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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2138
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Apoe
Name: apolipoprotein E
Acc ID: CHEBI:7931
Term: paricalcitol
Definition: A seco-cholestane that has formula C27H44O3.
Chemical ID: MESH:C084656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Apoemultiple interactionsISOApoe (Mus musculus)6480464CTDparicalcitol inhibits the reaction [APOE gene mutant form results in decreased abundance of Antioxidants]; paricalcitol inhibits the reaction [APOE gene mutant form results in increased abundance of Cholesterol]PMID:25037058
Apoemultiple interactionsISOAPOE (Homo sapiens)6480464CTD[Phosphorus co-treated with paricalcitol] results in decreased expression of APOE mRNAPMID:17715259
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