GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Apoe | affects response to substance | ISO | Apoe (Mus musculus) | 6480464 | CTD | APOE protein mutant form affects the susceptibility to Copper Sulfate | PMID:9568736 | Apoe | decreases expression | ISO | Apoe (Mus musculus) | 6480464 | CTD | Copper Sulfate results in decreased expression of APOE mRNA | PMID:18579281 | Apoe | increases response to substance | ISO | Apoe (Mus musculus) | 6480464 | CTD | APOE protein mutant form results in increased susceptibility to Copper Sulfate | PMID:9409251 | Apoe | multiple interactions | ISO | Apoe (Mus musculus) | 6480464 | CTD | APOE protein inhibits the reaction [Copper Sulfate results in increased expression of HMOX1 protein]; APOE protein inhibits the reaction [Copper Sulfate results in increased expression of NQO1 protein] | PMID:25749341 | |
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