoe
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39719,430,169 - 19,434,326 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl719,430,034 - 19,433,113 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38719,696,244 - 19,701,310 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,696,109 - 19,699,188 (-)Ensemblmm10GRCm38
MGSCv37720,281,593 - 20,284,515 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36718,854,794 - 18,857,554 (-)NCBIMGSCv36mm8
Celera717,102,329 - 17,105,251 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.94NCBI
Apoe
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555551,999,711 - 2,001,888 (+)Ensembl
ChiLan1.0NW_0049555551,998,170 - 2,002,003 (+)NCBIChiLan1.0ChiLan1.0
APOE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22051,065,455 - 51,069,038 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11952,937,264 - 52,940,847 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01941,853,669 - 41,857,252 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11950,459,906 - 50,463,490 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1950,459,906 - 50,463,490 (+)EnsemblpanPan2panpan1.1
APOE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11110,525,717 - 110,528,534 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1110,525,722 - 110,528,440 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1110,006,660 - 110,009,463 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01111,055,483 - 111,058,288 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1111,055,483 - 111,058,228 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11110,730,139 - 110,732,942 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01110,365,616 - 110,368,413 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01111,234,400 - 111,237,204 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Apoe
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,165,062 - 17,169,462 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367061,512,438 - 1,516,805 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl651,372,292 - 51,375,330 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1651,373,113 - 51,375,333 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2647,269,973 - 47,272,195 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6q1.2-q2.12NCBI
APOE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1638,377,154 - 38,381,219 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl638,376,887 - 38,381,438 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607317,947,315 - 17,951,250 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apoe
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249071,752,322 - 1,755,308 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Apoe
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12170,917,865 - 170,920,679 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Apoe
13 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:77
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000041891
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat

Markers in Region
RH94767  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,353,737 - 79,353,972 (+)MAPPERmRatBN7.2
Rnor_6.0180,612,708 - 80,612,942NCBIRnor6.0
Rnor_5.0181,878,186 - 81,878,420UniSTSRnor5.0
RGSC_v3.4179,003,448 - 79,003,682UniSTSRGSC3.4
Celera173,812,936 - 73,813,170UniSTS
Cytogenetic Map1q21UniSTS
RH94459  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,353,732 - 79,353,885 (+)MAPPERmRatBN7.2
Rnor_6.0180,612,703 - 80,612,855NCBIRnor6.0
Rnor_5.0181,878,181 - 81,878,333UniSTSRnor5.0
RGSC_v3.4179,003,443 - 79,003,595UniSTSRGSC3.4
Celera173,812,931 - 73,813,083UniSTS
Cytogenetic Map1q21UniSTS
UniSTS:532416  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8188,482,693 - 88,483,157 (+)Marker Load Pipeline
mRatBN7.2179,354,728 - 79,355,192 (+)MAPPERmRatBN7.2
Rnor_6.0180,613,699 - 80,614,162NCBIRnor6.0
Rnor_5.0181,879,177 - 81,879,640UniSTSRnor5.0
Celera173,813,927 - 73,814,390UniSTS
Cytogenetic Map1q21UniSTS


Genetic Models
This gene Apoe is modified in the following models/strains:
SD-Apoeem1Ejt     SS-Apoeem7Mcwi     SS-Apoeem8Mcwi     SS-Apoeem9Mcwi     SD-Apoeem1Sage    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_138828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC060313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J00705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J02582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000041891   ⟹   ENSRNOP00000050968
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl188,481,887 - 88,484,404 (-)Ensembl
mRatBN7.2 Ensembl179,353,922 - 79,356,787 (-)Ensembl
Rnor_6.0 Ensembl180,612,895 - 80,615,704 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080453   ⟹   ENSRNOP00000071702
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl188,481,890 - 88,485,855 (-)Ensembl
mRatBN7.2 Ensembl179,353,925 - 79,357,932 (-)Ensembl
Rnor_6.0 Ensembl180,612,895 - 80,617,057 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091574   ⟹   ENSRNOP00000068937
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl188,481,887 - 88,485,855 (-)Ensembl
mRatBN7.2 Ensembl179,353,922 - 79,357,891 (-)Ensembl
Rnor_6.0 Ensembl180,612,895 - 80,615,525 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099048   ⟹   ENSRNOP00000089743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl179,353,922 - 79,356,759 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108411   ⟹   ENSRNOP00000092257
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl188,481,385 - 88,484,699 (-)Ensembl
mRatBN7.2 Ensembl179,353,916 - 79,356,734 (-)Ensembl
RefSeq Acc Id: NM_001270681   ⟹   NP_001257610
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,481,889 - 88,484,699 (-)NCBI
mRatBN7.2179,353,924 - 79,356,734 (-)NCBI
Rnor_6.0180,612,894 - 80,615,704 (-)NCBI
Rnor_5.0181,878,372 - 81,882,298 (-)NCBI
Celera173,813,122 - 73,815,932 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270682   ⟹   NP_001257611
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,481,889 - 88,484,699 (-)NCBI
mRatBN7.2179,353,924 - 79,356,734 (-)NCBI
Rnor_6.0180,612,894 - 80,615,704 (-)NCBI
Rnor_5.0181,878,372 - 81,882,298 (-)NCBI
Celera173,813,122 - 73,815,932 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270683   ⟹   NP_001257612
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,481,889 - 88,485,816 (-)NCBI
mRatBN7.2179,353,924 - 79,357,852 (-)NCBI
Rnor_6.0180,612,894 - 80,616,820 (-)NCBI
Rnor_5.0181,878,372 - 81,882,298 (-)NCBI
Celera173,813,122 - 73,817,046 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270684   ⟹   NP_001257613
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,481,889 - 88,484,520 (-)NCBI
mRatBN7.2179,353,924 - 79,356,555 (-)NCBI
Rnor_6.0180,612,894 - 80,615,525 (-)NCBI
Rnor_5.0181,878,372 - 81,882,298 (-)NCBI
Celera173,813,122 - 73,815,753 (-)NCBI
Sequence:
RefSeq Acc Id: NM_138828   ⟹   NP_620183
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,481,889 - 88,484,699 (-)NCBI
mRatBN7.2179,353,924 - 79,356,734 (-)NCBI
Rnor_6.0180,612,894 - 80,615,704 (-)NCBI
Rnor_5.0181,878,372 - 81,882,298 (-)NCBI
RGSC_v3.4179,003,634 - 79,006,387 (-)RGD
Celera173,813,122 - 73,815,932 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001257610 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257611 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257612 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257613 (Get FASTA)   NCBI Sequence Viewer  
  NP_620183 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40755 (Get FASTA)   NCBI Sequence Viewer  
  AAA40756 (Get FASTA)   NCBI Sequence Viewer  
  AAH60313 (Get FASTA)   NCBI Sequence Viewer  
  AAH86581 (Get FASTA)   NCBI Sequence Viewer  
  CAA28650 (Get FASTA)   NCBI Sequence Viewer  
  EDM08150 (Get FASTA)   NCBI Sequence Viewer  
  EDM08151 (Get FASTA)   NCBI Sequence Viewer  
  EDM08152 (Get FASTA)   NCBI Sequence Viewer  
  EDM08153 (Get FASTA)   NCBI Sequence Viewer  
  EDM08154 (Get FASTA)   NCBI Sequence Viewer  
  EDM08155 (Get FASTA)   NCBI Sequence Viewer  
  EDM08156 (Get FASTA)   NCBI Sequence Viewer  
  EDM08157 (Get FASTA)   NCBI Sequence Viewer  
  EDM08158 (Get FASTA)   NCBI Sequence Viewer  
  EDM08159 (Get FASTA)   NCBI Sequence Viewer  
  EDM08160 (Get FASTA)   NCBI Sequence Viewer  
  EDM08161 (Get FASTA)   NCBI Sequence Viewer  
  EDM08162 (Get FASTA)   NCBI Sequence Viewer  
  EDM08163 (Get FASTA)   NCBI Sequence Viewer  
  EDM08164 (Get FASTA)   NCBI Sequence Viewer  
  EDM08165 (Get FASTA)   NCBI Sequence Viewer  
  EDM08166 (Get FASTA)   NCBI Sequence Viewer  
  EDM08167 (Get FASTA)   NCBI Sequence Viewer  
  EDM08168 (Get FASTA)   NCBI Sequence Viewer  
  EDM08169 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000050968
  ENSRNOP00000071702
  ENSRNOP00000092257
GenBank Protein P02650 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_620183   ⟸   NM_138828
- Peptide Label: precursor
- UniProtKB: P02650 (UniProtKB/Swiss-Prot),   A6J8R8 (UniProtKB/TrEMBL),   Q6PAH0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257612   ⟸   NM_001270683
- Peptide Label: precursor
- UniProtKB: P02650 (UniProtKB/Swiss-Prot),   A6J8R8 (UniProtKB/TrEMBL),   Q6PAH0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257611   ⟸   NM_001270682
- Peptide Label: precursor
- UniProtKB: P02650 (UniProtKB/Swiss-Prot),   A6J8R8 (UniProtKB/TrEMBL),   Q6PAH0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257610   ⟸   NM_001270681
- Peptide Label: precursor
- UniProtKB: P02650 (UniProtKB/Swiss-Prot),   A6J8R8 (UniProtKB/TrEMBL),   Q6PAH0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257613   ⟸   NM_001270684
- Peptide Label: precursor
- UniProtKB: P02650 (UniProtKB/Swiss-Prot),   A6J8R8 (UniProtKB/TrEMBL),   Q6PAH0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071702   ⟸   ENSRNOT00000080453
Ensembl Acc Id: ENSRNOP00000050968   ⟸   ENSRNOT00000041891
Ensembl Acc Id: ENSRNOP00000068937   ⟸   ENSRNOT00000091574
Ensembl Acc Id: ENSRNOP00000089743   ⟸   ENSRNOT00000099048
Ensembl Acc Id: ENSRNOP00000092257   ⟸   ENSRNOT00000108411

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P02650-F1-model_v2 AlphaFold P02650 1-312 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689780
Promoter ID:EPDNEW_R304
Type:initiation region
Name:Apoe_1
Description:apolipoprotein E
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0180,615,673 - 80,615,733EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2138 AgrOrtholog
BioCyc Gene G2FUF-60488 BioCyc
Ensembl Genes ENSRNOG00000018454 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000041891 ENTREZGENE
  ENSRNOT00000080453 ENTREZGENE
  ENSRNOT00000108411 ENTREZGENE
Gene3D-CATH Apolipoprotein UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6919048 IMAGE-MGC_LOAD
  IMAGE:7307758 IMAGE-MGC_LOAD
InterPro ApoA_E UniProtKB/Swiss-Prot
  Apolipoprotein_A1/A4/E UniProtKB/Swiss-Prot
KEGG Report rno:25728 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105323 IMAGE-MGC_LOAD
  MGC:72690 IMAGE-MGC_LOAD
NCBI Gene 25728 ENTREZGENE
PANTHER APOLIPOPROTEIN UniProtKB/Swiss-Prot
  APOLIPOPROTEIN E UniProtKB/Swiss-Prot
Pfam Apolipoprotein UniProtKB/Swiss-Prot
PharmGKB APOE RGD
PhenoGen Apoe PhenoGen
RatGTEx ENSRNOG00000018454 RatGTEx
Superfamily-SCOP Apolipoprotein A-I UniProtKB/Swiss-Prot
TIGR TC204356
UniProt A0A0G2K151_RAT UniProtKB/TrEMBL
  A0A8I6ADM8_RAT UniProtKB/TrEMBL
  A0A8L2QPE1_RAT UniProtKB/TrEMBL
  A0A8L2R071_RAT UniProtKB/TrEMBL
  A6J8R5_RAT UniProtKB/TrEMBL
  A6J8R8 ENTREZGENE, UniProtKB/TrEMBL
  A6J8S2_RAT UniProtKB/TrEMBL
  A6J8S3_RAT UniProtKB/TrEMBL
  A6J8S4_RAT UniProtKB/TrEMBL
  A6J8S6_RAT UniProtKB/TrEMBL
  A6J8S8_RAT UniProtKB/TrEMBL
  A6J8T1_RAT UniProtKB/TrEMBL
  A6J8T2_RAT UniProtKB/TrEMBL
  APOE_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6PAH0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Apoe  apolipoprotein E    Apolipoprotein E,  Name updated 629478 APPROVED
2002-06-10 Apoe  Apolipoprotein E,      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may act to decrease atherosclerosis by decreasing the penetration of triglyceride-rich particles (TGRPs) into the arterial wall 634663
gene_process plays a role in plasma lipoprotein transport 634663