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ONTOLOGY REPORT - ANNOTATIONS

Term:interleukin-6-mediated signaling pathway
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Accession:GO:0070102 term browser browse the term
Definition:The series of molecular signals initiated by interleukin-6 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: interleukin-6-mediated signalling pathway
 related_synonym: IL-6-mediated signaling pathway
 xref: Reactome:R-HSA-1059683 "Interleukin-6 signaling"


show annotations for term's descendants           Sort by:
interleukin-6-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cebpa CCAAT/enhancer binding protein alpha involved_in ISO
IEA 		(PMID:24429361)
GO_REF:0000107 		RGD
Ensembl		 PMID:24429361 GO_REF:0000107 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309 		JBrowse link
G Ctr9 CTR9 component of Paf1/RNA polymerase II complex involved_in IEA
ISO 		GO_REF:0000107
(PMID:17911113) 		Ensembl
RGD		 PMID:17911113 GO_REF:0000107 NCBI chr 1:174,571,952...174,601,974
Ensembl chr 1:174,571,928...174,602,130 		JBrowse link
G Fer FER tyrosine kinase involved_in ISO
IEA 		(PMID:19147545)
GO_REF:0000107 		RGD
Ensembl		 PMID:19147545 GO_REF:0000107 NCBI chr 9:110,967,317...111,274,315
Ensembl chr 9:110,967,390...111,274,315 		JBrowse link
G Gab1 GRB2-associated binding protein 1 acts_upstream_of_or_within ISO MGI:1926435 (PMID:10779359) RGD PMID:10779359 NCBI chr19:44,035,693...44,143,617
Ensembl chr19:44,035,063...44,143,617 		JBrowse link
G Il6 interleukin 6 involved_in
acts_upstream_of_or_within 		ISS
ISO
IEA
IBA
IDA 		GO_REF:0000024
(PMID:31101051)
(PMID:16330325), (PMID:27893700), (PMID:8910279)
(PMID:1312474)
(PMID:11884403), (PMID:12552091), (PMID:12829785), (PMID:16946298), (PMID:27893700), (PMID:28433754), (PMID:30670152), (PMID:31145836), (PMID:7749983)
GO_REF:0000117
GO_REF:0000033
PMID:29702085 		UniProt
RGD
GO_Central		 PMID:1312474 PMID:7749983 PMID:8910279 PMID:11884403 PMID:12552091 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000117, RGD:13800534 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Il6r interleukin 6 receptor involved_in
acts_upstream_of_or_within 		ISS
ISO
IBA 		GO_REF:0000024
(PMID:31101051)
(PMID:27893700)
(PMID:1312474)
(PMID:11884403), (PMID:12643274)
GO_REF:0000033
(PMID:31145836)
(PMID:12829785) 		UniProt
RGD
GO_Central		 PMID:1312474 PMID:11884403 PMID:12643274 PMID:12829785 PMID:27893700 More... GO_REF:0000024 GO_REF:0000033 NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221 		JBrowse link
G Il6st interleukin 6 cytokine family signal transducer involved_in IMP
ISO
IEA 		(PMID:31101051)
(PMID:25731159)
GO_REF:0000117
(PMID:11884403), (PMID:12643274), (PMID:12829785), (PMID:2261637), (PMID:25731159)
GO_REF:0000107 		RGD
UniProt
Ensembl		 PMID:2261637 PMID:11884403 PMID:12643274 PMID:12829785 PMID:25731159 More... GO_REF:0000107 GO_REF:0000117, RGD:5686900 NCBI chr 2:45,798,872...45,839,501
Ensembl chr 2:45,799,380...45,843,182 		JBrowse link
G Jak1 Janus kinase 1 involved_in ISO
IEA 		(PMID:8272873)
GO_REF:0000107 		RGD
Ensembl		 PMID:8272873 GO_REF:0000107 NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:120,896,046...120,996,758 		JBrowse link
G Smad4 SMAD family member 4 involved_in IEA
ISO 		GO_REF:0000107
(PMID:16330325) 		Ensembl
RGD		 PMID:16330325 GO_REF:0000107 NCBI chr18:69,518,988...69,549,684
Ensembl chr18:69,518,988...69,549,684 		JBrowse link
G Spi1 Spi-1 proto-oncogene involved_in ISO
IEA 		(PMID:24429361)
GO_REF:0000107 		RGD
Ensembl		 PMID:24429361 GO_REF:0000107 NCBI chr 3:97,529,509...97,548,204
Ensembl chr 3:97,527,572...97,549,540 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in ISO (PMID:25731159) RGD PMID:25731159 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462 		JBrowse link
G St18 ST18 C2H2C-type zinc finger transcription factor involved_in ISO
IEA 		(PMID:18676404)
GO_REF:0000107 		RGD
Ensembl		 PMID:18676404 GO_REF:0000107 NCBI chr 5:17,369,383...17,701,094
Ensembl chr 5:17,371,000...17,458,676 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:12359225), (PMID:12552091), (PMID:16285960), (PMID:16835372), (PMID:16946298), (PMID:17324931), (PMID:24429361)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:12359225 PMID:12552091 PMID:16285960 PMID:16835372 PMID:16946298 More... GO_REF:0000024 GO_REF:0000107 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Tut4 terminal uridylyl transferase 4 involved_in ISO (PMID:19701194) RGD PMID:19701194 NCBI chr 5:128,354,975...128,535,288
Ensembl chr 5:128,431,719...128,535,656 		JBrowse link
G Yap1 Yes1 associated transcriptional regulator involved_in IEA
ISO 		GO_REF:0000107
(PMID:25731159) 		Ensembl
RGD		 PMID:25731159 GO_REF:0000107 NCBI chr 8:13,380,551...13,451,640
Ensembl chr 8:13,380,551...13,451,437 		JBrowse link
negative regulation of interleukin-6-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6st interleukin 6 cytokine family signal transducer involved_in ISO (PMID:8353278) RGD PMID:8353278 NCBI chr 2:45,798,872...45,839,501
Ensembl chr 2:45,799,380...45,843,182 		JBrowse link
G Mir125a microRNA 125a acts_upstream_of_or_within ISO UniProtKB:P05231 (PMID:30670152) RGD PMID:30670152 NCBI chr 1:67,350,675...67,350,759
Ensembl chr 1:67,350,675...67,350,759 		JBrowse link
G Mir125b1 microRNA 125b-1 involved_in ISO (PMID:26455324) RGD PMID:26455324 NCBI chr 8:50,850,036...50,850,122
Ensembl chr 8:50,850,036...50,850,122 		JBrowse link
G Mir125b2 microRNA 125b-2 involved_in ISO (PMID:26455324) RGD PMID:26455324 NCBI chr11:29,732,572...29,732,659 JBrowse link
G Mir146a microRNA 146a involved_in ISO (PMID:28433754) RGD PMID:28433754 NCBI chr10:28,349,996...28,350,090 JBrowse link
G Mir26a1 microRNA 26a-1 involved_in ISO (PMID:23389848) RGD PMID:23389848 NCBI chr 8:127,633,048...127,633,137
Ensembl chr 8:127,633,048...127,633,137 		JBrowse link
G Mir98 microRNA 98 involved_in ISO UniProtKB:P05231 (PMID:26587789), (PMID:31886314) RGD PMID:26587789 PMID:31886314 NCBI chr  X:24,460,648...24,460,755
Ensembl chr  X:24,460,648...24,460,755 		JBrowse link
G Mir99a microRNA 99a involved_in ISO (PMID:26455324) RGD PMID:26455324 NCBI chr11:29,687,392...29,687,472
Ensembl chr11:29,687,392...29,687,472 		JBrowse link
G Mirlet7a1 microRNA let-7a-1 involved_in ISO (PMID:19878981) RGD PMID:19878981 NCBI chr17:16,320,133...16,320,226
Ensembl chr17:16,320,135...16,320,234 		JBrowse link
G Mirlet7c-1 microRNA let-7c involved_in ISO (PMID:26455324) RGD PMID:26455324 NCBI chr11:29,688,112...29,688,205
Ensembl chr11:29,688,107...29,688,214 		JBrowse link
G Mirlet7c-2 microRNA let-7a-3 involved_in ISO (PMID:19878981) RGD PMID:19878981 NCBI chr 7:118,683,623...118,683,717
Ensembl chr 7:118,683,623...118,683,717 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISO
IEA
ISS 		(PMID:12359225)
(PMID:20484139)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
UniProt		 PMID:12359225 PMID:20484139 GO_REF:0000024 GO_REF:0000107 NCBI chr18:63,498,890...63,564,571
Ensembl chr18:63,498,890...63,564,481 		JBrowse link
positive regulation of interleukin-6-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qtnf4 C1q and TNF related 4 involved_in ISO (PMID:21658842) RGD PMID:21658842 NCBI chr 3:97,310,220...97,328,818
Ensembl chr 3:97,327,670...97,342,587 		JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor involved_in ISO
IEA 		(PMID:11060035)
GO_REF:0000107 		RGD
Ensembl		 PMID:11060035 GO_REF:0000107 NCBI chr14:2,185,489...2,204,191
Ensembl chr14:2,187,286...2,196,730 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in ISO
IEA 		(PMID:31827280)
GO_REF:0000107
GO_REF:0000117
(PMID:31827281) 		RGD
Ensembl
UniProt		 PMID:31827280 PMID:31827281 GO_REF:0000107 GO_REF:0000117 NCBI chr17:31,044,983...31,077,167
Ensembl chr17:31,044,994...31,077,167 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19754
    cellular process 18919
      signal transduction 7260
        cell surface receptor signaling pathway 2949
          cytokine-mediated signaling pathway 519
            interleukin-6-mediated signaling pathway 29
              negative regulation of interleukin-6-mediated signaling pathway 12
              positive regulation of interleukin-6-mediated signaling pathway 3
              regulation of interleukin-6-mediated signaling pathway + 15
Path 2
Term Annotations click to browse term
  biological_process 19754
    response to stimulus 10811
      response to chemical 5937
        response to peptide 1295
          response to cytokine 1270
            cellular response to cytokine stimulus 1123
              cytokine-mediated signaling pathway 519
                interleukin-6-mediated signaling pathway 29
                  negative regulation of interleukin-6-mediated signaling pathway 12
                  positive regulation of interleukin-6-mediated signaling pathway 3
                  regulation of interleukin-6-mediated signaling pathway + 15
paths to the root