WNT4 (Wnt family member 4) - Rat Genome Database

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Gene: WNT4 (Wnt family member 4) Canis lupus familiaris
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Symbol: WNT4
Name: Wnt family member 4
RGD ID: 12189742
Description: ENCODES a protein that exhibits frizzled binding (ortholog); receptor ligand activity (ortholog); transcription corepressor activity (ortholog); INVOLVED IN adrenal gland development (ortholog); anatomical structure development (ortholog); branching involved in ureteric bud morphogenesis (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH 46,XX Sex Reversal with Dysgenesis of Kidneys, Adrenals, and Lungs (ortholog); acute kidney failure (ortholog); Dwarfism (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); extracellular matrix (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: protein Wnt-4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1277,112,045 - 77,129,702 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl277,101,300 - 77,127,111 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha273,605,854 - 73,632,899 (+)NCBI
ROS_Cfam_1.0277,660,017 - 77,687,063 (+)NCBI
UMICH_Zoey_3.1274,480,520 - 74,507,565 (+)NCBI
UNSW_CanFamBas_1.0275,489,331 - 75,516,389 (+)NCBI
UU_Cfam_GSD_1.0276,493,182 - 76,520,234 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
anatomical structure development  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
branching morphogenesis of an epithelial tube  (ISO)
canonical Wnt signaling pathway  (ISO)
cell differentiation  (ISO)
cell fate commitment  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to hydrostatic pressure  (ISO)
cellular response to starvation  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
embryonic epithelial tube formation  (ISO)
epithelial to mesenchymal transition  (ISO)
female gonad development  (ISO)
female sex determination  (ISO)
gamete generation  (ISO)
hormone metabolic process  (ISO)
immature T cell proliferation in thymus  (ISO)
kidney development  (ISO)
kidney morphogenesis  (ISO)
liver development  (ISO)
male gonad development  (ISO)
mammary gland epithelium development  (ISO)
mesenchymal to epithelial transition  (ISO)
mesonephric tubule development  (ISO)
mesonephros development  (ISO)
metanephric nephron development  (ISO)
metanephric nephron morphogenesis  (ISO)
metanephric tubule formation  (ISO)
metanephros development  (ISO)
negative regulation of androgen biosynthetic process  (ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of cell differentiation  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of fibroblast growth factor receptor signaling pathway  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of male gonad development  (ISO)
negative regulation of steroid biosynthetic process  (ISO)
negative regulation of testicular blood vessel morphogenesis  (ISO)
negative regulation of testosterone biosynthetic process  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
negative regulation of wound healing  (ISO)
nephron development  (ISO)
non-canonical Wnt signaling pathway  (ISO)
non-canonical Wnt signaling pathway via MAPK cascade  (ISO)
oocyte development  (ISO)
paramesonephric duct development  (ISO)
positive regulation of aldosterone biosynthetic process  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of cortisol biosynthetic process  (ISO)
positive regulation of dermatome development  (ISO)
positive regulation of focal adhesion assembly  (ISO)
positive regulation of GTPase activity  (ISO)
positive regulation of meiotic nuclear division  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
regulation of cell-cell adhesion  (ISO)
renal vesicle formation  (ISO)
renal vesicle induction  (ISO)
response to estradiol  (ISO)
sex differentiation  (ISO)
smooth muscle cell differentiation  (ISO)
somatotropin secreting cell differentiation  (ISO)
T cell differentiation in thymus  (ISO)
tertiary branching involved in mammary gland duct morphogenesis  (ISO)
thyroid-stimulating hormone-secreting cell differentiation  (ISO)
tube morphogenesis  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:28365713  


Genomics

Comparative Map Data
WNT4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1277,112,045 - 77,129,702 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl277,101,300 - 77,127,111 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha273,605,854 - 73,632,899 (+)NCBI
ROS_Cfam_1.0277,660,017 - 77,687,063 (+)NCBI
UMICH_Zoey_3.1274,480,520 - 74,507,565 (+)NCBI
UNSW_CanFamBas_1.0275,489,331 - 75,516,389 (+)NCBI
UU_Cfam_GSD_1.0276,493,182 - 76,520,234 (+)NCBI
WNT4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl122,117,313 - 22,143,969 (-)EnsemblGRCh38hg38GRCh38
GRCh38122,117,308 - 22,143,981 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37122,443,806 - 22,469,590 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36122,316,385 - 22,342,106 (-)NCBINCBI36hg18NCBI36
Build 34122,191,504 - 22,214,916NCBI
Celera120,766,732 - 20,792,452 (-)NCBI
Cytogenetic Map1p36.12NCBI
HuRef120,687,456 - 20,707,677 (-)NCBIHuRef
CHM1_1122,556,295 - 22,576,527 (-)NCBICHM1_1
Wnt4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394137,004,946 - 137,026,812 (+)NCBIGRCm39mm39
GRCm39 Ensembl4137,004,800 - 137,027,037 (+)Ensembl
GRCm384137,277,635 - 137,299,501 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4137,277,489 - 137,299,726 (+)EnsemblGRCm38mm10GRCm38
MGSCv374136,833,550 - 136,852,694 (+)NCBIGRCm37mm9NCBIm37
MGSCv364136,549,711 - 136,568,855 (+)NCBImm8
Celera4135,495,983 - 135,515,320 (+)NCBICelera
Cytogenetic Map4D3NCBI
Wnt4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25149,513,573 - 149,535,415 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl5149,514,018 - 149,532,859 (+)Ensembl
Rnor_6.05155,649,238 - 155,668,065 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5155,649,217 - 155,672,579 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05159,405,855 - 159,424,682 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45156,064,371 - 156,083,198 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15156,074,409 - 156,093,237 (+)NCBI
Celera5147,911,190 - 147,930,012 (+)NCBICelera
Cytogenetic Map5q36NCBI
Wnt4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554522,319,446 - 2,344,989 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554522,319,446 - 2,344,740 (-)NCBIChiLan1.0ChiLan1.0
WNT4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1122,252,344 - 22,264,858 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl122,255,056 - 22,268,801 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0121,310,228 - 21,335,985 (-)NCBIMhudiblu_PPA_v0panPan3
Wnt4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505841,798,680 - 41,823,413 (-)NCBI
SpeTri2.0NW_0049364747,623,462 - 7,635,416 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1680,110,238 - 80,138,165 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2674,137,827 - 74,165,540 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNT4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120110,517,391 - 110,543,802 (+)NCBI
ChlSab1.1 Ensembl20110,517,564 - 110,541,203 (+)Ensembl
Vero_WHO_p1.0NW_0236660335,754,333 - 5,781,060 (-)NCBI
Wnt4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247646,913,027 - 6,934,650 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 5 4 1
Low 3 15 6 6 2 6 12 2 7 4
Below cutoff 5 2 6 6 3 1

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005617834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038463310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038463311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038470809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038470810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038531672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038531673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038595904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038595905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038659982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038659983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_850097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000023308   ⟹   ENSCAFP00000021644
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl277,101,300 - 77,127,111 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000084923   ⟹   ENSCAFP00000050650
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl277,123,999 - 77,127,111 (+)Ensembl
RefSeq Acc Id: XM_005617834   ⟹   XP_005617891
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1277,112,045 - 77,129,702 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038463310   ⟹   XP_038319238
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha273,605,854 - 73,632,899 (+)NCBI
RefSeq Acc Id: XM_038463311   ⟹   XP_038319239
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha273,605,854 - 73,632,899 (+)NCBI
RefSeq Acc Id: XM_038470809   ⟹   XP_038326737
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1274,480,520 - 74,507,565 (+)NCBI
RefSeq Acc Id: XM_038470810   ⟹   XP_038326738
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1274,480,520 - 74,507,565 (+)NCBI
RefSeq Acc Id: XM_038531672   ⟹   XP_038387600
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0276,493,182 - 76,520,234 (+)NCBI
RefSeq Acc Id: XM_038531673   ⟹   XP_038387601
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0276,493,182 - 76,520,234 (+)NCBI
RefSeq Acc Id: XM_038595904   ⟹   XP_038451832
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0275,489,331 - 75,516,389 (+)NCBI
RefSeq Acc Id: XM_038595905   ⟹   XP_038451833
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0275,489,331 - 75,516,389 (+)NCBI
RefSeq Acc Id: XM_038659982   ⟹   XP_038515910
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0277,660,017 - 77,687,063 (+)NCBI
RefSeq Acc Id: XM_038659983   ⟹   XP_038515911
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0277,660,017 - 77,687,063 (+)NCBI
RefSeq Acc Id: XM_850097   ⟹   XP_855190
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1277,112,050 - 77,129,702 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005617891   ⟸   XM_005617834
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_855190   ⟸   XM_850097
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCAFP00000050650   ⟸   ENSCAFT00000084923
RefSeq Acc Id: ENSCAFP00000021644   ⟸   ENSCAFT00000023308
RefSeq Acc Id: XP_038326737   ⟸   XM_038470809
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038326738   ⟸   XM_038470810
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038451832   ⟸   XM_038595904
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038451833   ⟸   XM_038595905
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038515910   ⟸   XM_038659982
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038515911   ⟸   XM_038659983
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038319238   ⟸   XM_038463310
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038319239   ⟸   XM_038463311
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038387600   ⟸   XM_038531672
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038387601   ⟸   XM_038531673
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014661 Ensembl, ENTREZGENE
NCBI Gene WNT4 ENTREZGENE
VGNC ID VGNC:48424 ENTREZGENE