RGD Reference Report - Apolipoprotein E alleles and sensorineural hearing loss. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Apolipoprotein E alleles and sensorineural hearing loss.

Authors: O'Grady, G  Boyles, AL  Speer, M  DeRuyter, F  Strittmatter, W  Worley, G 
Citation: O'Grady G, etal., Int J Audiol. 2007 Apr;46(4):183-6.
RGD ID: 7771593
Pubmed: PMID:17454231   (View Abstract at PubMed)
DOI: DOI:10.1080/14992020601145294   (Journal Full-text)

The purpose of this paper is to determine if a relationship exists between APOE alleles and nonsyndromic, sensorineural hearing loss (SNHL) in adults. APOE genotype was determined on DNA obtained from a sample of 89 subjects with nonsyndromic, adult onset SNHL. Median age was 64 years old, and 51 (57%) were males. Allele frequencies in the study population were compared to those in the general population. Subjects were divided into two groups, one by severity of hearing loss and another by severity of impairment of word recognition. Each group was stratified by severity, and allele frequencies were compared to the general population. The study found that the APOE allele epsilon 4 was less prevalent in the study population with SNHL than in the general population. No relationship was found between the epsilon 4 allele and severity of hearing loss or severity of impairment of word recognition. The study revealed that the APOE epsilon 4 allele was under-represented in the study sample as compared to the general population. Future studies associating the epsilon 4 allele with SNHL need to be population-based, longitudinal, or done in younger subjects.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
sensorineural hearing loss susceptibilityIAGP 7771593DNA:polymorphism:exon:RGD 
sensorineural hearing loss susceptibilityISOAPOE (Homo sapiens)7771593; 7771593DNA:polymorphism:exon:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Apoe  (apolipoprotein E)

Genes (Mus musculus)
Apoe  (apolipoprotein E)

Genes (Homo sapiens)
APOE  (apolipoprotein E)


Additional Information