RGD Reference Report - Confounding effect of obstructive jaundice in the interpretation of proteomic plasma profiling data for pancreatic cancer. - Rat Genome Database

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Confounding effect of obstructive jaundice in the interpretation of proteomic plasma profiling data for pancreatic cancer.

Authors: Yan, L  Tonack, S  Smith, R  Dodd, S  Jenkins, RE  Kitteringham, N  Greenhalf, W  Ghaneh, P  Neoptolemos, JP  Costello, E 
Citation: Yan L, etal., J Proteome Res. 2009 Jan;8(1):142-8.
RGD ID: 2317548
Pubmed: PMID:19055369   (View Abstract at PubMed)
DOI: DOI:10.1021/pr800451h   (Journal Full-text)

It is well established that variation in sampling, processing and storage protocols can alter the levels of potential biomarkers in serum and plasma. Here, using pancreatic cancer as an example, we demonstrate that consideration of clinical parameters related to the patient's illness is equally important when seeking cancer-specific biomarkers. Bile duct-obstruction is a feature of pancreatic disease that can cause jaundice. Comparing patients with pancreatic cancer, chronic pancreatitis or biliary duct obstruction, we observed that the plasma levels of apolipoprotein A1, transthyretin, and apolipoprotein E, when examined in isolation, were each associated with pancreatic cancer. However, when the effect of bile duct obstruction was considered, only transthyretin levels were independently associated with cancer likelihood. Our results demonstrate the importance of accounting for disease-related confounding factors when analyzing data for the detection of cancer biomarkers.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cholestasis  IEP 2317548associated with Pancreatic Neoplasms and protein:increased expression:plasmaRGD 
cholestasis  ISOAPOE (Homo sapiens)2317548; 2317548associated with Pancreatic Neoplasms and protein:increased expression:plasmaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Apoe  (apolipoprotein E)

Genes (Mus musculus)
Apoe  (apolipoprotein E)

Genes (Homo sapiens)
APOE  (apolipoprotein E)


Additional Information