Wnt4 (Wnt family member 4) - Rat Genome Database

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Gene: Wnt4 (Wnt family member 4) Rattus norvegicus
Analyze
Symbol: Wnt4
Name: Wnt family member 4
RGD ID: 621348
Description: Predicted to enable cytokine activity; frizzled binding activity; and transcription corepressor activity. Involved in cellular response to estradiol stimulus; response to benzoic acid; and response to retinoic acid. Predicted to be located in cell surface; cytoplasm; and extracellular matrix. Predicted to be active in extracellular space. Used to study acute kidney failure. Human ortholog(s) of this gene implicated in Mullerian aplasia and hyperandrogenism. Orthologous to human WNT4 (Wnt family member 4); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; basal cell carcinoma pathway; INTERACTS WITH 1,3-dinitrobenzene; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC112773; protein Wnt-4; wingless-related MMTV integration site 4; wingless-type MMTV integration site family, member 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85154,797,245 - 154,818,565 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5154,797,311 - 154,817,128 (+)EnsemblGRCr8
mRatBN7.25149,513,573 - 149,535,415 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5149,514,018 - 149,532,859 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5152,211,413 - 152,230,231 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05153,985,716 - 154,004,530 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05153,967,711 - 153,986,525 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05155,649,238 - 155,668,065 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5155,649,217 - 155,672,579 (+)Ensemblrn6Rnor6.0
Rnor_5.05159,405,855 - 159,424,682 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45156,064,371 - 156,083,198 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5147,911,190 - 147,930,012 (+)NCBICelera
RGSC_v3.15156,074,409 - 156,093,237 (+)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(R)-adrenaline  (ISO)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,3-dinitrobenzene  (EXP)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-nitrotoluene  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
Abemaciclib  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (EXP)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beryllium sulfate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bromobenzene  (EXP)
bromochloroacetic acid  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
cadmium sulfate  (ISO)
caffeine  (EXP)
calciol  (ISO)
camptothecin  (ISO)
cantharidin  (ISO)
chlordecone  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP,ISO)
D-glucose  (EXP)
dexamethasone  (EXP)
diazinon  (EXP)
dibutyl phthalate  (EXP,ISO)
dieldrin  (EXP)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
Ethylenethiourea  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (EXP)
hydroquinone  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP)
L-methionine  (ISO)
lead nitrate  (ISO)
lead(0)  (ISO)
lead(II) chloride  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
N-Vinyl-2-pyrrolidone  (EXP)
nickel atom  (EXP,ISO)
nickel sulfate  (EXP)
nicotine  (ISO)
Nutlin-3  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
organophosphorus compound  (EXP)
oxybenzone  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
picene  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
progesterone  (EXP,ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
sotorasib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
branching morphogenesis of an epithelial tube  (ISO)
canonical Wnt signaling pathway  (IBA,ISO)
cell differentiation  (ISO)
cell fate commitment  (IBA,ISO)
cellular response to estradiol stimulus  (IEP)
cellular response to hydrostatic pressure  (IEP)
cellular response to starvation  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
embryonic epithelial tube formation  (ISO)
epithelial to mesenchymal transition  (ISO)
female gonad development  (ISO)
female sex determination  (ISO)
gamete generation  (ISO)
hormone metabolic process  (ISO)
immature T cell proliferation in thymus  (ISO)
kidney development  (ISO)
kidney morphogenesis  (ISO)
liver development  (ISO)
male gonad development  (ISO)
mammary gland epithelium development  (ISO)
mesenchymal to epithelial transition  (ISO)
mesonephric tubule development  (ISO)
mesonephros development  (ISO)
metanephric nephron development  (ISO)
metanephric nephron morphogenesis  (ISO)
metanephric tubule formation  (ISO)
metanephros development  (ISO)
negative regulation of androgen biosynthetic process  (ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of cell differentiation  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of fibroblast growth factor receptor signaling pathway  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of male gonad development  (ISO)
negative regulation of Ras protein signal transduction  (ISO)
negative regulation of steroid biosynthetic process  (ISO)
negative regulation of testicular blood vessel morphogenesis  (ISO)
negative regulation of testosterone biosynthetic process  (ISO)
negative regulation of wound healing  (ISO)
nephron development  (ISO)
neuron differentiation  (IBA)
non-canonical Wnt signaling pathway  (ISO)
oocyte development  (ISO)
paramesonephric duct development  (ISO)
positive regulation of aldosterone biosynthetic process  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of cortisol biosynthetic process  (ISO)
positive regulation of dermatome development  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of focal adhesion assembly  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of meiotic nuclear division  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of stress fiber assembly  (ISO)
regulation of cell-cell adhesion  (ISO)
renal vesicle formation  (ISO)
renal vesicle induction  (ISO)
response to benzoic acid  (IEP)
response to estradiol  (IEP)
response to retinoic acid  (HEP,IEP)
sex differentiation  (ISO)
smooth muscle cell differentiation  (ISO)
somatotropin secreting cell differentiation  (ISO)
T cell differentiation in thymus  (ISO)
tertiary branching involved in mammary gland duct morphogenesis  (ISO)
thyroid-stimulating hormone-secreting cell differentiation  (ISO)
tube morphogenesis  (ISO)
Wnt signaling pathway  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A WNT4 mutation associated with Mullerian-duct regression and virilization in a 46,XX woman. Biason-Lauber A, etal., N Engl J Med. 2004 Aug 19;351(8):792-8.
2. Expression and hormone regulation of Wnt2, 3, 4, 5a, 7a, 7b and 10b in normal human endometrium and endometrial carcinoma. Bui TD, etal., Br J Cancer. 1997;75(8):1131-6.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. Huguet EL, etal., Cancer Res. 1994 May 15;54(10):2615-21.
6. Differential expression patterns of Wnt and beta-catenin/TCF target genes in the uterus of immature female rats exposed to 17alpha-ethynyl estradiol. Katayama S, etal., Toxicol Sci. 2006 Jun;91(2):419-30. Epub 2006 Mar 21.
7. Hydrostatic pressure promotes Wnt10b and Wnt4 expression dependent and independent on ERK signaling in early-osteoinduced MSCs. Liu J, etal., Biochem Biophys Res Commun. 2009 Feb 6;379(2):505-9. Epub 2008 Dec 30.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. The expression of Wnt4 is regulated by estrogen via an estrogen receptor alpha-dependent pathway in rat pituitary growth hormone-producing cells. Miyakoshi T, etal., Acta Histochem Cytochem. 2009 Dec 29;42(6):205-13. Epub 2009 Dec 22.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. The Wnt Homepage Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
18. All-Trans Retinoic Acid Disrupts Development in Ex Vivo Cultured Fetal Rat Testes. I: Altered Seminiferous Cord Maturation and Testicular Cell Fate. Spade DJ, etal., Toxicol Sci. 2019 Feb 1;167(2):546-558. doi: 10.1093/toxsci/kfy260.
19. All-trans Retinoic Acid Disrupts Development in Ex Vivo Cultured Fetal Rat Testes. II: Modulation of Mono-(2-ethylhexyl) Phthalate Toxicity. Spade DJ, etal., Toxicol Sci. 2019 Mar 1;168(1):149-159. doi: 10.1093/toxsci/kfy283.
20. Expression and function of the developmental gene Wnt-4 during experimental acute renal failure in rats. Terada Y, etal., J Am Soc Nephrol 2003 May;14(5):1223-33.
21. Alternative wnt signaling is initiated by distinct receptors. van Amerongen R, etal., Sci Signal. 2008 Sep 2;1(35):re9.
Additional References at PubMed
PMID:7990960   PMID:8167409   PMID:9356179   PMID:9989404   PMID:10654605   PMID:10733525   PMID:11265645   PMID:11283799   PMID:11507767   PMID:11948913   PMID:12399432   PMID:12477932  
PMID:12841867   PMID:12844346   PMID:12949260   PMID:14695376   PMID:15040835   PMID:15162500   PMID:15265686   PMID:15312687   PMID:15581876   PMID:16054034   PMID:16546160   PMID:16700629  
PMID:16818445   PMID:16959810   PMID:16981135   PMID:17708712   PMID:17720811   PMID:17848411   PMID:17976063   PMID:18182450   PMID:18346943   PMID:18351662   PMID:18617424   PMID:18847325  
PMID:19301398   PMID:19830824   PMID:20040500   PMID:20106871   PMID:20200966   PMID:20454446   PMID:21245194   PMID:21295565   PMID:21350016   PMID:23027131   PMID:23260145   PMID:23362348  
PMID:24681597   PMID:25270402   PMID:25674206   PMID:29429512   PMID:29921370   PMID:30002385  


Genomics

Comparative Map Data
Wnt4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85154,797,245 - 154,818,565 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5154,797,311 - 154,817,128 (+)EnsemblGRCr8
mRatBN7.25149,513,573 - 149,535,415 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5149,514,018 - 149,532,859 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5152,211,413 - 152,230,231 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05153,985,716 - 154,004,530 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05153,967,711 - 153,986,525 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05155,649,238 - 155,668,065 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5155,649,217 - 155,672,579 (+)Ensemblrn6Rnor6.0
Rnor_5.05159,405,855 - 159,424,682 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45156,064,371 - 156,083,198 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5147,911,190 - 147,930,012 (+)NCBICelera
RGSC_v3.15156,074,409 - 156,093,237 (+)NCBI
Cytogenetic Map5q36NCBI
WNT4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38122,117,313 - 22,143,097 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl122,117,313 - 22,143,969 (-)Ensemblhg38GRCh38
GRCh37122,443,806 - 22,469,590 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36122,316,385 - 22,342,106 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34122,191,504 - 22,214,916NCBI
Celera120,766,732 - 20,792,452 (-)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef120,687,456 - 20,707,677 (-)NCBIHuRef
CHM1_1122,556,295 - 22,576,527 (-)NCBICHM1_1
T2T-CHM13v2.0121,941,071 - 21,966,860 (-)NCBIT2T-CHM13v2.0
Wnt4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394137,004,946 - 137,026,812 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4137,004,800 - 137,027,037 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384137,277,635 - 137,299,501 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4137,277,489 - 137,299,726 (+)Ensemblmm10GRCm38
MGSCv374136,833,550 - 136,852,694 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364136,549,711 - 136,568,855 (+)NCBIMGSCv36mm8
Celera4135,495,983 - 135,515,320 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map469.8NCBI
Wnt4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554522,319,446 - 2,344,989 (-)Ensembl
ChiLan1.0NW_0049554522,319,446 - 2,344,740 (-)NCBIChiLan1.0ChiLan1.0
WNT4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21204,797,117 - 204,824,726 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11203,909,033 - 203,935,541 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0121,310,228 - 21,335,985 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1122,252,344 - 22,264,858 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl122,255,056 - 22,268,801 (-)EnsemblpanPan2panpan1.1
WNT4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1277,112,045 - 77,129,702 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl277,101,300 - 77,127,111 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha273,605,854 - 73,632,899 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0277,660,017 - 77,687,063 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl277,659,490 - 77,687,070 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1274,480,520 - 74,507,565 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0275,489,331 - 75,516,389 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0276,493,182 - 76,520,234 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Wnt4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505841,798,680 - 41,823,413 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364747,623,463 - 7,635,664 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364747,623,462 - 7,635,416 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1680,110,238 - 80,138,165 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2674,137,827 - 74,165,540 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNT4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120110,517,391 - 110,543,802 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20110,517,564 - 110,541,203 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660335,754,333 - 5,781,060 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnt4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247646,921,811 - 6,933,392 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247646,913,027 - 6,934,650 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Wnt4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1120,900,945 - 20,919,904 (-)NCBIRrattus_CSIRO_v1

Variants

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Variants in Wnt4
96 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:102
Count of miRNA genes:85
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000018064
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5149805999162987697Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5149661912166600247Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat

Markers in Region
Wnt4  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85154,814,871 - 154,815,035 (+)Marker Load Pipeline
mRatBN7.25149,531,461 - 149,531,625 (+)MAPPERmRatBN7.2
Rnor_6.05155,666,660 - 155,666,823NCBIRnor6.0
Rnor_5.05159,423,277 - 159,423,440UniSTSRnor5.0
RGSC_v3.45156,081,793 - 156,081,956UniSTSRGSC3.4
Celera5147,928,607 - 147,928,770UniSTS
Cytogenetic Map5q36UniSTS
Wnt4  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85154,814,868 - 154,815,140 (+)Marker Load Pipeline
mRatBN7.25149,531,458 - 149,531,729 (+)MAPPERmRatBN7.2
Rnor_6.05155,666,657 - 155,666,927NCBIRnor6.0
Rnor_5.05159,423,274 - 159,423,544UniSTSRnor5.0
RGSC_v3.45156,081,790 - 156,082,060UniSTSRGSC3.4
Celera5147,928,604 - 147,928,874UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 156 91 90 59 71 59 6 335 171 11 133 81 92 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000018064   ⟹   ENSRNOP00000018064
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5154,797,311 - 154,817,128 (+)Ensembl
mRatBN7.2 Ensembl5149,514,018 - 149,532,859 (+)Ensembl
Rnor_6.0 Ensembl5155,649,217 - 155,668,057 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081893   ⟹   ENSRNOP00000069363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5155,660,553 - 155,672,579 (+)Ensembl
RefSeq Acc Id: NM_053402   ⟹   NP_445854
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85154,797,450 - 154,816,277 (+)NCBI
mRatBN7.25149,514,039 - 149,532,867 (+)NCBI
Rnor_6.05155,649,238 - 155,668,065 (+)NCBI
Rnor_5.05159,405,855 - 159,424,682 (+)NCBI
RGSC_v3.45156,064,371 - 156,083,198 (+)RGD
Celera5147,911,190 - 147,930,012 (+)RGD
Sequence:
RefSeq Acc Id: XM_039110876   ⟹   XP_038966804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85154,797,245 - 154,818,565 (+)NCBI
mRatBN7.25149,513,573 - 149,535,415 (+)NCBI
Protein Sequences
Protein RefSeqs NP_445854 (Get FASTA)   NCBI Sequence Viewer  
  XP_038966804 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF15589 (Get FASTA)   NCBI Sequence Viewer  
  AAH98752 (Get FASTA)   NCBI Sequence Viewer  
  EDL80832 (Get FASTA)   NCBI Sequence Viewer  
  EDL80833 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018064
GenBank Protein Q9QXQ5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_445854   ⟸   NM_053402
- Peptide Label: precursor
- UniProtKB: Q9QXQ5 (UniProtKB/Swiss-Prot),   A6ITD2 (UniProtKB/TrEMBL),   Q4G052 (UniProtKB/TrEMBL),   F7ELZ2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018064   ⟸   ENSRNOT00000018064
Ensembl Acc Id: ENSRNOP00000069363   ⟸   ENSRNOT00000081893
RefSeq Acc Id: XP_038966804   ⟸   XM_039110876
- Peptide Label: isoform X1
- UniProtKB: A6ITD2 (UniProtKB/TrEMBL),   Q4G052 (UniProtKB/TrEMBL),   F7ELZ2 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QXQ5-F1-model_v2 AlphaFold Q9QXQ5 1-351 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694176
Promoter ID:EPDNEW_R4701
Type:single initiation site
Name:Wnt4_1
Description:Wnt family member 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05155,649,151 - 155,649,211EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621348 AgrOrtholog
BioCyc Gene G2FUF-39480 BioCyc
Ensembl Genes ENSRNOG00000013166 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000018064 ENTREZGENE
Gene3D-CATH 3.30.2460.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7369699 IMAGE-MGC_LOAD
InterPro Wnt UniProtKB/Swiss-Prot
  Wnt4 UniProtKB/Swiss-Prot
  Wnt_C UniProtKB/Swiss-Prot
  Wnt_CS UniProtKB/Swiss-Prot
KEGG Report rno:84426 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112773 IMAGE-MGC_LOAD
NCBI Gene 84426 ENTREZGENE
PANTHER PROTEIN WNT-4 UniProtKB/Swiss-Prot
  PTHR12027 UniProtKB/Swiss-Prot
Pfam wnt UniProtKB/Swiss-Prot
PhenoGen Wnt4 PhenoGen
PRINTS WNT4PROTEIN UniProtKB/Swiss-Prot
  WNTPROTEIN UniProtKB/Swiss-Prot
PROSITE WNT1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013166 RatGTEx
SMART WNT1 UniProtKB/Swiss-Prot
UniProt A0ABZ3NNE1_RAT UniProtKB/TrEMBL
  A6ITD1_RAT UniProtKB/TrEMBL
  A6ITD2 ENTREZGENE, UniProtKB/TrEMBL
  F7ELZ2 ENTREZGENE, UniProtKB/TrEMBL
  Q4G052 ENTREZGENE
  Q9QXQ5 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-29 Wnt4  Wnt family member 4  Wnt4  wingless-type MMTV integration site family, member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-14 Wnt4  wingless-type MMTV integration site family, member 4  Wnt4  wingless-related MMTV integration site 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Wnt4  wingless-related MMTV integration site 4    wingless-type MMTV integration site family, member 4  Name updated 1299863 APPROVED
2002-08-07 Wnt4  wingless-type MMTV integration site family, member 4      Symbol and Name status set to provisional 70820 PROVISIONAL