RGD Reference Report - The usefulness of measuring body fat deposition for detecting obesity and atherogenesity in Japanese school children. - Rat Genome Database

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The usefulness of measuring body fat deposition for detecting obesity and atherogenesity in Japanese school children.

Authors: Takahashi, H  Hashimoto, N  Kawasaki, T  Kikuchi, T  Uchiyama, M 
Citation: Takahashi H, etal., Acta Paediatr Jpn. 1996 Dec;38(6):634-9.
RGD ID: 1601191
Pubmed: PMID:9002300   (View Abstract at PubMed)

Body fat deposition was measured in overweight and non-overweight children using a bioelectrical impedance method, and its relationship with serum lipids and apolipoproteins was investigated in 90 overweight children (over 120% of their ideal weight) and 241 non-overweight children aged 10-15 years in Niigata Prefecture. The results were as follows. Overweight boys had significantly higher levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), atherogenic index (AI), RLP-cholesterol (RLP-C), apoA1, apoA2, apoB, apoC2, apoC3, apoE and the ratio of apoB to apoA1 than non-overweight boys. Overweight girls had significantly higher levels of TC, LDL-C, AI, remnant-like lopoprotein cholesterol (RLP-C), apoA2, apoB, apoC2, apoC3, apoE and the ratio of apoB to apoA1 than non-overweight girls. It has been reported that of all children studied 2.1% had higher levels of RLP-C than its upper limit known for adults (12 mg/dL). Of the overweight children in the present study, 4.4% had a high level of RLP-C whereas only 1.2% of non-overweight children had a high RLP-C level. No difference in the lipoprotein levels was found between overweight and non-overweight children. In both boys and girls, relative weight, body fat, skinfold thickness and body mass index (BMI) were correlated with the lipoprotein levels. Non-overweight boys whose body fat was over 20% had significantly higher levels of TC, LDL-C, apoA2, apoB, apoC2, apoE and apoB/A1 than those whose body fat was less than 20%. It was concluded that the measurement of body fat deposition, together with relative weight, was useful for detecting obesity and atherogenesity in Japanese school children.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
obesity  IEP 1601191; 1601191; 1601191; 1601191protein:increased expression:serumRGD 
obesity  ISOAPOA2 (Homo sapiens)1601191; 1601191protein:increased expression:serumRGD 
obesity  ISOAPOC2 (Homo sapiens)1601191; 1601191protein:increased expression:serumRGD 
obesity  ISOAPOC3 (Homo sapiens)1601191; 1601191protein:increased expression:serumRGD 
obesity  ISOAPOE (Homo sapiens)1601191; 1601191protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Apoa2  (apolipoprotein A2)
Apoc2  (apolipoprotein C2)
Apoc3  (apolipoprotein C3)
Apoe  (apolipoprotein E)

Genes (Mus musculus)
Apoa2  (apolipoprotein A-II)
Apoc2  (apolipoprotein C2)
Apoc3  (apolipoprotein C-III)
Apoe  (apolipoprotein E)

Genes (Homo sapiens)
APOA2  (apolipoprotein A2)
APOC2  (apolipoprotein C2)
APOC3  (apolipoprotein C3)
APOE  (apolipoprotein E)


Additional Information