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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2138
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Apoe
Name: apolipoprotein E
Acc ID: CHEBI:23414
Term: copper(II) sulfate
Definition: A metal sulfate compound having copper(2+) as the metal ion.
Chemical ID: MESH:D019327
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Apoeaffects response to substanceISOApoe (Mus musculus)6480464CTDAPOE protein mutant form affects the susceptibility to Copper SulfatePMID:9568736
Apoedecreases expressionISOApoe (Mus musculus)6480464CTDCopper Sulfate results in decreased expression of APOE mRNAPMID:18579281
Apoeincreases response to substanceISOApoe (Mus musculus)6480464CTDAPOE protein mutant form results in increased susceptibility to Copper SulfatePMID:9409251
Apoemultiple interactionsISOApoe (Mus musculus)6480464CTDAPOE protein inhibits the reaction [Copper Sulfate results in increased expression of HMOX1 protein]; APOE protein inhibits the reaction [Copper Sulfate results in increased expression of NQO1 protein]PMID:25749341
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