GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Apoe | affects response to substance | ISO | Apoe (Mus musculus) | 6480464 | CTD | APOE gene mutant form affects the susceptibility to Folic Acid | PMID:17118406 | Apoe | decreases expression | ISO | APOE (Homo sapiens) | 6480464 | CTD | Folic Acid results in decreased expression of APOE mRNA | PMID:21867686 | Apoe | multiple interactions | ISO | Apoe (Mus musculus) | 6480464 | CTD | [APOE gene mutant form affects the susceptibility to Folic Acid] which results in decreased abundance of 8-epi-prostaglandin F2alpha; [APOE gene mutant form affects the susceptibility to Folic Acid] which results in decreased expression of APOB protein; [APOE gene mutant form affects the susceptibility to Folic Acid] which results in increased abundance of Cholesterol, HDL analog; [APOE gene mutant form affects the susceptibility to Folic Acid] which results in increased abundance of Cholesterol, LDL; [APOE gene mutant form affects the susceptibility to Folic Acid] which results in increased abundance of Cholesterol, VLDL; [APOE gene mutant form affects the susceptibility to Folic Acid] which results in increased expression of APOA1 protein; [APOE gene mutant form affects the susceptibility to Folic Acid] which results in increased expression of APOA2 protein; [APOE gene mutant form affects the susceptibility to Folic Acid] which results in increased expression of APOA4 mRNA; [APOE gene mutant form affects the susceptibility to Folic Acid] which results in increased expression of APOA4 protein; Folic Acid affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of CCL2 mRNA]; Folic Acid affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of CCL2 protein]; Folic Acid affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of DNMT1 mRNA]; Folic Acid affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of DNMT3A mRNA]; Folic Acid affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of DNMT3B mRNA]; Folic Acid affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of VEGFA mRNA]; Folic Acid affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of VEGFA protein]; Folic Acid affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the methylation of CCL2 promoter]; Folic Acid affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the methylation of VEGFA promoter] | PMID:17118406 PMID:28475147 | |
Go Back to source page | Continue to Ontology report |