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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2138
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Apoe
Name: apolipoprotein E
Acc ID: CHEBI:16113
Term: cholesterol
Definition: A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3beta-hydroxy group.
Chemical ID: MESH:D002784
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Apoeaffects localizationEXP 6480464CTDCholesterol affects the localization of APOE proteinPMID:21169230
Apoemultiple interactionsEXP 6480464CTDCholesterol promotes the reaction [APOE protein binds to CAV1 protein]PMID:21169230
Apoeaffects localizationISOApoe (Mus musculus)6480464CTDCholesterol affects the localization of APOE proteinPMID:21169230
Apoeaffects response to substanceISOApoe (Mus musculus)6480464CTDAPOE protein affects the susceptibility to CholesterolPMID:16179587
Apoeincreases abundanceISOApoe (Mus musculus)6480464CTDAPOE gene mutant form results in increased abundance of CholesterolPMID:24933211 PMID:25037058
Apoeincreases exportISOApoe (Mus musculus)6480464CTDAPOE protein results in increased export of CholesterolPMID:22022523
Apoemultiple interactionsISOApoe (Mus musculus)6480464CTD24-diamino-5-phenylthiazole inhibits the reaction [T0901317 promotes the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Cholesterol]]; [[Air Pollutants results in increased abundance of Particulate Matter] promotes the reaction [APOE protein affects the susceptibility to Dietary Fats]] which affects the abundance of Cholesterol; [APOE affects the susceptibility to Dietary Fats] which affects the abundance of Cholesterol; APOE gene mutant form promotes the reaction [Dietary Fats results in increased abundance of Cholesterol]; APOE inhibits the reaction [Cholesterol, Dietary results in increased abundance of Cholesterol]; Capsaicin inhibits the reaction [[APOE affects the susceptibility to Dietary Fats] which affects the abundance of Cholesterol]; CAV1 protein affects the reaction [Cholesterol affects the localization of APOE protein]; Enalapril inhibits the reaction [APOE gene mutant form results in increased abundance of Cholesterol]; methyl-beta-cyclodextrin inhibits the reaction [Cholesterol affects the localization of APOE protein]; N-butyloxycarbonyl-methionyl-aspartyl-glycyl-cysteinyl-glutamyl-leucine inhibits the reaction [[[Air Pollutants results in increased abundance of Particulate Matter] promotes the reaction [APOE protein affects the susceptibility to Dietary Fats]] which affects the abundance of Cholesterol]; notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased abundance of Cholesterol]; paricalcitol inhibits the reaction [APOE gene mutant form results in increased abundance of Cholesterol]; T0901317 promotes the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Cholesterol]PMID:11397713 PMID:12472773 PMID:21169230 PMID:21908651 PMID:24933211 PMID:25037058 PMID:32853627 PMID:34673409
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