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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2138
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Apoe
Name: apolipoprotein E
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Apoeaffects response to substanceISOApoe (Mus musculus)6480464CTDAPOE gene mutant form affects the susceptibility to Folic AcidPMID:17118406
Apoedecreases expressionISOAPOE (Homo sapiens)6480464CTDFolic Acid results in decreased expression of APOE mRNAPMID:21867686
Apoemultiple interactionsISOApoe (Mus musculus)6480464CTD[APOE gene mutant form affects the susceptibility to Folic Acid] which results in decreased abundance of 8-epi-prostaglandin F2alpha; [APOE gene mutant form affects the susceptibility to Folic Acid] which results in decreased expression of APOB protein; [APOE gene mutant form affects the susceptibility to Folic Acid] which results in increased abundance of Cholesterol, HDL analog; [APOE gene mutant form affects the susceptibility to Folic Acid] which results in increased abundance of Cholesterol, LDL; [APOE gene mutant form affects the susceptibility to Folic Acid] which results in increased abundance of Cholesterol, VLDL; [APOE gene mutant form affects the susceptibility to Folic Acid] which results in increased expression of APOA1 protein; [APOE gene mutant form affects the susceptibility to Folic Acid] which results in increased expression of APOA2 protein; [APOE gene mutant form affects the susceptibility to Folic Acid] which results in increased expression of APOA4 mRNA; [APOE gene mutant form affects the susceptibility to Folic Acid] which results in increased expression of APOA4 protein; Folic Acid affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of CCL2 mRNA]; Folic Acid affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of CCL2 protein]; Folic Acid affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of DNMT1 mRNA]; Folic Acid affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of DNMT3A mRNA]; Folic Acid affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of DNMT3B mRNA]; Folic Acid affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of VEGFA mRNA]; Folic Acid affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of VEGFA protein]; Folic Acid affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the methylation of CCL2 promoter]; Folic Acid affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the methylation of VEGFA promoter]PMID:17118406 PMID:28475147
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