RGD Reference Report - Apolipoprotein E epsilon4 allele is associated with left ventricular systolic dysfunction. - Rat Genome Database

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Apolipoprotein E epsilon4 allele is associated with left ventricular systolic dysfunction.

Authors: Bleumink, GS  Van Duijn, CM  Kingma, JH  Witteman, JC  Hofman, A  Stricker, BH 
Citation: Bleumink GS, etal., Am Heart J. 2004 Apr;147(4):685-9.
RGD ID: 11039488
Pubmed: PMID:15077085   (View Abstract at PubMed)
DOI: DOI:10.1016/j.ahj.2003.11.016   (Journal Full-text)

BACKGROUND: Apolipoprotein (APOE) epsilon4 allele has been associated with cardiac dysfunction in Alzheimer's disease and beta-thalassemia. We investigated the association between APOE genotypes and left ventricular dysfunction in a population of community-dwelling elderly subjects. METHODS: This study was performed in the Rotterdam Study, a population-based prospective cohort study among elderly subjects. For 2206 participants, a baseline echocardiogram and blood specimens for APOE typing were available. Cardiac dysfunction was considered present when fractional shortening was or=65 years. CONCLUSION: The APOE epsilon4 allele is an independent risk factor for cardiac dysfunction in elderly people. Besides well-known effects on atherosclerosis and cholesterol levels, there may be other mechanisms, such as apoptosis, through which this allele exerts negative effects on myocardial performance.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Ventricular Dysfunction, Left  IAGP 11039488 RGD 
Ventricular Dysfunction, Left  ISOAPOE (Homo sapiens)11039488; 11039488 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Apoe  (apolipoprotein E)

Genes (Mus musculus)
Apoe  (apolipoprotein E)

Genes (Homo sapiens)
APOE  (apolipoprotein E)


Additional Information