RGD Reference Report - Liver X receptors regulate cholesterol homeostasis in oligodendrocytes. - Rat Genome Database

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Liver X receptors regulate cholesterol homeostasis in oligodendrocytes.

Authors: Nelissen, K  Mulder, M  Smets, I  Timmermans, S  Smeets, K  Ameloot, M  Hendriks, JJ 
Citation: Nelissen K, etal., J Neurosci Res. 2012 Jan;90(1):60-71. doi: 10.1002/jnr.22743. Epub 2011 Oct 3.
RGD ID: 6903911
Pubmed: PMID:21972082   (View Abstract at PubMed)
DOI: DOI:10.1002/jnr.22743   (Journal Full-text)

Cholesterol synthesis and transport in oligodendrocytes are essential for optimal myelination and remyelination in pathological conditions such as multiple sclerosis. However, little is known about cholesterol homeostasis in the myelin-forming oligodendrocytes. Liver X receptors (LXRs) are nuclear oxysterol receptors that regulate genes involved in cholesterol homeostasis and may therefore play an important role in de- and remyelination. We investigated whether LXRs regulate cholesterol homeostasis in oligodendrocytes. mRNA expression of genes encoding LXR-alpha and LXR-beta and their target genes (ABCA1, ABCG1, ABCG4, apoE, and LDLR) was detected in oligodendrocytes derived from both neonatal and adult rats using quantitative real-time PCR. The expression of LXR-beta and several target genes was increased during oligodendrocyte differentiation. We further demonstrated that treatment of primary neonatal rat oligodendrocytes with the synthetic LXR agonist T0901317 induced the expression of several established LXR target genes, including ABCA1, ABCG1, apoE, and LDLR. Treatment of oligodendrocytes with T0901317 resulted in an enhanced cholesterol efflux in the presence of apolipoprotein A-I or high-density lipoprotein particles. These data show that LXRs are involved in regulating cholesterol homeostasis in oligodendrocytes.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
oligodendrocyte differentiation  IEP 6903911 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Apoe  (apolipoprotein E)


Additional Information