RGD Reference Report - Effect of fungal polysaccharides on the modulation of plasma proteins in streptozotocin-induced diabetic rats. - Rat Genome Database

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Effect of fungal polysaccharides on the modulation of plasma proteins in streptozotocin-induced diabetic rats.

Authors: Kim, SW  Hwang, HJ  Kim, HM  Lee, MC  Shik Lee, M  Choi, JW  Yun, JW 
Citation: Kim SW, etal., Proteomics. 2006 Oct;6(19):5291-302.
RGD ID: 1599198
Pubmed: PMID:16947119   (View Abstract at PubMed)
DOI: DOI:10.1002/pmic.200500933   (Journal Full-text)

To search out novel biomarkers for monitoring diabetes prognosis, we examined the effect of hypoglycemic fungal exopolysaccharides (EPS) on the differential levels of plasma proteins in streptozotocin-induced diabetic rats. The orally administrated EPS exhibited an excellent hypoglycemic effect, lowering the average plasma glucose level, and increasing insulin secretion in diabetic rats. The 2-DE analysis of rat plasma demonstrated that about 500 visualized spots were differentially regulated, of which 20 spots were identified as principal diabetes-associated proteins. The distinct effect of diabetes induction on the pattern of rat plasma proteins includes the down-regulation of albumin, apolipoprotein E (Apo E), alpha1-inhibitor-3, fetuin beta, Gc-globulin, hemopexin, vitronectin, and transthyretin (TTR) monomer, and the up-regulation of Apo A-I, Apo A-IV, ceruloplasmin, alpha1-antitrypsin, serine protease inhibitor III, and transferrin. Those protein levels were interestingly restored to those of healthy rats by EPS treatment, although the order of magnitude of the changes differed widely. Two proteins of interest showed distinct differential expression with opposite trends: TTR tetramer was significantly down-regulated and immunoglobulin (Ig) kappa light chain was significantly up-regulated upon diabetes induction, both of which were also normalized to those of healthy groups after EPS treatment.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Diabetes Mellitus  ISOApoe (Rattus norvegicus)1599198; 1599198protein:decreased expression:plasma (rat)RGD 
Experimental Diabetes Mellitus  IEP 1599198protein:decreased expression:plasma (rat)RGD 
Experimental Diabetes Mellitus  ISOCp (Rattus norvegicus)1599198; 1599198Protein:increased expression:plasmaRGD 
Experimental Diabetes Mellitus  IEP 1599198Protein:increased expression:plasmaRGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
extracellular space  IDA 1599198 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Apoe  (apolipoprotein E)
Cp  (ceruloplasmin)

Genes (Mus musculus)
Apoe  (apolipoprotein E)
Cp  (ceruloplasmin)

Genes (Homo sapiens)
APOE  (apolipoprotein E)
CP  (ceruloplasmin)


Additional Information