GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Apoe | affects localization | EXP | | 6480464 | CTD | Cholesterol affects the localization of APOE protein | PMID:21169230 | Apoe | multiple interactions | EXP | | 6480464 | CTD | Cholesterol promotes the reaction [APOE protein binds to CAV1 protein] | PMID:21169230 | Apoe | affects localization | ISO | Apoe (Mus musculus) | 6480464 | CTD | Cholesterol affects the localization of APOE protein | PMID:21169230 | Apoe | affects response to substance | ISO | Apoe (Mus musculus) | 6480464 | CTD | APOE protein affects the susceptibility to Cholesterol | PMID:16179587 | Apoe | increases abundance | ISO | Apoe (Mus musculus) | 6480464 | CTD | APOE gene mutant form results in increased abundance of Cholesterol | PMID:24933211 PMID:25037058 | Apoe | increases export | ISO | Apoe (Mus musculus) | 6480464 | CTD | APOE protein results in increased export of Cholesterol | PMID:22022523 | Apoe | multiple interactions | ISO | Apoe (Mus musculus) | 6480464 | CTD | 24-diamino-5-phenylthiazole inhibits the reaction [T0901317 promotes the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Cholesterol]]; [[Air Pollutants results in increased abundance of Particulate Matter] promotes the reaction [APOE protein affects the susceptibility to Dietary Fats]] which affects the abundance of Cholesterol; [APOE affects the susceptibility to Dietary Fats] which affects the abundance of Cholesterol; APOE gene mutant form promotes the reaction [Dietary Fats results in increased abundance of Cholesterol]; APOE inhibits the reaction [Cholesterol, Dietary results in increased abundance of Cholesterol]; Capsaicin inhibits the reaction [[APOE affects the susceptibility to Dietary Fats] which affects the abundance of Cholesterol]; CAV1 protein affects the reaction [Cholesterol affects the localization of APOE protein]; Enalapril inhibits the reaction [APOE gene mutant form results in increased abundance of Cholesterol]; methyl-beta-cyclodextrin inhibits the reaction [Cholesterol affects the localization of APOE protein]; N-butyloxycarbonyl-methionyl-aspartyl-glycyl-cysteinyl-glutamyl-leucine inhibits the reaction [[[Air Pollutants results in increased abundance of Particulate Matter] promotes the reaction [APOE protein affects the susceptibility to Dietary Fats]] which affects the abundance of Cholesterol]; notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased abundance of Cholesterol]; paricalcitol inhibits the reaction [APOE gene mutant form results in increased abundance of Cholesterol]; T0901317 promotes the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Cholesterol] | PMID:11397713 PMID:12472773 PMID:21169230 PMID:21908651 PMID:24933211 PMID:25037058 PMID:32853627 PMID:34673409 | |
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