RGD Reference Report - Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis. - Rat Genome Database

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Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis.

Authors: Wilhelmus, MM  Bol, JG  Van Haastert, ES  Rozemuller, AJ  Bu, G  Drukarch, B  Hoozemans, JJ 
Citation: Wilhelmus MM, etal., Am J Pathol. 2011 Nov;179(5):2152-6. doi: 10.1016/j.ajpath.2011.07.021. Epub 2011 Sep 9.
RGD ID: 7771591
Pubmed: PMID:21907175   (View Abstract at PubMed)
PMCID: PMC3204035   (View Article at PubMed Central)
DOI: DOI:10.1016/j.ajpath.2011.07.021   (Journal Full-text)

Parkinson's disease (PD) is characterized by alpha-synuclein-containing Lewy bodies (LBs) and loss of melanized neurons in the substantia nigra (SN). Recently, a link between apolipoprotein E (ApoE) expression, alpha-synuclein aggregation, and neurodegeneration was suggested. Here, we report on ApoE expression appearing in melanized neurons of the SN and in LBs in both PD and incidental LB disease cases. Interestingly, increased expression of the low-density lipoprotein receptor-related protein 1 (the receptor for ApoE) was also observed in incidental LB disease and PD. Our data suggest that alterations in lipoprotein homeostasis/signaling in melanized neurons of the SN are an early event during PD pathogenesis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Lewy body dementia  IEP 7771591protein:increased expression:neuron:RGD 
Lewy body dementia  ISOAPOE (Homo sapiens)7771591; 7771591protein:increased expression:neuron:RGD 
Parkinson's disease  IEP 7771591protein:increased expression:neuron:RGD 
Parkinson's disease  ISOAPOE (Homo sapiens)7771591; 7771591protein:increased expression:neuron:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Apoe  (apolipoprotein E)

Genes (Mus musculus)
Apoe  (apolipoprotein E)

Genes (Homo sapiens)
APOE  (apolipoprotein E)


Additional Information