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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2138
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Apoe
Name: apolipoprotein E
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Apoedecreases expressionEXP 6480464CTDSimvastatin results in decreased expression of APOE mRNA; Simvastatin results in decreased expression of APOE proteinPMID:25055962 PMID:8289597 PMID:8461338
Apoemultiple interactionsEXP 6480464CTDPolystyrenes analog inhibits the reaction [Simvastatin results in decreased expression of APOE protein]PMID:8461338
Apoeaffects response to substanceISOApoe (Mus musculus)6480464CTDAPOE affects the susceptibility to SimvastatinPMID:11947894
Apoeaffects response to substanceISOAPOE (Homo sapiens)6480464CTDAPOE polymorphism affects the susceptibility to SimvastatinPMID:11849659 PMID:12901521
Apoedecreases expressionISOAPOE (Homo sapiens)6480464CTDSimvastatin results in decreased expression of APOE; Simvastatin results in decreased expression of APOE mRNAPMID:18270459 PMID:19461118
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